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Browsing Theses and Dissertations (Pharmacology) by Title
Now showing items 1-20 of 100
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(University of Pretoria, 2018)Introduction: Diabetes mellitus is considered one of the four major non-communicable disease with the global prevalence of this disease nearly doubling over the past 40 years, making it one of the leading causes of morbidity ...
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(University of Pretoria, 2018)Numerous publications outlining the quantitative determination and semi-quantitative screening for both parent and metabolites of the natural plant derived cannabinoids have been reviewed due to the widespread use and abuse ...
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(University of Pretoria, 2013)Signal transducer and activator of transcription (STAT) is a family of intracellular proteins that are responsible for carrying the signal from the cell surface to the nucleus in response to specific ligands. Once in the ...
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(University of Pretoria, 2006-03-13)Phytosterols and their glucosides (sterolins) have many therapeutic indications e.g. immune modulation, hypercholesterolaemia and benign prostatic hyperplasia (BPH). In this study sterolslsterolins in three BPH phytotherapeutics ...
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(University of Pretoria, 2008-08-12)Since the introduction of Auranofin in 1985 there has been no new clinically approved gold containing drugs introduced. Although promising results were achieved with a gold(I) phosphine complex [Au(dppe) 2]Cl (Hoke et al., ...
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(University of Pretoria, 2011-07-14)3-[3-(7-chloro-quinolin-4-yl amino) phenyl]-1-(4-methoxy-phenyl) prop-2-enone citrate “CITme” is a substituted quinoline derivative, synthesized as a potential antitumour agent. The aim of this study was to investigate ...
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(University of Pretoria, 2015)Resident skin flora are usually non-pathogenic and prevent colonization of harmful microbes by competing for nutrients and stimulation of the immune system. However, these resident microbes can enter the bloodstream ...
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(University of Pretoria, 2020-07-31)Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality. It is particularly prevalent in people in sub-Saharan Africa, ...
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(University of Pretoria, 2019)Introduction: Pharmacokinetic variability in response to pharmacotherapy contribute to adverse drug reactions, drug-drug interaction and therapeutic failure seen in clinical practice. Poor therapeutic response to medication ...
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(University of Pretoria, 2020-08)Dressings enhancing wound healing can improve the outcome of wounds where tissue replacement is required, like for burns and ulcers. Treatment of these wounds is complex due to their depth and excessive tissue loss. ...
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(University of Pretoria, 2023-08)Alzheimer’s disease (AD) is the predominant form of dementia which primarily affects the elderly. To date the aetiology of AD has not been fully elucidated, though may include: loss of cholinergic transmission; excessive ...
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(University of Pretoria, 2023)Introduction: The inclusion of a patient information leaflet (PIL) in medicine packaging is a legal requirement in most countries and ensures the patient has the latest product information. The advancement in technology ...
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(University of Pretoria, 2018)Plasmodium falciparum is the causative agent of the most commonly fatal form of malaria in Africa with annual deaths of more than 300 000. The rapid development and spread of antimalarial drug resistance by the parasite ...
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(University of Pretoria, 2017)Parkinson’s disease (PD) is an incurable, progressive disease characterised by loss of dopaminergic neurons in the substantia nigra of the brain. The main cause of dopaminergic neuron loss is attributed to oxidative ...
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(University of Pretoria, 2008-06-02)Combretaceae contain several species with bioactive properties - especially the genera Combretum and Terminalia. Pteleopsis myrtifolia and Quisqualis littorea belong to this family and have not previously been thoroughly ...
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(University of Pretoria, 2011-07-14)Bacterial infections remain a significant threat to human health. Due to the emergence of widespread antibiotic resistance, development of novel antibiotics is required in order to ensure that effective treatment remains ...
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(University of Pretoria, 2013)Introduction: Chronic wounds are a great burden to care-givers and patients alike and are the main cause of many preventable amputations. Such wounds are treated with wound dressings but providing a wound environment that ...
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(University of Pretoria, 2015)The most severe form of malaria in humans is caused by the intracellular parasite Plasmodium falciparum. The African continent bears the greatest burden of malaria with 90% of all malaria deaths occurring in sub-Saharan ...
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(University of Pretoria, 2017)Plasmodium falciparum is a protozoan parasite responsible for causing the most severe form of malaria in humans. This species is responsible for over 90% of malaria mortalities which occur predominantly in Africa. An ...
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(University of Pretoria, 2023)Drug-induced hepatotoxicity is a major contributor towards post-marketed drug withdrawals. Most of these liver injuries can be associated with drug metabolism, which is primarily performed by hepatic cytochrome P450 enzymes, ...
Now showing items 1-20 of 100