• Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease 

  Maboko, Lerato Mamabote (University of Pretoria, 2023-08)

  Alzheimer’s disease (AD) is the predominant form of dementia which primarily affects the elderly. To date the aetiology of AD has not been fully elucidated, though may include: loss of cholinergic transmission; excessive ...
• Characterising select hepatocyte cultures for improved hepatotoxicity testing 

  Mashaba, Clement Vutivi (University of Pretoria, 2023)

  Drug-induced hepatotoxicity is a major contributor towards post-marketed drug withdrawals. Most of these liver injuries can be associated with drug metabolism, which is primarily performed by hepatic cytochrome P450 enzymes, ...
• Assessing the feasibility of quick response codes for patient information delivery in the Tshwane district 

  Singh, Githa (University of Pretoria, 2023)

  Introduction: The inclusion of a patient information leaflet (PIL) in medicine packaging is a legal requirement in most countries and ensures the patient has the latest product information. The advancement in technology ...
• Effect of glioblastoma cells on brain endothelial cell growth, migration, permeability, and tight junction proteins in vitro 

  Mokoena, Xolisile (University of Pretoria, 2023)

  Introduction: Invasion of cancer cells within the central nervous system (CNS) can impact the blood-brain barrier (BBB) directly through cell invasion or indirectly through the cancer secretome. The BBB, formed mainly by ...
• Investigation of non-prostatic in vitro prostate-specific membrane antigen expression in MCF-7 and MDA-MB-231 breast tumour cells 

  Tshabalala, Malvin Thabani (University of Pretoria, 2020)

  Introduction Breast and prostate cancer mutually represent the most commonly occurring malignancies worldwide in women and men, respectively. The mutative state, recurrence capacity, resistance to conventional chemotherapy, ...
• Mechanisms facilitating uptake of carboxyl-polyethylene glycol-functionalised gold nanoparticles into multicellular spheroids 

  Fobian, Seth-Frerich (University of Pretoria, 2021)

  The drug discovery pipeline is hindered by confounding and non-representative in vitro cellular models. Traditionally, monolayer cell cultures have been used to evaluate drug toxicity and efficacy; however, are not ...
• Prevalence of SLCO1B1 single nucleotide variations, and their association with statin intolerance in hypercholesterolaemic patients in Gauteng, South Africa 

  De Beer, René (University of Pretoria, 2020)

  Statins, the standard treatment for hypercholesterolaemia, have been associated with side effects, including statin intolerance. This study determined the prevalence of SLCO1B1 single nucleotide variations (SNVs) and ...
• Erythropoietin treatment in anaemic patients at the Nephrology Unit of the Steve Biko Academic Hospital - a retrospective, cross-sectional study 

  Kok, Elandre (University of Pretoria, 2020)

  Anaemia in chronic kidney disease (CKD) mostly results from a decrease in the production of erythropoietin (EPO) by the failing kidney. CKD progression requires treatment with erythropoiesis-stimulating agents and iron ...
• Assessing modified chitosan wound dressings to enhance wound healing in the porcine model 

  Khathide, Bongai (University of Pretoria, 2020-08)

  Dressings enhancing wound healing can improve the outcome of wounds where tissue replacement is required, like for burns and ulcers. Treatment of these wounds is complex due to their depth and excessive tissue loss. ...
• Assessing cardiotonic steroids involvement in hypertensive rat models with Helicobacter pylori infections 

  Masso, Zelie Flavienne (University of Pretoria, 2020-07-31)

  Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality. It is particularly prevalent in people in sub-Saharan Africa, ...
• Prescription patterns and drug duplication in specialist outpatient clinics at a tertiary hospital in the greater Tshwane metropolitan area 

  Ncube, Musawenkosi Genius (University of Pretoria, 2020)

  Background: Tertiary hospitals have multiple specialist outpatient clinics attended by patients suffering from various comorbid diseases. This results in individuals attending more than one clinic per month, since dedicated ...
• Assessing inter-method agreement of drug-based phenotyping metrics between dried blood spot and plasma sampling 

  Leuschner, Machel (University of Pretoria, 2019)

  Introduction: Pharmacokinetic variability in response to pharmacotherapy contribute to adverse drug reactions, drug-drug interaction and therapeutic failure seen in clinical practice. Poor therapeutic response to medication ...
• Identification of single nucleotide polymorphisms in inflammatory bowel disease patients on azathioprine therapy 

  Adam, Lyla (University of Pretoria, 2019)

  Azathioprine, an immunosuppressant used for many years in the medical sector to maintain long term disease remission in inflammatory bowel disease has a side effect profile that has raised many concerns over the years with ...
• Comparison of metabalome attenuation in monolayer and three dimensional hepatocyte cultures 

  De Koker, Gerben (University of Pretoria, 2019)

  Introduction: Drugs have been removed from the market for years due to toxicity screening. The highest attrition from the market can be seen by drugs that cause hepatotoxicity. Most drugs are metabolised by phase I cytochrome ...
• Identification of mycolic acid class ratios from Mycobacterium species using liquid chromatography-mass spectrometry 

  Naicker, Brendon (University of Pretoria, 2019)

  Alongside the recent technology advancements in liquid chromatography (LC) and mass spectrometry (MS) instrumentation there has also been steady progress made with respect to the systematic lipidomic studies of Mycobacterium ...
• Mass spectrometric proteomic profiling of acute wound healing processes in the porcine model 

  Sheva, Kim Lisa (University of Pretoria, 2019)

  Wounds are a common occurrence and generally heal well within a short time depending on whether tissue needs to be replaced or not. Although there is an understanding of the physiological processes taking place during wound ...
• Spatial characterization of the BT-20 triple negative breast cancer spheroidal model 

  Ncube, Keith Ntokozo (University of Pretoria, 2019)

  Breast cancer is a commonly diagnosed cancer in women, with increasing diagnosis and mortality rates. The triple-negative sub-type of the disease is characterised by lack of hormone-receptor overexpression, exhibition of ...
• The effect of three Ghanaian plants on fibroblast migration, inflammation and bacterial growth in vitro 

  Yahaya, Ewura Seidu (University of Pretoria, 2018)

  Medical conditions which cause morbidity and mortality, such as chronic wounds and infection, lead to significant medical costs. Much of the world's population is dependent on alternative medicine, of which herbal medicine ...
• The combined effects or arsenic cadmium and mercury on hepatocarcinoma and neuroblastoma cells in vitro 

  Yousaf, Muhammad (University of Pretoria, 2018)

  Among several heavy metallic elements, arsenic, cadmium and mercury are most toxic in the environment. These metals are acquired by humans through food and water, which result in severe health related issues. One of the ...
• Comparative analysis of a two-dimensional and three-dimensional model of BT-20 triple negative breast carcinoma cells in response to an antiproliferative agent 

  Wang, Jie (University of Pretoria, 2018)

  Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor-alpha, progesterone receptor and human epidermal growth factor receptor 2 (HER2). The lack of dependence on estrogen by TNBC cells makes ...

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