Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

Scriba, Thomas Jens; Treurnicht, Florette K.; Zeier, Michelle D.; Engelbrecht, Susan; Janse van Rensburg, Estrelita

UPSpace Home
→
Health Sciences
→
Medical Virology
→
Estrelita Janse van Rensburg Collection
→
Media & Communication (Estrelita Janse van Rensburg)
→
View Item

dc.contributor.author	Scriba, Thomas Jens
dc.contributor.author	Treurnicht, Florette K.
dc.contributor.author	Zeier, Michelle D.
dc.contributor.author	Engelbrecht, Susan
dc.contributor.author	Janse van Rensburg, Estrelita
dc.date.accessioned	2007-07-31T09:55:38Z
dc.date.available	2007-07-31T09:55:38Z
dc.date.issued	2001-05
dc.description	The publisher does not allow open access to the full text of this sequence note. If you however need access to the full text, please contact the Collection Administrator, or access the item via the e-journal collection.	en
dc.description.abstract	To acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.	en
dc.description.sponsorship	This work was supported by grants from the South African AIDS Vaccine Initiative and the Poliomyelitis Research Foundation	en
dc.format.extent	406732 bytes
dc.format.mimetype	application/pdf
dc.identifier.citation	Scriba, TJ, Treurnicht, FK, Zeier, M, Engelbrecht, S & Janse van Rensburg, E 2001,'Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes', Aids Research and Human Retroviruses, vol. 17, no. 6, pp. 775-781. [http://www.liebertonline.com/aid?]	en
dc.identifier.issn	0889-2229
dc.identifier.other	10.1089/088922201750237059
dc.identifier.uri	http://hdl.handle.net/2263/3218
dc.language.iso	en	en
dc.publisher	Mary Ann Liebert	en
dc.rights	Mary Ann Liebert.	en
dc.subject	HIV-1	en
dc.subject.lcsh	HIV (Viruses) -- Genetic aspects
dc.subject.lcsh	HIV (Viruses) -- Research -- South Africa
dc.subject.lcsh	AIDS vaccines -- South Africa
dc.title	Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes	en
dc.type	Text	en