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dc.contributor.author | Holtzhausen, W.D. (Wendy Dianne)![]() |
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dc.contributor.author | Nicolson, Sue W.![]() |
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dc.date.accessioned | 2007-07-17T06:23:01Z | |
dc.date.available | 2007-07-17T06:23:01Z | |
dc.date.issued | 2007-04 | |
dc.description.abstract | This paper reports the effects of different diuretic factors on the Malpighian tubules of beetles. Calcitonin (CT)-like peptides from silkmoth and mosquito increase fluid secretion in a dose-dependent manner in the tubules of Tenebrio molitor, but the cockroach CT-like peptide, Dippu-DH31, has no effect. Thapsigargin induces a small but significant increase in tubule secretion rates. The interactions between different factors in mealworm tubules were explored by testing CT-like peptides, thapsigargin and the mealworm CRF-related diuretic factor Tenmo-DH37 in various combinations, but no synergistic effects were observed. C-terminal fragments of the CRF-related diuretic peptides Locmi-DH46 and Dippu-DH46 fail to increase fluid secretion in mealworm tubules, unlike their corresponding whole peptides. Cross-reactivity of factors between beetle species was investigated using the scarabaeid Onthophagus gazella. Tenmo-DH37 increases fluid secretion in isolated tubules of O. gazella in a dose-dependent manner, revealing a high degree of cross-reactivity in this distantly related beetle species. However, homogenates of O. gazella brains inhibited fluid secretion in mealworm tubules. | en |
dc.format.extent | 402117 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | Holtshausen, WD & Nicolson, SW 2007, ‘Beetle diuretic peptides: The response of mealworm (Tenebrio molitor) Malpighian tubules to synthetic peptides, and cross-reactivity studies with a dung beetle’, Journal of Insect Physiology, vol.53, issue 4, pp. 361-369.[http://www.sciencedirect.com/science/journal/00221910] | en |
dc.identifier.issn | 0022-1910 | |
dc.identifier.other | 10.1016/j.jinsphys.2006.12.010 | |
dc.identifier.uri | http://hdl.handle.net/2263/3050 | |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.rights | Elsevier | en |
dc.subject | CRF-related peptides | en |
dc.subject | Calcitonin-like peptides | en |
dc.subject | Fluid secretion | en |
dc.subject | Coleoptera | en |
dc.subject.lcsh | Malpighian vessels | |
dc.subject.lcsh | Beetles | |
dc.subject.lcsh | Diuretics | |
dc.subject.lcsh | Peptides | |
dc.subject.lcsh | Meal worms | |
dc.subject.lcsh | Dung beetles | |
dc.title | Beetle diuretic peptides : the response of mealworm (Tenebrio molitor) Malpighian tubules to synthetic peptides, and cross-reactivity studies with a dung beetle (Onthophagus gazella) | en |
dc.type | Postprint Article | en |