Beetle diuretic peptides : the response of mealworm (Tenebrio molitor) Malpighian tubules to synthetic peptides, and cross-reactivity studies with a dung beetle (Onthophagus gazella)

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dc.contributor.author Holtzhausen, W.D. (Wendy Dianne)
dc.contributor.author Nicolson, Sue W.
dc.date.accessioned 2007-07-17T06:23:01Z
dc.date.available 2007-07-17T06:23:01Z
dc.date.issued 2007-04
dc.description.abstract This paper reports the effects of different diuretic factors on the Malpighian tubules of beetles. Calcitonin (CT)-like peptides from silkmoth and mosquito increase fluid secretion in a dose-dependent manner in the tubules of Tenebrio molitor, but the cockroach CT-like peptide, Dippu-DH31, has no effect. Thapsigargin induces a small but significant increase in tubule secretion rates. The interactions between different factors in mealworm tubules were explored by testing CT-like peptides, thapsigargin and the mealworm CRF-related diuretic factor Tenmo-DH37 in various combinations, but no synergistic effects were observed. C-terminal fragments of the CRF-related diuretic peptides Locmi-DH46 and Dippu-DH46 fail to increase fluid secretion in mealworm tubules, unlike their corresponding whole peptides. Cross-reactivity of factors between beetle species was investigated using the scarabaeid Onthophagus gazella. Tenmo-DH37 increases fluid secretion in isolated tubules of O. gazella in a dose-dependent manner, revealing a high degree of cross-reactivity in this distantly related beetle species. However, homogenates of O. gazella brains inhibited fluid secretion in mealworm tubules. en
dc.format.extent 402117 bytes
dc.format.mimetype application/pdf
dc.identifier.citation Holtshausen, WD & Nicolson, SW 2007, ‘Beetle diuretic peptides: The response of mealworm (Tenebrio molitor) Malpighian tubules to synthetic peptides, and cross-reactivity studies with a dung beetle’, Journal of Insect Physiology, vol.53, issue 4, pp. 361-369.[http://www.sciencedirect.com/science/journal/00221910] en
dc.identifier.issn 0022-1910
dc.identifier.other 10.1016/j.jinsphys.2006.12.010
dc.identifier.uri http://hdl.handle.net/2263/3050
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject CRF-related peptides en
dc.subject Calcitonin-like peptides en
dc.subject Fluid secretion en
dc.subject Coleoptera en
dc.subject.lcsh Malpighian vessels
dc.subject.lcsh Beetles
dc.subject.lcsh Diuretics
dc.subject.lcsh Peptides
dc.subject.lcsh Meal worms
dc.subject.lcsh Dung beetles
dc.title Beetle diuretic peptides : the response of mealworm (Tenebrio molitor) Malpighian tubules to synthetic peptides, and cross-reactivity studies with a dung beetle (Onthophagus gazella) en
dc.type Postprint Article en


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