Recently added

Research Articles (Pharmacology): Recent submissions

  • Ivermectin in the treatment of COVID-19-friend or foe? 
    Schellack, Natalie; Padayachee, N.; Schellac, G. (Medpharm publications, 2021-03-10)
    The global number of deaths due to COVID-19 is almost at the two million mark, with over 35 000 deaths in South Africa. Although there are hopes of a safe and effective vaccination programme, the increasing number of ...
  • Wounds : an overlooked burden (Part 3) - Chronic wounds : a conundrum of complications 
    Parkar, Hafiza; Mlambo, Shamiso Shelter; Naude, L.; Strydom, H.; Naahid, N.; Cromarty, Allan Duncan (Medpharm publications, 2021-05-06)
    Wound healing is a complex process which may be hindered by a range of interfering factors, especially in patients with underlying pathologies. This results in the formation of chronic, non-healing wounds which subject ...
  • Focus on azithromycin 
    Padayachee, N.; Milne, M; Schellack, Natalie (MedPharm Publications, 2021)
    Azithromycin is a second-generation macrolide that was developed in the early 1980s as a semi-synthetic derivative of erythromycin. This broad-spectrum antibiotic is known for its activity against some Gram-negative organisms ...
  • An overview of central nervous system tumours 
    Flepisi, Brian Thabile; Balmith, Marissa (Ital Publication, 2021-12)
    Central nervous system (CNS) tumours refer to tumours that occur in the tissues of the brain and/or spinal cord. These tumours arise as a result of abnormal growth of cells and may begin in different parts of the brain or ...
  • An appraisal of the regulatory policies governing the use of herbal traditional medicine 
    Netzer, Keren; Balmith, Marissa; Flepisi, Brian Thabile (TMR, 2021-10-26)
    The regulation of herbal traditional medicine (HTM) is of much importance as it ensures the safety, quality and efficacy thereof. However, there are variations in the regulation of HTM worldwide with some countries being ...
  • International train the trainer neonatal antibiotic stewardship program for South African pharmacists 
    Goff, Debra A.; Prusakov, Pavel; Mangino, Julie E.; Sanchez, Pablo J.; Nwomeh, Benedict; Messina, Angeliki P.; Schellack, Natalie; Annor, Ama S.; Cassim, Azraa; Kolman, Sonya; Van Tonder, Lindie; Mawela, Dini; Velaphi, Sithembiso C.; Chirwa, Pinky Lea; Van den Bergh, Dena (Wiley, 2021-12)
    Hospital-acquired antimicrobial-resistant infections are a leading cause of neonatal mortality in South African (SA) neonatal intensive care units (NICU). There is an urgent need for NICU Antibiotic Stewardship Programs ...
  • Driving antibiotic stewardship awareness through the minibus-taxi community across the Tshwane District, South Africa 
    Mokoena, Tumelo T.W.; Schellack, Natalie; Brink, Adrian J. (Oxford University Press, 2021)
    BACKGROUND : The minibus-taxi community plays an integral role within society, and for years this community has been neglected. Of late, studies on minibus-taxi operators’ health and their perceptions of HIV have emerged. ...
  • Challenges and innovations brought about by the COVID-19 pandemic regarding medical and pharmacy education especially in Africa and implications for the future 
    Etando, Ayukafangha; Amu, Adefolarin A.; Haque, Mainul; Schellack, Natalie; Kurdi, Amanj; Alrasheedy, Alian A.; Timoney, Angela; Mwita, Julius; Rwegerera, Godfrey Mutashambara; Patrick, Okwen; Niba, Loveline Lum; Boahen-Boaten, Baffour Boaten; Tabi, Felicity Besong; Amu, Olufunke Y.; Acolatse, Joseph; Incoom, Robert; Sefah, Israel Abebrese; Guantai, Anastasia Nkatha; Opanga, Sylvia; Chikowe, Ibrahim; Khuluza, Felix; Kibuule, Dan; Kalemeera, Francis; Hango, Ester; Lates, Jennie; Fadare, Joseph; Ogunleye, Olayinka O.; Saleem, Zikria; Oosthuizen, Frasia; Cordier, Werner; Matlala, Moliehi; Meyer, Johanna C.; Schellack, Gustav; Massele, Amos; Malande, Oliver Ombeva; Kalungia, Aubrey Chichonyi; Sichone, James; Banda, Sekelani S.; Zaranyika, Trust; Campbell, Stephen; Godman, Brian (MDPI, 2021-12-13)
    BACKGROUND : Multiple measures introduced early to restrict COVID-19 have dramatically impacted the teaching of medical and pharmacy students, exacerbated by the lack of infrastructure and experience with e-learning at ...
  • The use of nonsteroidal anti-inflammatory drugs by COVID-19 patients – in a nutshell 
    Flepisi, Brian Thabile; Schellack, Natalie (Medpharm Publications, 2021-06)
    Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a large scale of morbidities and mortalities worldwide, posing a significant threat to global health. ...
  • Irritant contact dermatitis during COVID-19 : preventing the virus while keeping the itch at bay 
    Cordier, Werner (Medpharm Publications, 2021-08)
    Hand hygiene practices have been bolstered during the COVID-19 pandemic to curb the spread of SARS-CoV-2. Unfortunately, such prevention strategies come with a risk of excessive physical damage to the skin and exposure ...
  • Enoxaparin 
    Padayachee, N.; Schoeman, N.; Schellack, Natalie (Medpharm Publications, 2021-05)
    The development of low-molecular and ultra-low-molecular weight heparins has changed anticoagulation treatment options. Enoxaparin is a low-molecular weight heparin (LMWH), which works on Factor Xa and is indicated for ...
  • A 2021 update : approach to asthma management in adults 
    Schellack, Natalie; Truter, A.; Ntuli, P.N.; Mokwele, N.; Mogale, K.; Esterhuizen, A. (Medpharm Publications, 2021-08)
    Asthma is a chronic inflammatory disease that causes hyper-responsiveness of the bronchial tree, with reversible airflow obstruction. The condition places a significant burden on our healthcare system. Chronic asthma can ...
  • β-cell-specific deletion of PFKFB3 restores cell fitness competition and physiological replication under diabetogenic stress 
    Min, Jie; Ma, Feiyang; Seyran, Berfin; Pellegrini, Matteo; Greeff, O.B.W. (Oppel Bernhardt Wilhelm); Moncada, Salvador; Tudzarova, Slavica (Nature Research, 2022-03-22)
    HIF1α and PFKFB3 play a critical role in the survival of damaged β-cells in type–2 diabetes while rendering β-cells non-responsive to glucose stimulation. To discriminate the role of PFKFB3 from HIF1α in vivo, we generated ...
  • Editorial : Translational research and drug repurposing for non-communicable diseases (NCDs) 
    Akindele, Abidemi J.; Fatokun, Amos A.; Uzochukwu, Ikemefuna C.; Steenkamp, Vanessa; Agyare, Christian; Familoni, Oluwole; James, Margaret O. (Frontiers Media S.A., 2022-03-21)
    No abstract available.
  • Management of children admitted to hospitals across Bangladesh with suspected or confirmed COVID-19 and the implications for the future : a nationwide cross-sectional study 
    Chowdhury, Kona; Haque, Mainul; Nusrat, Nadia; Adnan, Nihad; Islam, Salequl; Lutfor, Afzalunnessa Binte; Begum, Dilara; Rabbany, Arif; Karim, Enamul; Malek, Abdul; Jahan, Nasim; Akter, Jesmine; Ashraf, Sumala; Hasan, Mohammad Nazmul; Hassan, Mahmuda; Akhter, Najnin; Mazumder, Monika; Sihan, Nazmus; Naher, Nurun; Akter, Shaheen; Zaman, Sifat Uz; Chowdhury, Tanjina; Nesa, Jebun; Biswas, Susmita; Islam, Mohammod Didarul; Hossain, Al Mamun; Rahman, Habibur; Biswas, Palash Kumar; Shaheen, Mohammed; Chowdhury, Farah; Kumar, Santosh; Kurdi, Amanj; Mustafa, Zia Ul; Schellack, Natalie; Gowere, Marshall; Meyer, Johanna C.; Opanga, Sylvia; Godman, Brian (MDPI, 2022-01)
    There is an increasing focus on researching children admitted to hospital with new variants of COVID-19, combined with concerns with hyperinflammatory syndromes and the overuse of antimicrobials. Paediatric guidelines have ...
  • Differential effects of normoxic versus hypoxic derived breast cancer paracrine factors on brain endothelial cells 
    Rado, Mariam; Flepisi, Brian Thabile; Fisher, David (MDPI, 2021-11-27)
    BACKGROUND : The blood-brain barrier (BBB) is a central nervous system protective barrier formed primarily of endothelial cells that regulate the entry of substances and cells from entering the brain. However, the BBB ...
  • The effect of normoxic and hypoxic U-87 glioblastoma paracrine secretion on the modulation of brain endothelial cells 
    Rado, Mariam; Flepisi, Brian Thabile; Fisher, David (MDPI, 2022-01-14)
    Please read abstract in the article.
  • Pilot study on the current management of children with COVID-19 In hospitals in Bangladesh : findings and implications 
    Nusrat, Nadia; Haque, Mainul; Chowdhury, Kona; Adnan, Nihad; Lutfor, Afzalunnessa Binte; Karim, Enamul; Hassan, Mahmuda; Rabbany, Arif; Begum, Dilara; Mohammad Nazmul Hasan; Sihan, Nazmus; Zaman, Sifat Uz; Islam, Salequl; Schellack, Natalie; Gowere, Marshall; Kurdi, Amanj; Godman, Brian (Bangladesh Academy of Sciences, 2021-09)
    OBJECTIVE : The focus on COVID-19 in children in low- and middle-income countries including Bangladesh has been on addressing key issues including poor vaccination rates as well as mental health issues, domestic violence ...
  • The response to COVID 19 across countries and the implications for future pandemics 
    Haque, Mainul; Gowere, Marshall; Nusrat, Nadia; Chowdhury, Kona; Godman, Brian (Bangladesh Academy of Sciences, 2021)
    No abstract available.
  • A national, multicentre, web-based point prevalence survey of antimicrobial use and quality indices among hospitalised paediatric patients across South Africa 
    Skosana, P.P.; Schellack, Natalie; Godman, Brian; Kurdi, A.; Bennie, M.; Kruger, D.; Meyer, J.C. (Elsevier, 2022-06)
    OBJECTIVES : Data on antimicrobial consumption among the paediatric population in public hospitals in South Africa are limited. This needs to be addressed to improve future antimicrobial use and reduce antimicrobial ...