• Insomnia : what is currently available 

  Marais, Andre; Osuch, Elzbieta (Medpharm Publications, 2023)

  Insomnia is an important public health burden and is the most ubiquitous sleep disorder in the general population, requiring accurate diagnosis and effective treatment. Sleep hygiene and cognitive behavioural therapy form ...
• Prevalence of chronic kidney disease and associated risk factors among people living with HIV in a rural population of Limpopo province, South Africa 

  Choshi, Joel; Flepisi, Brian Thabile; Mabhida, Sihle E.; Sekgala, Machoene Derrick; Mokoena, Haskly; Nkambule, Bongani B.; Ndwandwe, Duduzile; Mchiza, Zandile J.; Nqebelele, Unati; Kengne, Andre P.; Dludla, Phiwayinkosi V.; Hanser, Sidney (Frontiers Media, 2024-07)

  BACKGROUND: Limited evidence informs on the prevalence of chronic kidney disease (CKD) in people living with HIV (PLWH) in South Africa. Thus, this study aimed to determine the prevalence of CKD and its associated risk ...
• An evaluation of knowledge and perception of pharmacology in undergraduate oral hygiene students and recent graduates at a single higher institution in Pretoria 

  Balmith, Marissa; Cordier, Werner; Bhayat, Ahmed; Basson, Charlize; Morule, Mpho; Schellack, Natalie (Wiley, 2024-11)

  INTRODUCTION : Pharmacology is an increasingly important area of study for oral hygienists, as it provides the scientific basis for safe and effective oral healthcare. However, a lack of fundamental understanding of the ...
• Evolution of drug development and regulatory affairs: the demonstrated power of artificial intelligence 

  Nene, Linda; Flepisi, Brian Thabile; Brand, Sarel Jacobus; Basson, Charlize; Balmith, Marissa (Elsevier, 2024-08)

  PURPOSE : Artificial intelligence (AI) refers to technology capable of mimicking human cognitive functions and has important applications across all sectors and industries, including drug development. This has considerable ...
• Off-label and unlicenced medicine use among hospitalised children in South Africa : practice and policy implications 

  Mathevula, Hlayiseka; Schellack, Natalie; Orubu, Samuel; Godman, Brian; Matlala, Moliehi (MDPI, 2023-12)

  BACKGROUND : Information regarding off-label and unlicensed medicine use among South African children is limited. This is a concern as the prescribing of off-label and unlicensed medicines can lead to issues of effectiveness ...
• Bioanalytical method optimization for simultaneous quantification of structurally related probe drugs in a phenotyping cocktail using liquid chromatography-tandem mass spectrometry 

  Leuschner, Machel; Cromarty, Duncan (Wiley, 2024-03)

  The physicochemical diversity of the structurally related aromatic probe drugs, used together in a drug cocktail to assess metabolic and transport phenotypes, require optimized analytical procedures for simultaneous ...
• Potential strategies to limit inappropriate purchasing of antibiotics without a prescription in a rural province in South Africa : pilot study and the implications 

  Sono, Tiyani Milta; Maluleke, Morgan Tiyiselani; Jelić, Ana Golić; Campbell, Stephen; Markovic-Pekovic, Vanda; Schellack, Natalie; Kumar, Santosh; Godman, Brian; Meyer, Johanna Catharina (Medknow Publications, 2024-01)

  INTRODUCTION: There is considerable concern with rising rates of antimicrobial resistance (AMR) with its subsequent impact on morbidity, mortality and costs. In low- and middle-income countries, a key driver of AMR is the ...
• Challenges and success stories of the implementation of infection control and antimicrobial stewardship strategies : proceedings of the 5th Global Ministerial Summit on Patient Safety, 2023 

  Büchler, Andrea C.; Galas, Murielle Haddad; Buetti, Niccolò; Alp, Emine; Apisarnthanarak, Anucha; Dziekan, Gerald; Fabre, Valeria; Gottwalt, Simon; Jindai, Kazuaki; Ndoye, Babacar; Villareal, Hilda Márquez; Otaiza, Fernando; Pittet, Didier; Schellack, Natalie; Gardiol, Céline; Harbarth, Stephan (BMC, 2024-02)

  The 5th edition of the Global Ministerial Summit on Patient Safety was held in Montreux, Switzerland, in February 2023, delayed by three years due to the COVID-19 pandemic. The overarching theme of the summit was “Less Harm, ...
• The potential antidiabetic properties of green and purple tea [Camellia sinensis (L.) O Kuntze], purple tea ellagitannins, and urolithins 

  Tolmie, Morné; Bester, Megan Jean; Serem, June Cheptoo; Nell, Margo Judith; Apostolides, Zeno (Elsevier, 2023-06)

  ETHNOPHARMACOLOGICAL RELEVANCE : Tea (Camellia sinensis) has been consumed for centuries as traditional medicine for various diseases, including diabetes. The mechanism of action of many traditional medicines, including ...
• Cytostatic and cytotoxic effects of a hot water and methanol extract of Acokanthera oppositifolia in HepG2 hepatocarcinoma cells 

  Cordier, Werner; Steenkamp, Paul; Steenkamp, Vanessa (Elsevier, 2023-10)

  ETHNOPHARMACOLOGICAL RELEVANCE : Herb-induced liver injury is poorly described for African herbal remedies, such as Acokanthera oppositifolia. Although a commonly used treatment for pain, snake bites and anthrax, it is ...
• Prospective antimicrobial stewardship interventions by multidisciplinary teams to reduce neonatal antibiotic use in South Africa : the neonatal antimicrobial stewardship (NeoAMS) study 

  Dramowski, Angela; Prusakov, Pavel; Goff, Debra A.; Brink, Adrian; Govender, Nelesh; Annor, Ama Sakoa; Balfour, Liezl; Bekker, Adrie; Cassim, Azraa; Gijzelaar, Michelle; Holgate, Sandi L.; Kolman, Sonya; Messina, Angeliki; Tootla, Hafsah; Schellack, Natalie; Van Jaarsveld, Andriette; Reddy, Kessendri; Pillay, Shakti; Conradie, Lucinda; Van Niekerk, Anika M.; Bester, Tarina; Alexander, Pearl; Andrews, Antoinette; Dippenaar, Magdel; Bamford, Colleen; Brits, Sharnel; Chirwa, Pinky; Erasmus, Hannelie; Ekermans, Pieter; Gounden, Pebenita; Kriel, Teresa; Mawela, Dini; Moncho, Masego; Mphuthi, Tonia; Nhari, Ronald; Charani, Esmita; Sanchez, Pablo J.; Van den Bergh, Dena (Elsevier, 2024-09)

  BACKGROUND : Hospitalized neonates are vulnerable to infection and have high rates of antibiotic utilization. METHODS : Fourteen South African neonatal units (seven public, seven private sector) assembled multidisciplinary ...
• What to expect when being inspected : an overview of the processes involved in the inspecting of community pharmacies 

  Eksteen, M.; Maimin, J.; De Beer, N.; Padayachee, N.; Schellack, Natalie (Medpharm Publications, 2023)

  Pharmacy council inspectors play a crucial role in ensuring the quality, safety, and compliance of pharmacies with established regulations and standards. These inspectors are typically appointed by pharmacy regulatory ...
• Hypertension : back to basics 

  Ker, James A.; Outhoff, Kim (Medpharm Publications, 2023)

  This article outlines the principles of blood pressure, including normal and dysfunctional physiology, mathematical equations of pressure, definitions of hypertension and diagnosis, and hence the rationale for and mechanisms ...
• Current controversies on generic substitution in the transplant community 

  Leuschner, Machel; De Beer, N.; Schellack, Natalie (Medpharm Publications, 2023)

  For drugs with a narrow therapeutic index (NTI) like tacrolimus, small changes in dosage can lead to significant changes in blood levels, which can affect both the effectiveness of the drug and the risk of adverse effects. ...
• An overview of sore throat, strep throat and tonsilitis 

  Ncube, Keith Ntokozo; Nel, A. (Medpharm Publications, 2023)

  Pharyngitis and tonsilitis are common reasons why people seek medical care. These diseases are commonly caused by viral and bacterial infections, with group A β-haemolytic streptococcus being pharyngitis's most common ...
• Clinical recommendations for the use of Neurotropic B vitamins (B1, B6, and B12) for the management of peripheral neuropathy : consensus from a multidisciplinary expert panel 

  Pinzon, Rizaldy T.; Schellack, Natalie; Matawaran, Bien J.; Tsang, Man W.; Deerochanawong, Chaicharn; Hiew, Fu L.; Nafach, Jalal; Khadilkar, Satish (Association of Physicians of India, 2023-07)

  INTRODUCTION : Peripheral neuropathy (PN) is an insidious disease that is often asymptomatic during the early stages but which can have a significant impact on quality of life at later stages when nerve damage occurs. There ...
• Knowledge and perceptions of antimicrobial stewardship concepts among final year veterinary students in South Africa 

  Fick, Line; Crafford, Lucille; Schoeman, Johan P.; Schellack, Natalie (University of Toronto Press, 2024)

  Antimicrobial resistance (AMR) has become a major global public health crisis due to inappropriate use in humans, animals, and crops. Studies to assess the knowledge and perceptions of antimicrobial stewardship (AMS) ...
• Isolation and identification of the primary toxin in the smoke of the Namibian milk bush, Euphorbia damarana 

  Degashu, Mmankeko Petunia; Meyer, Jacobus Johannes Marion; Alberts, Paul S.F.; Meyer, Nicole L.; Blignaut, Monique; Makhaba, Masixole; Hussein, Ahmed A. (Elsevier, 2024-07)

  Please read abstract in the article.
• Current rates of purchasing of antibiotics without a prescription across sub-Saharan Africa; rationale and potential programmes to reduce inappropriate dispensing and resistance 

  Sono, Tiyani Milta; Yeika, Eugene; Cook, Aislinn; Kalungia, Aubrey Chichonyi; Opanga, Sylvia; Acolatse, Joseph Elikem Efui; Sefah, Israel; Jelić, Ana Golić; Campbell, Stephen; Lorenzetti, Giulia; Ul Mustafa, Zia; Marković-Peković, Vanda; Kurdi, Amanj; Anand Paramadhas, Bene D.; Rwegerera, Godfrey Mutashambara; Amu, Adefolarin A.; Alabi, Mobolaji Eniola; Wesangula, Evelyn; Oluka, Margaret; Khuluza, Felix; Chikowe, Ibrahim; Fadare, Joseph O.; Ogunleye, Olayinka O.; Kibuule, Dan; Hango, Ester; Schellack, Natalie; Ramdas, Nishana; Massele, Amos; Mudenda, Steward; Hoxha, Iris; Moore, Catrin E.; Godman, Brian; Meyer, Johanna C. (Taylor and Francis, 2023)

  INTRODUCTION : Antimicrobial resistance (AMR) is a global concern. Currently, the greatest mortality due to AMR is in Africa. A key driver continues to be high levels of dispensing of antibiotics without a prescription. AREAS ...
• International survey of antibiotic dosing and monitoring in adult intensive care units 

  Williams, Paul G.; Tabah, Alexis; Cotta, Menino Osbert; Sandaradura, Indy; Kanji, Salmaan; Scheetz, Marc H.; Imani, Sahand; Elhadi, Muhammed; Luque‑Pardos, Sonia; Schellack, Natalie; Sanches, Cristina; Timsit, Jean‑Francois; Xie, Jiao; Farkas, Andras; Wilks, Kathryn; Roberts, Jason A. (BMC, 2023-06-19)

  BACKGROUND : In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization ...

View more