BACKGROUND: Therapeutic drug monitoring (TDM) is an effective method for individualising antimicrobial therapy in critically ill patients. The 2021 ADMIN-intensive care unit survey studied a wide range
of intensive care ...
Mmakola, Khomotso Madimetsa Shelboy; Balmith, Marissa [; Steel, Helen C.; Said, Mohamed; Potjo, Moliehi; Van der Mescht, Mieke Adri; Hlatshwayo, Nomsa; Meyer, Pieter Willem Adriaan; Tintinger, Gregory Ronald; Anderson, Ronald; Cholo, Moloko C.(MDPI, 2024-12-04)
Multidrug-resistant tuberculosis (MDR-TB) patients are treated with a standardised, short
World Health Organization (WHO) regimen which includes clofazimine (CFZ) and bedaquiline
(BDQ) antibiotics. These two antibiotics ...
BACKGROUND : Dietitians ensure that patients receive tailored medical nutrition therapy to integrate with pharmacotherapy safely. Dietitians require a pharmacological understanding to prevent detrimental food-drug interactions ...
BACKGROUND : Glioblastoma (GBM) is an aggressive therapy-resistant brain tumour that may impacts the integrity of the blood–brain barrier (BBB). The BBB is a protective barrier of the central nervous system formed mainly ...
INTRODUCTION : Obesity is increasing worldwide. Due to the unavailability of affordable obesity drugs in most parts of Nigeria, many overweight and obese people rely on medicinal plants to manage obesity. Thus, the aim of ...
BACKGROUND : The inclusion of a patient information leaflet (PIL) in medicine packaging is a legal requirement in most countries.
OBJECTIVE : To evaluate the feasibility of using quick response (QR) codes for electronic ...
Ramdas, Nishana; Meyer, Johanna C.; Schellack, Natalie; Godman, Brian; Turawa, Eunice; Campbell, Stephen M.(MDPI, 2025-01)
BACKGROUND/OBJECTIVES : Antimicrobial resistance (AMR) is a major global health challenge, particularly in low- and middle-income countries (LMICs). Understanding the knowledge, attitudes, motivations, and expectations of ...
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization ...
INTRODUCTION: Snakebite envenomation has been declared a neglected tropical disease by the WHO since 2017. The disease is endemic in affected areas due to the lack of availability and access to antivenom, despite it being ...
BACKGROUND :
Osteogenic Bone Matrix (Altis™ OBM) is a tissue-engineered, porcine-derived demineralized bone matrix prepared using a humanization processing technology that confers biocompatibility and improved osteoinductivity. ...
The impact of activated c-Jun N-terminal kinase isoform JNK1 chemical pathways in insulin biosynthesis poses a potential health risk of glucose intolerance. Blocking the activity of JNK1 is a promising route for the design ...
Insomnia is an important public health burden and is the most ubiquitous sleep disorder in the general population, requiring accurate
diagnosis and effective treatment. Sleep hygiene and cognitive behavioural therapy form ...
BACKGROUND: Limited evidence informs on the prevalence of chronic kidney
disease (CKD) in people living with HIV (PLWH) in South Africa. Thus, this study
aimed to determine the prevalence of CKD and its associated risk ...
INTRODUCTION :
Pharmacology is an increasingly important area of study for oral hygienists, as it provides the scientific basis for safe and effective oral healthcare. However, a lack of fundamental understanding of the ...
PURPOSE :
Artificial intelligence (AI) refers to technology capable of mimicking human cognitive functions and has important applications across all sectors and industries, including drug development. This has considerable ...
BACKGROUND : Information regarding off-label and unlicensed medicine use among South African children is limited. This is a concern as the prescribing of off-label and unlicensed medicines can lead to issues of effectiveness ...
Leuschner, Machel; Cromarty, Allan Duncan(Wiley, 2024-03)
The physicochemical diversity of the structurally related aromatic probe drugs, used together in a drug cocktail to assess metabolic and transport phenotypes, require optimized analytical procedures for simultaneous ...
Sono, Tiyani Milta; Maluleke, Morgan Tiyiselani; Jelić, Ana Golić; Campbell, Stephen; Markovic-Pekovic, Vanda; Schellack, Natalie; Kumar, Santosh; Godman, Brian; Meyer, Johanna Catharina(Medknow Publications, 2024-01)
INTRODUCTION: There is considerable concern with rising rates of antimicrobial resistance (AMR) with its subsequent impact on morbidity, mortality and costs. In low- and middle-income countries, a key driver of AMR is the ...
The 5th edition of the Global Ministerial Summit on Patient Safety was held in Montreux, Switzerland, in February
2023, delayed by three years due to the COVID-19 pandemic. The overarching theme of the summit was “Less
Harm, ...