Browsing Research Articles (Neurology) by Type "Article"

Browsing Research Articles (Neurology) by Type "Article"

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  • Acute obstructive hydrocephalus in posterior reversible encephalopathy syndrome 
    Hiesgen, Juliane; Annor, T.N. (Health and Medical Publishing Group, 2023-01)
    Posterior reversible encephalopathy syndrome (PRES) is an uncommon, subacute neurological disorder that presents radiologically with a pattern of bilateral parieto-occipital areas of vasogenic oedema. Conditions commonly ...
  • Addressing the gap for racially diverse research involvement : the King's model for minority ethnic research participant recruitment 
    Chaudhuri, K.Ray; Podlewska, A.; Lau, Yue Hui; Gonde, C.; McIntosh, A.; Qamar, M.A.; O’Donoghue, S.; Larcombe, K.; Adeeko, M.; Gupta, A.; Bajwah, S.; Lafond, S.; Awogbemila, O.; Van Coller, Riaan; Murtagh, A.M.; Ocloo, J.E. (Elsevier, 2023-12)
    OBJECTIVES : Ethnic minorities (EM) are still underrepresented in research recruitment. Despite wide literature outlining the barriers, enablers and recommendations for driving inclusion and diversity in research, there ...
  • AIDS-related progressive multifocal leukoencephalopathy (PML) : a retrospective study from Pretoria, South Africa 
    Schutte, Clara-Maria; Ranchhod, N.; Kakaza, Mandisa; Pillay, M. (Health and Medical Publishing Group, 2013-06)
    INTRODUCTION AND OBJECTIVES: Progressive multifocal leukoencephalopathy (PML), caused by the John Cunningham (JC) virus, results from lytic infection of predominantly oligodendrocytes. Following the HIV pandemic, the ...
  • Analysis of HIV-related mortality data in a tertiary South African neurology unit, 2006 - 2012 
    Schutte, Clara-Maria (Health and Medical Publishing Group, 2013-11)
    BACKGROUND. South Africa (SA) has a high prevalence of HIV infection with almost 11% of the population aged >2 years living with HIV. At the Steve Biko Academic Hospital, Pretoria, the Neurology Department has seen a steady ...
  • Autoimmune encephalitis : epidemiology, pathophysiology and clinical spectrum (Part 1) 
    Hiesgen, Juliane; Schutte, Clara-Maria (South African Medical Association, 2023-03)
    Since the identification of anti-N-methyl-D-aspartate (NMDA) receptor antibodies about 15 years ago, many patients with rapidly progressing psychiatric symptoms, abnormal movements, seizures or unexplained coma have been ...
  • Autoimmune encephalitis : epidemiology, pathophysiology and clinical spectrum (Part 2) 
    Hiesgen, J.; Schutte, Clara-Maria (South African Medical Association, 2023-04)
    Autoimmune encephalitis (AE) represents a growing number of severe autoimmune-inflammatory diseases affecting both the white and grey matter of the brain. In part 1 of this series, we focused on the epidemiology, ...
  • Awaking a sleeping epidemic 
    Van Coller, Riaan; Van Rensburg, Elna; Schutte, Clara-Maria; Brink, Delene; Welthagen, Gerhard Frederick; Dove, Mike G. (South African Medical Association, 2007-04)
    Two patients with African sleeping sickness (SS) presented to the neurology unit, Pretoria Academic Hospital, during 2004 and 2005. SS has shown a recent resurgence, with epidemics in the Sudan, Angola and the Democratic ...
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) 
    Retief, Chris; Schutte, Clara-Maria; Baker, Malcolm Kevin (Health and Medical Publishing Group, 2009-06)
    BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco-encephalopathy (CADASIL) is a hereditary autosomal dominant non-atherosclerotic nonamyloid cerebral arteriopathy. The disease was ...
  • Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson’s disease 
    Mahne, A.C.; Carr, J.A.; Bardien, S.; Schutte, Clara-Maria (Health and Medical Publishing Group, 2016-06)
    BACKGROUND. Parkinson’s disease (PD), with a prevalence of up to 4% in Western countries, appears to be less common in Africa, possibly in part because of genetic factors. African studies investigating the genetic causation ...
  • Comparison of HTLV-associated myelopathy (HAM) in HIV-positive and HIV-negative patients at a tertiary South African hospital 
    Schutte, Clara-Maria; Townsend, T.; Van Coller, Riaan; Olorunju, Steve A.S. (Health and Medical Publishing Group, 2013-01)
    BACKGROUND. HTLV-1 associated myelopathy (HAM), or tropical spastic paraparesis, is caused by a retrovirus, the human T-cell lymphotropic virus (HTLV). Although patients with HAM and HIV infection have been described, to ...
  • Developing and testing a South African Brief Cognitive Score in literate and illiterate people of mixed language groups 
    Schutte, Clara-Maria; Tsikane, Mukhethwa; Nchoe, Keorapetse (AOSIS, 2021-05-27)
    BACKGROUND: The Folstein mini mental state exam (MMSE) is the most commonly administered assessment of cognitive functioning; however, its utility in illiterate individuals is limited. In South Africa, more than eight ...
  • Efficacy of deep brain stimulation of the anterior-medial globus pallidus internus in tic and non-tic related symptomatology in refractory Tourette syndrome 
    Kisten, Ravendran; Van Coller, Riaan; Cassimjee, Nafisa; Lubbe, Elsabeth (Elsa); Vaidyanathan, Janardan; Slabbert, Pieter; Enslin, Nico; Schutte, Clara-Maria (Elsevier, 2022)
    INTRODUCTION : Although refractory Tourette Syndrome (TS) is rare, it poses great challenges in clinical practice. Co-morbid psychiatric symptoms often occur, negatively impacting quality of life. Deep brain stimulation ...
  • Eryptosis as a marker of Parkinson’s disease 
    Pretorius, Etheresia; Swanepoel, A.C. (Albe Carina); Buys, A.V. (Antonia Vergina); Vermeulen, Natasha; Duim, Wiebren; Kell, Douglas B. (Impact Journals, 2014-10)
    A major trend in recent Parkinson’s disease (PD) research is the investigation of biological markers that could help in identifying at‐risk individuals or to track disease progression and response to therapies. Central ...
  • Fiat lux : light and pedagogy for the 21st century 
    Lech, James C.; Halma, Matthew T.J.; Obajuluwa, Adejoke O.; Baker, Malcolm Kevin; Hamblin, Michael R. (Sage, 2023-04)
    BACKGROUND : The relationship between the quality of the learning environment and student outcomes is receiving more serious attention from educational psychologists, neurologists, ophthalmologists, orthopedists, surgeons, ...
  • Guest editorial : Autoimmune encephalitis 
    Hiesgen, Juliane; Schutte, Clara-Maria (South African Medical Association, 2023-03)
    Since the identification of anti-N-methyl-D-aspartate (NMDA) receptor antibodies about 15 years ago, many patients with rapidly progressing psychiatric symptoms, abnormal movements, seizures or unexplained coma, have been ...
  • The HGR motif is the antiangiogenic determinant of vasoinhibin : implications for a therapeutic orally active oligopeptide 
    Pablo Robles, Juan; Zamora, Magdalena; Siqueiros-Marquez, Lourdes; Adan-Castro, Elva; Ramirez-Hernandez, Gabriela; Freinet Nunez, Francisco; Lopez-Casillas, Fernando; Millar, Robert P.; Bertsch, Thomas; Martínez de la Escalera, Gonzalo; Triebel, Jakob; Clapp, Carmen (Springer, 2022-02)
    The hormone prolactin acquires antiangiogenic and antivasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, an endogenous prolactin fragment of 123 or more amino acids that inhibits the action ...
  • Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2 
    Corbett, Mark A.; Kroes, Thessa; Veneziano, Liana; Bennett, Mark F.; Florian, Rahel; Schneider, Amy L.; Coppola, Antonietta; Licchetta, Laura; Franceschetti, Silvana; Suppa, Antonio; Wenger, Aaron; Mei, Davide; Pendziwiat, Manuela; Kaya, Sabine; Delledonne, Massimo; Straussberg, Rachel; Xumerle, Luciano; Regan, Brigid; Crompton, Douglas; Van Rootselaar, Anne-Fleur; CorrelL, Anthony; Catford, Rachael; Bisulli, Francesca; Chakraborty, Shreyasee; Baldassari, Sara; Tinuper, Paolo; Barton, Kirston; Carswell, Shaun; Smith, Martin; Berardelli, Alfredo; Carroll, Renee; Gardner, Alison; Friend, Kathryn L.; Blatt, Ilan; Lacomino, Michele; Di Bonaventura, Carlo; Striano, Salvatore; Buratti, Julien; Keren, Boris; Nava, Caroline; Forlani, Sylvie; Rudolf, Gabrielle; Hirsch, Edouard; Leguern, Eric; Labauge, Pierre; Balestrini, Simona; Sander, Josemir W.; Afawi, Zaid; Helbig, Ingo; Ishiura, Hiroyuki; Tsuji, Shoji; Sisodiya, Sanjay M.; Casari, Giorgio; Sadleir, Lynette G.; Van Coller, Riaan; Tijssen, Marina A.J.; Klein, Karl Martin; Van den Maagdenberg, Arn M.J.M.; Zara, Federico; Guerrini, Renzo; Berkovic, Samuel F.; Pippucci, Tommaso; Canafoglia, Laura (Nature Research, 2019-10)
    Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor usually from the second decade of life and overt myoclonic or generalised tonic-clonic seizures. Four independent loci have been ...
  • Isolated posterior fossa involvement of progressive multifocal leucoencephalopathy in HIV : a case series with review of the literature 
    Mudau, Adziambei; Suleman, Farhana Ebrahim; Schutte, Clara-Maria; Lockhat, Zarina I. (Health and Medical Publishing Group, 2017-11-14)
    Progressive multifocal leucoencephalopathy (PML) is a progressive demyelinating condition resulting from infection with the John Cunningham virus and precipitated by immunocompromised states. The HIV pandemic, especially ...
  • Late-onset efavirenz toxicity : a descriptive study from Pretoria, South Africa 
    Munsami, Lyneshree; Schutte, Clara-Maria; De Villiers, Maryke; Hiesgen, Juliane (AOSIS, 2023-01-19)
    BACKGROUND : The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. ...
  • Life-threatening Listeria meningitis : need for revision of South African acute bacterial meningitis treatment guidelines 
    Schutte, Clara-Maria; Van der Meyden, C.H. (Kees); Kakaza, Mandisa; Lockhat, Zarina I.; Van der Walt, Elizabeth (Health and Medical Publishing Group, 2019)
    BACKGROUND: The recent listeriosis outbreak in South Africa (SA) received widespread attention in the media. More than 1 000 laboratoryconfirmed cases of listeriosis occurred during an 18-month period, with a case fatality ...