Recently added

Research Articles (Internal Medicine): Recent submissions

  • Calcium-dependent potentiation of the pro-inflammatory functions of human neutrophils by tigecycline in vitro 
    Cockeran, Riana; Mutepe, Ndiafhi Daphney; Theron, Annette J.; Tintinger, Gregory Ronald; Steel, Helen C.; Stivaktas, Paraskevi Irene; Richards, Guy A.; Feldman, Charles; Anderson, Ronald (Oxford University Press, 2012)
    OBJECTIVES: Tigecycline is the prototype of the recently introduced, intravenously administered glycylcycline class of antibiotics, developed in response to the increasing problem of antibiotic resistance in Gram-positi ...
  • The indications of leukodepleting blood or blood products, and the importance of using bedside blood-product filters during neonatal transfusion 
    Morudu, Letennwe Josephine (Medpharm Publications, 2012-01)
    Transfusion therapy remains one of the most commonly used regimens to treat critically ill neonates. Neonatal intensive care professional nurses have a responsibility to ensure that the procedure is as effective, and as ...
  • Soluble triggering receptor expressed on myeloid cells in sputum of patients with community-acquired pneumonia or pulmonary tuberculosis : a pilot study 
    Tintinger, Gregory Ronald; Van der Merwe, J.J.; Ficki, H.; Rheeder, Paul; Feldman, Charles; Anderson, Ronald (Springer, 2012-01)
    Soluble triggering receptor expressed on myeloid cells is upregulated on the surface of inflammatory cells in the presence of bacterial infections apparently excluding those due to Mycobacterium tuberculosis. Therefore, ...
  • Obstructive sleep apnoea and obesity 
    Tintinger, Gregory Ronald; Pretorius, L.; Labadarios, D. (Health and Medical Publishing Group, 2011)
    The global obesity epidemic continues to gain momentum, and South Africa is one of those countries with an extremely high prevalence of obesity. The reported association between obstructive sleep apnoea (OSA) and obesity ...
  • Metabolic surgery : a concise overview and understanding of potential complications 
    Potgieter, A.J.; Van der Merwe, Maria-Teresa (Health and Medical Publishing Group, 2011)
    Bariatric surgery, despite a relatively short history, has had a tremendous impact on the discipline of surgery. In addition, it has had a profound influence on the development of laparoscopic surgery and the treatment ...
  • Secondary hypertension 
    Ker, James A. (South African Academy of Family Practice, 2011-09)
    Secondary hypertension is rare and the diagnosis may be challenging although, on occasion, there are clinical features indicative of a specific underlying cause. The more commonly encountered causes include renal parenchymal ...
  • Providing clinicians with information on laboratory test costs leads to reduction in hospital expenditure 
    Ellemdin, Shiraz; Rheeder, Paul; Soma, Prashilla (Health and Medical Publishing Group, 2011-10)
    OBJECTIVES: We aimed to ascertain the efficacy of an intervention in which laboratory test costs were provided to clinicians as a pocketsized brochure, in reducing laboratory test costs over a 4-month period. METHODS: This ...
  • Vitamin D in acute and chronic disease 
    Ker, James A. (Health and Medical Publishing Group, 2011)
    It has emerged over the past 10-20 years that the change in our lifestyle has led to the widespread deficiency of vitamin D. These lifestyle changes include the avoidance of sunlight (voluntary or greater reliance on ...
  • Upper limb pain syndromes 
    Ally, Mahmood Moosa Tar Mahomed (Health and Medical Publishing Group, 2011-08)
    This review addresses common questions about upper limb pain that are encountered in practice.
  • Lower limb pain syndromes 
    Ally, Mahmood Moosa Tar Mahomed; Suleman, Farhana Ebrahim (Health and Medical Publishing Group, 2011-08)
    Lower limb pain is a common presenting complaint in primary care with aetiological factors such as trauma, repetitive strain injury and systemic inflammatory disorders. This review focuses on some commonly encountered ...
  • Hypertension 
    Ker, James A. (South African Academy of Family Practice/Primary Care, 2011-07)
    Approximately one in four adults has hypertension, a prevalence that increases with age and may reach to two out of three adults older than 70 years of age. In the Framingham Heart Study 65-75% of hypertension in the elderly ...
  • Impact of FDG PET on the management of TBC treatment 
    Sathekge, Mike Machaba; Maes, Alex; Kgomo, Mbo; Stoltz, Anton Carel; Pottel, Hans; Van de Wiele, Christophe (Schattauer, 2010)
    The AIM: of this study is to assess the potential impact of double-phase FDG PET versus routine staging in HIV-negative patients suffering from tuberculosis. PATIENTS, METHODS: 16 consecutive patients suffering from ...
  • Montelukast sodium : administration to children to control intermittent asthma 
    Gravett, Cornelia M.; Tintinger, Gregory Ronald; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Green, Robin J. (Libertas Academica, 2010)
    The prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the chemotherapy of exercise-induced asthma. It has also been used as add-on therapy in patients ...
  • Decreased CD10 expression in the bone marrow neutrophils of HIV positive patients 
    Van de Vyver, Annemarie; Delport, Eluned F.; Visser, Adele (Open Journal System, 2010-11)
    BACKGROUND: HIV-1 infection is associated with various quantitative and qualitative changes in haemopoietic cells. Clear distinction between primary myelodysplastic syndrome (MDS) and secondary dysplasia may not always be ...
  • Effects of moxifloxacin on human neutraphil and T-lymphocyte functions in vitro 
    Potjo, Moliehi; Cockeran, Riana; Theron, Annette J.; Feldman, Charles; Anderson, Ronald (Molecular Diversity Preservation International, 2010)
    Moxifloxacin is useful in the treatment of respiratory infections, including community-acquired pneumonia, and also shows promise in the treatment of tuberculosis, a clinical setting which necessitates extended administration ...
  • Beneficial and harmful interactions of antibiotics with microbial pathogens and the host innate immune system 
    Anderson, Ronald; Tintinger, Gregory Ronald; Cockeran, Riana; Potjo, Moliehi; Feldman, Charles (Molecular Diversity Preservation International, 2010-05)
    In general antibiotics interact cooperatively with host defences, weakening and decreasing the virulence of microbial pathogens, thereby increasing vulnerability to phagocytosis and eradication by the intrinsic antimicrobial ...
  • The treatment of cholesterol : issues, effects and targets 
    Ker, James A. (South African Academy of Family Practice/Primary Care, 2010-11)
    Statins are the most powerful cholesterol lowering drugs currently available. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase, which leads to reduced cholesterol synthesis. In addition, low-density ...
  • Routine monitoring of diabetes mellitus in adults at primary health care level, and self-monitoring of blood glucose (SMBG) 
    Kemp, Tanja (Health and Medical Publishing Group, 2010-10)
    Diabetes care extends beyond glycaemic control, and several interventions to improve diabetes outcome are supported by evidence from large trials. Most of the recommendations included here are based on the Society for ...
  • Evaluation of glucose uptake by skeletal muscle tissue and subcutaneous fat in HIV-infected patients with and without lipodystrophy using FDG-PET 
    Sathekge, Mike Machaba; Maes, Alex; Kgomo, Mbo; Stoltz, Anton Carel; Ankrah, Alfred O.; Van de Wiele, Christophe (Lippincott Williams & Wilkins, 2010)
    OBJECTIVE: To evaluate differences in glucose uptake by skeletal muscle tissue and subcutaneous fat in HIV patients on HAART (highly active antiretroviral therapy) presenting with and without lipodystrophy as well as in ...
  • Rheumatoid arthritis 
    Visser, C.C.; Ally, Mahmood Moosa Tar Mahomed (South African Orthopaedic Association, 2010)
    RA is a chronic inflammatory disease resulting in severe morbidity and premature mortality. This review explores in a series of two articles, the current developments in the pathogenesis, diagnosis, monitoring and management ...