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Research Articles (Internal Medicine): Recent submissions

  • Fatal attraction 
    Ker, James A. (New Media Publishing, 2016-04)
    Hypertension and diabetes are linked and could be considered a fatal attraction. Elevated blood pressure is twice as common in people with diabetes as compared to people without diabetes.
  • Pneumolysin mediates platelet activation in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2016-08)
    This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply [10–80 nanograms (ng)/ml], platelet activation and cytosolic Ca2+ concentrations ...
  • Association of Adipose tissue inflammation with histologic severity of nonalcoholic fatty liver disease 
    Du Plessis, Johannie; Van Pelt, Jos; Korf, Hannelie; Mathieu, Chantal; Van der Schueren, Bart; Lannoo, Matthias; Oyen, Tom; Topal, Baki; Fetter, Gary; Nayler, Simon; Van der Merwe, Tessa; Windmolders, Petra; Van Gaal, Luc; Verrijken, An; Hubens, Guy; Gericke, Martin; Cassiman, David; Francque, Sven; Nevens, Frederik; Van der Merwe, Schalk (Elsevier, 2015-09)
    BACKGROUND & AIMS : The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the obesity pandemic. We analyzed the transcriptional profiles of subcutaneous adipose tissue (SAT) and visceral adipose ...
  • Pneumolysin activates neutrophil extracellular trap formation 
    Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)
    The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
  • Hypercholesterolaemia and coronary risk 
    Ker, James A. (New Media Publishing, 2016-05)
    Studies have shown that only 10.6% of people with hypercholesterolaemia receive a statin or treatment. There is a within-person variability of cholesterol measurements and therefore a one-time measurement of cholesterol ...
  • Rheumatoid Arthritis 
    Ally, Mahmood Moosa Tar Mahomed; Hodkinson, Bridget (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor & Francis Group, 2016)
    Immune-mediated inflammatory disorders include a clinically diverse group of conditions sharing similar pathogenic mechanisms. Conditions such as rheumatoid arthritis, psoriasis, spondyloarthropathy, inflammatory bowel ...
  • Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and cirrhosis of the liver : a case report and literature review 
    Kgomo, Mpho K.; Elganar, Ali A.; Jeske, Christian; Nagel, Jackoo (Health and Medical Publishing Group, 2016-05)
    Patients with cirrhosis of the liver usually present with a small, shrunken liver and a large spleen. The presence of an unusually huge liver should prompt the treating doctor to look for another cause, as this may be ...
  • Acute kidney injury in pregnancy 
    Van Hougenhouck-Tulleken, Wesley G.; Roche, Nathalie; Muranda, A.Z. (Albert) (In House Publications, 2016)
    Pregnancy related acute kidney injury (PrAKI) is a relatively rare syndrome, and is associated with many pregnancy-unique diseases. Due to the physiological changes of pregnancy, PrAKI is difficult to diagnose, hard to ...
  • Review of pregnancy and fertility issues in women with rheumatic diseases 
    Kalpee, R. (In House Publications, 2016)
    Rheumatic diseases occur more commonly in women and often during child bearing age. SLE is 10-15 times more common in women than in men.1 Most SLE patients present with their disease between 15 and 64 years age.2 ...
  • The Influence of the HEQC's institutional audits on teaching and learning at three South African universities 
    Matsebetlela, E.M. (Emmanuel) (CSSALL Publishers, 2015)
    Institutional audits constitute one of the ways through which South Africa’s Higher Education Quality Committee (HEQC) executes its quality assurance mandate. The study investigated the effect of the HEQC’s institutional ...
  • Time to fibrinolytics for acute myocardial infarction : reasons for delays at Steve Biko Academic Hospital, Pretoria, South Africa 
    Meel, R.; Goncalves, R. (Health and Medical Publishing Group, 2016-01)
    BACKGROUND. Fibrinolytic therapy is a time-critical intervention proven to reduce mortality and morbidity in patients with ST-elevation myocardial infarction (STEMI). Limited data exist in South Africa (SA) regarding time ...
  • Neutrophil extracellular traps and their role in health and disease 
    Nel, Jan Gert; Theron, Annette J.; Pool, Roger; Durandt, Chrisna; Tintinger, Gregory Ronald; Anderson, Ronald (AOSIS OpenJournals, 2016-01)
    The human innate immune system is indispensable for protection against potentially invasive microbial and viral pathogens, either neutralising them or containing their spread until effective mobilisation of the slower, adaptive ...
  • New amniotic membrane based biocomposite for future application in reconstructive urology 
    Adamowicz, Jan; Pokrywczyńska, Marta; Tworkiewicz, Jakub; Kowalczyk, Tomasz; Van Breda, Shane Vontelin; Tyloch, Dominik; Kloskowski, Tomasz; Bodnar, Magda; Skopinska-Wisniewska, Joanna; Marszałek, Andrzej; Frontczak-Baniewicz, Malgorzata; Kowalewski, Tomasz A.; Drewa, Tomasz (Public Library of Science, 2016-01-14)
    OBJECTIVE Due to the capacity of the amniotic membrane (Am) to support re-epithelisation and inhibit scar formation, Am has a potential to become a considerable asset for reconstructive urology i.e., reconstruction of ...
  • The prevalence and associations of erectile dysfunction in a South African male diabetic urban population 
    Kemp, Tanja; Rheeder, Paul (MedPharm Publications, 2015)
    BACKGROUND : Erectile dysfunction (ED) is a common condition in patients with type 1 or type 2 diabetes mellitus. The prevalence and predictors in our patient population are unknown since minimal data exist for this ...
  • Reliable and cost-effective serodiagnosis of rheumatoid arthritis 
    Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Anderson, Ronald (Springer, 2016-06)
    Early diagnosis of patients with rheumatoid arthritis (RA) optimises therapeutic benefit and the probability of achieving disease remission. Notwithstanding clinical acumen, early diagnosis is dependent on access to reliable ...
  • Thrombotic complications 
    Ker, James A. (New Media Publishing, 2015-09)
    There have been significant advances in the treatment of heart failure (HF) with a reduction in mortality. Despite this improvement in mortality, HF still has a bad prognosis and research is ongoing to find ways to improve ...
  • Higher protein intake reduce risk of hypertension 
    Ker, James A. (New Media Publishing, 2015-11)
    Hypertension remains the most important treatable risk factor for cardiac disease worldwide.In the Dietary Approaches to Stop Hypertension (DASH) trials the importance of diet patterns to reduce blood pressure (BP), were shown.
  • Inflammation of the heart 
    Ker, James A. (New Media Publishing, 2015-10)
    Endocarditis is best viewed as an inflammation of the endocardial surface of the heart which includes the heart valves, mural endocardium and the endocardial surface that covers implanted material (prosthetic valves, ...
  • Broken heart syndrome 
    Ker, James A. (Media 24, 2015)
    Takotsubo was first described in Japan in 1990, but subsequently it was described globally and in 2013 there were 1879 publications on the subject. The main characteristic is transient reversible systolic dysfunction of ...
  • Basedow paraplegia : a possible misnomer 
    Smith, Lizl; Kemp, Tanja; Van der Meyden, C.H. (Kees); Schutte, Clara-Maria (Health and Medical Publishing Group, 2015-10)
    Thyrotoxic myopathy frequently occurs in clinical practice; however, the association of hyperthyroidism with a flaccid, areflexic paraplegia, so-called Basedow paraplegia, appears to represent a controversial and doubtful ...