Browsing Research Articles (Internal Medicine) by Title

Browsing Research Articles (Internal Medicine) by Title

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  • A 10-year audit of pregnancies affected by diabetic ketoacidosis at the Pretoria Academic Complex 
    Maseko, Ncamsile F.; Van Zyl, Danie G.; Adam, Sumaiya (Wiley, 2022-09)
    BACKGROUND : Diabetic ketoacidosis (DKA) during pregnancy is associated with increased rates of maternal and perinatal mortality and morbidity. DKA management guidelines are designed to ensure optimal management and minimize ...
  • 15 Leading misperceptions about bariatric surgery and obesity 
    Van der Merwe, Tessa (New Media Publishing, 2018-09)
    There are some mistaken beliefs that exist about bariatric surgery and obesity. Here are 15 common ones.
  • Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa 
    Van der Mescht, Mieke Adri; De Beer, Zelda; Steel, Helen C.; Anderson, Ronald; Masenge, Andries; Moore, Penny L.; Bastard, Paul; Casanova, Jean-Laurent; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2024-09)
    The African continent reported the least number of COVID-19 cases and deaths of all the continents, although the exact reasons for this are still unclear. In addition, little is known about the immunological profiles ...
  • The ability of primary healthcare clinics to provide quality diabetes care : an audit 
    Webb, Elizabeth M.; Rheeder, Paul; Wolvaardt, Jacqueline Elizabeth (Liz) (AOSIS Open Journals, 2019-10-17)
    BACKGROUND : In South Africa, much of diabetes care takes place at primary healthcare (PHC) facilities where screening for diabetic complications is often low. Clinics require access to equipment, resources and a functional ...
  • Absence of Helicobacter pylori within the oral cavities of members of a healthy South African community 
    Olivier, Brenda J.; Bond, Robert P.; Van Zyl, Walda B.; Delport, Maraliese; Slavik, Tomas; Ziady, Christopher; Terhaar sive Droste, Jochim S.; Lastovica, Albert; Van der Merwe, Schalk Willem (American Society for Microbiology, 2006-02)
    Our study aimed to evaluate the oral cavity as a reservoir from where Helicobacter pylori may be transmitted. Histology and PCR amplification were performed. Eighty-four percent of the stomach biopsies tested positive; ...
  • Acute kidney injury in pregnancy 
    Van Hougenhouck-Tulleken, Wesley G.; Roche, Nathalie; Muranda, A.Z. (Albert) (In House Publications, 2016)
    Pregnancy related acute kidney injury (PrAKI) is a relatively rare syndrome, and is associated with many pregnancy-unique diseases. Due to the physiological changes of pregnancy, PrAKI is difficult to diagnose, hard to ...
  • Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 
    Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)
    The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
  • Adapted full-face snorkel masks as an alternative for COVID-19 personal protection during aerosol generating procedures in South Africa 
    Herselman, Ronel; Lalloo, Vidya; Ueckermann, Veronica; Van Tonder, Daniel Johannes; De Jager, Edwin John; Spijkerman, Sandra; Van der Merwe, Wanda; Du Pisane, Marizane; Hattingh, Fanie; Stanton, David; Hofmeyr, Ross (Elsevier, 2021-12)
    INTRODUCTION : SARS-CoV-2 has resulted in increased worldwide demand for personal protective equipment (PPE). With pressure from ongoing epidemic and endemic episodes, we assessed an adapted snorkel mask that provides full-face ...
  • Adapting a diabetes nutrition education programme for adults with type 2 diabetes from a primary to tertiary healthcare setting 
    Muchiri, Jane Wanjiku; Gericke, Gerda J.; Rheeder, Paul (NISC (Pty), Medpharm Publications, and Informa UK Limited, 2021)
    OBJECTIVE: The purpose of this study was to adapt a diabetes nutrition education programme (NEP) developed for a primary healthcare setting for implementation in a tertiary healthcare setting. This manuscript describes ...
  • Adiponectin DNA methylation in South African women with gestational diabetes mellitus : effects of HIV infection 
    Dias, Stephanie Charmaine; Adam, Sumaiya; Abrahams, Yoonus; Rheeder, Paul; Pheiffer, Carmen (Public Library of Science, 2021-03)
    DNA methylation is increasingly recognized as a potential biomarker of metabolic disease. However, there is limited information on the impact of human immunodeficiency virus (HIV) infection on the candidacy of DNA ...
  • Adjunctive use of statins for COVID-19 
    Sathekge, Mike Machaba; Byttebier, Geert; De Spiegeleer, Bart; Saxberg, Bo; Ueckermann, Veronica; Belmans, Luc; Alexander, Myriam; Fedson, David (MDPI, 2021-04-01)
    The interaction between obesity, cardiometabolic disorders and COVID-19 represents a syndemic that requires both social intervention and a multipharmacological approach. The risks associated with diabetes, obesity and ...
  • Adjustment of insulin pump settings in Type 1 diabetes management : Advisor Pro device compared to physicians’ recommendations 
    Nimri, Revital; Oron, Tal; Muller, Ido; Kraljevic, Ivana; Alonso, Montserrat Martin; Keskinen, Paivi; Milicic, Tanja; Oren, Asaf; Christoforidis, Athanasios; Den Brinker, Marieke; Bozzetto, Lutgarda; Bolla, Andrea Mario; Krcma, Michal; Rabini, Rosa Anna; Tabba, Shadi; Smith, Lizl; Vazeou, Andriani; Maltoni, Giulio; Giani, Elisa; Atlas, Eran; Phillip, Moshe (Sage, 2022-03)
    AIMS : To compare insulin dose adjustments made by physicians to those made by an artificial intelligence-based decision support system, the Advisor Pro, in people with type 1 diabetes (T1D) using an insulin pump and ...
  • Adolescent girls and young women : policy-to-implementation gaps for addressing sexual and reproductive health needs in South Africa 
    Davids, Eugene Lee; Kredo, T.; Gerritsen, A.A.M.; Mathews, Catherine; Slingers, N.; Nyirenda, M.; Abdullah, Fareed (Health and Medical Publishing Group, 2020-09)
    Sexual and reproductive health (SRH) services for adolescent girls and young women (AGYW) remain inadequate – both globally and in South Africa (SA). We systematically scoped the available policies and guidelines for ...
  • ADP-mediated upregulation of expression of CD62P on human platelets is critically dependent on co-activation of P2Y1 and P2Y12 receptors 
    Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)
    This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
  • Adults living with type 2 diabetes experiences of a randomised adapted diabetes nutrition education programme : a qualitative process evaluation 
    Muchiri, Jane Wanjiku; Gericke, Gerda J.; Rheeder, Paul (NISC (Pty) Ltd and Informa UK Limited (trading as the Taylor & Francis Group), 2024)
    AIM : The purpose of this study was to investigate how a randomised controlled trial (RCT) of an adapted diabetes nutrition education programme (NEP) was received by adults with sub-optimally controlled (HbA1c of ≥ 8%) ...
  • Adverse effects of biologic anti-inflammatory agents on the respiratory system : a review 
    Joseph, Darren; Tintinger, Gregory Ronald; Ker, James A.; Pannell, N. (South African Medical Association NPC, 2021)
    The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function ...
  • An African origin for the intimate association between humans and Helicobacter pylori 
    Linz, Bodo; Balloux, Francois; Moodley, Yoshan; Manica, Andrea; Liu, Hua; Roumagnac, Philippe; Falush, Daniel; Stamer, Christiana; Prugnolle, Franck; Van der Merwe, Schalk Willem; Yamaoka, Yoshio; Graham, David Y.; Perez-Trallero, Emilio; Wadstrom, Torkel; Suerbaum, Sebastian; Achtman, Mark (Nature Publishing Group, 2007-02)
    Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic differentiation the age of an ...
  • Agenesis of the dorsal mesentery presenting in an adolescent 
    Chacko, Anith; Ismail, Farzanah; Ellemdin, Shiraz (Health and Medical Publishing Group, 2013)
    Agenesis of the dorsal mesentery is a rare occurrence that usually presents in children. It is associated with proximal small-bowel malrotation as well as high jejunal atresia with discontinuity of the small bowel. We ...
  • Altered genome-wide DNA methylation in peripheral blood of South African women with gestational diabetes mellitus 
    Dias, Stephanie Charmaine; Adam, Sumaiya; Rheeder, Paul; Louw, Johan; Pheiffer, Carmen (MDPI Publishing, 2019-11-20)
    Increasing evidence implicate altered DNA methylation in the pathophysiology of gestational diabetes mellitus (GDM). This exploratory study probed the association between GDM and peripheral blood DNA methylation patterns ...
  • Anaemia in chronic kidney disease 
    Van Hougenhouck-Tulleken, W.G. (Wesley) (Medpharm Publications, 2023)
    Anaemia, occurring in over 50% of patients with stages 3 to 5 chronic kidney disease (CKD), often causes fatigue, shortness of breath, cardiac dysfunction and cognitive impairment. The major causes include disorders of ...