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Internal Medicine: Recent submissions

  • Maternally inherited diabetes and deafness with a variable presentation across three generations within a pedigree, South Africa 
    Makgopa, Herbert; Kemp, Tanja; Meldau, Surita; Honey, Engela M.; Chale-Matsau, Bettina (AOSIS, 2024-05)
    INTRODUCTION: Maternally inherited diabetes and deafness (MIDD) is caused by the m.3243A>G pathogenic variant in maternally inherited mitochondrial DNA. Diabetes is prevalent in our setting; however, MIDD is rarely diagnosed. ...
  • Hypertension : back to basics 
    Ker, James A.; Outhoff, Kim (Medpharm Publications, 2023)
    This article outlines the principles of blood pressure, including normal and dysfunctional physiology, mathematical equations of pressure, definitions of hypertension and diagnosis, and hence the rationale for and mechanisms ...
  • Anaemia in chronic kidney disease 
    Van Hougenhouck-Tulleken, W.G. (Wesley) (Medpharm Publications, 2023)
    Anaemia, occurring in over 50% of patients with stages 3 to 5 chronic kidney disease (CKD), often causes fatigue, shortness of breath, cardiac dysfunction and cognitive impairment. The major causes include disorders of ...
  • The impact of diabetes during pregnancy on neonatal outcomes among the Aboriginal population in Western Australia : a whole-population study 
    Ahmed, Marwan Awad; Bailey, Helen D.; Pereira, Gavin; White, Scott W.; Wong, Kingsley; McNamara, Bridgette J.; Rheeder, Paul; Marriott, Rhonda; Shepherd, Carrington C.J. (Oxford University Press, 2023-10)
    BACKGROUND : Aboriginal and Torres Strait Islander (hereafter Aboriginal) women have a high prevalence of diabetes in pregnancy (DIP), which includes pre-gestational diabetes mellitus (PGDM) and gestational diabetes ...
  • Comparison of platelet-and endothelial-associated biomarkers of disease activity in people hospitalized with Covid-19 with and without HIV co-infection 
    Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa (Frontiers Media, 2023-08-14)
    INTRODUCTION : SARS-CoV-2 elicits a hyper-inflammatory response that contributes to increased morbidity and mortality in patients with COVID-19. In the case of HIV infection, despite effective anti-retroviral therapy, ...
  • Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination 
    Motsoeneng, Boitumelo M.; Manamela, Nelia; Kaldine, Haajira; Kgagudi, Prudence; Hermanus, Tandile; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Van der Mescht, Mieke Adri; Abdullah, Fareed; Boswell, Michael; Ueckermann, Veronica; Rossouw, Theresa; Madhi, Shabir A.; Moore, Penny L.; Richardson, Simone I. (Frontiers Media, 2023-08-03)
    The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in ...
  • Comparison of the effects of electronic cigarette vapours and tobacco smoke extracts on human neutrophils in vitro 
    Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory (European Respiratory Society, 2023-05)
    BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than ...
  • Spontaneous resolution of a patient with a symptomatic pheochromocytoma 
    Jackson, Brandon Spencer; Ndhlebe, Gugulethu; Suleman, Farhana Ebrahim (Elsevier, 2024-07)
    A 56-year-old woman presented with a 2-year history of chronic persistent right upper quadrant abdominal pain that was associated with intermittent nausea, vomiting, and unintentional weight loss. She had been on ...
  • Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 
    Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)
    A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
  • Changes in prevalence and seasonality of pathogens identified in acute respiratory tract infections in hospitalised individuals in rural and urban settings in South Africa; 2018–2022 
    Davids, Michaela; Johnstone, Siobhan; Mendes, Adriano; Brecht, Gadean; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; De Villiers, Maryke; Page, N.A. (Nicola); Venter, Marietjie (MDPI, 2024-03)
    Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and ...
  • Healthcare delivery 
    Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)
    We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
  • Profile of human papillomavirus genotypes in breast and oesophageal cancer patients in Pretoria, South Africa 
    Maroga, N.; Mokoena, Taole; Musekiwa, Alfred; Bida, Meshack; Kgomo, Mpho K.; Lebelo, R. (South African Medical Association, 2023-07)
    BACKGROUND : The association between human papillomavirus (HPV) and cervical cancer is well established, and cervical cancer can be prevented through HPV vaccination. Little has been reported on the association between HPV ...
  • What are health policy and systems research priorities for universal health coverage in South Africa? 
    Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)
    We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
  • COVID-19 severity and in-hospital mortality in an area with high HIV prevalence 
    Boswell, Michael; Maimela, T.C.R. (Tshegofatso); Hameiri-Bowen, Dan; Riley, George; Malan, Albertus; Steyn, Nickietta; Nolutshungu, Nomonde; De Villiers, Talita R.; De Beer, Zelda; Mathabathe, John; Tshabalala, Khanyisile; Abdullah, Fareed; Ramlall, Rajiev; Heystek, Marthinus J.; Basu, Debashis; Rheeder, Paul; Ueckermann, Veronica; Van Hougenhouck-Tulleken, Wesley G. (AOSIS, 2023-01-27)
    BACKGROUND : HIV infection causes immune dysregulation affecting T-cell and monocyte function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology. OBJECTIVES : We investigated the associations among ...
  • Late-onset efavirenz toxicity : a descriptive study from Pretoria, South Africa 
    Munsami, Lyneshree; Schutte, Clara-Maria; De Villiers, Maryke; Hiesgen, Juliane (AOSIS, 2023-01-19)
    BACKGROUND : The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. ...
  • Budget impact analysis of empagliflozin in the treatment of patients with type 2 diabetes with established cardiovascular disease in South Africa 
    De Beer, Janetta Catharina; Snyman, Jacques; Ker, James A.; Miller-Janson, Helen; Stander, Marthinus (Elsevier, 2023-01)
    OBJECTIVES : This study aimed to estimate the budget impact and affordability of empagliflozin added to usual care compared with usual care alone, in a diabetic population with established cardiovascular disease, from a ...
  • Factors associated with COVID-19 vaccine uptake among schoolgoing adolescent girls and young women in South Africa 
    Bergh, Kate; Jonas, Kim; Duby, Zoe; Govindasamy, Darshini; Mathews, Catherine; Reddy, Tarylee; Slingers, Nevilene; Whittle, Granville; Abdullah, Fareed (MDPI, 2023-10-11)
    BACKGROUND : By October 2022, vaccination rates with at least one dose of a COVID-19 vaccine were low among adolescent girls aged 12–17 (38%) and young women aged 18–34 (45%) in South Africa. This study aimed to measure ...
  • Cavernous transformation of the portal vein a rare phenomenon 
    Bosenberg, L.H.; Thomas, P. (In House Publications, 2022)
    Cavernous transformation of the portal vein is a complication of a prior portal vein thrombosis and carries a very poor prognosis. It is associated with portal hypertension, and the massive ascites that develops as a ...
  • Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 
    Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)
    There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
  • Cryptogenic, embolic stroke-looking backstage 
    Ker, James A. (Elsevier, 2022-05)
    Stroke is a common and devastating event and the majority of cases are caused by thromboembolism from the left atrium, left ventricle or left sided valves. This case report describes a case of embolic stroke with the origin ...