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Internal Medicine: Recent submissions

  • Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 
    Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)
    A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
  • Changes in prevalence and seasonality of pathogens identified in acute respiratory tract infections in hospitalised individuals in rural and urban settings in South Africa; 2018–2022 
    Davids, Michaela; Johnstone, Siobhan; Mendes, Adriano; Brecht, Gadean; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; De Villiers, Maryke; Page, N.A. (Nicola); Venter, Marietjie (MDPI, 2024-03)
    Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and ...
  • Healthcare delivery 
    Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)
    We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
  • Profile of human papillomavirus genotypes in breast and oesophageal cancer patients in Pretoria, South Africa 
    Maroga, N.; Mokoena, Taole; Musekiwa, Alfred; Bida, Meshack; Kgomo, Mpho K.; Lebelo, R. (South African Medical Association, 2023-07)
    BACKGROUND : The association between human papillomavirus (HPV) and cervical cancer is well established, and cervical cancer can be prevented through HPV vaccination. Little has been reported on the association between HPV ...
  • What are health policy and systems research priorities for universal health coverage in South Africa? 
    Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)
    We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
  • COVID-19 severity and in-hospital mortality in an area with high HIV prevalence 
    Boswell, Michael; Maimela, T.C.R. (Tshegofatso); Hameiri-Bowen, Dan; Riley, George; Malan, Albertus; Steyn, Nickietta; Nolutshungu, Nomonde; De Villiers, Talita R.; De Beer, Zelda; Mathabathe, John; Tshabalala, Khanyisile; Abdullah, Fareed; Ramlall, Rajiev; Heystek, Marthinus J.; Basu, Debashis; Rheeder, Paul; Ueckermann, Veronica; Van Hougenhouck-Tulleken, Wesley G. (AOSIS, 2023-01-27)
    BACKGROUND : HIV infection causes immune dysregulation affecting T-cell and monocyte function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology. OBJECTIVES : We investigated the associations among ...
  • Late-onset efavirenz toxicity : a descriptive study from Pretoria, South Africa 
    Munsami, Lyneshree; Schutte, Clara-Maria; De Villiers, Maryke; Hiesgen, Juliane (AOSIS, 2023-01-19)
    BACKGROUND : The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. ...
  • Budget impact analysis of empagliflozin in the treatment of patients with type 2 diabetes with established cardiovascular disease in South Africa 
    De Beer, Janetta Catharina; Snyman, Jacques; Ker, James A.; Miller-Janson, Helen; Stander, Marthinus (Elsevier, 2023-01)
    OBJECTIVES : This study aimed to estimate the budget impact and affordability of empagliflozin added to usual care compared with usual care alone, in a diabetic population with established cardiovascular disease, from a ...
  • Factors associated with COVID-19 vaccine uptake among schoolgoing adolescent girls and young women in South Africa 
    Bergh, Kate; Jonas, Kim; Duby, Zoe; Govindasamy, Darshini; Mathews, Catherine; Reddy, Tarylee; Slingers, Nevilene; Whittle, Granville; Abdullah, Fareed (MDPI, 2023-10-11)
    BACKGROUND : By October 2022, vaccination rates with at least one dose of a COVID-19 vaccine were low among adolescent girls aged 12–17 (38%) and young women aged 18–34 (45%) in South Africa. This study aimed to measure ...
  • Cavernous transformation of the portal vein a rare phenomenon 
    Bosenberg, L.H.; Thomas, P. (In House Publications, 2022)
    Cavernous transformation of the portal vein is a complication of a prior portal vein thrombosis and carries a very poor prognosis. It is associated with portal hypertension, and the massive ascites that develops as a ...
  • Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 
    Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)
    There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
  • Cryptogenic, embolic stroke-looking backstage 
    Ker, James A. (Elsevier, 2022-05)
    Stroke is a common and devastating event and the majority of cases are caused by thromboembolism from the left atrium, left ventricle or left sided valves. This case report describes a case of embolic stroke with the origin ...
  • Adjustment of insulin pump settings in Type 1 diabetes management : Advisor Pro device compared to physicians’ recommendations 
    Nimri, Revital; Oron, Tal; Muller, Ido; Kraljevic, Ivana; Alonso, Montserrat Martin; Keskinen, Paivi; Milicic, Tanja; Oren, Asaf; Christoforidis, Athanasios; Den Brinker, Marieke; Bozzetto, Lutgarda; Bolla, Andrea Mario; Krcma, Michal; Rabini, Rosa Anna; Tabba, Shadi; Smith, Lizl; Vazeou, Andriani; Maltoni, Giulio; Giani, Elisa; Atlas, Eran; Phillip, Moshe (Sage, 2022-03)
    AIMS : To compare insulin dose adjustments made by physicians to those made by an artificial intelligence-based decision support system, the Advisor Pro, in people with type 1 diabetes (T1D) using an insulin pump and ...
  • Decreased severity of disease during the first global Omicron variant COVID-19 outbreak in a large hospital in Tshwane, South Africa 
    Abdullah, Fareed; Myers, J.; Basu, Debashis; Tintinger, Gregory; Ueckermann, Veronica; Mathebula, M.; Ramlall, R.; Spoor, S.; De Villiers, T.; Van der Walt, Z.; Cloete, Jeane; Soma-Pillay, Priya; Rheeder, Paul; Paruk, Fathima; Engelbrecht, Adel; Lalloo, Vidya; Myburg, M.; Kistan, J.; Van Hougenhouck-Tulleken, Wesley G.; Boswell, Michael T.; Gray, G.; Welch, R.; Blumberg, Lucille Hellen; Jassat, W. (Elsevier, 2022-03)
    INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
  • Frontliners on the move : a quantitative analysis of the prevalence of COVID-19 reinfection among healthcare workers 
    Kurra, Nithin C.; Sriram, Krithika; Gandrakota, Nikhila; Nagarajan, Jai Sivanandan; Khasnavis, Sujoy; Ramakrishnan, Manju; Dalal, Suhani; Irfan, Shayan A; Khan, Sarah; JK, Hariniska; Patel, Dhruv; Samudrala, Gayathri (Cureus, Inc., 2022-05-01)
    This study was conducted to review relevant articles and demonstrate the prevalence of coronavirus disease 2019 (COVID-19) reinfection among healthcare workers (HCWs). A systemic search was conducted on PubMed and Medline ...
  • SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity 
    Richardson, Simone I.; Manamela, Nelia P.; Motsoeneng, Boitumelo M.; Kaldine, Haajira; Ayres, Frances; Makhado, Zanele; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Sullivan, Nancy J.; Misasi, John; Gray, Glenda G.; Bekker, Linda‑Gail; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Moore, Penny L. (Cell Press, 2022-02-15)
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic ...
  • Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 
    Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)
    The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
  • A risk measurement tool for targeted HIV prevention measures amongst young pregnant and lactating women in South Africa 
    Ramraj, Trisha; Abdelatif, Nada A.; Chirinda, Witness; Abdullah, Fareed; Kindra, Gurpreet; Goga, Ameena Ebrahim (BMC, 2022-06-30)
    BACKGROUND : We aimed to develop and validate a tool to identify which pregnant/lactating young South African women (≤ 24 years) are at risk of HIV infection. METHODS : Data from three national South African Prevention ...
  • Characteristics and outcomes of patients admitted to a tertiary academic hospital in Pretoria with HIV and severe pneumonia : a retrospective cohort study 
    Ueckermann, Veronica; Janse van Rensburg, Luricke; Pannell, N.; Ehlers, Marthie Magdaleen (BMC, 2022-06-15)
    BACKGROUND : Human immunodeficiency virus (HIV) contributes significantly to morbidity and mortality in South Africa. Pneumonia and opportunistic infections remain a major cause for hospital admission among those living ...
  • An unusual cause of dyspnoea – can you spot the diagnosis? 
    Joseph, Darren; Pannell, N.; Tintinger, Gregory (South African Medical Association, 2022)
    A 66-year-old man presented with a complaint of shortness of breath. He had a significant smoking history but no known medical conditions. Two years prior, he had been involved in a motor vehicle accident and sustained ...