• The association of smoking and alcohol in colorectal cancer in black patients - case-control study 

  Kgomo, Mpho K.; Zingoni, Ratidzo L.; Becker, Piet J. (AOSIS, 2024-10)

  BACKGROUND : Studies have focused on smoking and alcohol as risk factors for colorectal cancer (CRC). Caucasians and other populations have been studied worldwide, and both smoking and alcohol have been validated as ...
• Cannabinoid hyperemesis syndrome 

  Elnagar, Ali; Kgomo, Mpho K.; Mokone, Modise; Yousif, Badreldin (BMJ Publishing Group, 2024-04)

  Cannabis use is legalised in many countries. We present a patient in their 40s who complained of recurrent abdominal pain and associated nausea and vomiting. The patient was previously seen in various hospitals, treated ...
• Epidemiology and aetiology of moderate to severe diarrhoea in hospitalised patients ≥5 years old living with HIV in South Africa, 2018- 2021 : a case-control analysis 

  Johnstone, Siobhan; Erasmus, Linda; Thomas, Juno; Groome, Michelle J.; Du Plessis, Nicolette Marie; Avenant, Theunis Johannes; De Villiers, Maryke; Page, N.A. (Nicola) (Public Library of Science, 2023-09-08)

  Diarrhoea is a recognised complication of HIV-infection, yet there are limited local aetiological data in this high-risk group. These data are important for informing public health interventions and updating diagnostic ...
• Adults living with type 2 diabetes experiences of a randomised adapted diabetes nutrition education programme : a qualitative process evaluation 

  Muchiri, Jane Wanjiku; Gericke, Gerda J.; Rheeder, Paul (NISC (Pty) Ltd and Informa UK Limited (trading as the Taylor & Francis Group), 2024)

  AIM : The purpose of this study was to investigate how a randomised controlled trial (RCT) of an adapted diabetes nutrition education programme (NEP) was received by adults with sub-optimally controlled (HbA1c of ≥ 8%) ...
• SARS-CoV-2 BA.4/5 infection triggers more cross-reactive FcγRIIIa signaling and neutralization than BA.1, in the context of hybrid immunity 

  Richardson, Simone I.; Mzindle, Nonkululeko; Motlou, Thopisang; Manamela, Nelia; Van der Mescht, Mieke Adri; Lambson, Bronwen E.; Everatt, Josie; Amoako, Daniel Gyamfi; Balla, Sashkia; Von Gottberg, Anne; Wolter, Nicole; De Beer, Zelda; De Villiers, Talita Roma; Bodenstein, Annie; Van den Berg, Gretha; Abdullah, Fareed; Rossouw, Theresa M.; Boswell, M.T.; Ueckermann, Veronica; Bhiman, Jinal N.; Moore, Penny L. (American Society for Microbiology, 2024-07)

  SARS-CoV-2 variants of concern (VOCs) differentially trigger neutralizing and antibody-dependent cellular cytotoxic (ADCC) antibodies with variable cross-reactivity. Omicron BA.4/5 was approved for inclusion in bivalent ...
• Suboptimal control and failure to intensify therapy for South Africans with type 2 diabetes : an audit of diabetes management at primary health care facilities 

  Ngassa Piotie, Patrick; Webb, Elizabeth M.; Rheeder, Paul (NISC (Pty) Ltd, Medpharm Publications, and Informa UK Limited, 2024)

  BACKGROUND : The management of people living with type 2 diabetes (T2D) in primary care in a South African district was audited, focusing on glycaemic, cholesterol, and blood pressure (BP) control to identify gaps in ...
• Tobacco use in diabetes mellitus : a retrospective cohort study to determine the effect of snuff tobacco use on diabetes mellitus complications over a period of nine years 

  Ally, Raihaan M.; Van Zyl, Danie G. (NISC (Pty) Ltd, Medpharm Publications, and Informa UK Limited, 2024)

  BACKGROUND : Diabetes mellitus (DM) affects millions of people worldwide, with associated morbidity and premature mortality exacerbated by all forms of smoking. The effects of smokeless tobacco, such as snuff and chewing ...
• Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa 

  Van der Mescht, Mieke Adri; De Beer, Zelda; Steel, Helen C.; Anderson, Ronald; Masenge, Andries; Moore, Penny L.; Bastard, Paul; Casanova, Jean-Laurent; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2024-09)

  The African continent reported the least number of COVID-19 cases and deaths of all the continents, although the exact reasons for this are still unclear. In addition, little is known about the immunological profiles ...
• Implementation research : a protocol for two three-arm pragmatic randomised controlled trials on continuous glucose monitoring devices in people with type 1 diabetes in South Africa and Kenya 

  Marban-Castro, Elena; Muhwava, Lorrein; Kamau, Yvonne; Safary, Elvis; Rheeder, Paul; Karsas, Maria; Kemp, Tanja; Freitas, Johane; Carrihill, Michelle; Dave, Joel; Katambo, Daniel; Kimetto, Joan; Allie, Razana; Ndungu, Joseph; Sigwebela, Ntombi; Akach, Dorcas; Girdwood, Sarah; Erkosar, Berra; Nichols, Brooke E.; Haldane, Cathy; Vetter, Beatrice; Shilton, Sonjelle (BMC, 2024-05)

  BACKGROUND : Self-monitoring of glucose is an essential component of type 1 diabetes (T1D) management. In recent years, continuous glucose monitoring (CGM) has provided an alternative to daily fingerstick testing for ...
• Maternally inherited diabetes and deafness with a variable presentation across three generations within a pedigree, South Africa 

  Makgopa, Herbert; Kemp, Tanja; Meldau, Surita; Honey, Engela M.; Chale-Matsau, Bettina (AOSIS, 2024-05)

  INTRODUCTION: Maternally inherited diabetes and deafness (MIDD) is caused by the m.3243A>G pathogenic variant in maternally inherited mitochondrial DNA. Diabetes is prevalent in our setting; however, MIDD is rarely diagnosed. ...
• Hypertension : back to basics 

  Ker, James A.; Outhoff, Kim (Medpharm Publications, 2023)

  This article outlines the principles of blood pressure, including normal and dysfunctional physiology, mathematical equations of pressure, definitions of hypertension and diagnosis, and hence the rationale for and mechanisms ...
• Anaemia in chronic kidney disease 

  Van Hougenhouck-Tulleken, W.G. (Wesley) (Medpharm Publications, 2023)

  Anaemia, occurring in over 50% of patients with stages 3 to 5 chronic kidney disease (CKD), often causes fatigue, shortness of breath, cardiac dysfunction and cognitive impairment. The major causes include disorders of ...
• The impact of diabetes during pregnancy on neonatal outcomes among the Aboriginal population in Western Australia : a whole-population study 

  Ahmed, Marwan Awad; Bailey, Helen D.; Pereira, Gavin; White, Scott W.; Wong, Kingsley; McNamara, Bridgette J.; Rheeder, Paul; Marriott, Rhonda; Shepherd, Carrington C.J. (Oxford University Press, 2023-10)

  BACKGROUND : Aboriginal and Torres Strait Islander (hereafter Aboriginal) women have a high prevalence of diabetes in pregnancy (DIP), which includes pre-gestational diabetes mellitus (PGDM) and gestational diabetes ...
• Comparison of platelet-and endothelial-associated biomarkers of disease activity in people hospitalized with Covid-19 with and without HIV co-infection 

  Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa (Frontiers Media, 2023-08-14)

  INTRODUCTION : SARS-CoV-2 elicits a hyper-inflammatory response that contributes to increased morbidity and mortality in patients with COVID-19. In the case of HIV infection, despite effective anti-retroviral therapy, ...
• Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination 

  Motsoeneng, Boitumelo M.; Manamela, Nelia; Kaldine, Haajira; Kgagudi, Prudence; Hermanus, Tandile; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Van der Mescht, Mieke Adri; Abdullah, Fareed; Boswell, Michael; Ueckermann, Veronica; Rossouw, Theresa; Madhi, Shabir A.; Moore, Penny L.; Richardson, Simone I. (Frontiers Media, 2023-08-03)

  The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in ...
• Comparison of the effects of electronic cigarette vapours and tobacco smoke extracts on human neutrophils in vitro 

  Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory (European Respiratory Society, 2023-05)

  BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than ...
• Spontaneous resolution of a patient with a symptomatic pheochromocytoma 

  Jackson, Brandon Spencer; Ndhlebe, Gugulethu; Suleman, Farhana Ebrahim (Elsevier, 2024-07)

  A 56-year-old woman presented with a 2-year history of chronic persistent right upper quadrant abdominal pain that was associated with intermittent nausea, vomiting, and unintentional weight loss. She had been on ...
• Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 

  Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)

  A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
• Changes in prevalence and seasonality of pathogens identified in acute respiratory tract infections in hospitalised individuals in rural and urban settings in South Africa; 2018–2022 

  Davids, Michaela; Johnstone, Siobhan; Mendes, Adriano; Brecht, Gadean; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; De Villiers, Maryke; Page, N.A. (Nicola); Venter, Marietjie (MDPI, 2024-03)

  Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and ...
• Healthcare delivery 

  Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)

  We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...

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