Browsing Chemical Pathology by Type "Postprint Article"

Now showing items 1-20 of 29

Alterations in male reproductive hormones in relation to environmental DDT exposure

Bornman, Maria S. (Riana); Delport, Rhena; Farías, Paulina; Aneck-Hahn, Natalie Hildegard; Patrick, Sean Mark; Millar, Robert P.; De Jager, Christiaan (Elsevier, 2018-04)

DDT [1, 1, 1-trichloro-2,2-bis (p-chlorophenyl)-ethane] compounds are used for indoor residual spraying (IRS) to control malaria mosquitoes. DDT is an endocrine disruptor chemical in experimental conditions, but little is ...
Assessment of professionalism : recommendations from the Ottawa 2010 Conference

Hodges, Brian David; Ginsburg, Shiphra; Cruess, Richard; Cruess, Sylvia; Delport, Rhena; Hafferty, Fred; Ho, Ming-Jung; Holmboe, Eric; Holtman, Matthew; Ohbu, Sadayoshi; Rees, Charlotte; Ten Cate, Olle; Tsugawa, Yusuke; Van Mook, Walther; Wass, Val; Wilkinson, Tim; Wade, Winnie (Routledge, 2011-05)

Over the past 25 years, professionalism has emerged as a substantive and sustained theme, the operationalization and measurement of which has become a major concern for those involved in medical education. However, how to ...
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point : the SABPA study

Malan, Leoné; Hamer, Mark; Von Känel, Roland; Lambert, Gavin W.; Delport, Rhena; Steyn, Hendrik S.; Malan, Nicolaas T. (Elsevier, 2017-11)

BACKGROUND : Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ...
Comparison of equations for the calculation of LDL-cholesterol in hospitalized patients

Martins, J.; Olorunju, Steve A.S.; Murray, L.M.; Pillay, Tahir S. (Elsevier, 2015-04)

BACKGROUND : The Friedewald equation is widely used to calculate LDL-C for cardiovascular risk prediction but is less accurate with comorbidities and extreme lipid values. Several novel formulae have been reported ...
Computational screening of promising beta-secretase 1 inhibitors through multi-step molecular docking and molecular dynamics simulations - pharmacoinformatics approach

Gupta, Shruti; Parihar, Devendra; Shah, Mokshada; Yadav, Shivali; Managori, Husain; Bhowmick, Shovonlal; Patil, Preeti Chunarkar; Alissa, Siham A.; Wabaidur, Saikh Mohammad; Islam, Md Ataul (Elsevier, 2020-04)

Alzheimer’s disease (AD) is a neurodegenerative disorder generally developed with aging. AD slowly hammers the memory and cognitive abilities which eventually leads to abnormal behaviour, and ultimately left with disability ...
Decline in antibody responses to SARS-CoV-2 post-vaccination poses a risk to health care workers

Worsley, Catherine M.; Van der Mescht, Mieke Adri; Hoffmann, Daniel; Meyer, Pieter Willem Adriaan; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2022-09)

No abstract available.
Diabetes mellitus caused by mutations in human insulin : analysis of impaired receptor binding of insulins Wakayama, Los Angeles and Chicago using pharmacoinformatics

Islam, Md Ataul; Bhayye, Sagar; Adeniyi, Adebayo A.; Soliman, Mahmoud E.S.; Pillay, Tahir S. (Taylor and Francis, 2017-03)

Several naturally occuring mutations in the human insulin gene are associated with diabetes mellitus. The three known mutant molecules, Wakayama, Los Angeles and Chicago were evaluated using molecular docking and molecular ...
Efavirenz interference in urine screening immunoassays for tetrahydrocannabinol

Oosthuizen, Nicholette M.; Laurens, Johannes B. (Royal Society of Medicine Press, 2012-03)

BACKGROUND: It has been known for some time that the antiretroviral drug, efavirenz (EFV), cross-reacts in urine immunoassays for tetrahydrocannabinol (THC). Because published studies investigating this phenomenon are ...
Exploration of the structural requirements of HIV-protease inhibitors using pharmacophore, virtual screening and molecular docking approaches for lead identification

Islam, Md Ataul; Pillay, Tahir S. (Elsevier, 2015-03)

Please abstract in the article.
Humoral hypercalcaemia in an infant : a diagnostic dilemma

Chale-Matsau, Bettina (BMJ Publishing Group Group, 2021-06)

Hypercalcaemia is seldom encountered in paediatric patients, and calcium levels are not routinely included in investigations. Associated symptoms such as nausea, vomiting, dehydration and abdominal pain are non-specific, ...
Identification of promising DNA GyrB inhibitors for Tuberculosis using pharmacophore-based virtual screening, molecular docking and molecular dynamics studies

Islam, Md Ataul; Pillay, Tahir S. (Wiley, 2017-08)

In the current study, we searched for potential DNA GyrB inhibitors using pharmacophorebased virtual screening followed by molecular docking and molecular dynamics simulation approaches. For this purpose, a set of 248 ...
Identification of selective Lyn inhibitors from the chemical databases through integrated molecular modelling approaches

Shetve, V.V.; Bhowmick, Shovonlal; Alissa, Siham A.; Alothman, Z.A.; Wabaidu, S.M.; Asmary, F.A.; Alhajri, Hassna Mohammed; Islam, Md Ataul (Taylor and Francis, 2021)

In the current study, the Asinex and ChEBI databases were virtually screened for the identification of potential Lyn protein inhibitors. Therefore, a multi-steps molecular docking study was carried out using the VSW utility ...
Identification of structural requirements of estrogen receptor modulators using pharmacoinformatics techniques for application to estrogen therapy

Islam, Md Ataul; Patel, Darshakkumar Ashokbhai; Rathod, Savansinh Ghanshyamsinh; Chunarkar, Preeti; Pillay, Tahir S. (Springer, 2016-03)

An attempt was made in the present study to explore the structural requirements of known estrogen receptor (ER) modulators for biological activity using pharmacoinformatics approaches to elucidate critical functionalities ...
Ketamine : friend or foe?

Steyn, Nicolene (BMJ Publishing Group, 2023-09)

Ketamine, a dissociative anaesthetic drug, acts on the central nervous system (CNS) primarily through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Methods of administration include intravenous, intramuscular, ...
Lack of association of rs3798220 with small apolipoprotein(a) isoforms and high lipoprotein(a) levels in East and Southeast Asians

Khalifa, Mahmoud; Noureen, Asma; Ertelthalner, Kathrin; Bandegi, Ahmad Reza; Delport, Rhena; Firdaus, Wance J.J.; Geethanjali, Finney S.; Luthra, Kalpana; Makemaharn, Orawan; Pang, Richard W.C.; Salem, Abdel-Halim; Sasaki, Jun; Schiefenhoevel, Wulf; Lingenhel, Arno; Kronenberg, Florian; Utermann, Gerd; Schmidt, Konrad (Elsevier, 2015-10)

OBJECTIVE : The variant allele of rs3798220 in the apolipoprotein(a) gene (LPA) is used to assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with short alleles of the Kringle IV-2 (KIV-2) ...
Molecular dynamics and combined docking studies for the identification of Zaire ebola virus inhibitors

Sulaiman, Kazeem O.; Kolapo, Temitope U.; Onawole, Abdulmujeeb T.; Islam, Md Ataul; Adegokeg, Rukayat O.; Badmus, Suaibu O. (Taylor and Francis, 2019)

Ebola virus (EBOV) is a lethal human pathogen with a risk of global spread of its zoonotic infections, and Ebolavirus Zaire specifically has the highest fatality rate amongst other species. There is a need for continuous ...
Multi-step molecular docking and dynamics simulation-based screening of large antiviral specific chemical libraries for identification of Nipah virus glycoprotein inhibitors

Kalbhor, Malti Sanjay; Bhowmick, Shovonlal; Alanazi, Amer M.; Patil, Pritee Chunarkar; Islam, Md Ataul (Elsevier, 2021-03)

Nipah virus (NiV) infections are highly contagious and can cause severe febrile encephalitis. An outbreak of NiV infection has reported high mortality rates in Southeast Asian countries including Bangladesh, East Timor, ...
Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition

Savale, Rutuja Umesh; Bhowmick, Shovonlal; Osman, Sameh Mohamed; Alasmary, Fatmah Ali; Almutairi, Tahani Mazyad; Abdullah, Dalal Saied; Patil, Pritee Chunarkar; Islam, Md Ataul (Elsevier, 2021-03)

In the current study, a structure-based virtual screening paradigm was used to screen a small molecular database against the Non-structural protein 15 (Nsp15) endoribonuclease of Severe Acute Respiratory Syndrome Coronavirus ...
Pharmacoinformatics-based identification of anti-bacterial catalase-peroxidase enzyme inhibitors

Jangam, Chaitanya Sadashiv; Bhowmick, Shovonlal; Chorge, Rekha Dhondiram; Bharatrao, Lomate Dhanraj; Patil, Pritee Chunarkar; Chikhale, Rupesh V.; AlFaris, Nora Abdullah; ALTamimi, Jozaa zaidan; Wabaidur, Saikh Mohammad; Islam, Md Ataul (Elsevier, 2019-12)

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). In the present age, due to the rapid increase in antibiotic resistance worldwide, TB has become a major threat to human life. Regardless ...
Pharmacoinformatics-based identification of chemically active molecules against Ebola virus

Islam, Md Ataul; Pillay, Tahir S. (Taylor and Francis, 2019)

Ebola is a dangerous virus transmitted by animals and humans and to date there is no curable agent for such a deadly infectious disease. In this study, pharmacoinformatics-based methods were adopted to find effective novel ...

Now showing items 1-20 of 29

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