• Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 

  Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)

  Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
• In silico bioinformatics analysis on the role of long non-coding RNAs as drivers and gatekeepers of androgen-independent prostate cancer using LNCaP and PC-3 cells 

  Mbeje, Mandisa; Kandhavelu, Jeyalakshmi; Penny, Clement; Kgoebane-Maseko, Minah; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2023-09-01)

  Prostate cancer (PCa) is the leading cancer in men globally. The association between PCa and long non-coding RNAs (lncRNAs) has been reported. Aberrantly expressed lncRNAs have been documented in each of the cancer ...
• Transorbital neuroendoscopy-assisted resection of a giant optic pathway glioma in a neonate 

  Maseko, Rodney; Mabogo, Maanda; Lockhat, Zarina I.; Makunyane, P.S. (Priscilla); Ahmad, Samia; Bida, Meshack; Padayachy, Llewellyn (Springer, 2023-09)

  Congenitalgiant orbital tumors in infancy are relatively rare, especially when the tumors are associated with significant intracranial extension. We describe the use of a transorbital neuroendoscopy-assisted resection of ...
• Renal papillary necrosis (RPN) in an African population : disease patterns, relevant pathways, and management 

  Gaudji, Guy Roger; Bida, M.; Conradie, Marius; Damane, Botle Precious; Bester, Megan (MDPI, 2023-01)

  Renal papillary necrosis (RPN) is characterized by coagulative necrosis of the renal medullary pyramids and papillae. Multiple conditions and toxins are associated with RPN. Several RPN risk factors, or POSTCARDS, have ...
• Profile of human papillomavirus genotypes in breast and oesophageal cancer patients in Pretoria, South Africa 

  Maroga, N.; Mokoena, Taole; Musekiwa, Alfred; Bida, Meshack; Kgomo, Mpho K.; Lebelo, R. (South African Medical Association, 2023-07)

  BACKGROUND : The association between human papillomavirus (HPV) and cervical cancer is well established, and cervical cancer can be prevented through HPV vaccination. Little has been reported on the association between HPV ...
• Superficial spreading cervical squamous cell carcinoma in situ with extensive endomyometrial infiltration masquerading as a primary endometrial cancer 

  Olivier, H.J.; Snyman, Leon Cornelius; Oliva, E.; Slavik, Tomas (MedPharm Publications, 2022-12)

  The presence of squamous cell carcinoma (SCC) on endometrial histology raises the possibility of a primary endometrial carcinoma, as well as secondary endometrial involvement by SCC from another site, especially the cervix. ...
• New horizons in the diagnosis of tuberculosis of the spine : the role of whole genome sequencing 

  Ngcelwane, M.V. (Mthunzi); Omar, Shaheed V.; Said, H.M. (Halima Mohammed); Bida, Nndweleni Meshack (Korean Society of Spine Surgery, 2023-06)

  STUDY DESIGN : Prospective study. PURPOSE : To evaluate the utility of whole genome sequencing (WGS) in drug resistance testing, lineage of the organisms, and organism-related factors responsible for bacilli settling in ...
• Underdiagnosis of iron deficiency anaemia in HIV-infected individuals : a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis 

  Mankgele, Mahlatse; Variava, Ebrahim; Moloantoa, Tumelo; Otwombe, Kennedy; Hlongwane, Khuthadzo; Disenyane, Dineo; Bida, Meshack; Chikwati, Raylton; Snyman, Tracy; Martinson, Neil; Mahlangu, Johnny (BMJ Publishing Group, 2023-08)

  AIM : We compared soluble transferrin receptors (sTfR), serum ferritin, mean cell volume (MCV) of red cells and the sTfR-ferritin index with the intensive method bone marrow trephine (BMT) iron stores in the diagnosis of ...
• Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis 

  Lerch, Julia M.; Pai, Rish K.; Brown, Ian; Gill, Anthony J.; Jain, Dhanpat; Kovari, Bence; Kushima, Ryoji; Sheahan, Kieran; Slavik, Tomas; Srivastava, Amitabh; Lauwers, Gregory Y.; Langner, Cord (Springer, 2022-06)

  The extent of gastric intestinal metaplasia (GIM) can be used to determine the risk of gastric cancer. Eleven international gastrointestinal expert pathologists estimated the extent of GIM on haematoxylin and eosin (H&E)- ...
• Discrepancies between clinical diagnoses and autopsy findings : a comparative study conducted in South Africa 

  Joubert, Doret M.; Rossouw, Servaas Hofmeyr; Solomon, C.; Meyer, Pieter Willem Adriaan (Health and Medical Publishing Group, 2022-11)

  BACKGROUND. The anatomical pathology autopsy serves several purposes, notably as a quality management tool for evaluation of accuracy in clinical diagnosis. Despite its value, for various reasons there has been an ...
• Subtyping intestinal metaplasia in patients with chronic atrophic gastritis : an interobserver variability study 

  Lerch, Julia M.; Pai, Rish K.; Brown, Ian; Gill, Anthony J.; Jain, Dhanpat; Kovari, Bence; Kushima, Ryoji; Sheahan, Kieran; Slavik, Tomas; Srivastava, Amitabh; Lauwers, Gregory Y.; Langner, Cord (Elsevier, 2022-04)

  Incomplete gastric intestinal metaplasia (GIM) is associated with an increased risk of gastric cancer. We aimed to examine the interobserver variability of GIM subtyping (incomplete vs complete) in histological diagnosis ...
• Primary giant cell tumour of the breast with recurrence : a rare case report 

  Suleman, Farhana Ebrahim; Vilakazi, Moipone N.; Bida, Nndweleni Meshack; Edwards, Richard (AOSIS, 2022-04-20)

  Giant cell tumour (GCT) arising from the soft tissues of the breast is a rare disease with only eight cases previously reported in the literature. We present a case of histologically proven GCT of the breast, which ...
• Concomitant congenital intraoral dermoid cyst and heterotopic gastrointestinal cyst 

  Robinson, Liam; Sengoatsi, Tshepang; Van Heerden, Willem Francois Petrus (Springer, 2021-03)

  Sublingual dermoid cysts and oral heterotopic gastrointestinal cysts are well-documented causes of sublingual swellings in infants. However, the simultaneous occurrence of both cysts is an extremely rare phenomenon, with ...
• Suprasellar cyst presenting with bobble-head doll syndrome 

  George, Roshan; Gaxa, Luvo; Lockhat, Zarina I.; Hlahla, Stevens Kgomotso; Van der Meyden, Cornelis Hendrikus; Kisten, Ravendran; Bida, Nndweleni Meshack (Elsevier, 2020-01)

  BACKGROUND : Bobble-head doll syndrome is a rare neurological syndrome presenting with repetitive anteroposterior head movements. It is usually associated with expansile cystic lesions in the third ventricular region. CASE ...
• Potato tuber corky cracks caused by multiple Rhizoctonia species 

  Gush, Sasha-Lee (Plaas Media, 2020-07)

  Potato (Solanum tuberosum L.) is the most consumed and economically important vegetable crop in the world. Nutritionally, potato is ideal for human consumption and provides a balanced source of starch, high-quality proteins, ...
• A de novo 2.2 Mb recurrent 17q23.1q23.2 deletion unmasks novel putative regulatory non-coding SNVs associated with lethal lung hypoplasia and pulmonary hypertension : a case report 

  Karolak, Justyna A.; Gambin, Tomasz; Honey, Engela M.; Slavik, Tomas; Popek, Edwina; Stankiewicz, Paweł (BioMed Central, 2020-03-06)

  BACKGROUND : Application of whole genome sequencing (WGS) enables identification of non-coding variants that play a phenotype-modifying role and are undetectable by exome sequencing. Recently, non-coding regulatory single ...
• The diagnosis of clinically significant oesophageal Candida infections : a reappraisal of clinicopathological findings 

  Hissong, Erika; Schechter, Shula; Mowers, Jonathan; Yantiss, Rhonda.K.; Slavik, Tomas; Cheng, Jerome; Lamps, Laura W. (Wiley, 2020-04)

  AIMS : Distinguishing true oesophageal Candida infections from oral contaminants is a common diagnostic issue. Historically, histological features believed to indicate true infection included epithelial invasion by ...
• Merkel cell carcinoma of the head in a young African Albino woman with HIV/HTLV-1 coinfection associated with multiple squamous cell carcinomas 

  Tenea, Daniela; Dinkel, Jurgen Erich; Becker, Jurgen C.; Van der Walt, Elizabeth (Karger, 2019)

  Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm of presumed neuroendocrine origin, with aggressive behavior and poor prognosis, that tends to have an increased incidence among elderly Caucasians and immunosuppressed ...
• Uterine PEComas : a morphologic, immunohistochemical, and molecular analysis of 32 tumors 

  Bennett, Jennifer A.; Braga, Ana C.; Pinto, Andre; Van de Vijver, Koen; Cornejo, Kristine; Pesci, Anna; Zhang, Lei; Morales-Oyarvide, Vicente; Kiyokawa, Takako; Franco Zannoni, Gian; Carlson, Joseph; Slavik, Tomas; Tornos, Carmen; Antonescu, Cristina R.; Oliva, Esther (Lippincott, Williams & Wilkins, 2018-10)

  Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms that may show overlapping morphology and immunohistochemistry with uterine smooth muscle tumors. In this study, we evaluated the morphologic, ...
• HPV types in cervical cancer tissue in South Africa : a head-to-head comparison by mRNA and DNA tests 

  Rad, Amir; Sorbye, Sveinung Wergeland; Dreyer, Greta; Hovland, Siri; Falang, Bente Marie; Louw, Melanie; Skjeldestad, Finn Egil (Lippincott, Williams and Wilkins, 2017)

  Accurate identification of human papillomavirus (HPV)-types in cervical cancer tissue may be important for tailoring tests for primary screening and types to be included in a vaccine. The aim of this study was to compare ...

View more