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Paediatrics and Child Health: Recent submissions

  • Where are the pregnant and breastfeeding women in new pre-exposure prophylaxis trials? The imperative to overcome the evidence gap 
    Davey, Dvora L. Joseph; Bekker, Linda‑Gail; Bukusi, Elizabeth A.; Chi, Benjamin H.; Delany-Moretlwe, Sinead; Goga, Ameena Ebrahim; Lyerly, Anne Drapkin; Mgodi, Nyaradzo M.; Mugo, Nelly; Myer, Landon; Noguchi, Lisa M.; Stranix-Chibanda, Lynda; Slack, Catherine; Pintye, Jillian (Elsevier, 2022-03)
    Pregnant and breastfeeding populations are at substantial risk of acquiring HIV in some settings, yet are underrepresented in clinical trials of new pre-exposure prophylaxis (PrEP) agents. Several PrEP formulations are in ...
  • MPS VII – Extending the classical phenotype 
    Oldham, A.; Oxborrow, N.J.; Woolfson, P.; Jenkins, P.; Gadepalli, C.; Ashworth, J.; Saxena, A.; Rothera, M.; Hendriksz, Christian J.; Tol, G.; Jovanovic, A. (Elsevier, 2022-12)
    Mucopolysaccharidosis VII (or Sly syndrome) is an autosomal recessive disorder characterised by a deficiency in the enzyme Beta-glucuronidase (GUSB). Partial degradation of glycosaminoglycans (GAGs); chondroitin sulfate ...
  • Addressing the need for patient-friendly medical communications: adaptation of the 2019 recommendations for the management of MPS VI and MPS IVA 
    Bruce, Iain A.; Ezgu, Fatih S.; Kampmann, Christoph; Kenis, Vladimir; Mackenzie, William; Stevens, Bob; Walker, Robert; Hendriksz, Christian J. (BioMed Central, 2022-03)
    BACKGROUND : Patients are the most important stakeholders in the care of any disease and have an educational need to learn about their condition and the treatment they should receive. Considering this need for patient-focused ...
  • A case for genomic medicine in South African paediatric patients with neuromuscular disease 
    Raga, Sharika V.; Wilmshurst, Jo Madeleine; Smuts, Izelle; Meldau, Surita; Bardien, Soraya; Schoonen, Maryke; Van der Westhuizen, Francois Hendrikus (Frontiers Media, 2022-11-17)
    Paediatric neuromuscular diseases are under-recognised and under-diagnosed in Africa, especially those of genetic origin. This may be attributable to various factors, inclusive of socioeconomic barriers, high burden of ...
  • Targeted gene sanger sequencing should remain the first-tier genetic test for children suspected to have the five common X-linked inborn errors of immunity 
    Chan, Koon-Wing; Wong, Chung-Yin; Leung, Daniel; Yang, Xingtian; Fok, Susanna F.S.; Mak, Priscilla H.S.; Yao, Lei; Ma, Wen; Mao, Huawei; Zhao, Xiaodong; Liang, Weiling; Singh, Surjit; Barbouche, Mohamed-Ridha; He, Jian-Xin; Jiang, Li-Ping; Liew, Woei-Kang; Thi Le, Minh Huong; Muktiarti, Dina; Santos-Ocampo, Fatima Johanna; Djidjik, Reda; Belaid, Brahim; Ismail, Intan Hakimah; Latiff, Amir Hamzah Abdul; Lee, Way Seah; Chen, Tong-Xin; Liu, Jinrong; Jin, Runming; Wang, Xiaochuan; Chien, Yin Hsiu; Yu, Hsin-Hui; Raj, Dinesh; Raj, Revathi; Vaughan, Jenifer; Urban, Michael; Van den Berg, Sylvia; Eley, Brian; Lee, AnselmChi-Wai; Isa, Mas Suhaila; Ang, Elizabeth Y.; Lee, Bee Wah; Juh Yeoh, Allen Eng; Shek, Lynette P.; Quynh Le, Nguyen Ngoc; Thi Nguyen, Van Anh; Nguyen Lien, Anh Phan; Capulong, Regina D.; Mallillin, Joanne Michelle; Villanu, Jose Carlo Miguel M.; Camonayan, Karol Anne B.; De Vera, Michelle; Casis-Hao, Roxanne J.; Lobo, Rommel Crisenio M.; Foronda, Ruby; Binas, Vicky Wee Eng; Boushaki, Soraya; Kechout, Nadia; Phongsamart, Gun; Wongwaree, Siriporn; Jiratchaya, Chamnanrua; Lao-Araya, Mongkol; Trakultivakorn, Muthita; Suratannon, Narissara; Jirapongsananuruk, Orathai; Chantveerawong, Teerapol; Kamchaisatian, Wasu; Chan, Lee Lee; Koh, Mia Tuang; Wong, Ke Juin; Fong, Siew Moy; Thong, Meow-Keong; Latiff, Zarina Abdul; Noh, Lokman Mohd; De Silva, Rajiva; Jouhadi, Zineb; Al-Saad, Khulood; Vignesh, Pandiarajan; Jindal, Ankur Kumar; Rawat, Amit; Gupta, Anju; Suri, Deepti; Yang, Jing; Au, Elaine Yuen-Ling; Kwok, Janette Siu-Yin; Chan, Siu-Yuen; Hui, Wayland Yuk-Fun; Chua, Gilbert T.; Duque, Jaime Rosa; Cheong, Kai-Ning; Chong, Patrick Chun Yin; Ho, Marco Hok Kung; Lee, Tsz-Leung; Wong, Wilfred Hing-Sang; Yang, Wanling; Lee, Pamela P.; Tu, Wenwei; Yang, Xi-Qiang; Lau, Yu Lung (Frontiers Media, 2022-07-08)
    To address inborn errors of immunity (IEI) which were underdiagnosed in resource-limited regions, our centre developed and offered free genetic testing for the most common IEI by Sanger sequencing (SS) since 2001. With ...
  • Conference report on the 14th International Society of Paediatric Oncology African Continental Meeting, 16-18 March 2022, Kampala, Uganda 
    Van Heerden, Jaques; Irumba, Lisa Christine; Assani, Karim; Downing, Julia; Davidson, Alan; Hessissen, Laila; Schoeman, Judy; Israels, Trijn; Cox, Sharon; Abdelhafeez, Hafeez; Arao, Shauna Odongo; Parkes, Jeannette; Balagadde-Kambugu, Joyce; Geel, Jennifer (Cancer Intelligence, 2022-07-07)
    Together with the Africa Continental Branch of the International Society of Paediatric Oncology (SIOP Africa), the Uganda Cancer Institute, a tertiary governmental institution for specialised cancer care services, research ...
  • Relationships between health professionals and the pharmaceutical industry : achieving a balance 
    Kling, Sharon; Haus, Matthias (Allergy Society of South Africa, 2022-09)
    Health professionals and the pharmaceutical and medical-device industry have had a long and often problematic relationship. The interaction between for-profit companies trying to promote and market their products and the ...
  • Guest editorial 
    Green, Robin J. (Allergy Society of South Africa, 2022-03)
    Many authors have suggested that one of the most important contributing factors to the enhanced survival of the human population over time has been the vaccination of children. You only have to think of polio and how ...
  • Allergic sensitisation in South Africa : allergen-specific ige-component testing (ISAC) 
    Murray, Louise; Van Rooyen, Cathy; Van den Berg, Sylvia; Green, Robin J. (Allergy Society of South Africa, 2022-03)
    BACKGROUND : Allergic sensitisation patterns differ globally; therefore it is important to understand local South African sensitisation patterns to inhalant and food allergen components to enable clinicians to diagnose ...
  • COVID-19 vaccines : adverse events following immunisation 
    Van den Berg, Sylvia; Van Rooyen, Cathy; Wessels, Pieter Frederik; Brauer, Marieke; Green, Robin J. (Allergy Society of South Africa, 2022-03)
    Patients rely on healthcare providers as their most credible and frequent source of vaccine information. It is therefore crucial that healthcare providers are informed and have evidence-based, objective and clear guidance ...
  • Dr Spur's mystery case : a mystery case as old as time 
    Murray, Louise; Van den Berg, Sylvia; Van Rooyen, Cathy; Van Niekerk, Andre (Allergy Society of South Africa, 2022-03)
    Dear Dr Spur I would appreciate your advice on a complicated patient. This is a 21-year-old female who has suffered from eczema since childhood. The eczema used to be very severe during childhood, but is presently more ...
  • Dr Spur's mystery case : the case of the child who is always sick 
    Van den Berg, Sylvia; Van Rooyen, Cathy; Van Niekerk, Andre (Allergy Society of South Africa, 2022-06)
    Welcome to Dr Spur’s Immunology Clinic Referral letter...
  • Dr Spur's mystery case : new symptoms in a patient with selective IgA deficiency 
    Van Heerden, Carla; Van den Berg, Sylvia; Van Niekerk, Andre (Allergy Society of South Africa, 2022-12)
    A seven-year-old Caucasian girl known to my practice was diagnosed with selective IgA deficiency (sIgAD) two years ago, after recurrent episodes of sinopulmonary infections. Her serum IgA level at the time was <0.07 g/L, ...
  • Dr Spur's mystery case : the case of 'what now?' 
    Van den Berg, Sylvia; Van Rooyen, Cathy; Van Niekerk, Andre (Allergy Society of South Africa, 2022-09)
    Dear Dr Rodriques It is important to recognise a patient with an immunodeficiency in order to manage the patient appropriately and initiate treatment timeously. It cannot be emphasised enough that a high index of suspicion ...
  • Comparison of T-cell immune responses to SARS-CoV-2 spike (S) and nucleocapsid (N) protein using an in-house flow-cytometric assay in laboratory employees with and without previously confirmed COVID-19 in South Africa : nationwide cross-sectional study 
    Van Rooyen, Cathrine; Brauer, Marieke; Swanepoel, Petri; Van den Berg, Sylvia; Van der Merwe, Cassandre; Van der Merwe, Marischa; Green, Robin J.; Becker, Piet J. (BMJ Publishing Group, 2023-06)
    AIMS : To compare specific T-cell responses between laboratory employees in South Africa with and without previously diagnosed SARS-CoV-2 infection. METHODS : Employees at a private pathology laboratory in South Africa ...
  • High asymptomatic carriage with the Omicron variant in South Africa 
    Garrett, N.; Tapley, Asa; Andriesen, Jessica; Seocharan, Ishen; Fisher, Leigh H.; Bunts, Lisa; Epsy, Nicole; Wallis, Carole L.; Randhawa, April Kaur; Miner, Maurine D.; Ketter, Nzeera; Yacovone, Margaret; Goga, Ameena Ebrahim; Huang, Yunda; Hural, John; Kotze, Philip; Bekker, Linda‑Gail; Gray, Glenda E.; Corey, Lawrence; Ubuntu Study Team (Oxford University Press, 2022-07)
    We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before ...
  • Impact of antenatal antiretroviral drug exposure on the growth of children who are HIV‑exposed uninfected : the national South African Prevention of Mother to Child Evaluation cohort study 
    Ramokolo, Vundli; Kuhn, Louise; Lombard, Carl; Jackson, Debra; Goga, Ameena Ebrahim (BMC, 2022-12-06)
    BACKGROUND : The relationship between in-utero antiretroviral (ARV) drug exposure and child growth needs further study as current data provide mixed messages. We compared postnatal growth in the first 18-months of life ...
  • Diagnostic testing practices for diarrhoeal cases in South African public hospitals 
    Johnstone, Siobhan; Page, Nicola Anne; Groome, Michelle J.; Du Plessis, Nicolette Marie; Thomas, Juno (BMC, 2022-11-09)
    BACKGROUND : Stool samples submitted for diagnostic testing represent a proportion of diarrhoeal cases seeking healthcare, and an even smaller proportion of diarrhoeal cases in the community. Despite this, surveillance ...
  • Risk factors for progression of chronic kidney disease : an investigation in prepubertal children 
    Van Biljon, Gertruida; Meintjes, Cornelius J.; Becker, Piet J.; Karusseit, V.O.L. (Otto) (Wiley, 2023-05)
    AIM : Previous studies on progression of chronic kidney disease (CKD) in children have included older post-pubertal subjects. This study attempted to evaluate risk factors for progression of CKD in pre-pubertal ...
  • Challenges in the provision of tuberculosis preventive therapy to children in Gauteng Province, South Africa 
    Philip, R.T.; Feucht, Ute Dagmar (Health and Medical Publishing Group, 2022-03)
    BACKGROUND : Tuberculosis preventive therapy (TPT) offered to children who come into contact with infectious adult pulmonary tuberculosis (TB) cases is an important childhood TB prevention strategy OBJECTIVES : To document ...