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Paediatrics and Child Health: Recent submissions

  • Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV 
    Annamalay, Alicia A.; Abbott, Salome; Sikazwe, Chisha; Khoo, Siew-Kim; Bizzintino, Joelene; Zhang, Guicheng; Laing, Ingrid; Chidlow, Glenys R.; Smith, David W.; Gern, James; Goldblatt, Jack; Lehmann, Deborah; Green, Robin J.; Le Souëf, Peter N. (Elsevier, 2016-08)
    BACKGROUND : Human rhinovirus (RV) is the most common respiratory virus and has been associated with frequent and severe acute lower respiratory infections (ALRI). The prevalence of RV species among HIV-infected children ...
  • Mucopolysaccharidoses 
    Smuts, Izelle (New Media Publishing, 2016-08)
    A group of 7 progressive, multi-system disorders with at least 11 different lysosomal enzyme deficiencies.
  • Enhancing HIV treatment access and outcomes amongst HIV infected children and adolescents in resource limited settings 
    Goga, Ameena Ebrahim; Singh, Yagespari; Singh, Michelle; Noveve, Nobuntu; Magasana, Vuyolwethu; Ramraj, Trisha; Abdullah, Fareed; Coovadia, Ashraf H.; Bhardwaj, Sanjana; Sherman, Gayle G. (Springer, 2017)
    INTRODUCTION : Increasing access to HIV-related care and treatment for children aged 0–18 years in resource-limited settings is an urgent global priority. In 2011–2012 the percentage increase in children accessing a ...
  • The microbiome in chronic inflammatory airway disease : a threatened species 
    Green, Robin J.; Van Niekerk, Andre; Jeevarathnum, A.C.; Feldman, Charles; Richards, Guy A. (Health and Medical Publishing Group, 2016-08)
    The human body is exposed to a multitude of microbes and infectious organisms throughout life. Many of these organisms colonise the skin, gastrointestinal tract (GIT) and airway. We now recognise that this colonisation ...
  • The three waves in implementation of facility-based kangaroo mother care : a multi-country case study from Asia 
    Bergh, Anne-Marie; De Graft-Johnson, Joseph; Khadka, Neena; Om’Iniabohs, Alyssa; Udani, Rekha; Pratomo, Hadi; De Leon-Mendoza, Socorro (BioMed Central, 2016-01-27)
    BACKGROUND : Kangaroo mother care has been highlighted as an effective intervention package to address high neonatal mortality pertaining to preterm births and low birth weight. However, KMC uptake and service coverage have ...
  • Advances in the laboratory diagnosis of food allergy 
    Van Rooyen, Cathy; Van den Berg, Sharon (Allergy Society of South Africa, 2016-06)
    A great number of advances have been made in the diagnostic tools and testing methods available for foodallergy diagnosis. Improved and new methodologies have become available not only to identify the presence of a food ...
  • Gastroschisis in a developing country : poor resuscitation is a more significant predictor of mortality than postnatal transfer time 
    Stevens, Paul S.; Muller, Ernst W.; Becker, P. (Health and Medical Publishing Group, 2016-03)
    BACKGROUND : The time from birth to the first paediatric surgical consultation of neonates with gastroschisis is a predictor of mortality in developing countries. This is contrary to findings in the developed world. We ...
  • Growth in HIV-infected children on long-term antiretroviral therapy 
    Feucht, Ute Dagmar; Van Bruwaene, Lore; Becker, Piet J.; Kruger, Mariana (Wiley, 2016-05)
    OBEJECTIVES : To describe growth in HIV‐infected children on long‐term antiretroviral therapy (ART) and to assess social, clinical, immunological and virological factors associated with suboptimal growth. METHODS : This ...
  • Acute viral bronchiolitis : dawn of a new era for the prevention of respiratory syncytial virus infection through vaccination 
    Madhi, S.A.; Green, Robin J. (Health and Medical Publishing Group, 2016-05)
    Many cases of bronchiolitis are caused by the respiratory syncytial virus (RSV), which was first identified in 1956 as causing illness in humans. Despite ongoing efforts since the 1960s to develop an RSV vaccine, it has ...
  • Acute viral bronchiolitis in South Africa : viral aetiology and clinical epidemiology 
    White, D.A.; Madhi, S.A.; Jeena, P.; Zar, Heather J.; Morrow, B.M.; Masekela, R.; Risenga, S.; Green, Robin J. (Health and Medical Publishing Group, 2016-05)
    Bronchiolitis is a viral-induced lower respiratory tract infection that occurs predominantly in children <2 years of age, particularly infants. Many viruses have been proven or attributed to cause bronchiolitis, including ...
  • Acute viral bronchiolitis in South Africa : intensive care management for severe disease 
    Morrow, B.M.; Feldman, Charles; Green, Robin J. (Health and Medical Publishing Group, 2016)
    It is estimated that 2 - 3% of children will be hospitalised with viral bronchiolitis during their first year of life, and a small proportion of them will have a severe course of the disease, requiring intensive care and ...
  • Acute viral bronchiolitis in South Africa : strategies for management and prevention 
    Zar, Heather J.; Madhi, S.A.; White, D.A.; Masekela, R.; Risenga, S.; Lewis, H.; Feldman, Charles; Morrow, B.; Jeena, P. (Health and Medical Publishing Group, 2016-04)
    Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, ...
  • Acute viral bronchiolitis in South Africa : diagnosis and current management 
    Green, Robin J.; Zar, Heather J. (Health and Medical Publishing Group, 2016-04)
    This issue of CME profiles acute viral bronchiolitis – a common condition that is often not serious. Nonetheless, each year a number of infants, particularly those with an underlying susceptibility to severe disease, ...
  • Acute viral bronchiolitis in South Africa : diagnostic flow 
    White, D.A.; Zar, Heather J.; Madhi, S.A; Jeena, P.; Morrow, B.; Masekela, R.; Risenga, S.; Green, Robin J. (Health and Medical Publishing Group, 2016-04)
    Bronchiolitis may be diagnosed on the basis of clinical signs and symptoms. In a young child, the diagnosis can be made on the clinical pattern of wheezing and hyperinflation. Clinical symptoms and signs typically start ...
  • Serious bacterial infections in febrile young children : lack of value of biomarkers 
    Karsas, Maria; Becker, Piet J.; Green, Robin J. (Health and Medical Publishing Group, 2016-03)
    BACKGROUND : Serious infections in children are difficult to determine from symptoms and signs alone. Fever is both a marker of insignificant viral infection, as well as more serious bacterial sepsis. Therefore, seeking ...
  • Usefulness of ultrasonography and biochemical features in the diagnosis of cholestatic jaundice in infants 
    Choopa, M.S.; Kock, Celeste; Manda, S.O.M. (Samuel); Terblanche, Alta J.; Wittenberg, Dankwart F. (Health and Medical Publishing Group, 2016-03)
    BACKGROUND : Biliary atresia is a common cause of cholestasis. In our experience, patients with biliary atresia are referred late, with the diagnosis based on an absent gall bladder at ultrasonography. Such late referrals ...
  • Taking kangaroo mother care forward in South Africa : the role of district clinical specialist teams 
    Feucht, Ute Dagmar; Van Rooyen, Elise; Skhosana, R.; Bergh, Anne-Marie (Health and Medical Publishing Group, 2016-01)
    The global agenda for improved neonatal care includes the scale-up of kangaroo mother care (KMC) services. The establishment of district clinical specialist teams (DCSTs) in South Africa (SA) provides an excellent opportunity ...
  • Burn surgeons in South Africa : a rare species 
    Allorto, N.L.; Zoepke, S.; Clarke, D.L.; Rode, H. (Health and Medical Publishing Group, 2016-02)
    BACKGROUND. The high burden of burn injuries in South Africa (SA) requires surgeons skilled in burn care. However, there are few dedicated burn surgeons and properly equipped units or centres. OBJECTIVES. To quantify the ...
  • Observational clinical study of 22 adult-onset Pompe disease patients undergoing enzyme replacement therapy over 5 years 
    Stepien, Karolina M.; Hendriksz, Christian J.; Roberts, Mark; Sharma, Reena (Elsevier, 2016-01)
    Pompe disease is an autosomal recessive disease resulting from deficiency of the acid alpha-glucosidase (GAA). The late-onset Pompe Disease (LOPD) patients develop muscular and respiratory complications later in ...
  • Severe pneumonia in HIV-infected and exposed infants in a paediatric ICU 
    Cloete, Jeane; Becker, Piet J.; Masekela, Refiloe; Pentz, Adele; Wijnant, Wim; De Campos, R.; Kitchin, Omolemo P.; Green, Robin J. (Health and Medical Publishing Group, 2015-08)
    BACKGROUND. Pneumocystis jiroveci pneumonia is still a common cause of severe disease in HIV-infected infants <5 months of age. Despite attention to the prevention of mother-to-child transmission programme in South Africa ...