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Paediatrics and Child Health: Recent submissions

  • A landscape analysis of preterm birth in South Africa : systemic gaps and solutions 
    Ramokolo, Vundli; Malaba, Thokozile; Rhoda, Natasha; Kauchali, Shuaib K.; Goga, Ameena Ebrahim (Health Systems Trust, 2019-03)
    Lack of accurate nationally representative preterm birth estimates limit our epidemiological understanding of this syndrome and the extent to which health services can respond appropriately.
  • Achieving universal health coverage for adolescents in South Africa : health sector progress and imperatives 
    Jonas, Kim; Ramraj, Trisha; Goga, Ameena Ebrahim; Bhana, Arvin; Mathews, Catherine (Health Systems Trust, 2019-03)
    Investment in adolescent health and wellbeing today will bring multiple benefits, leading to better long-term health for this generation and generations to come.
  • Antimicrobial resistance global crisis 
    Du Plessis, Nicolette Marie (New Media Publishing, 2019-09)
    Antimicrobial resistance (AMR) is a global health threat. Although resistance to antimicrobial agents can occur naturally in organisms, the misuse of antimicrobials in humans and animals has led to an accelerated ...
  • Toileting Abilities Survey as a surrogate outcome measure for cognitive function : findings from neuronopathic mucopolysaccharidosis II patients treated with idursulfase and intrathecal idursulfase 
    Hogan, Melissa J.; Stephens, Kim; Smith, Erin; Jalazo, Elizabeth R.; Hendriksz, Christian J.; Edwards, Lloyd J.; Bjoraker, Kendra J. (Elsevier, 2020-12)
    An outcome measure of toileting skills, the Toileting Abilities Survey or TAS, with sensitivity to detect change in a neurodegenerative disorder such as MPS II, was developed. The TAS was used in a research study of ...
  • Congenital rubella syndrome surveillance in South Africa using a sentinel site approach : a cross-sectional study 
    Motaze, Nkengafac Villyen; Manamela, Jack; Smit, Sheilagh; Rabie, Helena; Harper, Kim; Du Plessis, Nicolette Marie; Reubenson, Gary; Coetzee, Melantha; Ballot, Daynia; Moore, David; Nuttall, James; Linley, Lucy; Tooke, Lloyd; Kriel, Jeannette; Hallbauer, Ute; Sutton, Christopher; Moodley, Pravi; Hardie, Diana; Mazanderani, Ahmad Haeri; Goosen, Felicity; Kyaw, Thanda; Leroux, Dave; Hussain, Akhtar; Singh, Radhika; Kelly, Christopher; Ducasse, Graham; Muller, Michelle; Blaauw, Magdaleen; Hamese, Mohlabi; Leeuw, Tumelo; Mekgoe, Omphile; Rakgole, Philemon; Dungwa, Norman; Maphosa, Thulisile; Sanyane, Kgomotso; Preiser, Wolfgang; Cohen, Cheryl; Suchard, Melinda (Oxford University Press, 2019-05-15)
    BACKGROUND. Congenital rubella syndrome (CRS) includes disorders associated with intrauterine rubella infection. Incidence of CRS is higher in countries with no rubella-containing vaccines (RCV) in their immunization ...
  • Mechanisms of mitochondrial dysfunction in lysosomal storage disorders : a review 
    Stepien, Karolina M.; Roncaroli, Federico; Turton, Nadia; Hendriksz, Christian J.; Roberts, Mark; Heaton, Robert A.; Hargreaves, Iain (MDPI, 2020-08)
    Mitochondrial dysfunction is emerging as an important contributory factor to the pathophysiology of lysosomal storage disorders (LSDs). The cause of mitochondrial dysfunction in LSDs appears to be multifactorial, although ...
  • When 'B' becomes 'A' : the emerging threat of influenza B virus 
    Green, Robin J. (Health and Medical Publishing Group, 2020-11)
    Influenza is a serious condition that affects millions of people (and especially children) annually, around the world and in South Africa. Many people (including many children) die of the disease annually. Last year, the ...
  • Strengthening quality of care for children who are HEU 
    Goga, Ameena Ebrahim (Elsevier, 2020-01)
    The analysis by Amy Slogrove and colleagues in The Lancet Global Health contributes to increased understanding of the extent of future health needs of children in low-income and middle-income countries (LMICs) with high ...
  • Steep declines in pediatric AIDS mortality in South Africa, despite poor progress toward pediatric diagnosis and treatment targets 
    Johnson, Leigh F.; Patrick, Sean Mark; Stephen, C.R. (Cindy) (Lippincott Williams and Wilkins, 2020-09)
    BACKGROUND : Few attempts have been made to monitor progress toward HIV diagnosis and antiretroviral treatment (ART) coverage targets in children, and the impact that ART and prevention of mother-to-child transmission ...
  • Evaluation of intussusception after oral monovalent rotavirus vaccination in South Africa 
    Groome, Michelle J.; Tat, Jacqueline E.; Arnold, Marion; Chitnis, Milind; Cox, Sharon; De Vos, Corne; Kirsten, Mari; Le Grange, Susanna M.; Loveland, Jerome; Machaea, Sello; Maharaj, Ashwini; Andrews, Nick; Madhi, Shabir A.; Parashar, Umesh D. (Oxford University Press (OUP), 2020-04)
    BACKGROUND: Postlicensure studies have shown an association between rotavirus vaccination and intussusception. We assessed the risk of intussusception associated with Rotarix (RV1) administration, at 6 and 14 weeks of ...
  • ‘We are the advocates for the babies’ - understanding interactions between patients and health care providers during the prevention of mother-to-child transmission of HIV in South Africa : a qualitative study 
    Heerink, Fiona; Krumeich, Anja; Feron, Frans; Goga, Ameena Ebrahim (Taylor and Francis Open, 2019)
    BACKGROUND : HIV/AIDS has had a significant impact on maternal and child health in South Africa. It is thus of vital importance to implement interventions to prevent mother-to-child transmission of HIV (PMTCT) as early ...
  • Hepatitis A virus seroprevalence in South Africa - estimates using routine laboratory data, 2005–2015 
    Mazanderani, Ahmad Haeri; Motaze, Nkengafac Villyen; McCarthy, Kerrigan; Suchard, Melinda; Du Plessis, Nicolette Marie (Public Library of Science, 2019-06)
    INTRODUCTION : South Africa is considered highly endemic for hepatitis A virus (HAV) although few seroprevalence studies have been conducted over the past two decades. The World Health Organization recommends integrating ...
  • Recommendations for the management of MPS IVA : systematic evidence- and consensus-based guidance 
    Akyol, Mehmet Umut; Alden, Tord D.; Amartino, Hernan; Ashworth, Jane; Belani, Kumar; Berger, Kenneth I.; Borgo, Andrea; Braunlin, Elizabeth; Eto, Yoshikatsu; Gold, Jeffrey I.; Jester, Andrea; Jones, Simon A.; Karsli, Cengiz; Mackenzie, William; Marinho, Diane Ruschel; McFadyen, Andrew; McGill, Jim; Mitchell, John J.; Muenzer, Joseph; Okuyama, Torayuki; Orchard, Paul J.; Stevens, Bob; Thomas, Sophie; Walker, Robert; Wynn, Robert; Giugliani, Roberto; Harmatz, Paul; Hendriksz, Christian J.; Scarpa, Maurizio (BioMed Central (BMC), 2019-06)
    INTRODUCTION: Mucopolysaccharidosis (MPS) IVA or Morquio A syndrome is an autosomal recessive lysosomal storage disorder (LSD) caused by deficiency of the N-acetylgalactosamine-6-sulfatase (GALNS) enzyme, which impairs ...
  • Recommendations for patient screening in ultra-rare inherited metabolic diseases : what have we learned from Niemann-Pick disease type C? 
    Sobrido, Maria-Jesus; Bauer, Peter; De Koning, Tom; Klopstock, Thomas; Nadjar, Yann; Patterson, Marc C.; Synofzik, Matthis; Hendriksz, Christian J. (BioMed Central (BMC), 2019-01)
    BACKGROUND: Rare and ultra-rare diseases (URDs) are often chronic and life-threatening conditions that have a profound impact on sufferers and their families, but many are notoriously difficult to detect. Niemann-Pick ...
  • Disease progression of alpha-mannosidosis and impact on patients and carers – a UK natural history survey 
    Adam, Jacqueline; Malone, Rachel; Lloyd, Sioned; Lee, Jennifer; Hendriksz, Christian J.; Ramaswami, Uma (Elsevier, 2019-09)
    INTRODUCTION: Alpha-mannosidosis is an ultra-rare lysosomal storage disorder resulting from the deficient activity of lysosomal alpha-mannosidase. Alpha-mannosidosis presents as a highly heterogenous condition with large ...
  • Tracking epilepsy and autism 
    Lamb, Gregory V.; Green, Robin J.; Olorunju, S. (SpringerOpen, 2019-08-22)
    BACKGROUND : There is conflicting data as to the prevalence of seizures and the relevance of epileptiform EEGs in autistic children. With the focus primarily on aetiology in autism research, very little emphasis has been ...
  • Mortality and morbidity of very low-birthweight and extremely low-birthweight infants in a tertiary hospital in Tshwane 
    Tshehla, Rosine Marie; Coetzee, Melantha; Becker, Piet J. (Health and Medical Publishing Group, 2019-06)
    BACKGROUND: Since 2000, South Africa (SA) has had a relatively static neonatal mortality rate, estimated to be 12/1 000 live births, with complications of prematurity being the leading cause of neonatal mortality. Survival ...
  • OLA-simple : a software-guided HIV-1 drug resistance test for low-resource laboratories 
    Panpradist, Nuttada; BecK, Ingrid A.; Vrana, Justin; Higa, Nikki; McIntyre, David; Ruth, Parker S.; So, Isaac; Kline, Enos C.; Kanthula, Ruth; Wong-On-Wing, Annie; Lim, Jonathan; Ko, Daisy; Milne, Ross; Rossouw, Theresa M.; Feucht, Ute Dagmar; Chung, Michael; Jourdain, Gonzague; Ngo-Giang-Huong, Nicole; Laomanit, Laddawan; Soria, Jaime; Lai, James; Klavins, Eric D.; Frenkel, Lisa M.; Lutz, Barry R. (Elsevier, 2019-12)
    BACKGROUND : HIV drug resistance (HIVDR) testing can assist clinicians in selecting treatments. However, high complexity and cost of genotyping assays limit routine testing in settings where HIVDR prevalence has reached ...
  • Unmasking the vulnerabilities of uninfected children exposed to HIV 
    Ramokolo, Vundli; Goga, Ameena Ebrahim; Slogrove, Amy L.; Powis, Kathleen M. (BMJ Publishing Group, 2019)
    Although programmes to reduce vertical transmission of HIV mean fewer children are acquiring HIV, more needs to be done to understand the longer term outcomes of exposure.
  • Increasing male engagement in the prevention of vertical transmission of HIV : what works in sub-Saharan Africa? 
    Aliyu, Muktar H.; Agudu, Nadia A. Sam; Shenoi, Sheela; Goga, Ameena Ebrahim; Ramraj, Trisha; Vermund, Sten H.; Audet, Carolyn M. (BMJ Publishing Group, 2019)
    Ending vertical transmission of HIV, or maternal-to-infant passage of HIV during pregnancy, labour, or postpartum, in sub- Saharan Africa will require innovations beyond current biomedical tools. Available evidence ...