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Paediatrics and Child Health: Recent submissions

  • COVID-19 : lessons and experiences from South Africa’s first surge 
    Moonasar, Devanand; Pillay, Anban; Leonard, Elizabeth; Naidoo, Raveen; Mngemane, Shadrack; Ramkrishna, Wayne; Jamaloodien, Khadija; Lebese, Lebogang; Chetty, Kamy; Bamford, Lesley; Tanna, Gaurang; Ntuli, Nhlanhla; Mlisana, Koleka; Madikizela, Lindiwe; Modisenyane, Moeketsi; Engelbrecht, Christie; Maja, Popo; Bongweni, Funeka; Furumele, Tsakani; Mayet, Natalie; Goga, Ameena Ebrahim; Talisuna, Ambrose; Ramadan, Otim Patrick Cossy; Pillay, Yogan (BMJ Publishing Group, 2021)
    On 5 March 2020, South Africa recorded its first case of imported COVID-19. Since then, cases in South Africa have increased exponentially with significant community transmission. A multisectoral approach to containing ...
  • Managing and preventing childhood pneumonia in South Africa : updated South African guidelines 
    Green, Robin J.; Zar, Heather J.; Madhi, Shabir A. (Health and Medical Publishing Group, 2020-08)
    The two articles in this edition of CME follow up on those in the previous edition, i.e. epidemiology/aetiology and diagnosis of community-acquired pneumonia (CAP) in children. The articles in this issue cover recommendations ...
  • Parental access to hospitalised children during infectious disease pandemics such as COVID-19 
    Goga, Ameena Ebrahim; Feucht, Ute Dagmar; Pillay, S.; Reubenson, G.; Jeena, P.; Madhi, S.; Mayet, N.T.; Velaphi, S.; McKerrow, N.; Mathivha, L.R.; Makubalo, N.; Green, Robin J.; Gray, G. (Health and Medical Publishing Group, 2021-02)
    The COVID-19 pandemic has resulted in many hospitals severely limiting or denying parents access to their hospitalised children. This article provides guidance for hospital managers, healthcare staff, district-level ...
  • Mitochondrial DNA parameters in blood of infants receiving lopinavir/ritonavir or lamivudine prophylaxis to prevent breastfeeding transmission of HIV-1 
    Monnin, Audrey; Nagot, Nicolas; Peries, Marianne; Vallo, Roselyne; Meda, Nicolas; Singata-Madliki, Mandisa; Tumwine, James K.; Kankasa, Chipepo; Ngandu, Nobubelo Kwanele; Goga, Ameena Ebrahim; Reynier, Pascal; Tylleskar, Thorkild; Van de Perre, Philippe; Moles, Jean-Pierre (MDPI, 2020-09)
    Children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) accumulate maternal HIV and antiretroviral exposures through pregnancy, postnatal prophylaxis, and breastfeeding. Here, we compared the ...
  • Protecting asthmatics from COVID-19 
    Green, Robin J.; Van Bruwaene, Lore; Mustafa, Fatima; Van Niekerk, Andre (Allergy Society of South Africa, 2020)
    The coronavirus disease 2019 (COVID-19) is caused by a severe acute respiratory syndrome 2 virus (SARS-CoV-2). Infections were first detected in Wuhan, China in late 2019 and the infection has recently spread worldwide and ...
  • Allergy prevention – reality or not? 
    Warner, John O.; Green, Robin J.; Mustafa, Fatima (Allergy Society of South Africa, 2020-12)
    While the epidemic of respiratory allergy (asthma and rhinitis) which began 50–60 years ago has begun to taper off in some parts of the world, most notably in affluent countries, a second wave involving food allergy and ...
  • Non-indicated scheduled caesarean deliveries in low-risk pregnancies have harmful effects on gene expression and immune function 
    Van Niekerk, Andre; Delport, Suzanne D. (Allergy Society of South Africa, 2020-10)
    Medicalised birth is increasing on a global scale. Scheduled caesarean deliveries have become the most common delivery mode in the South African private sector despite evidence that a vaginal delivery is the safest delivery ...
  • Guest editorial 
    Green, Robin J.; Mustafa, Fatima (Allergy Society of South Africa, 2020-10)
    The year 2020 is almost a bygone. What a year it’s been for medical science and healthcare! We have all been affected by the COVID-19 crisis, each in our own way. Most congresses have been cancelled and international travel ...
  • The immunology of mind control : exploring the relationship between the microbiome and the brain (Part V) 
    Karsas, Maria; Green, Robin J.; Lamb, Greg (Allergy Society of South Africa, 2020-10)
    The final part of this series concludes the evaluation of the relationship between the human species and the human gut microbiome, focusing on whether their relationship is symbiotic, parasitic or somewhere in between. The ...
  • Dr Spur's mystery case : primary immunodeficiency disorders 
    Van den Berg, Sylvia; Van Rooyen, Cathy; Green, Robin J. (Allergy Society of South Africa, 2020-10)
    No abstract available.
  • Practical management of food allergy 
    Spickett, Gavin; Van Rooyen, Cathrine (Allergy Society of South Africa, 2020)
    Food allergy is on the increase, particularly in Africa and Asia. Significant regional variations in the key food allergens are determined by diet and inhalant allergy cross-reactivities. A good clinical history, supported ...
  • Does in utero HIV exposure and the early nutritional environment influence infant development and immune outcomes? Findings from a pilot study in Pretoria, South Africa 
    White, Marina; Feucht, Ute Dagmar; Duffley, Eleanor; Molokoane, Felicia; Durandt, Chrisna; Cassol, Edana; Rossouw, Theresa M.; Connor, Kristin L. (BMC, 2020-12-11)
    BACKGROUND : As mother-to-child transmission of HIV decreases, and the population of infants who are born HIV-exposed, but uninfected (HEU) continues to rise, there is a growing need to understand the development and health ...
  • The impact of cytokine levels in young South African children with and without HIV-associated acute lower respiratory infections 
    Annamalay, Alicia A.; Abbott, Salome; Khoo, Siew‐Kim; Hibbert, Julie; Bizzintino, Joelene; Zhang, Guicheng; Laing, Ingrid; Currie, Andrew; Le Souef, Peter N.; Green, Robin J. (Wiley, 2021-06)
    Altered host immune responses are considered to play a key role in the pathogenesis of acute lower respiratory infections (ALRI). The existing literature on cytokine responses in ALRI is largely focussed on adults from ...
  • Diagnosis and management of community-acquired pneumonia in children : South African Thoracic Society guidelines 
    Zar, Heather J.; Moore, D.P.; Andronikou, S.; Argent, A.C.; Avenant, Theunis Johannes; Cohen, C.; Green, Robin J.; Itzikowitz, G.; Jeena, P.; Masekela, R.; Nicol, M.P.; Pillay, A.; Reubenson, G.; Madhi, S.A. (South African Medical Association, 2020-09)
    BACKGROUND: Pneumonia remains a major cause of morbidity and mortality amongst South African children. More comprehensive immunisation regimens, strengthening of HIV programmes, improvement in socioeconomic conditions and ...
  • Management of acute fever in children : consensus recommendations for community and primary healthcare providers in Sub-Saharan Africa 
    Green, Robin J.; Webb, David; Jeena, Prakash Mohan; Wells, Mike; Butt, Nadia; Hangoma, Jimmy Mapenzi; Moodley, Rajatheran Sham; Maimin, Jackie; Wibbelink, Margreet; Mustafa, Fatima (Elsevier, 2021-06)
    Fever is one of the most common reasons for unwell children presenting to pharmacists and primary healthcare practitioners. Currently there are no guidelines for assessment and management of fever specifically for community ...
  • Successful antibiotic stewardship in hospitalised children in a developing nation 
    Mustafa, Fatima; Koekemoer, L.A.; Green, Robin J.; Turner, A.C. (Astrid); Becker, Piet J.; Van Biljon, Gertruida (Elsevier, 2020-12)
    OBJECTIVES : Increasing antimicrobial resistance has become a looming threat to paediatric health and, therefore, health facilities are obliged to practice antimicrobial stewardship. This study was undertaken to review ...
  • Global retinoblastoma presentation and analysis by national income level 
    Fabian, Ido Didi; Abdallah, Elhassan; Abdullahi, Shehu U.; Global Retinoblastoma Study Group; Reynders, David; Schoeman, Judy (American Medical Association, 2020-02-27)
    IMPORTANCE : Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child’s life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To ...
  • Clinical outcomes in an adult patient with mannose phosphate isomerase-congenital disorder of glycosylation who discontinued mannose therapy 
    Naoman, Kinza; Hendriksz, Christian J.; Radcliffe, Graham; Roncaroli, Federico; Moreea, Sulleman; Hussain, Afifah; Stepien, Karolina M. (Elsevier, 2020-12)
    The mannose phosphate isomerase-congenital disorder of glycosylation (MPI-CDG) is caused by phosphomannose isomerase deficiency. Clinical features include hyperinsulinaemic hypoglycaemia, protein losing enteropathy, hepatomegaly ...
  • Critical clinical situations in adult patients with Mucopolysaccharidoses (MPS) 
    Stepien, Karolina M.; Gevorkyan, Anait K.; Hendriksz, Christian J.; Lobzhanidze, Tinatin V.; Perez-Lopez, Jordi; Tol, Govind; Del Toro Riera, Mireia; Vashakmadze, Nato D.; Lampe, Christina (BioMed Central, 2020-05-14)
    BACKGROUND : Mucopolysaccharidoses (MPS) are rare, inherited disorders associated with enzyme deficiencies that result in glycosaminoglycan (GAG) accumulation in multiple organ systems. Management of MPS is evolving ...
  • The position of the common facial vein in neonates : an alternate route for central venous catheter placement 
    Van Tonder, Daniel Johannes; Keough, Natalie; Van Niekerk, Martin Louis; Van Schoor, Albert-Neels (Wiley, 2021-05)
    INTRODUCTION : We determine the location of the common facial vein (CFV) in a sample of neonates and assess the safety of this vein as an alternative access route for a central venous catheter (CVC). MATERIALS AND METHODS ...