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Paediatrics and Child Health: Recent submissions

  • South African neonates with mild and moderate hypoxic-ischaemic encephalopathy 
    Malan, Roxanne; Van der Linde, Jeannie; Kritzinger, Alta M. (Aletta Margaretha); Coetzee, Melantha; Graham, Marien Alet; Kruger, Esedra (South African Medical Journal, 2022-09)
    BACKGROUND. Clear risk profiles of neonates with mild and moderate hypoxic-ischaemic encephalopathy (HIE) are lacking. OBJECTIVE. To describe and compare factors associated with mild and moderate HIE in South African ...
  • Hepatitis A virus seroprevalence among children and adolescents in a high‑burden HIV setting in urban South Africa 
    Du Plessis, Nicolette Marie; Mazanderani, Ahmad Haeri; Motaze, Nkengafac Villyen; Ngobese, Makhosazane; Avenant, Theunis Johannes (Nature Research, 2022-11-30)
    Hepatitis A virus (HAV) infection is one of the most important global causes of viral hepatitis. Recent reviews suggested that HAV endemicity in South Africa could shift from high to intermediate. A hospital-based HAV ...
  • Allergy and household living conditions among adolescents living near gold mine tailing dumps in the Gauteng and North West Provinces of South Africa 
    Olajide-Ibiejugba, Abike O.; Nkosi, Vusumuzi; Takalani-Rathogwa, Funzani; Shirinde, Joyce; Wichmann, Janine; Green, Robin J.; Voyi, K.V.V. (Kuku) (MDPI, 2022-01)
    This quantitative exploratory baseline study aimed to investigate whether allergy among adolescents was associated with household living conditions, including living near gold mine tailing dumps in South Africa. A questionnaire ...
  • Quality and consistency of clinical practice guidelines on the prevention of food allergy and atopic dermatitis : systematic review protocol 
    Leung, Agnes Sze Yin; Tham, Elizabeth Huiwen; Samuel, Miny; Munblit, Daniel; Chu, Derek K.; Dahdah, Lamia; Yamamoto-Hanada, Kiwako; Trikamjee, Thulja; Warad, Vijay; Van Niekerk, Andre; Martinez, Santiago; Ellis, Anne; Bielory, Leonard; Cuadros, Gustavo; Van Bever, Hugo; Wallace, Dana; Tang, Mimi; Sublett, James; Wong, Gary Wing Kin (Elsevier, 2022-09)
    BACKGROUND AND AIMS : Allergy prevention strategies have gained significant traction as a means to attenuate the growing burden of allergic diseases over the past decade. As the evidence base for primary prevention of food ...
  • Prophylaxis is the new standard of care in patients with haemophilia 
    Mahlangu, J.; Bassa, F.; Bassingthwaighte, M.; Cruickshank, A-L.; Du Plessis, J.; Goga, Y.; Joubert, J.; Louw, V.; Mahlachana, N.; Mathew, R.; Neethling, B.; Potgieter, J.; Rapiti, N.; Rayner, B.; Reynders, David; Sutton, C.; Van Zyl, A. (Health and Medical Publishing Group, 2022-06)
    Randomised controlled clinical trial evidence on prophylaxis as optimal care for patients with haemophilia was generated more than a decade ago. However, this knowledge has not translated into clinical practice in South ...
  • Sisonke phase 3B open-label study : lessons learnt for national and global vaccination scale-up during epidemics 
    Goga, Ameena Ebrahim; Bekker, L-G.; Garrett, Nigel; Takuva, Simbarashe G.; Sanne, I.; Odhiambo, J.; Mayat, F.; Fairall, L.; Brey, Z.; Bamford, L.; Tanna, G.; Gray, G. (Health and Medical Publishing Group, 2022-05)
    Sisonke is a multicentre, open-label, single-arm phase 3B vaccine implementation study of healthcare workers (HCWs) in South Africa, with prospective surveillance for 2 years. The primary endpoint is the rate of severe ...
  • There's something new in the air 
    Green, Robin J. (New Media Publishing, 2021-03)
    Before considering the role of a new agent to treat and improve care of allergic rhinitis (AR), it seems wise to follow the immunological journey from exposure to an antigen to the final overwhelming inflammatory cascade ...
  • Investigating the quality of HIV rapid testing practices in public antenatal health care facilities, South Africa 
    Nsibande, Duduzile Faith; Woldesenbet, Selamawit; Puren, Adrian; Barron, Peter; Maduna, Vincent I.; Lombard, Carl; Cheyip, Mireille; Mogashoa, Mary; Pillay, Yogan; Magasana, Vuyolwethu; Ramraj, Trisha; Kufa, Tendesayi; Kindra, Gurpreet; Goga, Ameena Ebrahim; Chirinda, Witness (Public Library of Science, 2022-08-29)
    Monitoring HIV prevalence using antenatal HIV sentinel surveillance is important for efficient epidemic tracking, programme planning and resource allocation. HIV sentinel surveillance usually employs unlinked anonymous ...
  • Growth and the pubertal growth spurt in South African adolescents living with perinatally-acquired HIV infection 
    Mwambenu, Bilema; Ramoloko, Vundli; Laubscher, Ria; Feucht, Ute Dagmar (Public Library Science, 2022-01-25)
    BACKGROUND : The majority children living with HIV infection now survive into adulthood because of effective antiretroviral therapy (ART), but few data exist on their growth during adolescent years. This study investigated ...
  • Safety evaluation of the single-dose Ad26. COV2.S vaccine among healthcare workers in the Sisonke study in South Africa : a phase 3b implementation trial 
    Takuva, Simbarashe G.; Takalani, Azwidhwi; Seocharan, shen; Yende-Zuma, Nonhlanhla; Reddy, Tarylee; Engelbrecht, Imke; Faesen, Mark; Khuto, Kentse; Whyte, Carmen J.; Bailey, Veronique; Trivella, Valentina; Peter, Jonathan; Opie, Jessica; Louw, Vernon; Rowji, Pradeep; Jacobson, Barry; Groenewald, Pamela; Dorrington, Rob E.; Laubscher, Ria; Bradshaw, Debbie; Moultrie, Harry; Fairall, Lara; Sanne, Ian; GailBekker, Linda; Gray, Glenda; Goga, Ameena Ebrahim; Garrett, Nigel (Public Library Science, 2022-06-21)
    Real-world evaluation of the safety profile of vaccines after licensure is crucial to accurately characterise safety beyond clinical trials, support continued use, and thereby improve public confidence. The Sisonke study ...
  • Bronchiectasis in African children : challenges and barriers to care 
    Verwey, Charl; Gray, Diane M.; Dangor, Ziyaad; Ferrand, Rashida A.; Ayuk, Adaeze C.; Marangu, Diana; Owusu, Sandra Kwarteng; Mapani, Muntanga K.; Goga, Ameena Ebrahim; Masekela, Refiloe (Frontiers Media S.A., 2022-07-25)
    Bronchiectasis (BE) is a chronic condition aecting the bronchial tree. It is characterized by the dilatation of large and medium-sized airways, secondary to damage of the underlying bronchial wall structural elements ...
  • Asthma in South African children : reflection on new recommendations for care 
    Green, Robin J.; Manjra, A.I.; Zar, Heather J. (Health and Medical Publishing Group, 2021-05)
    The South African Childhood Asthma Working Group (SACAWG), a subcommittee of the Allergy Society of South Africa (ALLSA), published the first national asthma guidelines for children in 1992. Since then, the understanding ...
  • Childhood asthma : a best-practice strategy for diagnosis and assessment of control in South Africa 
    Van Niekerk, A.; White, D.A.; Goussard, P.; Risenga, S.M. (Health and Medical Publishing Group, 2021-08)
    The South African (SA) Childhood Asthma Working Group of the Allergy Society of SA (ALLSA) advises on best-practice strategy for childhood asthma management. The strategy is in accordance with current evidence and consensus. ...
  • Quality and turnaround times of viral load monitoring under prevention of mother-to-child transmission of HIV Option B+ in six South African districts with a high antenatal HIV burden 
    Ngandu, Nobubelo Kwanele; Nsibande, Duduzile Faith; Magasana, V.; Chirinda, W.; Mbira, T.; Sherman, G.G.; Goga, Ameena Ebrahim (Health and Medical Publishing Group, 2021-08)
    BACKGROUND : Barriers to monitoring maternal HIV viral load (VL) and achieving 90% viral suppression during pregnancy and breastfeeding still need to be understood in South Africa (SA). OBJECTIVES : To measure quality ...
  • Summary of childhood asthma guidelines, 2021 : a consensus document 
    Manjra, Ahmed I.; Van Niekerk, A.; White, D.A.; Kling, S.; Zar, Heather J.; Masekela, R.; Levin, M.; Kritzinger, F.E.; Green, Robin J. (Health and Medical Publishing Group, 2021-05)
    Asthma is the most common chronic illness of childhood. The prevalence is rising and the mortality and morbidity from asthma are unacceptably high in South Africa. It is important to make a correct diagnosis based, most ...
  • Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy should not be discontinued in low- and middle-income countries 
    Ballot, Daynia E.; Ramdin, Tanusha D.; Bandini, Rossella M.; Nakwa, Firdose; Velaphi, Sithembiso; Coetzee, Melantha; Masemola, Khomotso; Kali, Gugulabatembunamahlubi J.D.; Horn, Alan R.; Pillay, Shakti; Van Rensburg, Jeanne; Pepper, Michael Sean (Health and Medical Publishing Group, 2021-12)
    Perinatal asphyxia is a major cause of death and disability in children. Therapeutic hypothermia (TH) has become a standard of care for newborn infants who have sustained hypoxic ischaemic encephalopathy (HIE) due to ...
  • Pediatric Index of Mortality 3 - an evaluation of function among ICUs in South Africa 
    Solomon, Lincoln J.; Naidoo, Kuban D.; Appel, Ilse; Doedens, Linda G.; Green, Robin J.; Long, Michael A.; Morrow, Brenda; Parker, Noor M.; Parris, Denise; Robroch, Afke H.; Salie, Shamiel; Singh, Shivani A.; Argent, Andrew C. (Lippincott Williams and Wilkins, 2021-09)
    OBJECTIVES : To evaluate the performance of the Pediatric Index of Mortality 3 as mortality risk assessment model. DESIGN : This prospective study included all admissions 30 days to 18 years old for 12 months during 2016 ...
  • Viral infections, COVID-19 and asthma : preventing viral exacerbations of asthma 
    Green, Robin J. (Health and Medical Publishing Group, 2021-04)
    Asthmatics are particularly vulnerable to viral illnesses, which cause the vast majority of asthma exacerbations. The most common viruses responsible for these exacerbations are the human rhinovirus and influenza virus. ...
  • Prevalence of coeliac disease in children and adolescents with type 1 diabetes mellitus in a tertiary hospital in South Africa 
    Karsas, Maria; Terblanche, Alta J.; Kemp, Tanja; Van Dyk, Jacobus C. (Health and Medical Publishing Group, 2021-12-01)
    Background. International literature has shown the prevalence of coeliac disease (CD) in children and adolescents with diabetes to range from 1 - 10%. Prevalence rates in African countries are limited or unknown. Objective. ...
  • The critical need for pooled data on coronavirus disease 2019 in African children : an AFREhealth call for action through multicountry research collaboration 
    Sam-Agudu, Nadia A.; Rabie, Helena; Byamungu, Liliane Nsuli; Masekela, Refiloe; Van der Zalm, Marieke M.; Redfern, Andrew; Dramowski, Angela; Mukalay, Abdon; Gachuno, Onesmus W.; Mongweli, Nancy; Kinuthia, John; Ishoso, Daniel Katuashi; Amoako, Emmanuella; Agyare, Elizabeth; Agbeno, Evans K.; Jibril, Aishatu Mohammed; Abdullahi, Asara M.; Amadi, Oma; Umar, Umar Mohammed; Ayele, Birhanu T.; Machekano, Rhoderick N.; Nyasulu, Peter S.; Hermans, Michel P.; Otokoye Otshudiema, John; Nswe, Christian Bongo-Pasi; Kayembe, Jean-Marie N.; Mbala-Kingebeni, Placide; Muyembe-Tamfum, Jean-Jacques; Aanyu, Hellen Tukamuhebwa; Musoke, Philippa; Fowler, Mary Glenn; Sewankambo, Nelson; Suleman, Fatima; Adejumo, Prisca; Mteta, Alfred; Noormahomed, Emilia V.; Deckelbaum, Richard J.; Zumla, Alimuddin; Landu, Don Jethro Mavungu; Tshilolo, Leon; Zigabe, Serge; Goga, Ameena Ebrahim; Mills, Edward J.; Umar, Lawal W.; Kruger, Mariana; Mofenson, Lynne M.; Nachega, Jean B. (Oxford University Press, 2021-11)
    Globally, there are prevailing knowledge gaps in the epidemiology, clinical manifestations, and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among children and adolescents; and these ...