Browsing Research Articles (Nuclear Medicine) by Type "Article"

Browsing Research Articles (Nuclear Medicine) by Type "Article"

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  • [18F]FDG PET and CT findings at therapy completion of pulmonary tuberculosis: comparison between HIV-positive and HIV-negative patients and impact on treatment response assessment 
    Ismaila, Aisha; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mathebula, Matsontso; Moagi, Ingrid; Mokoala, Kgomotso; Honest, Ndlovu; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hikuam, Chris; Hatherill, Mark; Fourie, P.B. (Petrus Bernardus); Sathekge, Mike Machaba (Springer, 2024)
    BACKGROUND : [18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...
  • 213Bi-PSMA-617 targeted alpha-radionuclide therapy in metastatic castration-resistant prostate cancer 
    Sathekge, Mike Machaba; Knoesen, Otto; Meckel, Marian; Modiselle, Moshe; Vorster, Mariza; Marx, Sebastian (Springer, 2017-06)
    Prostate-specific membrane antigen radioligand therapy (PSMA-RLT) with 177Lu-PSMA holds great promise as a safe treatment option in patients with metastasized castration-resistant prostate cancer (mCRPC) with ...
  • 225Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer : a pilot study 
    Sathekge, Mike Machaba; Bruchertseifer, Frank; Knoesen, Otto; Reyneke, Florette; Lawal, Ismaheel Opeyemi; Lengana, Thabo; Davis, Cindy; Mahapane, Johncy; Corbett, Ceceila; Vorster, Mariza; Morgenstern, Alfred (Springer, 2019-01)
    BACKGROUND : A remarkable therapeutic efficacy has been demonstrated with 225Ac-prostate-specific membrane antigen (PSMA)- 617 in heavily pre-treated metastatic castration-resistant prostate cancer (mCRPC) patients.We ...
  • 225Ac-PSMA-617 radioligand therapy of de novo metastatic hormone-sensitive prostate carcinoma (mHSPC): preliminary clinical findings 
    Sathekge, Mike Machaba; Bruchertseifer, Frank; Vorster, Mariza; Lawal, Ismaheel Opeyemi; Mokoala, Kgomotso M.G.; Reed, Janet D.; Maserumule, Letjie; Ndlovu, Honest; Hlongwa, Khanyi; Maes, Alex; Morgenstern, Alfred; Van de Wiele, Christophe (Springer, 2023-06)
    PURPOSE : 225Ac-PSMA-617 has demonstrated good anti-tumor effect as a treatment option for metastatic castration-resistant prostate cancer (mCRPC) patients. No study has previously assessed treatment outcome and survival ...
  • 68Ga-FAPI-PET/CT in patients with various gynecological malignancies 
    Dendl, Katharina; Koerber, Stefan A.; Finck, Rebecca; Mokoala, Kgomotso M.G.; Staudinger, Fabian; Schillings, Lisa; Heger, Ulrike; Rohrich, Manuel; Kratochwil, Clemens; Sathekge, Mike Machaba; Jager, Dirk; Debus, Jurgen; Haberkorn, Uwe; Giesel, Frederik L. (Springer, 2021-11)
    PURPOSE : 68Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising radiotracer for PET/CT imaging. The aim of this retrospective analysis is to explore the potential of FAPI-PET/CT in gynecological ...
  • 68Ga-nitroimidazole PET/CT imaging of hypoxia in tuberculosis : a case series 
    Bresser, Philppa Lynn; Reed, Janet D.; Sathekge, Mike Machaba; Vorster, Mariza (Wiley Open Access, 2022-12)
    Tuberculosis (TB) lesions in humans have been proven to be severely hypoxic with hypoxia leading to latency and dormancy of disease. Dormant TB lesions become less susceptible to standard TB treatment regimens with varying ...
  • 68Ga-PSMA-11 PET/CT in primary staging of prostate carcinoma : preliminary results on differences between black and white South-Africans 
    Sathekge, Mike Machaba; Lengana, Thabo; Maes, Alex; Vorster, Mariza; Zeevaart, Jan Rijn; Lawal, Ismaheel Opeyemi; Ebenhan, Thomas; Van de Wiele, Christophe (Springer, 2018-02)
    PURPOSE : The incidence of prostate cancer is 60% higher and the mortality rate is two- to three-times greater in black versus white men. We report on differences in 68Ga-PSMA-11 PET/CT imaging findings in 77 black ...
  • 68Ga-PSMA-HBED-CC PET imaging in breast carcinoma patients 
    Sathekge, Mike Machaba; Lengana, Thabo; Modiselle, Moshe; Vorster, Mariza; Zeevaart, Jan Rijn; Maes, Alex; Ebenhan, Thomas; Van de Wiele, Christophe (Springer, 2017-04)
    BACKGROUND : To report on imaging findings using 68Ga-PSMAHBED- CC PET in a series of 19 breast carcinoma patients. METHODS : 68Ga-PSMA-HBED-CC PET imaging results obtained were compared to routinely performed staging ...
  • [68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients : a comparison with18f[fdg] pet imaging 
    Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mahapane, Johncy; Kaufmann, Jens; Davis, Cindy; Ndlovu, Honest; Maserumule, Letjie C.; Mokoala, Kgomotso M.G.; Bouterfa, Hakim; Wester, Hans-Jurgen; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2020-12)
    People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we ...
  • 89Zr-Leukocyte labelling for cell trafficking : in vitro and preclinical investigations 
    Kahts, Maryke; Guo, Hua; Kommidi, Harikrishna; Yang, Yanping; Sayman, Haluk Burcak; Summers, Beverley; Ting, Richard; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Aras, Omer (SpringerOpen, 2023-11-06)
    BACKGROUND : The non-invasive imaging of leukocyte trafficking to assess inflammatory areas and monitor immunotherapy is currently generating great interest. There is a need to develop more robust cell labelling and ...
  • Activity quantification and dosimetry in radiopharmaceutical therapy with reference to 177Lutetium 
    Ramonaheng, Keamogetswe; Qebetu, Milani; Ndlovu, Honest; Swanepoel, Cecile; Smith, Liani; Mdanda, Sipho; Mdlophane, Amanda; Sathekge, Mike Machaba (Frontiers Media, 2024-03)
    Radiopharmaceutical therapy has been widely adopted owing primarily to the development of novel radiopharmaceuticals. To fully utilize the potential of these RPTs in the era of precision medicine, therapy must be optimized ...
  • The added value of [F-18]FDG PET/CT in the management of invasive fungal infections 
    Ankrah, Alfred O.; Creemers-Schild, Dina; De Keizer, Bart; Klein, Hans C.; Dierckx, Rudi A.J.O.; Kwee, Thomas C.; Span, Lambert F.R.; De Jong, Pim A.; Sathekge, Mike Machaba; Glaudemans, Andor W.J.M. (MDPI, 2021-01-17)
    Anatomy-based imaging methods are the usual imaging methods used in assessing invasive fungal infections (IFIs). [18F]FDG PET/CT has also been used in the evaluation of IFIs. We assessed the added value of [18F]FDG PET/CT ...
  • The adjunctive use of carbimazole during radioactive iodine treatment reduces the cure rate of Graves’ disease 
    Docrat, F.; Mokoena, Taole; Karusseit, V.O.L. (Otto); Ankrah, Alfred O. (Health and Medical Publishing Group, 2021-02)
    BACKGROUND : Radioactive iodine (RAI) is widely used in the treatment of hyperthyroidism. Adjunctive antithyroid drugs (ATDs) are commonly prescribed to treat the hyperthyroid state before the RAI has taken effect. However, ...
  • Adjunctive use of statins for COVID-19 
    Sathekge, Mike Machaba; Byttebier, Geert; De Spiegeleer, Bart; Saxberg, Bo; Ueckermann, Veronica; Belmans, Luc; Alexander, Myriam; Fedson, David (MDPI, 2021-04-01)
    The interaction between obesity, cardiometabolic disorders and COVID-19 represents a syndemic that requires both social intervention and a multipharmacological approach. The risks associated with diabetes, obesity and ...
  • Advances in PSMA alpha theragnostics 
    Vorster, Mariza; Sathekge, Mike Machaba (Elsevier, 2024-07)
    Alpha theranostics offer an attractive alternative form of therapy, which has best been investigated and documented with 225Ac-PSMA in patients with prostate cancer. Advantages offered by targeted alpha therapy include ...
  • Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging? 
    Gouws, Arno Christiaan; Kruger, Hendrik Gerhardus; Gheysens, Olivier; Zeevaart, Jan Rijn; Govender, Thavendran; Naicker, Tricia; Ebenhan, Thomas (Wiley, 2022-11)
    The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography ...
  • Antimicrobial peptides : their role as infection-selective tracers for molecular imaging 
    Ebenhan, Thomas; Gheysens, Olivier; Kruger, Hendrik G.; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (Hindawi Publishing, 2014-08)
    Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and, so far, hundreds of these structures have been isolated and characterised. They can be described ...
  • Apoptosis imaging in oncology by means of positron emission tomography 
    Van de Wiele, Christophe; Ustmert, Sezgin; De Spiegeleer, Bart; De Jonghe, Pieter-Jan; Sathekge, Mike Machaba; Alex, Maes (MDPI Publishing, 2021-03-09)
    To date, a wide variety of potential PET-apoptosis imaging radiopharmaceuticals targeting apoptosis-induced cell membrane asymmetry and acidification, as well as caspase 3 activation (substrates and inhibitors) have been ...
  • Appropriate indications for positron emission tomography/computed tomography : college of nuclear physicians of the colleges of medicine of South Africa 
    Sathekge, Mike Machaba; Warwick, J.M.; Doruyter, A.; Vorster, Mariza (Health and Medical Publishing Group, 2015-11)
    Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed ...
  • Appropriate indications for positron emission tomography/computed tomography, 2015 
    Vorster, Mariza; Doruyter, A.; Brink, A.; Mkhize, S.; Holness, J.; Malan, N.; Nyakale, Nozipho E.; Warwick, J.M.; Sathekge, Mike Machaba (Health and Medical Publishing Group, 2016-01)
    These recommendations are intended to serve an important and relevant role in advising referring physicians on the appropriate use of 18F-fluorodeoxyglucose (18F-FDG) and non-18F-FDG positron emission tomography/computed ...