Including poly(ADP-ribose) polymerase (PARP) inhibitors in managing patients with
inoperable tumors has significantly improved outcomes. The PARP inhibitors hamper single-strand
deoxyribonucleic acid (DNA) repair by ...
RATIONALE : Metastatic prostate cancer in the castration-resistant (mCRPC) setting remains challenging to treat. Prostate-specific membrane antigen (PSMA)-targeted alpha therapy (TAT) is emerging as a promising option. We ...
Breast cancer is the most frequently diagnosed cancer and leading cause of cancer-related
deaths worldwide. Timely decision-making that enables implementation of the most appropriate
therapy or therapies is essential for ...
Ionising radiation (IR) is a form of energy that travels as electromagnetic waves or
particles. While it is vital in medical and occupational health settings, IR can also
damage DNA, leading to mutations, chromosomal ...
Infection remains a major cause of morbidity and mortality, regardless of advances in antimicrobial therapy and improved knowledge of microorganisms. With the major global threat posed by antimicrobial resistance, fast and ...
Maes, Justine; Gesquière, Simon; Maes, Alex; Sathekge, Mike Machaba; Van de Wiele, Christophe(MDPI, 2024-10)
Positron emission tomography (PET) using radiolabeled prostate-specific membrane antigen targeting PET-imaging agents has been increasingly used over the past decade for imaging
and directing prostate carcinoma treatment. ...
Following on from the 2015 Lancet Oncology Commission on expanding global access to radiotherapy, Radiotherapy and theranostics: a Lancet Oncology Commission was created to assess the access and availability of radiotherapy ...
Radiopharmaceutical therapy has been widely adopted owing primarily to the
development of novel radiopharmaceuticals. To fully utilize the potential of
these RPTs in the era of precision medicine, therapy must be optimized ...
INTRODUCTION: Nuclear medicine infection imaging is routinely performed with the
use of leukocytes radiolabelled with technetium-99m hexamethylpropyleneamine
oxime ([99mTc]Tc-HMPAO) and single-photon emission computed ...
Pascual, Thomas N.B.; Paez, Diana; Iagaru, Andrei; Gnanasegaran, Gopi; Lee, Sze Ting; Sathekge, Mike Machaba; Buatti, John M.; Giammarile, Francesco; Al-Ibraheem, Akram; Pardo, Manuela Arevalo; Baum, Richard P.; De Bari, Berardino; Ben-Haim, Simona; Blay, Jean-Yves; Brink, Anita; Estrada-Lobato, Enrique; Fanti, Stefano; Golubic, Anja Tea; Hatazawa, Jun; Israel, Ora; Kiess, Ana; Knoll, Peter; Louw, Lizette; Mariani, Giuliano; Mirzaei, Siroos; Orellana, Pilar; Prior, John O.; Urbain, Jean-Luc; Vichare, Shrikant; Vinjamuri, Sobhan; Virgolini, Irene; Scott, Andrew M.(Springer, 2024-07)
PURPOSE :
The recent development and approval of new diagnostic imaging and therapy approaches in the field of theranostics have revolutionised nuclear medicine practice. To ensure the provision of these new imaging and ...
Kleynhans, Janke; Ebenhan, Thomas; Cleeren, Frederik; Sathekge, Mike Machaba(Springer, 2024-06)
Preclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these radionuclides, animal studies must be refined to produce the most translatable TAT ...
BACKGROUND :
[18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...
Mdanda, Sipho; Ngema, Lindokuhle M.; Mdlophane, Amanda; Sathekge, Mike Machaba; Zeevaart, Jan Rijn(MDPI, 2023-06-13)
The actinium-225 (225Ac) radioisotope exhibits highly attractive nuclear properties for
application in radionuclide therapy. However, the 225Ac radionuclide presents multiple daughter
nuclides in its decay chain, which ...