Mucopolysaccharidoses (MPS) are rare disorders associated with enzyme deficiencies, resulting in glycosaminoglycan (GAG) accumulation in multiple organ systems. As patients increasingly survive to adulthood, the need for ...

The focus of this thesis is the development and solution of problems that simultaneously involve the planning of the location of facilities and transportation decisions from such facilities to consumers. This has been ...

In this work, a transit network design problem is presented. The problem is identified as a typical large-scale complex system. Subsequently, it is decomposed into its sub-components. The first two sub-components, which ...

Cutting tool management in manufacturing firms constitutes an essential element in production cost optimization. In order to optimize the cutting tool stock level while concurrently minimizing production costs, a cost ...

Although project scope definition is regarded as a key element in successful project management, research on the subject is sparse. This paper investigates the relationship between project scope readiness and project ...

Access to cost-effective, high-quality and speedy public services is a legitimate requirement and expectation of all South Africans. However, despite massive increases in successive budgets and grants to the public sector, ...

One of the more recent advances in inventory management is the modelling of inventory systems consisting of items which are capable of growing during the course of the replen- ishment cycle. These items, such as livestock, ...

The paper presents an application of Bayesian structural time-series model to forecast long-term electricity demand. Accurate trend specification in long-term forecasting is important; otherwise erroneous forecasts could ...

In this paper, we extend our previous work on greedy constructive heuristics for the Mixed Capacitated Arc Routing Problem under Time Restrictions with Intermediate Facilities (MCARPTIF) by developing efficient local search ...

The paper is aimed at developing a model to measure the impact of Lean manufacturing deployment on organizational performance. The model will help industry practitioners to assess the impact of implementing Lean constructs ...