Isolation and relative stereochemistry of lippialactone, a new antimalarial compound from Lippia javanica
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| dc.contributor.author | Ludere, Margaret Tshimangadzo
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| dc.contributor.author | Van Ree, Teunis
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| dc.contributor.author | Vleggaar, Robert
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| dc.date.accessioned | 2013-07-15T12:11:02Z | |
| dc.date.available | 2013-07-15T12:11:02Z | |
| dc.date.issued | 2013-04 | |
| dc.description.abstract | The aerial parts of Lippia javanica were investigated for biologically active chemical compounds present in them. Chromatographic separation of the ethyl acetate extract of the aerial parts yielded a new antimalarial α-pyrone, lippialactone (2). Lippialactone is active against the chloroquinesensitive D10 strain of Plasmodium falciparum with an IC50 value of 9.1 μg/mL, and is also mildly cytotoxic. The relative stereochemistry of lippialactone was determined by molecular modeling based on the determination of the relative configuration by quantum mechanical GIAO 13C chemical shift calculations. | en_US |
| dc.description.librarian | hb2013 | en_US |
| dc.description.sponsorship | National Research Foundation. | en_US |
| dc.description.uri | http://www.elsevier.com/locate/fitote | en_US |
| dc.identifier.citation | Ludere, MT, Van Ree, T & Vleggaar, R 2013, 'Isolation and relative stereochemistry of lippialactone, a new antimalarial compound from Lippia javanica', Fitoterapia, vol. 86, no. 4, pp. 188-192. | en_US |
| dc.identifier.issn | 0367-326X (print) | |
| dc.identifier.issn | 1873-6971 (online) | |
| dc.identifier.other | 10.1016/j.fitote.2013.03.009 | |
| dc.identifier.uri | http://hdl.handle.net/2263/21962 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2013 Elsevier B.V. All rights reserved.Notice : this is the author’s version of a work that was accepted for publication in Fitoterapia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Fitoterapia, vol. 86, no. 4, 2013, doi.: 10.1016/j.fitote.2013.03.009 | en_US |
| dc.subject | Antiplasmodial | en_US |
| dc.subject | Lippialactone | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | Verbenaceae | en_US |
| dc.subject | Lippia javanica | en_US |
| dc.title | Isolation and relative stereochemistry of lippialactone, a new antimalarial compound from Lippia javanica | en_US |
| dc.type | Postprint Article | en_US |
