Abstract:
INTRODUCTION: Demineralised bone matrix (DBM) is an allograft
material widely used as a bone filler and bone graft substitute. DBM contains bone morphogenetic proteins (BMPs), which induce and regulate bone formation during embryogenesis and in postnatal life.
AIMS AND OBJECTIVES: To investigate the osteoinductivity
of DBM augmented with xenogeneic BMP-complex at different
doses.
MATERIALS AND METHODS: Rat DBM was augmented with
BMP-complex purified from porcine diaphyseal bone.
RESULTS: Dorsal subcutaneous implantation of 25 mg rat
allogeneic DBM augmented with 0, 3, 6 and 12 mg BMPcomplex
per gram of DBM resulted in dose dependant upregulation
of bone formation on day 21, as scored histologically and biochemically.
CONCLUSIONS: Allogeneic DBM can be augmented with xenogeneically
sourced BMP-complex to improve DBM performance in vivo. This work demonstrates the potential of BMP-complex augmented DBM to induce new bone formation with improved parameters of bone formation.
