The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum

Botha, C.J. (Christoffel Jacobus); Gehring, Ronette; Van Rooyen, J.M.; Venter, D.

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dc.contributor.author	Botha, C.J. (Christoffel Jacobus)
dc.contributor.author	Gehring, Ronette
dc.contributor.author	Van Rooyen, J.M.
dc.contributor.author	Venter, D.
dc.contributor.editor	Boomker, Jacob Diederik Frederik
dc.date.accessioned	2012-12-12T06:47:40Z
dc.date.available	2012-12-12T06:47:40Z
dc.date.created	2012
dc.date.issued	2002
dc.description	The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.	en_US
dc.description.abstract	Three cardiac glycosides were screened for pharmacological effects on isolated rat jejunum. The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine. The results indicate that all three bufadienolides cause contraction of jejunal smooth muscle. When combined with atropine (1X10ˉ⁶ M) the response of epoxyscillirosidin and tyledoside D decreased, indicating suppression of a cholinergic response caused by the cardiac glycosides.	en_US
dc.identifier.citation	Botha, CJ, Gehring, R, Van Rooyen, JM & Venter, D 2002, 'The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum’. Onderstepoort Journal of Veterinary Research, vol. 69, no. 3, pp. 243-246.	en_US
dc.identifier.issn	0030-2465
dc.identifier.other	7006558662
dc.identifier.other	O-5991-2014
dc.identifier.uri	http://hdl.handle.net/2263/20694
dc.language	en
dc.publisher	Published jointly by the Agricultural Research Council, ARC-Onderstepoort Veterinary Institute and the Faculty of Veterinary Science, University of Pretoria.	en_US
dc.rights	© ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © University of Pretoria. Dept of Library Services (digital).	en_US
dc.subject	Veterinary medicine	en_US
dc.subject	Bufadienolide	en_US
dc.subject	Cardiac glycosides	en_US
dc.subject	Cotyledoside	en_US
dc.subject	Epoxyscillirosidin	en_US
dc.subject	Methacholine	en_US
dc.subject	Rat jejunum	en_US
dc.subject	Tyledoside D	en_US
dc.subject.lcsh	Veterinary medicine -- South Africa
dc.title	The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum	en_US
dc.type	Article	en_US