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Research Articles (Surgery): Recent submissions

  • Surgical rib fixation as an alternative method of treatment for multiple rib fractures : an audit of results compared with traditional medical management 
    Monzon, Barbaro; Fingleson, L.M.; Moeng, M.S. (South African Medical Association, 2021-09)
    BACKGROUND : Rib fractures are a common cause of morbidity and chronic pain, delaying return to normal activities. Reports suggest that surgical fixation improves acute and long-term outcomes. METHOD : A single centre ...
  • South African guidelines on the determination of death 
    Thomson, D.; Joubert, I.; De Vasconcellos, K.; Paruk, Fathima; Mokogong, S.; McCulloch, M.; Morrow, B.; Bakeer, D.; Rossouw, B.; Mdladla, N.; Richards, G.A.; Welkovics, N.; Levy, B.; Coetzee, Isabella M.; Spruyt, M.; Ahmed, N.; Gopalan, D. (Health and Medical Publishing Group, 2021-03)
    Death is a medical occurrence that has social, legal, religious and cultural consequences requiring common clinical standards for its diagnosis and legal regulation. This document compiled by the Critical Care Society of ...
  • The adjunctive use of carbimazole during radioactive iodine treatment reduces the cure rate of Graves’ disease 
    Docrat, F.; Mokoena, Taole; Karusseit, V.O.L. (Otto); Ankrah, Alfred O. (Health and Medical Publishing Group, 2021-02)
    BACKGROUND : Radioactive iodine (RAI) is widely used in the treatment of hyperthyroidism. Adjunctive antithyroid drugs (ATDs) are commonly prescribed to treat the hyperthyroid state before the RAI has taken effect. However, ...
  • Rat bite injuries in children : description of a novel classification 
    Ngwenya, R.E.; Khulu, B.L.; Karusseit, V.O.L. (Otto); Mokoena, Taole (Springer, 2021-05)
    PURPOSE : Rats are common intruders into human settlements. Apart from their role as disease vectors, they can also cause bite injuries. We describe the clinical course of a series of children with rat bites, and characterise ...
  • Development of a clinical prediction model for in-hospital mortality from the South African cohort of the African surgical outcomes study 
    Kluyts, Hyla-Louise; Conradie, Wilhelmina; Cloete, Estie; Spijkerman, Sandra; Smith, Oliver; Alli, Ahmed; Koto, Modise Z.; Montwedi, Daniel; Govender, Komalan; Cronje, Larissa; Grobbelaar, Mariette; Omoshoro-Jones, Jones A.; Rorke, Nicolette F.; Anderson, Philip; Torborg, Alexandra; Alphonsus, Christella; Alexandris, Panagiotis; Peter, Aunel Mallier; Singh, Usha; Diedericks, Johan; Mrara, Busisiwe; Reed, Anthony; Davies, Gareth L.; Davids, Jody G.; Van Zyl, Hendrik A.; Govindasamy, Vishendran; Rodseth, Reitze; Matos-Puig, Roel; Bhat, Kajake A.P.; Naidoo, Noel; Roos, John; Jaworska, Magdalena; Steyn, Annemarie; Dippenaar, Johannes Marthinus (Tinus); Pearse, R.M.; Madiba, Thandinkosi; Biccard, Bruce McIure (Springer, 2021-02)
    BACKGROUND : Data on the factors that influence mortality after surgery in South Africa are scarce, and neither these data nor data on risk-adjusted in-hospital mortality after surgery are routinely collected. Predictors ...
  • Microbiomics in collusion with the nervous system in carcinogenesis : diagnosis, pathogenesis and treatment 
    Hull, Rodney; Lolas, Georgios; Makrogkikas, Stylianos; Jensen, Lasse D.; Syrigos, Konstantinos N.; Evangelou, George; Padayachy, Llewellyn; Egbor, Cyril; Mehrotra, Ravi; Makhafola, Tshepiso Jan; Oyomno, Meryl; Dlamini, Zodwa (MDPI, 2021-10-11)
    The influence of the naturally occurring population of microbes on various human diseases has been a topic of much recent interest. Not surprisingly, continuously growing attention is devoted to the existence of a gut ...
  • Human immunodeficiency virus infection is associated with a differential increase in cytokine response and increased risk of perforation in acute appendicitis 
    Wheeler, N.; Steel, Helen C.; Setlai, Botle Precious; Meintjes, F.; Mokoena, Taole (Oxford University Press, 2021-03)
    No abstract available.
  • Genetic drivers of head and neck squamous cell carcinoma : aberrant splicing events, mutational burden, hpv infection and future targets 
    Dlamini, Zodwa; Alaouna, Mohammed; Mbatha, Sikhumbuzo Z.; Bhayat, Ahmed; Mabongo, Mzubanzi; Chatziioannou, Aristotelis; Hull, Rodney (MDPI, 2021-03-15)
    Head and neck cancers include cancers that originate from a variety of locations. These include the mouth, nasal cavity, throat, sinuses, and salivary glands. These cancers are the sixth most diagnosed cancers worldwide. ...
  • Survey on worldwide trauma team activation requirement 
    Waydhas, Christian; Trentzsch, Heiko; Hardcastle, Timothy C.; Jensen, Kai Oliver; Abdelmotaleb, Khaled Tolba Younes; Saad, George Abi; Baacke, Markus; Baftiu, Nehat; Bartsokas, Christos; Becker, Lars; Berlusconi, Marco Luigi Maria; Bespalenko, Artem; Bieler, Dan; Brand, Martin; De Sousa Junior, Edilson Carvalho; Chotirosniramit, Narain; Chung, Yuhsuan; Crichton, Lesley; De Paepe, Peter; Dogjani, Agron; Doll, Dietrich; Molla, Ayene Gebremicheal; Hardcastle, Timothy C.; Haxhirexha, Kastriot; Jain, Kajal; Jensen, Kai Oliver; Korolev, Andrey; Zhanfei, Li; Lim, Jerry K.T.; Linder, Fredrik; Lubis, Nurhayati; Magnitskaya, Nina; MacDonald, Damian; Mauser, Martin; Matthes, Gerrit; Mbugua, Kimani; Mlyavykh, Sergey; Monzon, Barbaro I.; Togtmol, Munkhsaikhan; Mustafa, Khreshi; Mwandri, Michael; Navsaria, Pradeep; Nijs, Stefan; Olmedo, Francisco; Gonzalez, Maria C. Ortega; Fantilli, Jesus Palacios; Pirpiris, Marinis; Pitance, Francois; Pomeroy, Eoghan; Sadakah, M.A.; Sahoo, Tapas Kumar; Saratila, Iurie; Scarpelini, Sandro; Schweigkofler, Uwe; Selmani, Edvin; Soderlund, Tim; Stein, Michael Ashley; Thapa, Buland; Trentzsch, Heiko; Truta, Teodora Sorana; Uranues, Selman; Wolfl, Christoph G.; Yi, Sandar Thein; Yovenko, Ihor; Zapattini, Pablo (Springer, 2021-10)
    PURPOSE : trauma team activation (TTA) is thought to be essential for advanced and specialized care of very severely injured patients. However, non-specific TTA criteria may result in overtriage that consumes valuable ...
  • Immunosuppressive signaling pathways as targeted cancer therapies 
    Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)
    Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
  • MicroRNA and alternative mRNA splicing events in cancer drug response/resistance : potent therapeutic targets 
    Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen; Dlamini, Zodwa (MDPI, 2021-12-02)
    Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...
  • Emergency room thoracotomy (ERT) : a retrospective audit of results 
    Monzon, Barbaro I.; Ortega, Maria del Carmen; Goosen, Jacques; Doll, Dietrich; Moeng, Maeyane Stephen (Albanian Society for Trauma and Emergency Surgery, 2021-01-20)
    BACKGROUND : An Emergency Room Thoracotomy (ERT ) is a resource-intensive, high-risk procedure in which rapid decision-making is essential. In a resource-constrained system, identification of the group of patients that ...
  • Unilateral left spontaneous adrenal haemorrhage in a middle aged male. A case report 
    Zulu, Sphamandla (Elsevier, 2021-09)
    BACKGROUND : Adrenal haemorrhage is a rare condition, traditionally diagnosed at autopsy. Aetiology of adrenal haemorrhage can be traumatic or non-traumatic related. Rare cases of spontaneous adrenal haemorrhage, mostly ...
  • Suprasellar cyst presenting with bobble-head doll syndrome 
    George, Roshan; Gaxa, Luvo; Lockhat, Zarina I.; Hlahla, Stevens Kgomotso; Van der Meyden, Cornelis Hendrikus; Kisten, Ravendran; Bida, Nndweleni Meshack (Elsevier, 2020-01)
    BACKGROUND : Bobble-head doll syndrome is a rare neurological syndrome presenting with repetitive anteroposterior head movements. It is usually associated with expansile cystic lesions in the third ventricular region. CASE ...
  • Federation of Surgeons of South Africa consensus document for the resumption of elective surgery after level 5 COVID-19 “lockdown” period in South Africa 
    Van Waart, J.; Matley, P.J.; Brand, Martin (Health and Medical Publishing Group, 2020-06)
    Since the introduction of a national state of disaster at the end of March 2020 we have moved through levels of “lockdown” and as of 1 June 2020 it has been de-escalated to level 3. It is unclear as to how long this ...
  • Unintended consequences of the COVID-19 pandemic in Africa 
    Schewitz, Ivan Anton; Zar, Heather J.; Masekela, Refiloe; Gordon, Stephen; Ozoh, Obianuju; Kagima, Jacqueline; Gray, Diane; Binegdie, Amsalu; Irungu, Anne; Worodria, William (Scientific Scholar, 2020-09)
    As we write this, a patient is in a local South African Hospital on a ventilator following a cardiac arrest after a massive pulmonary embolus. He recently returned from overseas. When he arrived, he had a cough and phoned ...
  • Challenging beliefs : a review of the paradigm shift in the treatment of pectus excavatum from radical resection to minimally invasive bracing and non-surgical vacuum bell suction 
    Schewitz, Ivan Anton; Nuss, D. (Health and Medical Publishing Group, 2020-12)
    In 1997, Nuss introduced a minimally invasive non-destructive procedure for pectus excavatum, which revolutionised the treatment of the condition. This review will give a brief history on the management of this condition, ...
  • COVID-19 in Africa : preparing for the storm 
    Chakaya, J.; Binegdie, A.; Irungu, A.; Pearson, B.; Gray, D.; Zar, Heather J.; Schewitz, Ivan Anton; Kagima, J.; Mortimer, K.; Ozoh, O.B.; Masekela, R.; Gordon, S.B.; Worodria, W.; Aluoch, J. (International Union Against Tuberculosis and Lung Disease, 2020-07)
    In response to COVID-19, Africa should develop robust collaborative research programmes, funded by African governments and partners, to include epidemiological, health system, implementation, clinical trials, immunological ...
  • Many voices in a choir: tumor-induced neurogenesis and neuronal driven alternative splicing sound like suspects in tumor growth and dissemination 
    Dlamini, Zodwa; Mathabe, Kgomotso; Padayachy, Llewellyn; Marima, Rahaba; Evangelou, George; Syrigos, Konstantinos N.; Bianchi, Arianna; Lolas, Georgios; Hull, Rodney (MDPI, 2021-05)
    During development, as tissues expand and grow, they require circulatory, lymphatic, and nervous system expansion for proper function and support. Similarly, as tumors arise and develop, they also require the expansion ...
  • Prognostic alternative splicing signatures in esophageal carcinoma 
    Dlamini, Zodwa; Hull, Rodney; Mbatha, Sikhumbuzo Z.; Alaouna, Mohammed; Qiao, You-Lin; Yu, Herbert; Chatziioannou, Aristotelis (Dove Medical Press, 2021)
    Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of ...