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Research Articles (Surgery): Recent submissions

  • Holomics and artificial intelligence-driven precision oncology for medullary thyroid carcinoma : addressing challenges of a rare and aggressive disease 
    Luvhengo, Thifhelimbilu Emmanuel; Moeng, Maeyane Stephens; Sishuba, Nosisa T.; Makgoka, Malose; Jonas, Lusanda; Mamathuntsha, Tshilidzi G.; Mbambo, Thandanani; Kagodora, Shingirai B.; Dlamini, Zodwa (MDPI, 2024-10)
    BACKGROUND/OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare yet aggressive form of thyroid cancer comprising a disproportionate share of thyroid cancer-related mortalities, despite its low prevalence. MTC differs ...
  • Perforated peptic ulcer : a case series and an African perspective 
    Malefahlo, Thabiso M.; Montwedi, Daniel; Karusseit, V.O.L. (Otto) (Medpharm Publications, 2024-02)
    BACKGROUND: Perforation of peptic ulcer (PPU) is the most morbid complication of peptic ulcer disease (PUD) with scant recent reports from sub-Saharan Africa. The aim of this study was to describe a PPU series from a ...
  • Non-technical skills for neurosurgeons : an international survey 
    Cavallo, S.M.; Pellencin, E.; Carone, G.; Castelli, N.; Ayadi, R.; Olldashi, F.; Al Anazi, A.; Kanaan, I.; Garcia Colmena, F.; Ajler, P.; Socolovsky, M.; Knosp, E.; Raftopoulos, C.; Rodrigues, J.C., Jr.; Enchev, Y.P.; Xu, B.; Chul-Kee, P.; Rotim, K.; Posti, J.; Meyer, B.; Shimamoto, H.; Makhambetov, Y.; Frosen, J.; Chandra, S.P.; Cappabianca, P.; Piatelli, G.; Genitori, L.; Germanò, A.; Sabatino, G.; Bernucci, C.; Giussani, C.; Olivi, A.; Locatelli, D.; Stefini, R.; Castrioto, C.; Mangiola, A.; Fontanella, M.M.; Tacconi, L.; Conti, C.; Skrap, M.; El Abbadi, N.; Sharma, M.R.; Shamim, M.S.; Sharif, S.; Farias, J.P.; Florian, I.S.; Gushcha, A.O.; Rasulic, L.; Vulekovic, P.; Ang, B.T.; Lagares, A.; Diez Valle, R.; Ensenat, J.; Ley Urzaiz, L.; Barcia Albacar, J.A.; Kupanur, S.S.; Regli, L.; Dunn, I.F.; Adelson, D.; Bederson, J.; Levi, A.D.; Alturky, A.Y.; Matula, C.; Cortes, B.; Xiang, W.; Li, T.; El-Ghandour, N.M.F.; Kanai, R.; Patir, R.; Misra, B.K.; Dwarakanath, S.; Servadei, F.; Tomasello, F.; Casali, C.; Unsgard, G.; Morcos, J.J.; Souhil, T.; Khoja, I.; Kehayov, I.; Vukic, M.; Ziebell, M.; Gulisano, H.A.; Tange, M.; Kurozumi, K.; Locatelli, M.; Garbossa, D.; Gomez Amador, J.L.; Rodriguez, A.O.; Ashkan, K.; Lim, M.; Maleki, M.; Agrawal, A.; Naik, A.; Sciubba, D.M.; Kim, L.J.; Spinner, R.J.; McDonald, P.; Pavesi, G.; Moiyadi, A.; Padayachy, Llewellyn; Meling, T.R.; Di Meco, F.; Perin, A. (Elsevier, 2024)
    INTRODUCTION : Neurosurgery is considered a technically demanding specialty; nonetheless, it also requires non-technical skills (NTSs) to reach mastery. RESEARCH QUESTION : This study seeks to understand how important ...
  • Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 
    Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)
    Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
  • Position statement on the definition, incidence, diagnosis and outcome of acute on chronic pancreatitis 
    Bouca-Machado, Tiago; Bouwense, Stefan A.W.; Brand, Martin; Demir, Ihsan Ekin; Frokjær, Jens Brondum; Garg, Pramod; Hegyi, Peter; Lohr, J.-Matthias; De-Madaria, Enrique; Pandanaboyana, Sanjay; Pedersen, Jan Bech; Rebours, Vinciane; Sheel, Andrea; Singh, Vikesh; Smith, Martin; Windsor, John A.; Yadav, Dhiraj; Drewes, Asbjorn Mohr (Elsevier, 2023-03)
    BACKGROUND : Acute on chronic pancreatitis (ACP) is a relatively common condition, but there are significant gaps in our knowledge on the definition, incidence, diagnosis, treatment and prognosis. METHODS : A systematic ...
  • Immunomodulatory gene-splicing dysregulation in tumorigenesis : unmasking the complexity 
    Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Yasasve, Madhavan; Dlamini, Zodwa; Damane, Botle Precious (MDPI, 2023-08-10)
    Cancer is a global health concern with rising incidence, morbidity, and mortality. The interaction between the tumor and immune cells within the tumor microenvironment is facilitated by signaling pathways driven by ...
  • Noninvasive intracranial pressure assessment by optic nerve sheath diameter : automated measurements as an alternative to clinician-performed measurements 
    Netteland, Dag Ferner; Aarhus, Mads; Smistad, Erik; Sandset, Else Charlotte; Padayachy, Llewellyn; Helseth, Eirik; Brekken, Reidar (Frontiers Media, 2023-02-01)
    INTRODUCTION : Optic nerve sheath diameter (ONSD) has shown promise as a noninvasive parameter for estimating intracranial pressure (ICP). In this study, we evaluated a novel automated method of measuring the ONSD in ...
  • Targeting stem cells in the colorectal cancer microenvironment to avert drug resistance in pursuit of novel oncotherapies 
    Damane, Botle Precious; Marima, Rahaba; Mulaudzi, Thanyani; Dlamini, Zodwa (Biolife Sas, 2023-09)
    Several studies have demonstrated the heightened prevalence of colorectal cancer (CRC) among young black men. Most of these men present with already metastasized CRC. Cancer stem cells (CSCs) play a pivotal role in CRC ...
  • Spontaneous resolution of a patient with a symptomatic pheochromocytoma 
    Jackson, Brandon Spencer; Ndhlebe, Gugulethu; Suleman, Farhana Ebrahim (Elsevier, 2024-07)
    A 56-year-old woman presented with a 2-year history of chronic persistent right upper quadrant abdominal pain that was associated with intermittent nausea, vomiting, and unintentional weight loss. She had been on ...
  • Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 
    Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)
    A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
  • Transorbital neuroendoscopy-assisted resection of a giant optic pathway glioma in a neonate 
    Maseko, Rodney; Mabogo, Maanda; Lockhat, Zarina I.; Makunyane, P.S. (Priscilla); Ahmad, Samia; Bida, Meshack; Padayachy, Llewellyn (Springer, 2023-09)
    Congenitalgiant orbital tumors in infancy are relatively rare, especially when the tumors are associated with significant intracranial extension. We describe the use of a transorbital neuroendoscopy-assisted resection of ...
  • Unraveling the complex interconnection between specific Inflammatory signaling pathways and mechanisms involved in HIV-associated colorectal oncogenesis 
    Damane, Botle Precious; Mulaudzi, Thanyani Victor; Kader, Sayed Shakeel; Naidoo, Pragalathan; Savkovic, Suzana D.; Dlamini, Zodwa; Mkhize-Kwitshana, Zilungile Lynette (MDPI, 2023-02)
    The advancement of HIV treatment has led to increased life expectancy. However, people living with HIV (PLWH) are at a higher risk of developing colorectal cancers. Chronic inflammation has a key role in oncogenesis, ...
  • Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 
    Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)
    Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
  • Dissecting microbiome-derived SCFAs in prostate cancer : analyzing gut microbiota, racial disparities, and epigenetic mechanisms 
    Miya, Thabiso Victor; Marima, Rahaba; Damane, Botle Precious; Ledet, Elisa Marie; Dlamini, Zodwa (MDPI, 2023-08-14)
    Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with ...
  • Alternative splicing events and their clinical significance in colorectal cancer : targeted therapeutic opportunities 
    Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen; Dlamini, Zodwa (MDPI, 2023-08-07)
    Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
  • Renal papillary necrosis (RPN) in an African population : disease patterns, relevant pathways, and management 
    Gaudji, Guy Roger; Bida, M.; Conradie, Marius; Damane, Botle Precious; Bester, Megan (MDPI, 2023-01)
    Renal papillary necrosis (RPN) is characterized by coagulative necrosis of the renal medullary pyramids and papillae. Multiple conditions and toxins are associated with RPN. Several RPN risk factors, or POSTCARDS, have ...
  • The impact of colon injuries on the outcome of gunshot wounds to the abdomen 
    Singh, Yonita; Motilall, Sooraj; Khulu, Bongani L.; Jackson, Brandon Spencer (Springer, 2023-08)
    PURPOSE : Factors predicting morbidity and mortality in patients with colon-related gunshot injuries and the management of these injuries are not always straightforward. This aimed to assess the impact of abdominal gunshot ...
  • Profile of human papillomavirus genotypes in breast and oesophageal cancer patients in Pretoria, South Africa 
    Maroga, N.; Mokoena, Taole; Musekiwa, Alfred; Bida, Meshack; Kgomo, Mpho K.; Lebelo, R. (South African Medical Association, 2023-07)
    BACKGROUND : The association between human papillomavirus (HPV) and cervical cancer is well established, and cervical cancer can be prevented through HPV vaccination. Little has been reported on the association between HPV ...
  • Concordance of fine needle aspiration cytology and final histology of salivary gland tumours 
    Ndotora, F.R.; Jackson, Brandon Spencer (Medpharm Publications, 2023)
    BACKGROUND : Fine needle aspiration cytology (FNAC) is a widely used diagnostic tool to evaluate salivary gland tumours. The Milan system for reporting salivary gland cytopathology allows for standardisation and facilitates ...
  • Early detection of pancreatic adenocarcinoma 
    Jonas, Eduard; Brand, Martin (Medpharm Publications, 2023)
    No abstract available.