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Surgery: Recent submissions

  • Inflammatory pseudo-tumour of the colon mimicking acute appendicitis : a case report 
    Zulu, Sphamandla; Kruger, C.; Morare, N.; Montwedi, Daniel; Ngwenya, S. (Elsevier, 2022-01)
    INTRODUCTION : Inflammatory pseudo-tumour (IPT) of the colon is a rare entity with an obscure pathophysiology and largely indeterminate aetiology. PRESENTATION OF CASE : A young male patient presented with an Alvarado ...
  • Cardiothoracic surgery in South Africa : a history 
    Schewitz, Ivan Anton (AME Publishing, 2022-04)
    Cardiothoracic surgery in South Africa began in Cape Town spreading to the rest of the country, and since the end of apartheid slowly reaching other sub-Saharan African countries. It is a story of brilliant innovators, of ...
  • MicroRNA interrelated epithelial mesenchymal transition (EMT) in glioblastoma 
    Setlai, Botle Precious; Hull, Rodney; Reis, Rui Manuel; Agbor, Cyril; Ambele, Melvin Anyasi; Mulaudzi, Thanyani Victor; Dlamini, Zodwa (MDPI, 2022-01-27)
    MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing ...
  • Proximal tibial dimensions in a formalin-fixed neonatal cadaver sample : an intraosseous infusion approach 
    Van Tonder, D.J. (Daniel); Van Niekerk, Martin Louis; Van Schoor, Albert-Neels (Springer, 2022-02)
    PURPOSE : Methods to administer intramedullary medication and fluid infusion in both adults and children date to the early twentieth century. Studies have shown that intraosseous access in the proximal tibia is ideal for ...
  • Exploiting the molecular basis of oesophageal cancer for targeted therapies and biomarkers for drug response : guiding clinical decision-making 
    Mbatha, Sikhumbuzo Z.; Hull, Rodney; Dlamini, Zodwa (MDPI, 2022-09-22)
    Worldwide, oesophageal cancer is the sixth leading cause of deaths related to cancer and represents a major health concern. Sub-Saharan Africa is one of the regions of the world with the highest incidence and mortality ...
  • Does timing and type of surgery influence the WHO surgical checklist compliance? 
    Montwedi, Daniel; Jackson, Brandon Spencer (Springer, 2023-06)
    The timing and type of surgery may influence the World Health Organization (WHO) safety surgical checklist compliance. The aim was therefore to determine the prevalence of compliance and completion of the WHO surgical ...
  • Risk factors for progression of chronic kidney disease : an investigation in prepubertal children 
    Van Biljon, Gertruida; Meintjes, Cornelius J.; Becker, Piet J.; Karusseit, V.O.L. (Otto) (Wiley, 2023-05)
    AIM : Previous studies on progression of chronic kidney disease (CKD) in children have included older post-pubertal subjects. This study attempted to evaluate risk factors for progression of CKD in pre-pubertal ...
  • Microbiomes, epigenomics, immune response, and splicing signatures interplay : potential use of combination of regulatory pathways as targets for malignant mesothelioma 
    Setlai, Botle Precious; Mkhize-Kwitshana, Zilungile Lynette; Mehrotra, Ravi; Mulaudzi, Thanyani Victor; Dlamini, Zodwa (MDPI, 2022-08-12)
    Malignant mesotheliomas (MM) are hard to treat malignancies with poor prognosis and high mortality rates. This cancer is highly misdiagnosed in Sub-Saharan African countries. According to literature, the incidence of MM ...
  • Colorectal cancer liver metastases : management and five-year survival in a South African patient cohort 
    Brand, Martin; Gaylard, P.; Ramos, J. (South African Medical Association, 2021-03)
    BACKGROUND : Approximately 25% of patients with colorectal cancer (CRC) will be diagnosed with CRC liver metastases (CRCLM) during the course of their disease. No data regarding CRCLM presentation, management and survival ...
  • Surgical rib fixation as an alternative method of treatment for multiple rib fractures : an audit of results compared with traditional medical management 
    Monzon, Barbaro; Fingleson, L.M.; Moeng, M.S. (South African Medical Association, 2021-09)
    BACKGROUND : Rib fractures are a common cause of morbidity and chronic pain, delaying return to normal activities. Reports suggest that surgical fixation improves acute and long-term outcomes. METHOD : A single centre ...
  • South African guidelines on the determination of death 
    Thomson, D.; Joubert, I.; De Vasconcellos, K.; Paruk, Fathima; Mokogong, S.; McCulloch, M.; Morrow, B.; Bakeer, D.; Rossouw, B.; Mdladla, N.; Richards, G.A.; Welkovics, N.; Levy, B.; Coetzee, Isabella M.; Spruyt, M.; Ahmed, N.; Gopalan, D. (Health and Medical Publishing Group, 2021-03)
    Death is a medical occurrence that has social, legal, religious and cultural consequences requiring common clinical standards for its diagnosis and legal regulation. This document compiled by the Critical Care Society of ...
  • The adjunctive use of carbimazole during radioactive iodine treatment reduces the cure rate of Graves’ disease 
    Docrat, F.; Mokoena, Taole; Karusseit, V.O.L. (Otto); Ankrah, Alfred O. (Health and Medical Publishing Group, 2021-02)
    BACKGROUND : Radioactive iodine (RAI) is widely used in the treatment of hyperthyroidism. Adjunctive antithyroid drugs (ATDs) are commonly prescribed to treat the hyperthyroid state before the RAI has taken effect. However, ...
  • Rat bite injuries in children : description of a novel classification 
    Ngwenya, R.E.; Khulu, B.L.; Karusseit, V.O.L. (Otto); Mokoena, Taole (Springer, 2021-05)
    PURPOSE : Rats are common intruders into human settlements. Apart from their role as disease vectors, they can also cause bite injuries. We describe the clinical course of a series of children with rat bites, and characterise ...
  • Development of a clinical prediction model for in-hospital mortality from the South African cohort of the African surgical outcomes study 
    Kluyts, Hyla-Louise; Conradie, Wilhelmina; Cloete, Estie; Spijkerman, Sandra; Smith, Oliver; Alli, Ahmed; Koto, Modise Z.; Montwedi, Daniel; Govender, Komalan; Cronje, Larissa; Grobbelaar, Mariette; Omoshoro-Jones, Jones A.; Rorke, Nicolette F.; Anderson, Philip; Torborg, Alexandra; Alphonsus, Christella; Alexandris, Panagiotis; Peter, Aunel Mallier; Singh, Usha; Diedericks, Johan; Mrara, Busisiwe; Reed, Anthony; Davies, Gareth L.; Davids, Jody G.; Van Zyl, Hendrik A.; Govindasamy, Vishendran; Rodseth, Reitze; Matos-Puig, Roel; Bhat, Kajake A.P.; Naidoo, Noel; Roos, John; Jaworska, Magdalena; Steyn, Annemarie; Dippenaar, Johannes Marthinus (Tinus); Pearse, R.M.; Madiba, Thandinkosi; Biccard, Bruce McIure (Springer, 2021-02)
    BACKGROUND : Data on the factors that influence mortality after surgery in South Africa are scarce, and neither these data nor data on risk-adjusted in-hospital mortality after surgery are routinely collected. Predictors ...
  • Microbiomics in collusion with the nervous system in carcinogenesis : diagnosis, pathogenesis and treatment 
    Hull, Rodney; Lolas, Georgios; Makrogkikas, Stylianos; Jensen, Lasse D.; Syrigos, Konstantinos N.; Evangelou, George; Padayachy, Llewellyn; Egbor, Cyril; Mehrotra, Ravi; Makhafola, Tshepiso Jan; Oyomno, Meryl; Dlamini, Zodwa (MDPI, 2021-10-11)
    The influence of the naturally occurring population of microbes on various human diseases has been a topic of much recent interest. Not surprisingly, continuously growing attention is devoted to the existence of a gut ...
  • Human immunodeficiency virus infection is associated with a differential increase in cytokine response and increased risk of perforation in acute appendicitis 
    Wheeler, N.; Steel, Helen C.; Setlai, Botle Precious; Meintjes, F.; Mokoena, Taole (Oxford University Press, 2021-03)
    No abstract available.
  • Genetic drivers of head and neck squamous cell carcinoma : aberrant splicing events, mutational burden, hpv infection and future targets 
    Dlamini, Zodwa; Alaouna, Mohammed; Mbatha, Sikhumbuzo Z.; Bhayat, Ahmed; Mabongo, Mzubanzi; Chatziioannou, Aristotelis; Hull, Rodney (MDPI, 2021-03-15)
    Head and neck cancers include cancers that originate from a variety of locations. These include the mouth, nasal cavity, throat, sinuses, and salivary glands. These cancers are the sixth most diagnosed cancers worldwide. ...
  • Survey on worldwide trauma team activation requirement 
    Waydhas, Christian; Trentzsch, Heiko; Hardcastle, Timothy C.; Jensen, Kai Oliver; Abdelmotaleb, Khaled Tolba Younes; Saad, George Abi; Baacke, Markus; Baftiu, Nehat; Bartsokas, Christos; Becker, Lars; Berlusconi, Marco Luigi Maria; Bespalenko, Artem; Bieler, Dan; Brand, Martin; De Sousa Junior, Edilson Carvalho; Chotirosniramit, Narain; Chung, Yuhsuan; Crichton, Lesley; De Paepe, Peter; Dogjani, Agron; Doll, Dietrich; Molla, Ayene Gebremicheal; Hardcastle, Timothy C.; Haxhirexha, Kastriot; Jain, Kajal; Jensen, Kai Oliver; Korolev, Andrey; Zhanfei, Li; Lim, Jerry K.T.; Linder, Fredrik; Lubis, Nurhayati; Magnitskaya, Nina; MacDonald, Damian; Mauser, Martin; Matthes, Gerrit; Mbugua, Kimani; Mlyavykh, Sergey; Monzon, Barbaro I.; Togtmol, Munkhsaikhan; Mustafa, Khreshi; Mwandri, Michael; Navsaria, Pradeep; Nijs, Stefan; Olmedo, Francisco; Gonzalez, Maria C. Ortega; Fantilli, Jesus Palacios; Pirpiris, Marinis; Pitance, Francois; Pomeroy, Eoghan; Sadakah, M.A.; Sahoo, Tapas Kumar; Saratila, Iurie; Scarpelini, Sandro; Schweigkofler, Uwe; Selmani, Edvin; Soderlund, Tim; Stein, Michael Ashley; Thapa, Buland; Trentzsch, Heiko; Truta, Teodora Sorana; Uranues, Selman; Wolfl, Christoph G.; Yi, Sandar Thein; Yovenko, Ihor; Zapattini, Pablo (Springer, 2021-10)
    PURPOSE : trauma team activation (TTA) is thought to be essential for advanced and specialized care of very severely injured patients. However, non-specific TTA criteria may result in overtriage that consumes valuable ...
  • Immunosuppressive signaling pathways as targeted cancer therapies 
    Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)
    Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
  • MicroRNA and alternative mRNA splicing events in cancer drug response/resistance : potent therapeutic targets 
    Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen; Dlamini, Zodwa (MDPI, 2021-12-02)
    Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...