• Advances in nano-delivery of phytochemicals for glioblastoma treatment 

  Ambele, Melvin Anyasi; Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Kungoane, Tsholofelo; Damane, Botle Precious (SpringerOpen, 2024-12)

  Glioblastoma (GBM) is an aggressive brain tumor characterized by cellular and molecular diversity. This diversity presents significant challenges for treatment and leads to poor prognosis. Surgery remains the primary ...
• Gastric perforation biopsy : is it obsolete? 

  Steyn, Petre Francois; Karusseit, V.O.L. (Otto) (Springer, 2024-04-27)

  PURPOSE The aim of the study was to test the established hypothesis that biopsies of spontaneous gastric perforations should be taken to rule out cancer. METHODS A prospective observational study was performed. Consecutive ...
• The anatomical location of the great saphenous vein at the thigh and ankle : a neonatal cadaver study 

  Van Tonder, Daniel Johannes; Kathrada, Ahmad; Lokhandwala, Adnan; Van Niekerk, Martin Louis; Van Schoor, Albert-Neels (Spanish Association of Anatomy, 2024-03)

  No abstract available.
• Anatomical analysis of proximal tibia : selecting ideal sites for pediatric intraosseous infusion 

  Van Tonder, Daniel Johannes; Al Safadi, Layla; Samaha, Paula; Suleman, Farhana Ebrahim; Van Niekerk, Martin Louis; Van Schoor, Albert; Van Schoor, Albert-Neels (Spanish Association of Anatomy, 2024-07)

  Intraosseous access is a safe and efficient method to administer medications to patients that require advanced life support when intravenous access is not easily available. This study aims to narrow down the ideal insertion ...
• The clinicopathological landscape of thyroid cancer in South Africa—a multi-institutional review 

  Conradie, Wilhelmina; Luvhengo, Thifhelimbilu E.; Lubbe, Jeanne Adele; Afrogheh, Amir H.; Bestbier, Aneldi; Bhuiyan, Mirza; Bombil, Ifongo; Cacala, Sharon Raye; Cairncross, Lydia; Changfoot, Chanel; Edge, Jenny; Jackson, Brandon Spencer; Jehle, Hansjorg S.; Jonas, Lusanda; Lukusa, Mpoyi Ruphin; Makgoka, Malose; Martin, Lindi; Nel, Daniel; Patel, Mohamed Quraish; Sishuba, Nosisa Thabile; Razack, Rubina; Baatjes, Karin (Wiley, 2024-12)

  BACKGROUND : In South Africa (SA), data on the incidence of thyroid cancer is limited. Papillary thyroid carcinoma is by far the most common malignancy in developed countries; however, a preponderance of follicular ...
• Holomics and artificial intelligence-driven precision oncology for medullary thyroid carcinoma : addressing challenges of a rare and aggressive disease 

  Luvhengo, Thifhelimbilu Emmanuel; Moeng, Maeyane Stephens; Sishuba, Nosisa T.; Makgoka, Malose; Jonas, Lusanda; Mamathuntsha, Tshilidzi G.; Mbambo, Thandanani; Kagodora, Shingirai B.; Dlamini, Zodwa (MDPI, 2024-10)

  BACKGROUND/OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare yet aggressive form of thyroid cancer comprising a disproportionate share of thyroid cancer-related mortalities, despite its low prevalence. MTC differs ...
• Perforated peptic ulcer : a case series and an African perspective 

  Malefahlo, Thabiso M.; Montwedi, Daniel; Karusseit, V.O.L. (Otto) (Medpharm Publications, 2024-02)

  BACKGROUND: Perforation of peptic ulcer (PPU) is the most morbid complication of peptic ulcer disease (PUD) with scant recent reports from sub-Saharan Africa. The aim of this study was to describe a PPU series from a ...
• Non-technical skills for neurosurgeons : an international survey 

  Cavallo, S.M.; Pellencin, E.; Carone, G.; Castelli, N.; Ayadi, R.; Olldashi, F.; Al Anazi, A.; Kanaan, I.; Garcia Colmena, F.; Ajler, P.; Socolovsky, M.; Knosp, E.; Raftopoulos, C.; Rodrigues, J.C., Jr.; Enchev, Y.P.; Xu, B.; Chul-Kee, P.; Rotim, K.; Posti, J.; Meyer, B.; Shimamoto, H.; Makhambetov, Y.; Frosen, J.; Chandra, S.P.; Cappabianca, P.; Piatelli, G.; Genitori, L.; Germanò, A.; Sabatino, G.; Bernucci, C.; Giussani, C.; Olivi, A.; Locatelli, D.; Stefini, R.; Castrioto, C.; Mangiola, A.; Fontanella, M.M.; Tacconi, L.; Conti, C.; Skrap, M.; El Abbadi, N.; Sharma, M.R.; Shamim, M.S.; Sharif, S.; Farias, J.P.; Florian, I.S.; Gushcha, A.O.; Rasulic, L.; Vulekovic, P.; Ang, B.T.; Lagares, A.; Diez Valle, R.; Ensenat, J.; Ley Urzaiz, L.; Barcia Albacar, J.A.; Kupanur, S.S.; Regli, L.; Dunn, I.F.; Adelson, D.; Bederson, J.; Levi, A.D.; Alturky, A.Y.; Matula, C.; Cortes, B.; Xiang, W.; Li, T.; El-Ghandour, N.M.F.; Kanai, R.; Patir, R.; Misra, B.K.; Dwarakanath, S.; Servadei, F.; Tomasello, F.; Casali, C.; Unsgard, G.; Morcos, J.J.; Souhil, T.; Khoja, I.; Kehayov, I.; Vukic, M.; Ziebell, M.; Gulisano, H.A.; Tange, M.; Kurozumi, K.; Locatelli, M.; Garbossa, D.; Gomez Amador, J.L.; Rodriguez, A.O.; Ashkan, K.; Lim, M.; Maleki, M.; Agrawal, A.; Naik, A.; Sciubba, D.M.; Kim, L.J.; Spinner, R.J.; McDonald, P.; Pavesi, G.; Moiyadi, A.; Padayachy, Llewellyn; Meling, T.R.; Di Meco, F.; Perin, A. (Elsevier, 2024)

  INTRODUCTION : Neurosurgery is considered a technically demanding specialty; nonetheless, it also requires non-technical skills (NTSs) to reach mastery. RESEARCH QUESTION : This study seeks to understand how important ...
• Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 

  Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)

  Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
• Position statement on the definition, incidence, diagnosis and outcome of acute on chronic pancreatitis 

  Bouca-Machado, Tiago; Bouwense, Stefan A.W.; Brand, Martin; Demir, Ihsan Ekin; Frokjær, Jens Brondum; Garg, Pramod; Hegyi, Peter; Lohr, J.-Matthias; De-Madaria, Enrique; Pandanaboyana, Sanjay; Pedersen, Jan Bech; Rebours, Vinciane; Sheel, Andrea; Singh, Vikesh; Smith, Martin; Windsor, John A.; Yadav, Dhiraj; Drewes, Asbjorn Mohr (Elsevier, 2023-03)

  BACKGROUND : Acute on chronic pancreatitis (ACP) is a relatively common condition, but there are significant gaps in our knowledge on the definition, incidence, diagnosis, treatment and prognosis. METHODS : A systematic ...
• Immunomodulatory gene-splicing dysregulation in tumorigenesis : unmasking the complexity 

  Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Yasasve, Madhavan; Dlamini, Zodwa; Damane, Botle Precious (MDPI, 2023-08-10)

  Cancer is a global health concern with rising incidence, morbidity, and mortality. The interaction between the tumor and immune cells within the tumor microenvironment is facilitated by signaling pathways driven by ...
• Noninvasive intracranial pressure assessment by optic nerve sheath diameter : automated measurements as an alternative to clinician-performed measurements 

  Netteland, Dag Ferner; Aarhus, Mads; Smistad, Erik; Sandset, Else Charlotte; Padayachy, Llewellyn; Helseth, Eirik; Brekken, Reidar (Frontiers Media, 2023-02-01)

  INTRODUCTION : Optic nerve sheath diameter (ONSD) has shown promise as a noninvasive parameter for estimating intracranial pressure (ICP). In this study, we evaluated a novel automated method of measuring the ONSD in ...
• Targeting stem cells in the colorectal cancer microenvironment to avert drug resistance in pursuit of novel oncotherapies 

  Damane, Botle Precious; Marima, Rahaba; Mulaudzi, Thanyani; Dlamini, Zodwa (Biolife Sas, 2023-09)

  Several studies have demonstrated the heightened prevalence of colorectal cancer (CRC) among young black men. Most of these men present with already metastasized CRC. Cancer stem cells (CSCs) play a pivotal role in CRC ...
• Spontaneous resolution of a patient with a symptomatic pheochromocytoma 

  Jackson, Brandon Spencer; Ndhlebe, Gugulethu; Suleman, Farhana Ebrahim (Elsevier, 2024-07)

  A 56-year-old woman presented with a 2-year history of chronic persistent right upper quadrant abdominal pain that was associated with intermittent nausea, vomiting, and unintentional weight loss. She had been on ...
• Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 

  Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)

  A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
• Transorbital neuroendoscopy-assisted resection of a giant optic pathway glioma in a neonate 

  Maseko, Rodney; Mabogo, Maanda; Lockhat, Zarina I.; Makunyane, P.S. (Priscilla); Ahmad, Samia; Bida, Meshack; Padayachy, Llewellyn (Springer, 2023-09)

  Congenitalgiant orbital tumors in infancy are relatively rare, especially when the tumors are associated with significant intracranial extension. We describe the use of a transorbital neuroendoscopy-assisted resection of ...
• Unraveling the complex interconnection between specific Inflammatory signaling pathways and mechanisms involved in HIV-associated colorectal oncogenesis 

  Damane, Botle Precious; Mulaudzi, Thanyani Victor; Kader, Sayed Shakeel; Naidoo, Pragalathan; Savkovic, Suzana D.; Dlamini, Zodwa; Mkhize-Kwitshana, Zilungile Lynette (MDPI, 2023-02)

  The advancement of HIV treatment has led to increased life expectancy. However, people living with HIV (PLWH) are at a higher risk of developing colorectal cancers. Chronic inflammation has a key role in oncogenesis, ...
• Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 

  Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)

  Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
• Dissecting microbiome-derived SCFAs in prostate cancer : analyzing gut microbiota, racial disparities, and epigenetic mechanisms 

  Miya, Thabiso Victor; Marima, Rahaba; Damane, Botle Precious; Ledet, Elisa Marie; Dlamini, Zodwa (MDPI, 2023-08-14)

  Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with ...
• Alternative splicing events and their clinical significance in colorectal cancer : targeted therapeutic opportunities 

  Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen; Dlamini, Zodwa (MDPI, 2023-08-07)

  Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...

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