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Research Articles (Immunology): Recent submissions

  • T cell responses to SARS-CoV-2 spike cross-recognize Omicron 
    Keeton, Roanne; Tincho, Marius B.; Ngomti, Amkele; Baguma, Richard; Benede, Ntombi; Suzuki, Akiko; Khan, Khadija; Cele, Sandile; Bernstein, Mallory; Karim, Farina; Madzorera, Sharon V.; Moyo-Gwete, Thandeka; Mennen, Mathilda; Skelem, Sango; Adriaanse, Marguerite; Mutithu, Daniel; Aremu, Olukayode; Stek, Cari; Du Bruyn, Elsa; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Mendes, Adriano; Strydom, Amy; Venter, Marietjie; Giandhari, Jennifer; Naidoo, Yeshnee; Pillay, Sureshnee; Tegally, Houriiyah; Grifoni, Alba; Weiskopf, Daniela; Sette, Alessandro; Wilkinson, Robert J.; De Oliveira, Tulio; Bekker, Linda‑Gail; Gray, Glenda; Ueckermann, Veronica; Rossouw, Theresa; Boswell, M.T.; Bhiman, Jinal N.; Moore, Penny L.; Sigal, Alex; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Riou, Catherine (Nature Research, 2022-03-17)
    The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2 that contribute to viral escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other ...
  • Comparative molecular genetics of odontogenic keratocysts in sporadic and syndromic patients 
    Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus (Elsevier, 2023-01)
    Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
  • Immune and metabolic alterations in children with perinatal HIV exposure 
    Du Toit, Louise de Villiers; Prinsloo, Andrea; Steel, Helen C.; Feucht, Ute Dagmar; Louw, Roan; Rossouw, Theresa (MDPI, 2023-02)
    With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV ...
  • Phenylalanine metabolism and tetrahydrobiopterin bio-availability in COVID-19 and HIV 
    Mason, Shayne; Van Reenen, Mari; Rossouw, Theresa; Lindeque, Zander; Louw, Roan (Elsevier, 2023-03)
    Please read abstract in article.
  • Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility 
    Gocz, Balazs; Rumpler, Eva; Sarvari, Miklos; Skrapits, Katalin; Takacs, Szabolcs; Farkas, Imre; Csillag, Veronika; Trinh, Sarolta H.; Bardoczi, Zsuzsanna; Solymosi, Norbert; Poliska, Szilard; Bartoloni, Lucia; Zouaghi, Yassine; Messina, Andrea; Pitteloud, Nelly; Anderson, Ross Calley; Millar, Robert P.; Quinton, Richard; Manchishi, Stephen M.; Colledge, William H.; Hrabovszky, Erik (National Academy of Sciences, 2022-06-28)
    Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized ...
  • Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 
    Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)
    There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
  • The acidic tumour microenvironment : manipulating the immune response to elicit escape 
    Worsley, Catherine; Veale, Rob B.; Mayne, Elizabeth S. (Elsevier, 2022-05)
    The success of cancer treatment relies on the composition of the tumour microenvironment which is comprised of tumour cells, blood vessels, stromal cells, immune cells, and extracellular matrix components. Barriers to ...
  • Recent advances, patient selection & challenges in managing cancer patients undergoing treatment with immune checkpoint inhibitors 
    Rapoport, Bernardo Leon; Anderson, Ronald (Medknow Publications, 2022-02)
    Cancer immunotherapy with humanized monoclonal antibodies (mAbs) that target co-inhibitory immune checkpoint molecules (ICMs) is the most meaningful advance in the management of malignant diseases in recent years. This has ...
  • A South African breast implant-associated anaplastic large cell lymphoma : clinical presentation and six-year follow-up 
    Grubnik, Alexandra; Ramdas, Yastira; Van der Bergh, Barend; Nayler, Simon; Benn, Carol-Ann; Rapoport, Bernardo Leon (Hindawi, 2022-05-31)
    Breast augmentation is the most common surgical procedure for women globally, with 1,795,551 cases performed in 2019. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is highly uncommon, with 733 reported ...
  • Shared N417-dependent epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus variants 
    Moyo-Gwete, Thandeka; Madzivhandila, Mashudu; Mkhize, Nonhlanhla N.; Kgagudi, Prudence; Ayres, Frances; Lambson, Bronwen E.; Manamela, Nelia P.; Richardson, Simone, I.; Makhado, Zanele; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita Roma; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Rossouw, Theresa M.; Ueckermann, Veronica; Boswell, Michael T.; Moore, Penny L. (American Society for Microbiology, 2022-07)
    As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs have shown ...
  • Pharmacogenetics of CYP2A6, CYP2B6, and UGT2B7 in the context of HIV treatments in African populations 
    Ford, Graeme R.; Niehaus, Antoinette; Joubert, Fourie; Pepper, Michael Sean (MDPI, 2022-12)
    OBJECTIVES : This study focuses on identifying variations in selected CYP genes related to treatment responses in patients with HIV in African populations by investigating variant characteristics and effects in African ...
  • MicroRNA interrelated epithelial mesenchymal transition (EMT) in glioblastoma 
    Setlai, Botle Precious; Hull, Rodney; Reis, Rui Manuel; Agbor, Cyril; Ambele, Melvin Anyasi; Mulaudzi, Thanyani Victor; Dlamini, Zodwa (MDPI, 2022-01-27)
    MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing ...
  • Elucidation of repeat motifs R1- and R2-related TRIOBP variants in autosomal recessive nonsyndromic hearing loss DFNB28 among indigenous South African individuals 
    Kabahuma, Rosemary Ida; Schubert, Wolf-Dieter; Labuschagne, Christiaan; Yan, Denise; Pepper, Michael Sean; Liu, Xue-Zhong (Wiley Open Access, 2022-10)
    BACKGROUND : DFNB28, a recessively inherited nonsyndromic form of deafness in humans, is caused by mutations in the TRIOBP gene (MIM #609761) on chromosome 22q13. Its protein TRIOBP helps to tightly bundle F-actin filaments, ...
  • The effect of acute acid exposure on immunomodulatory protein secretion, cell survival, and cell cycle progression in tumour cell lines 
    Worsley, Catherine M.; Veale, Rob B.; Mayne, Elizabeth S. (Elsevier, 2023-02)
    Cancer develops when multiple systems fail to suppress uncontrolled cell proliferation. Breast cancers and oesophageal squamous cell carcinoma (OSCC) are common cancers prone to genetic instability. They typically occur ...
  • The influence of satisfaction with life, social contribution and environmental well-being on conscientious consumer decision-making in the South African emerging economy 
    Christie, Lorna; Sonnenberg, Nadine Cynthia (Routledge, 2023)
    Emerging economies harbour increasing consumption patterns with detrimental social and environmental consequences. This study postulated that satisfaction with life determines consumers’ social contribution and environmental ...
  • Coronavirus host genetics South Africa (COHG-SA) database—a variant database for gene regions associated with SARS-CoV-2 outcomes 
    Barmania, Fatima; Mellet, Juanita; Ryder, Megan A.; Ford, Graeme R.; Herd, Candice L.; Tamuhla, Tsaone; Hendricks, Candice Laverne; Giles, Rachel; Kalua, Thumbiko; Joubert, Fourie; Tiffin, Nicki; Pepper, Michael Sean (Springer nature, 2022-08)
    The SARS-CoV-2 virus is responsible for the COVID-19 global public health emergency, and the disease it causes is highly variable in its clinical presentation. Clinical phenotypes are heterogeneous both in terms of ...
  • The unexplored possibilities, perceptions and ethical implications of gene-editing allergic disease : engaging stakeholders in South Africa 
    Castelyn, Camille De Villebois (Allergy Society of South Africa, 2022-09)
    Clinically approved cell and gene therapies are opening up future possibilities to treat and prevent myriad diseases, which may include allergic diseases. In South Africa, this could help alleviate the high disease burden ...
  • Determinants of dental pulp stem cell heterogeneity 
    Nel, Sulette; Durandt, Chrisna; Murdoch, Candice; Pepper, Michael Sean (Elsevier, 2022-10)
    INTRODUCTION : The aim of this review is to provide a narrative review on the determinants of dental pulp stem cell (DPSC) heterogeneity that may affect the regenerative properties of these cells. METHODS : PubMed, Scopus, ...
  • SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity 
    Richardson, Simone I.; Manamela, Nelia P.; Motsoeneng, Boitumelo M.; Kaldine, Haajira; Ayres, Frances; Makhado, Zanele; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Sullivan, Nancy J.; Misasi, John; Gray, Glenda G.; Bekker, Linda‑Gail; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Moore, Penny L. (Cell Press, 2022-02-15)
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic ...
  • SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals 
    Richardson, Simone I.; Madzorera, Tatenda; Spencer, Holly; Manamela, Nelia P.; Van der Mescht, Mieke Adri; Lambson, Bronwen E.; Oosthuysen, Brent; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Mzindle, Nonkululeko; Motlou, Thopisang; Strydom, Amy; Mendes, Adriano; Tegally, Houriiyah; De Beer, Zelda; De Villiers, Talita Roma; Bodenstein, Annie; Van den Berg, Gretha; Venter, Marietjie; De Oliviera, Tulio; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Moore, Penny L. (Cell Press, 2022-03-24)
    The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses to other variants of concern (VOCs) remains unknown. We ...