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Research Articles (Immunology): Recent submissions

  • Metabolic alterations in mothers living with HIV and their HIV-exposed, uninfected infants 
    Du Toit, Louise de Villiers; Mason, Shayne; Van Reenen, Mari; Rossouw, Theresa; Louw, Roan (MDPI, 2024-02)
    HIV-exposed, uninfected (HEU) children present with suboptimal growth and a greater susceptibility to infection in early life when compared to HIV-unexposed, uninfected (HUU) children. The reasons for these findings are ...
  • Biomarkers for disease progression identified in psoriasis patients : a pilot study 
    Mkhize, Nomzamo; Kgokolo, Mahlatse C.M.; Steel, Helen C.; Meyer, Pieter W. A.; Kwofie, Luyanda Laura Illicia (Wiley, 2023-09)
    BACKGROUND : Psoriasis is an immune-mediated polygenic skin disorder. It is influenced by multiple genes as well as environmental factors including infection and trauma. Psoriasis is associated with molecular biomarkers ...
  • Filgrastim biosimilar (EP2006) : a review of 15 years’ post-approval evidence 
    Gascón, Pere; Harbeck, Nadia; Rapoport, Bernardo Leon; Anderson, Ronald; Brueckmann, Ines; Howe, Sebastian; Aapro, Matti (Elsevier, 2024-04)
    Filgrastim is approved for several indications, including reduction of the incidence and duration of chemotherapy-induced neutropenia and for stem cell mobilization. The filgrastim biosimilar, EP2006, has been available ...
  • Emerging markers of cancer cachexia and their relationship to sarcopenia 
    Lipshitz, Melanie; Visser, J.; Anderson, Ronald; Nel, D.G.; Smit, T.G. (Theunis); Steel, Helen C.; Rapoport, Bernardo Leon (Springer, 2023-12)
    PURPOSE : Emerging biomarkers of cancer cachexia and their roles in sarcopenia and prognosis are poorly understood. Baseline assessments of anthropometrics, sarcopenia, cachexia status and biomarkers of cachexia were ...
  • Comparative evaluation of the cytotoxicity of doxorubicin in BT-20 triple-negative breast carcinoma monolayer and spheroid cultures 
    Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)
    Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
  • Characteristics and outcomes of neonates with intrapartum asphyxia managed with therapeutic hypothermia in a public tertiary hospital in South Africa 
    Nakwa, Firdose Lambey; Sepeng, Letlhogonolo; Van Kwawegen, Alison; Thomas, Reenu; Seake, Karabo; Mogajane, Tshiamo; Ntuli, Nandi; Ondongo‑Ezhet, Claude; Kesting, Samantha; Kgwadi, Dikeledi Maureen; Kamanga, Noela Holo Bertha; Coetser, Annaleen; Van Rensburg, Jeanne; Pepper, Michael Sean; Velaphi, Sithembiso C. (BMC, 2023-01-31)
    BACKGROUND : In randomized clinical trials, therapeutic hypothermia (TH) has been shown to reduce death and/or moderate-to-severe disability in neonates with hypoxic ischemic encephalopathy (HIE) in high-income countries, while ...
  • 2023 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting 
    Herrstedt, J.; Clark-Snow, R.; Ruhlmann, C.H.; Molassiotis, A.; Olver, I.; Rapoport, Bernardo Leon; Aapro, M.; Dennis, K.; Hesketh, P.J.; Navari, R.M.; Schwartzberg, L.; Affronti, M.L.; Garcia-Del-Barrio, M.A.; Chan, A.; Celio, L.; Chow, R.; Fleury, M.; Gralla, R.J.; Giusti, R.; Jahn, F.; Iihara, H.; Maranzano, E.; Radhakrishnan, Venkatraman; Saito, Mitsue; Sayegh, Paula; Bosnjak, S.; Zhang, L.; Lee, J.; Ostwal, V.; Smit, T.; Zilic, A.; Jordan, Karin; Scotté, F. (Elsevier, 2024-02)
    Nausea and vomiting are still considered to be two of the most troublesome adverse events (AEs) for patients treated with antineoplastic therapy. To optimise the utility of available antiemetic prophylaxis, updated reviews ...
  • Glucocorticoids with or without fludrocortisone in septic shock : a narrative review from a biochemical and molecular perspective 
    Nethathe, Gladness D.; Lipman, Jeffrey; Anderson, Ronald; Fuller, Peter J.; Feldman, Charles (Elsevier, 2024-01)
    Two randomised controlled trials have reported a reduction in mortality when adjunctive hydrocortisone is administered in combination with fludrocortisone compared with placebo in septic shock. A third trial did not support ...
  • Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma 
    Kgokolo, C.M.; Malinga, Nonkululeko Z.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon (Elsevier, 2024-04)
    The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells ( n = 7) in a cohort of patients with ...
  • Allergic rhinitis : review of the diagnosis and management : South African Allergic Rhinitis Working Group 
    Richards, Guy A.; Gray, Claudia L.; De Waal, Pieter; Friedman, Ray; Hockman, Maurice; Karabus, Sarah J.; Lodder, Cornelia M.; Mabelane, Tshegofatso; Mosito, Sylvia M.; Nanan, Ashen; Peter, Jonny G.; Quitter, Traugott H.C.; Van den Berg, Sylvia; Van Niekerk, Andre; Vardas, Eftyhia; Feldman, Charles (AOSIS, 2023-10-30)
    BACKGROUND : Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of ...
  • COVID-19 severity and in-hospital mortality in an area with high HIV prevalence 
    Boswell, Michael; Maimela, T.C.R. (Tshegofatso); Hameiri-Bowen, Dan; Riley, George; Malan, Albertus; Steyn, Nickietta; Nolutshungu, Nomonde; De Villiers, Talita R.; De Beer, Zelda; Mathabathe, John; Tshabalala, Khanyisile; Abdullah, Fareed; Ramlall, Rajiev; Heystek, Marthinus J.; Basu, Debashis; Rheeder, Paul; Ueckermann, Veronica; Van Hougenhouck-Tulleken, Wesley G. (AOSIS, 2023-01-27)
    BACKGROUND : HIV infection causes immune dysregulation affecting T-cell and monocyte function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology. OBJECTIVES : We investigated the associations among ...
  • Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro 
    Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)
    The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
  • Emetic risk classification and evaluation of the emetogenicity of antineoplastic agents—updated MASCC/ESMO consensus recommendation 
    Jordan, Karin; Chan, Alexandre; Gralla, Richard J.; Jahn, Franziska; Rapoport, Bernardo Leon; Ruhlmann, Christina H.; Sayegh, Paula; Hesketh, Paul J. (Springer, 2024-01)
    PURPOSE : Our goal was to identify new anticancer agents approved by the US Food and Drug Administration (FDA) and the European Medical Agency (EMA) since the 2016 MASCC/ESMO antiemetic update and classify their emetic ...
  • A prospective, real‑world, multinational study of febrile neutropenia (FN) occurrence in oncology patients receiving chemotherapy with intermediate risk of FN : a MASCC neutropenia, infection, and myelosuppression study group initiative 
    Rapoport, Bernardo Leon; Garcia‑Morillo, Marcial; Font, Carme; Samoon, Zarka; Jabbar, Adnan Abdul; Kourie, Hampig Raphael; Kayumba, Aline; Esposito, Francis; Popescu, Razvan Andrei; Garcia‑Gomez, Jesus; Heyman, Liezl; Smit, Teresa; Krendyukov, Andriy; Mathieson, Nicola; Cooksley, Tim; Anderson, Ronald; Klastersky, Jean (Springer, 2023-10-13)
    PURPOSE : Limited knowledge is available on the incidence of febrile neutropenia (FN) in intermediate-risk patients and the rationale for use of granulocyte colony-stimulating factor (G-CSF) in these patients. We aimed to ...
  • 2023 updated MASCC/ESMO consensus recommendations : prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting 
    Rapoport, Bernardo Leon; Herrstedt, Jorn; Snow, Rebecca Clark; Radhakrishnan, Venkatraman; Saito, Mitsue; Navari, Rudolph M.; Smit, Teresa (Springer, 2024-01)
    PURPOSE : This review is an update of the MASCC/ESMO 2015 recommendations for the prophylaxis of acute and delayed nausea and vomiting induced by multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea ...
  • T cell responses to SARS-CoV-2 spike cross-recognize Omicron 
    Keeton, Roanne; Tincho, Marius B.; Ngomti, Amkele; Baguma, Richard; Benede, Ntombi; Suzuki, Akiko; Khan, Khadija; Cele, Sandile; Bernstein, Mallory; Karim, Farina; Madzorera, Sharon V.; Moyo-Gwete, Thandeka; Mennen, Mathilda; Skelem, Sango; Adriaanse, Marguerite; Mutithu, Daniel; Aremu, Olukayode; Stek, Cari; Du Bruyn, Elsa; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Mendes, Adriano; Strydom, Amy; Venter, Marietjie; Giandhari, Jennifer; Naidoo, Yeshnee; Pillay, Sureshnee; Tegally, Houriiyah; Grifoni, Alba; Weiskopf, Daniela; Sette, Alessandro; Wilkinson, Robert J.; De Oliveira, Tulio; Bekker, Linda‑Gail; Gray, Glenda; Ueckermann, Veronica; Rossouw, Theresa; Boswell, M.T.; Bhiman, Jinal N.; Moore, Penny L.; Sigal, Alex; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Riou, Catherine (Nature Research, 2022-03-17)
    The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2 that contribute to viral escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other ...
  • Comparative molecular genetics of odontogenic keratocysts in sporadic and syndromic patients 
    Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus (Elsevier, 2023-01)
    Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
  • Immune and metabolic alterations in children with perinatal HIV exposure 
    Du Toit, Louise de Villiers; Prinsloo, Andrea; Steel, Helen C.; Feucht, Ute Dagmar; Louw, Roan; Rossouw, Theresa (MDPI, 2023-02)
    With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV ...
  • Phenylalanine metabolism and tetrahydrobiopterin bio-availability in COVID-19 and HIV 
    Mason, Shayne; Van Reenen, Mari; Rossouw, Theresa; Lindeque, Zander; Louw, Roan (Elsevier, 2023-03)
    Please read abstract in article.
  • Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility 
    Gocz, Balazs; Rumpler, Eva; Sarvari, Miklos; Skrapits, Katalin; Takacs, Szabolcs; Farkas, Imre; Csillag, Veronika; Trinh, Sarolta H.; Bardoczi, Zsuzsanna; Solymosi, Norbert; Poliska, Szilard; Bartoloni, Lucia; Zouaghi, Yassine; Messina, Andrea; Pitteloud, Nelly; Anderson, Ross Calley; Millar, Robert P.; Quinton, Richard; Manchishi, Stephen M.; Colledge, William H.; Hrabovszky, Erik (National Academy of Sciences, 2022-06-28)
    Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized ...