• Identification of small-molecule antagonists targeting the growth hormone releasing hormone receptor (GHRHR) 

  Matsoukas, Minos-Timotheos; Radomsky, Tarryn; Panagiotopoulos, Vasilis; Du Preez, Robin; Papadourakis, Michail; Tsianakas, Konstantinos; Millar, Robert P.; Anderson, Ross Calley; Spyroulias, Georgios A.; Newton, Claire L. (American Chemical Society, 2024-08-29)

  The growth hormone-releasing hormone receptor (GHRHR) belongs to Class B1 of G protein-coupled receptors (GPCRs). Class B1 GPCR peptides such, as growth hormone-releasing hormone (GHRH), have been proposed to bind in a ...
• Patient-reported symptom monitoring: using (big) data to improve supportive care at the macro-, meso-, and micro-levels 

  Wang, Yan; Allsop, Matthew J.; Epstein, Joel B.; Howell, Doris; Rapoport, Bernardo Leon; Schofield, Penelope; Van Sebille, Ysabella; Thong, Melissa S.Y.; Walraven, Iris; Wolf, Julie Ryan; Van den Hurk, Corina J.G. (Springer, 2024-03)

  PURPOSE : This paper aims to provide a comprehensive understanding of the need for continued development of symptom monitoring (SM) implementation, utilization, and data usage at the macro-, meso-, and micro-levels. METHODS ...
• Radiologic specific growth rate of ameloblastomas : a clinicopathological correlation 

  Smit, Chane; Robinson, Liam; Van Heerden, Marlene B.; Meyer, Pieter Willem Adriaan; Fonseca, Felipe P.; Van Heerden, Willem Francois Petrus; Uys, Andre (Wiley, 2025-01)

  BACKGROUND : The study aimed to assess the radiologic-specific growth rate of ameloblastomas, evaluating potential associations with demographics, radiologic features, histopathologic variants and proliferation indices. ...
• Smoking, alcohol use, diabetes mellitus, and metabolic syndrome as risk factors for community-acquired pneumonia 

  Feldman, Charles; Anderson, Ronald (Elsevier, 2025-03)

  Community-acquired pneumonia (CAP) continues to be a cause of significant morbidity and mortality worldwide. Much recent attention in this area of research has been focused on host factors associated with the infection. ...
• Sodium, potassium-adenosine triphosphatase as a potential target of the anti-tuberculosis agents, clofazimine and bedaquiline 

  Mmakola, Khomotso Madimetsa Shelboy; Balmith, Marissa [; Steel, Helen C.; Said, Mohamed; Potjo, Moliehi; Van der Mescht, Mieke Adri; Hlatshwayo, Nomsa; Meyer, Pieter Willem Adriaan; Tintinger, Gregory Ronald; Anderson, Ronald; Cholo, Moloko C. (MDPI, 2024-12-04)

  Multidrug-resistant tuberculosis (MDR-TB) patients are treated with a standardised, short World Health Organization (WHO) regimen which includes clofazimine (CFZ) and bedaquiline (BDQ) antibiotics. These two antibiotics ...
• Building plumbing influences the microdiversity and community assembly of the drinking water microbiome 

  He, Huanqi; Huo, Linxuan; Oosthuizen-Vosloo, Solize; Pieper, Kelsey J.; Stubbins, Aron; Yoon, Byungman; Pinto, Ameet J. (Elsevier, 2025-05)

  Building plumbing microbial communities can significantly influence water quality at the point of use, particularly during periods of stagnation. Thus, a fine-scale understanding of factors governing community membership ...
• A possible genetic predisposition to suspected hypoxic-ischaemic encephalopathy 

  Holborn, Megan A.; Mellet, Juanita; Joubert, Fourie; Ballot, D.; Pepper, Michael Sean (Elsevier, 2025-04)

  Within the last decade, several studies have explored whether there might be a genetic component in hypoxic-ischaemic encephalopathy (HIE) that influences susceptibility to or outcomes following hypoxic-ischaemic injury. ...
• Vascular endothelial growth factor A : friend or foe in the pathogenesis of HIV and SARS-CoV-2 infections? 

  Van der Mescht, Mieke Adri; Steel, Helen C.; Anderson, Ronald; Rossouw, Theresa M. (Frontiers Media S.A., 2025-02)

  This review article discusses the role of vascular endothelial growth factor A (VEGF-A) in the pathogenesis of SARS-CoV-2 and HIV infection, both conditions being renowned for their impact on the vascular endothelium. The ...
• Guest editorial : Inborn errors of immunity 

  Van Niekerk, Andre (Allergy Society of South Africa, 2024-03)

  It was around 1973. Two years after the birth of David Vetter. David’s story captivated the mainstream media and the hearts of those who followed his sad case. He suffered from severe combined immunodeficiency (SCID) and his ...
• T-cell phenotypes and systemic cytokine profiles of people living with HIV admitted to hospital with COVID-19 

  Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Masenge, Andries; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa M. (MDPI, 2024-11)

  Whether SARS-CoV-2 infection leads to a higher mortality and morbidity in people living with HIV (PLWH) in Africa remains inconclusive. In this study, we explored the differences in the T-cell phenotypes between people ...
• A proof-of-concept study to investigate the radiolabelling of human mesenchymal and hematopoietic stem cells with [89Zr]Zr-Df-Bz-NCS 

  Kahts, Maryke; Mellet, Juanita; Durandt, Chrisna; Moodley, Kinosha; Summers, Beverley; Ebenhan, Thomas; Zeevaart, Jan Rijn; Aras, Omer; Pepper, Michael Sean (SpringerOpen, 2024-11)

  Please read abstract in article.
• Advances in nano-delivery of phytochemicals for glioblastoma treatment 

  Ambele, Melvin Anyasi; Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Kungoane, Tsholofelo; Damane, Botle Precious (SpringerOpen, 2024-12)

  Glioblastoma (GBM) is an aggressive brain tumor characterized by cellular and molecular diversity. This diversity presents significant challenges for treatment and leads to poor prognosis. Surgery remains the primary ...
• Phenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individuals 

  Mistry, Priyal; Potgieter, Joachim; Pepper, Michael Sean; Durandt, Chrisna (Springer, 2025)

  Human immunodeficiency virus (HIV-1) infection remains a significant global public health concern, particularly in sub-Saharan Africa where the majority of HIV-1 infections are concentrated. People living with HIV (PLWH) ...
• New drinking water genome catalog identifies a globally distributed bacterial genus adapted to disinfected drinking water systems 

  Sudarshan, Ashwin S.; Dai, Zihan; Gabrielli, Marco; Oosthuizen-Vosloo, Solize; Konstantinidis, Konstantinos T.; Pinto, Ameet J. (American Chemical Society, 2024-09)

  Genome-resolved insights into the structure and function of the drinking water microbiome can advance the effective management of drinking water quality. To enable this, we constructed and curated thousands of ...
• Editorial : Mesenchymal and induced-pluripotent stem cells as models to study biological processes 

  Ambele, Melvin Anyasi; Miranda, Catarina O. (Frontiers Media, 2024-07)

  No abstract available.
• Neonatal encephalopathy due to suspected hypoxic ischemic encephalopathy : pathophysiology, current, and emerging treatments 

  Babbo, Carina Corte-Real; Mellet, Juanita; Van Rensburg, Jeanette; Pillay, Shakti; Horn, Alan Richard; Nakwa, Firdose Lambey; Velaphi, Sithembiso Christopher; Kali, Gugulabatembunamahlubi Tenjiwe Jabulile; Coetzee, Melantha; Masemola, Mogomane Yvonne Khomotso; Ballot, Daynia Elizabeth; Pepper, Michael Sean (Springer, 2024-11)

  BACKGROUND : Neonatal encephalopathy (NE) due to suspected hypoxic-ischemic encephalopathy (HIE), referred to as NESHIE, is a clinical diagnosis in late preterm and term newborns. It occurs as a result of impaired ...
• Probing the effects of retinoblastoma binding protein 6 (RBBP6) knockdown on the sensitivity of cisplatin in cervical cancer cells 

  Mehta, Harshini; Ambele, Melvin Anyasi; Mokgautsi, Ntlotlang; Moela, Pontsho (MDPI, 2024-04-02)

  Cervical cancer is a major cause of death in women despite the advancement of current treatment modalities. The conventional therapeutic agent, cisplatin (CCDP), is the standard treatment for CC; however, resistance often ...
• Prescribing probiotic drugs in clinical practice - are they indicated? 

  Van Niekerk, Andre; Delport, Suzanne D. (Allergy Society of South Africa, 2024-06-01)

  The past two decades will be remembered for the rapid advances in our understanding of the significant role that the human microbiome plays in health, illness and longevity, but it remains a vast concept, one that is ...
• Sulfamoylated estradiol analogs targeting the actin and microtubule cytoskeletons demonstrate anti-cancer properties in vitro and in ovo 

  Mercier, Anne Elisabeth; Joubert, Anna Margaretha; Viallet, Jean; Desroches-Castan, Agnes; De Koning, Leanne; Mabeta, Peaceful Lucy; Helena, Jolene Michelle; Pepper, Michael Sean; Lafanechere, Laurence (MDPI, 2024-10)

  The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We therefore designed two 2-ME analogs ...
• Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells 

  Mellet, Juanita; Hendricks, Candice Laverne; Stivaktas, Voula; Durandt, Chrisna; Ambele, Melvin Anyasi; Pepper, Michael Sean (BMC, 2024-09)

  BACKGROUND : Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical cord blood (UCB) as a source of stem cells for ...

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