• Prescribing probiotic drugs in clinical practice - are they indicated? 

  Van Niekerk, Andre; Delport, Suzanne D. (Allergy Society of South Africa, 2024-06-01)

  The past two decades will be remembered for the rapid advances in our understanding of the significant role that the human microbiome plays in health, illness and longevity, but it remains a vast concept, one that is ...
• Sulfamoylated estradiol analogs targeting the actin and microtubule cytoskeletons demonstrate anti-cancer properties in vitro and in ovo 

  Mercier, Anne Elisabeth; Joubert, Anna Margaretha; Viallet, Jean; Desroches-Castan, Agnes; De Koning, Leanne; Mabeta, Peaceful Lucy; Helena, Jolene Michelle; Pepper, Michael Sean; Lafanechere, Laurence (MDPI, 2024-10)

  The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We therefore designed two 2-ME analogs ...
• Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells 

  Mellet, Juanita; Hendricks, Candice Laverne; Stivaktas, Voula; Durandt, Chrisna; Ambele, Melvin Anyasi; Pepper, Michael Sean (BMC, 2024-09)

  BACKGROUND : Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical cord blood (UCB) as a source of stem cells for ...
• Human cloning as reproductive means in future : a qualitative thematic study of underpinning values 

  Castelyn, Camille De Villebois; Van Staden, Werdie; Pepper, Michael Sean (Frontiers Media, 2024-02)

  BACKGROUND AND OBJECTIVE: The possibility of using human cloning to reproduce has been met with unease, shock, and prohibition in many countries, as well as the International Committee for Monitoring Assisted ...
• Leadership in healthcare during a pandemic : for a systems leadership approach 

  Castelyn, Camille De Villebois (Frontiers Media, 2024-05)

  No abstract available.
• The curious case of the hypothalamic-pituitary-gonadal axis dysfunction in subordinate female naked mole-rats (Heterocephalus glaber) : no apparent role of opioids and glucocorticoids 

  Hart, Daniel William; Roberts, Elise; O'Riain, M. Justin; Millar, Robert P.; Bennett, Nigel C. (Wiley, 2024-10)

  The naked mole-rat (Heterocephalus glaber) is a unique model mammal in which to study socially induced inhibition of the hypothalamic–pituitary–gonadal (HPG) axis. Naked mole-rat groups exhibit a high degree of reproductive ...
• Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer : a report of the international immuno-oncology biomarker working group on breast cancer 

  Thagaard, Jeppe; Broeckx, Glenn; Page, David B.; Jahangir, Chowdhury Arif; Verbandt, Sara; Kos, Zuzana; Gupta, Rajarsi R.; Khiroya, Reena; Abduljabbar, Khalid; Haab, Gabriela Acosta; Acs, Balazs; Akturk, Guray; Almeida, Jonas S.; Alvarado‐Cabrero, Isabel; Amgad, Mohamed; Azmoudeh‐Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Balslev, Eva; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R.M.; Botinelly Mendonça Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Chardas, Alexandros; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A.D.; Coosemans, M.; Corredor, German; Dahl, Anders B.; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Hansen, Johan Dore; Dudgeon, Sarah N.; Ebstrup, Thomas; Elghazawy, Mahmoud; Fernandez‐Martín, Claudio; Fox, Stephen B.; Gallagher, William M.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez‐Ericsson, Paula I.; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hart, Steven N.; Hartman, Johan; Hauberg, Søren; Hewitt, Stephen; Hida, Akira I.; Horlings, Hugo M.; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel A.M.; Kahila, Mohamed; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I.; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Kovacs, Aniko; Laenkholm, Anne‐Vibeke; Lang‐Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K.; Manur Narasimhamurthy, Vidya; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault‐Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto‐Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Reis‐Filho, Jorge S.; Ribeiro, Joana M.; Rimm, David; Roslind, Anne; Vincent-Salomon, Anne; Salto‐Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Scott, Ely; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Fineberg, Susan; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; Van der Laak, Jeroen; Van Diest, Paul J.; Verghese, Gregory E.; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Md Zin, Reena; Adams, Sylvia; Bartlett, John; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Stovgaard, Elisabeth Specht (Wiley, 2023-08-23)

  The clinical significance of the tumor-immune interaction in breast cancer is now established, and tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative ...
• UNITY : a low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings 

  Abate, F.; Adu-Amankwah, A.; Ae-Ngibise, K.A.; Agbokey, F.; Agyemang, V.A.; Agyemang, C.T.; Akgun, C.; Ametepe, J.; Arichi, T.; Asante, K.P.; Balaji, S.; Baljer, L.; Basser, P.J.; Beauchemin, J.; Bennallick, C.; Berhane, Y.; Boateng-Mensah, Y.; Bourke, N.J.; Bradford, L.; Bruchhage, M.M.K.; Cano Lorente, R.; Cawley, P.; Cercignani, M.; D Sa, V.; De Canha, A.; Navarro, N.D.; Dean, D.C., III; Delarosa, J.; Donald, K.A.; Dvorak, A.; Edwards, A.D.; Field, D.; Frail, H.; Freeman, B.; George, T.; Gholam, J.; Guerrero-Gonzalez, J.; Hajnal, J.V.; Haque, R.; Hollander, W.; Hoodbhoy, Z.; Huentelman, M.; Jafri, S.K.; Jones, D.K.; Joubert, Fourie; Karaulanov, T.; Kasaro, M.P.; Knackstedt, S.; Kolind, S.; Koshy, B.; Kravitz, R.; Lafayette, S.L.; Lee, A.C.; Lena, B.; Lepore, N.; Linguraru, M.; Ljungberg, E.; Lockhat, Zarina I.; Loth, E.; Mannam, P.; Masemola, K.M.; Moran, R.; Murphy, D.; Nakwa, F.L.; Nankabirwa, V.; Nelson, C.A.; North, K.; Nyame, S.; O Halloran, R.; O'Muircheartaigh, J.; Oakley, B.F.; Odendaal, H.; Ongeti, C.M.; Onyango, D.; Oppong, S.A.; Padormo, F.; Parvez, D.; Paus, T.; Pepper, Michael Sean; Phiri, K.S.; Poorman, M.; Ringshaw, J.E.; Rogers, J.; Rutherford, M.; Sabir, H.; Sacolick, L.; Seal, M.; Sekoli, M.L.; Shama, T.; Siddiqui, K.; Sindano, N.; Spelke, M.B.; Springer, P.E.; Suleman, Farhana Ebrahim; Sundgren, P.C.; Teixeira, R.; Terekegn, W.; Traughber, M.; Tuuli, M.G.; Van Rensburg, Jeanne; Váša, F.; Velaphi, S.; Velasco, P.; Viljoen, I.M.; Vokhiwa, M.; Webb, A.; Weiant, C.; Wiley, N.; Wintermark, P.; Yibetal, K.; Deoni, S.C.L.; Williams, S.C.R. (Elsevier, 2024-10)

  Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact ...
• Glycemic control and cardiometabolic risk in black Zimbabweans with Type 2 diabetes mellitus 

  Chiveto, Dexter Tadiwanashe; Musarurwa, Cuthbert; Mapira, Herbert T.; Kaseke, Farayi; Nyengerai, Tawanda; Kaseke, Timothy; Gori, Elizabeth (Dove Medical Press, 2024-08)

  PURPOSE : Type 2 diabetes mellitus (T2DM) frequently presents with modified cardiometabolic risk profiles, indicative of an elevated susceptibility to cardiovascular disease (CVD). Cardiometabolic risk factors such as ...
• Dataset of cell viability and analytes released by cancer cell lines exposed to low pH and conditioned medium 

  Worsley, Catherine M.; Veale, Rob B.; Mayne, Elizabeth S. (Elsevier, 2024-06)

  Cancer cells influence their microenvironment by secreting factors that promote tumour growth and survival while evading immune-mediated destruction. We previously determined the expression of secreted factors in breast ...
• Effect of 2-methoxyestradiol on mammary tumor initiation and progression 

  Peta, Kimberly; Durandt, Chrisna; Van Heerden, Marlene B.; Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2024-04)

  BACKGROUND : The anti-cancer agent 2-methoxyestradiol (2-ME) has been shown to have anti-proliferative and anti-angiogenic properties. Previously, the effect of 2-ME on early- and late-stage breast cancer (BC) was ...
• Th1 and Th2 epitopes of Cowdria polymorphic gene 1 of Ehrlichia ruminantium 

  Ngoepe, Tlou A.; Pretorius, Alri; Steyn, Helena C.; Van Kleef, Mirinda (AOSIS, 2023-03-23)

  Cowdria polymorphic gene 1 (cpg1, Erum2510, ERUM_RS01380) has been shown to induce 30% and 100% protection in sheep immunised by deoxyribonucleic acid (DNA) prime combined with DNA boost and DNA prime combined with protein ...
• SARS-CoV-2 BA.4/5 infection triggers more cross-reactive FcγRIIIa signaling and neutralization than BA.1, in the context of hybrid immunity 

  Richardson, Simone I.; Mzindle, Nonkululeko; Motlou, Thopisang; Manamela, Nelia; Van der Mescht, Mieke Adri; Lambson, Bronwen E.; Everatt, Josie; Amoako, Daniel Gyamfi; Balla, Sashkia; Von Gottberg, Anne; Wolter, Nicole; De Beer, Zelda; De Villiers, Talita Roma; Bodenstein, Annie; Van den Berg, Gretha; Abdullah, Fareed; Rossouw, Theresa M.; Boswell, M.T.; Ueckermann, Veronica; Bhiman, Jinal N.; Moore, Penny L. (American Society for Microbiology, 2024-07)

  SARS-CoV-2 variants of concern (VOCs) differentially trigger neutralizing and antibody-dependent cellular cytotoxic (ADCC) antibodies with variable cross-reactivity. Omicron BA.4/5 was approved for inclusion in bivalent ...
• Specific plasma microRNAs are associated with CD4+ T-cell recovery during suppressive antiretroviral therapy for HIV-1 

  Kroeze, Stefanie; Kootstra, Neeltje; Van Nuenen, Ad C.; Rossouw, Theresa M.; Kityo, Cissy M.; Siwale, Margaret; Akanmu, Sulaimon; Mandaliya, Kishor; De Jager, Marleen; Ondoa, Pascale; Wit, Ferdinand W.; Reiss, Peter; Rinke de Wit, Tobias F.; Hamers, Raph L. (Lippincott, Williams & Wilkins, 2024-05)

  OBJECTIVE: This study investigated the association of plasma microRNAs before and during antiretroviral therapy (ART) with poor CD4þ T-cell recovery during the first year of ART. DESIGN: MicroRNAs were retrospectively ...
• Global disparities in cystic fibrosis outcomes prior to CFTR modulators : a CF registries cohort study in South Africa and Canada 

  Zampoli, Marco; Sykes, Jenna; Verstraete, Janine; Cheng, Stephanie Y.; Morrow, Brenda; Pepper, Michael Sean; Stewart, Cheryl; Zar, Heather J.; Stephenson, Anne L. (Elsevier, 2024-03)

  BACKGROUND : Outcomes of cystic fibrosis (CF) differ between low-middle income and high-income countries, but comparative data are lacking. We compared South African (SA) and Canadian CF outcomes to explore what disparities ...
• Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa 

  Van der Mescht, Mieke Adri; De Beer, Zelda; Steel, Helen C.; Anderson, Ronald; Masenge, Andries; Moore, Penny L.; Bastard, Paul; Casanova, Jean-Laurent; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2024-09)

  The African continent reported the least number of COVID-19 cases and deaths of all the continents, although the exact reasons for this are still unclear. In addition, little is known about the immunological profiles ...
• Cellular therapy in lymphoma 

  Sureda, Anna; Lugtenburg, Pieternella J.; Kersten, Marie Jose; Subklewe, Marion; Spanjaart, Anne; Shah, Nirali N.; Kerbauy, Lucila N.; Roddie, Clarie; Pennings, Elise R.A.; Mahuad, Carolina; Poon, Michelle; Hendricks, Candice Laverne; Kamdar, Manali; Jacobson, Caron (Wiley, 2024)
• Inequalities in the career pathway for paediatric HSCT and cellular therapy physicians 

  Gurnari, Carmelo; Spadea, Manuela; Muratori, Rafaella; Jimenez, Valentine; Radici, Vera; Torrado, Sheila; Desai, Nihar; Ropero, Julio; Muhsen, Ibrahim N.; Ibrahimova, Azada; Du Toit, Justin; Hendricks, Candice Laverne; Gagelmann, Nico; Horga, Claire (Elsevier, 2023-07)

  No abstract available.
• Measuring oxytocin release in response to gavage : computational modelling and assay validation 

  Hassan, Shereen; El Baradey, Hala; Madi, Mohamed; Shebl, Mohamed; Leng, Gareth; Lozic, Mala; Ludwig, Mike; Menzies, John; MacGregor, Duncan (Wiley, 2023-06)

  In the present experiments, we tested the conclusion from previous electrophysiological experiments that gavage of sweet food and systemically applied insulin both stimulate oxytocin secretion. To do so, we measured ...
• Randomized, double-blind, placebo-controlled, global phase III trial of talimogene laherparepvec combined with pembrolizumab for advanced melanoma 

  Chesney, Jason A.; Ribas, Antoni; Long, Georgina V.; Kirkwood, John M.; Dummer, Reinhard; Puzanov, Igor; Hoeller, Christoph; Gajewski, Thomas F.; Gutzmer, Ralf; Rutkowski, Piotr; Demidov, Lev; Arenberger, Petr; Shin, Sang Joon; Ferrucci, Pier Francesco; Haydon, Andrew; Hyngstrom, John; Van Thienen, Johannes V.; Haferkamp, Sebastian; Guilera, Josep Malvehy; Rapoport, Bernardo Leon; VanderWalde, Ari; Diede, Scott J.; Anderson, James R.; Treichel, Sheryl; Chan, Edward L.; Bhatta, Sumita; Gansert, Jennifer; Hodi, Frank Stephen; Gogas, Helen (American Society of Clinical Oncology, 2023-01)

  PURPOSE : The combination of talimogene laherparepvec (T-VEC) and pembrolizumab previously demonstrated an acceptable safety profile and an encouraging complete response rate (CRR) in patients with advanced melanoma in ...

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