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Immunology: Recent submissions

  • Randomized, double-blind, placebo-controlled, global phase III trial of talimogene laherparepvec combined with pembrolizumab for advanced melanoma 
    Chesney, Jason A.; Ribas, Antoni; Long, Georgina V.; Kirkwood, John M.; Dummer, Reinhard; Puzanov, Igor; Hoeller, Christoph; Gajewski, Thomas F.; Gutzmer, Ralf; Rutkowski, Piotr; Demidov, Lev; Arenberger, Petr; Shin, Sang Joon; Ferrucci, Pier Francesco; Haydon, Andrew; Hyngstrom, John; Van Thienen, Johannes V.; Haferkamp, Sebastian; Guilera, Josep Malvehy; Rapoport, Bernardo Leon; VanderWalde, Ari; Diede, Scott J.; Anderson, James R.; Treichel, Sheryl; Chan, Edward L.; Bhatta, Sumita; Gansert, Jennifer; Hodi, Frank Stephen; Gogas, Helen (American Society of Clinical Oncology, 2023-01)
    PURPOSE : The combination of talimogene laherparepvec (T-VEC) and pembrolizumab previously demonstrated an acceptable safety profile and an encouraging complete response rate (CRR) in patients with advanced melanoma in ...
  • Image-based multiplex immune profiling of cancer tissues : translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer 
    Jahangir, Chowdhury Arif; Page, David B.; Broeckx, Glenn; Gonzalez, Claudia A.; Burke, Caoimbhe; Murphy, Clodagh; Reis-Filho, Jorge S.; Ly, Amy; Harms, Paul W.; Gupta, Rajarsi R.; Vieth, Michael; Hida, Akira I.; Kahila, Mohamed; Kos, Zuzana; Van Diest, Paul J.; Verbandt, Sara; Thagaard, Jeppe; Khiroya, Reena; Abduljabbar, Khalid; Haab, Gabriela Acosta; Acs, Balazs; Adams, Sylvia; Almeida, Jonas S.; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R.M.; Fujimoto, Luciana Botinelly Mendonca; Burgues, Octavio; Chardas, Alexandros; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A.D.; Coosemans, M.; Corredor, German; Portela, Flavio Luis Dantas; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N.; Elghazawy, Mahmoud; Fernandez-Martin, Claudio; Fineberg, Susan; Fox, Stephen B.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez-Ericsson, Paula, I.; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hart, Steven N.; Hartman, Johan; Hewitt, Stephen; Horlings, Hugo M.; Husain, Zaheed; Irshad, Sheeba; Janssen, Emiel A.M.; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Khramtsov, Andrey I.; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Akturk, Guray; Scott, Ely; Kovacs, Aniko; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Madabhushi, Anant; Maley, Sai K.; Narasimhamurthy, Vidya Manur; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Kharidehal, Durga; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Rimm, David; Vincent-Salomon, Anne; Saltz, Joel; Sayed, Shahin; Hytopoulos, Evangelos; Mahon, Sarah; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; Van der Laak, Jeroen; Verghese, Gregory E.; Viale, Giuseppe; Wahab, Noorul; Coetzee, Bernard Walter Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Bartlett, John; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Stovgaard, Elisabeth Specht; Salgado, Roberto; Gallagher, William M.; Rahman, Arman (Wiley, 2024-03)
    Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and ...
  • Restoring function to inactivating G protein-coupled receptor variants in the hypothalamic–pituitary–gonadal axis1 
    Radomsky, Tarryn; Anderson, Ross Calley; Millar, Robert P.; Newton, Claire L. (Wiley, 2024-09)
    G protein-coupled receptors (GPCRs) are central to the functioning of the hypothalamic–pituitary–gonadal axis (HPG axis) and include the rhodopsin-like GPCR family members, neurokinin 3 receptor, kappa-opioid receptor, ...
  • The haematological profile of a treatment-naïve HIV-positive cohort : a pilot study 
    Mashingaidze, Tsungai Vesta (University of Pretoria, 2024)
    Human immunodeficiency virus (HIV) infection has been observed to significantly impact both the immune system and haematopoiesis. Haematopoiesis is the regulated process of producing the cellular components of blood with ...
  • Haematopoietic stem-cell transplantation in an HIV endemic area : time to consider donors exposed to or living with HIV 
    Hendricks, Candice Laverne; Mellet, Juanita; Durandt, Chrisna; Brittain, David; Pepper, Michael Sean (Elsevier, 2023-11)
    South Africa has more than 8 million people living with HIV. However, the number of patients undergoing haematopoietic stem-cell transplantation (HSCT) in South Africa is far below the target number. Donor numbers are ...
  • Characterisation of umbilical cord blood derived haematopoietic stem and progenitor cells from HIV exposed infants that are HIV negative at birth 
    Hendricks, Candice Laverne (University of Pretoria, 2024-06)
    Umbilical cord blood (UCB) has been used for approximately 30 years as a source of haematopoietic stem and progenitor cells (HSPCs) for haematopoietic stem cell transplantation (HSCT). Advantages include less stringent ...
  • Revealing the indispensable role of the RFamide functionality using a novel acid labile benzofuranone based amine (ALBA) linker 
    Mudd, Gemma; Hendrikse, Megan; Shave, Steven; Houston, Douglas R.; Millar, Robert P.; Auer, Manfred (Wiley, 2024-04)
    The RFamide family of peptides represents an important class of GPCR ligand neuropeptides covering a wide range of biological functions. While many analogues of the highly conserved C-terminal RFamide motif within this ...
  • Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3 
    Rapoport, Bernardo Leon; Steel, Helen C.; Benn, Carol A.; Nayler, Simon; Smit, Teresa; Heyman, Liezl; Theron, Annette J.; Hlatshwayo, Nomsa; Kwofie, Luyanda Laura Illicia; Meyer, P.W.A. (Pieter Willem Adriaan); Anderson, Ronald (Frontiers Media, 2023-03-30)
    Neoadjuvant chemotherapy (NAC) may alter the immune landscape of patients with early breast cancer (BC), potentially setting the scene for more effective implementation of checkpoint-targeted immunotherapy. This issue ...
  • Spatial analyses of immune cell infiltration in cancer : current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer 
    Page, David B.; Broeckx, Glenn; Jahangir, Chowdhury Arif; Verbandt, Sara; Gupta, Rajarsi R.; Thagaard, Jeppe; Khiroya, Reena; Kos, Zuzana; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Almeida, Jonas S.; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R.M.; Botinelly Mendonca Fujimoto, Luciana; Burgues, Octavio; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A.D.; Coosemans, An; Corredor, German; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N.; Elghazawy, Mahmoud; Ely, Scott; Fernandez-Martin, Claudio; Fineberg, Susan; Fox, Stephen B.; Gallagher, William M.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I.; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hardas, Alexandros; Hart, Steven N.; Hartman, Johan; Hewitt, Stephen; Hida, Akira I.; Horlings, Hugo M.; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel A.M.; Kahila, Mohamed; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I.; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Kovacs, Aniko; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K.; Manur Narasimhamurthy, Vidya; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Reis-Filho, Jorge S.; Ribeiro, Joana M.; Rimm, David; Salomon, Anne-Vincent; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; Van Der Laak, Jeroen; Van Diest, Paul J.; Verghese, Gregory E.; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Adams, Sylvia; Bartlett, John Mark Seaverns; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth; Akturk, Guray; Bouchmaa, Najat (Wiley, 2023-08)
    Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized ...
  • Editorial : The immunological role of platelet activation in the pathophysiology of COVID-19 
    Rossouw, Theresa; Pretorius, Etheresia; Wool, Geoffrey D. (Frontiers Media, 2023-09)
    Platelets are increasingly recognized for their role as mediators of immune response and inflammation. As major components of the hematological system, they form an important bridge between immunity and coagulation. When ...
  • A data management plan for the NESHIE observational study 
    Strydom, Adele; Van Rensburg, Jeanne; Pepper, Michael Sean (Frontiers Media, 2023-12-06)
    With regard to the use and transfer of research participants’ personal information, samples and other data nationally and internationally, it is necessary to construct a data management plan. One of the key objectives ...
  • Comparison of platelet-and endothelial-associated biomarkers of disease activity in people hospitalized with Covid-19 with and without HIV co-infection 
    Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa (Frontiers Media, 2023-08-14)
    INTRODUCTION : SARS-CoV-2 elicits a hyper-inflammatory response that contributes to increased morbidity and mortality in patients with COVID-19. In the case of HIV infection, despite effective anti-retroviral therapy, ...
  • Consequences of HIV infection in the bone marrow niche 
    Herd, Candice; Mellet, Juanita; Mashingaidze, Nester; Durandt, Chrisna; Pepper, Michael Sean (Frontiers Media, 2023-07-11)
    Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular ...
  • Despite delayed kinetics, people living with HIV achieve equivalent antibody function after SARS-CoV-2 infection or vaccination 
    Motsoeneng, Boitumelo M.; Manamela, Nelia; Kaldine, Haajira; Kgagudi, Prudence; Hermanus, Tandile; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Van der Mescht, Mieke Adri; Abdullah, Fareed; Boswell, Michael; Ueckermann, Veronica; Rossouw, Theresa; Madhi, Shabir A.; Moore, Penny L.; Richardson, Simone I. (Frontiers Media, 2023-08-03)
    The kinetics of Fc-mediated functions following SARS-CoV-2 infection or vaccination in people living with HIV (PLWH) are not known. We compared SARS-CoV-2 spike-specific Fc functions, binding, and neutralization in ...
  • From Africa with love : a festschrift for Robert P. Millar 
    Ludwig, Mike; Newton, Claire L. (Wiley, 2024-10)
    Robert (Bob) Millar will retire in 2024, after a long and distinguished career in neuroendocrinology. Claire and I have been working with Bob for some years and took on the task of organising a Festschrift to celebrate his ...
  • Comparison of the effects of electronic cigarette vapours and tobacco smoke extracts on human neutrophils in vitro 
    Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory (European Respiratory Society, 2023-05)
    BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than ...
  • Relationships of emerging biomarkers of cancer cachexia with quality of life, appetite, and cachexia 
    Lipshitz, Melanie; Visser, J.; Anderson, Ronald; Nel, D.G.; Smit, T.G. (Theunis); Steel, Helen C.; Rapoport, Bernardo Leon (Springer, 2024-05)
    PURPOSE : Quality of life (QoL), appetite, cachexia, and biomarkers [albumin, hemoglobin (Hb), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), ...
  • Tachykinin receptor-selectivity of the potential glioblastoma-targeted therapy, DOTA-[Thi8,Met(O2)11]-substance P 
    Suthiram, Janine; Pieters, Ane; Moosa, Zulfiah Mohamed; Zeevaart, Jan Rijn; Sathekge, Mike Machaba; Ebenhan, Thomas; Anderson, Ross Calley; Newton, Claire L. (MDPI, 2023-01)
    Please read abstract in article.
  • The global burden of community-acquired pneumonia in adults, encompassing invasive pneumococcal disease and the prevalence of its associated cardiovascular events, with a focus on pneumolysin and macrolide antibiotics in pathogenesis and therapy 
    Anderson, Ronald; Feldman, Charles (MDPI, 2023-07)
    Despite innovative advances in anti-infective therapies and vaccine development technologies, community-acquired pneumonia (CAP) remains the most persistent cause of infection-related mortality globally. Confronting the ...
  • Pro-tumorigenic and thrombotic activities of platelets in lung cancer 
    Anderson, Ronald; Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J. (MDPI, 2023-07)
    Aside from their key protective roles in hemostasis and innate immunity, platelets are now recognized as having multifaceted, adverse roles in the pathogenesis, progression and outcome of many types of human malignancy. ...