Browsing Immunology by Type "Article"

Browsing Immunology by Type "Article"

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  • 2023 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting 
    Herrstedt, J.; Clark-Snow, R.; Ruhlmann, C.H.; Molassiotis, A.; Olver, I.; Rapoport, Bernardo Leon; Aapro, M.; Dennis, K.; Hesketh, P.J.; Navari, R.M.; Schwartzberg, L.; Affronti, M.L.; Garcia-Del-Barrio, M.A.; Chan, A.; Celio, L.; Chow, R.; Fleury, M.; Gralla, R.J.; Giusti, R.; Jahn, F.; Iihara, H.; Maranzano, E.; Radhakrishnan, Venkatraman; Saito, Mitsue; Sayegh, Paula; Bosnjak, S.; Zhang, L.; Lee, J.; Ostwal, V.; Smit, T.; Zilic, A.; Jordan, Karin; Scotté, F. (Elsevier, 2024-02)
    Nausea and vomiting are still considered to be two of the most troublesome adverse events (AEs) for patients treated with antineoplastic therapy. To optimise the utility of available antiemetic prophylaxis, updated reviews ...
  • 2023 updated MASCC/ESMO consensus recommendations : prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting 
    Rapoport, Bernardo Leon; Herrstedt, Jorn; Snow, Rebecca Clark; Radhakrishnan, Venkatraman; Saito, Mitsue; Navari, Rudolph M.; Smit, Teresa (Springer, 2024-01)
    PURPOSE : This review is an update of the MASCC/ESMO 2015 recommendations for the prophylaxis of acute and delayed nausea and vomiting induced by multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea ...
  • Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa 
    Van der Mescht, Mieke Adri; De Beer, Zelda; Steel, Helen C.; Anderson, Ronald; Masenge, Andries; Moore, Penny L.; Bastard, Paul; Casanova, Jean-Laurent; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2024-09)
    The African continent reported the least number of COVID-19 cases and deaths of all the continents, although the exact reasons for this are still unclear. In addition, little is known about the immunological profiles ...
  • Absence of Helicobacter pylori within the oral cavities of members of a healthy South African community 
    Olivier, Brenda J.; Bond, Robert P.; Van Zyl, Walda B.; Delport, Maraliese; Slavik, Tomas; Ziady, Christopher; Terhaar sive Droste, Jochim S.; Lastovica, Albert; Van der Merwe, Schalk Willem (American Society for Microbiology, 2006-02)
    Our study aimed to evaluate the oral cavity as a reservoir from where Helicobacter pylori may be transmitted. Histology and PCR amplification were performed. Eighty-four percent of the stomach biopsies tested positive; ...
  • Acceptability of home-based HIV care offered by community health workers in Tshwane District, South Africa : a survey 
    Ngcobo, Sanele; Rossouw, Theresa M. (Mary Ann Liebert, 2022-02)
    Human immunodeficiency virus (HIV) remains the biggest public health challenge faced by South Africa (SA). To alleviate overcrowding in health facilities, ward-based primary health care outreach teams, consisting of community ...
  • Access to novel therapies for COVID-19 – distributive justice and Russian roulette? 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2020-12)
    In an ideal world, universal access to healthcare should be achievable; all COVID-19 patients should have access to therapies that improve outcomes. These include existing, repurposed and novel therapies. Novel therapies ...
  • Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 
    Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)
    The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
  • Adipogenesis : a complex interplay of multiple molecular determinants and pathways 
    Ambele, Melvin Anyasi; Dhanraj, Priyanka; Giles, Rachel; Pepper, Michael Sean (MDPI Publishing, 2020-06-16)
    The formation of adipocytes during embryogenesis has been largely understudied. However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem cells which migrate from the mesoderm to their anatomical ...
  • ADP-mediated upregulation of expression of CD62P on human platelets is critically dependent on co-activation of P2Y1 and P2Y12 receptors 
    Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)
    This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
  • The African genomic medicine training initiative (AGMT) : showcasing a community and framework driven genomic medicine training for nurses in Africa 
    Nembaware, Victoria; African Genomic Medicine Training Initiative; Mulder, Nicola (Frontiers Media, 2019-12-20)
    The potential of genomic medicine in improving the quality of healthcare both at population and individual-level is well-recognized globally. However, successful adoption of genetic and genomic evidence into clinical ...
  • Age of the association between Helicobacter pylori and man 
    Moodley, Yoshan; Linz, Bodo; Bond, Robert P.; Nieuwoudt, Martin J.; Soodyall, Himla; Schlebusch, Carina M.; Bernhoft, Steffi; Hale, James; Suerbaum, Sebastian; Mugisha, Lawrence; Van der Merwe, Schalk Willem; Achtman, Mark (Public Library of Science, 2021-05-10)
    When modern humans left Africa ca. 60,000 years ago (60 kya), they were already infected with Helicobacter pylori, and these bacteria have subsequently diversified in parallel with their human hosts. But how long were ...
  • Age of the association between Helicobacter pylori and man 
    Moodley, Yoshan; Linz, Bodo; Bond, Robert P.; Nieuwoudt, Martin J.; Soodyall, Himla; Schlebusch, Carina M.; Bernhoft, Steffi; Hale, James; Suerbaum, Sebastian; Mugisha, Lawrence; Van der Merwe, Schalk Willem; Achtman, Mark; Ochman, Howard (Public Library of Science, 2012-05-10)
    When modern humans left Africa ca. 60,000 years ago (60 kya), they were already infected with Helicobacter pylori, and these bacteria have subsequently diversified in parallel with their human hosts. But how long were ...
  • Allergic rhinitis : review of the diagnosis and management : South African Allergic Rhinitis Working Group 
    Richards, Guy A.; Gray, Claudia L.; De Waal, Pieter; Friedman, Ray; Hockman, Maurice; Karabus, Sarah J.; Lodder, Cornelia M.; Mabelane, Tshegofatso; Mosito, Sylvia M.; Nanan, Ashen; Peter, Jonny G.; Quitter, Traugott H.C.; Van den Berg, Sylvia; Van Niekerk, Andre; Vardas, Eftyhia; Feldman, Charles (AOSIS, 2023-10-30)
    BACKGROUND : Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of ...
  • Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 are possible common genetic Alterations in oral cancer patients 
    Ambele, Melvin Anyasi; Van Zyl, Andre; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Frontiers Media, 2020-04-30)
    The lack of clinical biomarkers for head and neck cancer subtypes limits early diagnosis and monitoring of disease progression. This study investigates genetic alterations in clinically identical tumor, tumor-adjacent ...
  • Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant 
    Richardson, Simone I.; Kgagudi, Prudence; Manamela, Nelia P.; Kaldine, Haajira; Venter, Elizabeth M.; Pillay, Thanusha; Lambson, Bronwen E.; Van der Mescht, Mieke Adri; Hermanus, Tandile; Balla, Sashkia R.; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Du Pisanie, Marizane; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Abdullah, Fareed; Ueckermann, Veronica; Rossouw, Theresa; Boswell, Michael T.; Moore, Penny L. (Cell Press, 2023-01)
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4 and BA.5 variants caused major waves of infections. Here, we assess the sensitivity of BA.4 to binding, neutralization, and antibodydependent cellular ...
  • Application of the AMLprofiler diagnostic microarray in the South African setting 
    Kappala, S.S.; Alessandrini, Marco; Matlhako, T.; Beltchev, E.; Pool, Roger; Pepper, Michael Sean (Hindawi Publishing Corporation, 2017-11-07)
    Acute myeloid leukemia (AML) is characterized by proliferation of the myeloid lineage and accumulation of immature hematopoietic cells in the bone marrow and is typified by marked heterogeneity both in response to treatment ...
  • The application of the Consumer Protection Act in the South African health care context : concerns and recommendations 
    Nothling-Slabbert, Melodie; Maister, B.; Botes, M.; Pepper, Michael Sean (Institute for Foreign and Comparative Law, UNISA, 2011)
    The article examines the application of the Consumer Protection Act 68 of 2008 in the health care context. Issues specifically considered are the introduction of no-fault liability and how this new development impacts on ...
  • ARV options in drug resistance 
    Rossouw, Theresa M. (New Media Publishing JHB, 2015-05)
    Antiretroviral treatment (ART) has dramatically changed the course of (HIV) infection, allowing for control of the virus in the peripheral circulation, signifi cant reconstitution of the immune system and achievement of ...
  • ARV options in drug resistance 
    Rossouw, Theresa M. (New Media Publishing, 2016-01)
    Antiretroviral treatment (ART) has dramatically changed the course of (HIV) infection, allowing for control of the virus in the peripheral circulation, significant reconstitution of the immune system and achievement of ...
  • ASSAf consensus study on the ethical, legal and social implications of genetics and genomics in South Africa 
    Pepper, Michael Sean; Dandara, Collet; De Vries, Jantina; Dhai, Amaboo; Labuschaigne, Melodie; Mnyongani, Freddy; Moodley, Keymanthri; Olckers, Antonel; Pope, Anne; Ramesar, Raj; Ramsay, Michele; Soodyall, Himla; Towers, Wayne (Academy of Science of South Africa, 2018-11-27)
    South Africa is home to one of the most genetically diverse populations in the world, which, combined with its high disease burden and high-quality infrastructure, makes our country a prime location for conducting genetics ...