• T-cell phenotypes and systemic cytokine profiles of people living with HIV admitted to hospital with COVID-19 

  Van der Mescht, Mieke Adri; Steel, Helen C.; De Beer, Zelda; Masenge, Andries; Abdullah, Fareed; Ueckermann, Veronica; Anderson, Ronald; Rossouw, Theresa M. (MDPI, 2024-11)

  Whether SARS-CoV-2 infection leads to a higher mortality and morbidity in people living with HIV (PLWH) in Africa remains inconclusive. In this study, we explored the differences in the T-cell phenotypes between people ...
• A proof-of-concept study to investigate the radiolabelling of human mesenchymal and hematopoietic stem cells with [89Zr]Zr-Df-Bz-NCS 

  Kahts, Maryke; Mellet, Juanita; Durandt, Chrisna; Moodley, Kinosha; Summers, Beverley; Ebenhan, Thomas; Zeevaart, Jan Rijn; Aras, Omer; Pepper, Michael Sean (SpringerOpen, 2024-11)

  Please read abstract in article.
• Advances in nano-delivery of phytochemicals for glioblastoma treatment 

  Ambele, Melvin Anyasi; Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Kungoane, Tsholofelo; Damane, Botle Precious (SpringerOpen, 2024-12)

  Glioblastoma (GBM) is an aggressive brain tumor characterized by cellular and molecular diversity. This diversity presents significant challenges for treatment and leads to poor prognosis. Surgery remains the primary ...
• Phenotypic characterisation of bone marrow-derived haematopoietic stem/progenitor cells from HIV-infected individuals 

  Mistry, Priyal; Potgieter, Joachim; Pepper, Michael Sean; Durandt, Chrisna (Springer, 2025)

  Human immunodeficiency virus (HIV-1) infection remains a significant global public health concern, particularly in sub-Saharan Africa where the majority of HIV-1 infections are concentrated. People living with HIV (PLWH) ...
• New drinking water genome catalog identifies a globally distributed bacterial genus adapted to disinfected drinking water systems 

  Sudarshan, Ashwin S.; Dai, Zihan; Gabrielli, Marco; Oosthuizen-Vosloo, Solize; Konstantinidis, Konstantinos T.; Pinto, Ameet J. (American Chemical Society, 2024-09)

  Genome-resolved insights into the structure and function of the drinking water microbiome can advance the effective management of drinking water quality. To enable this, we constructed and curated thousands of ...
• Editorial : Mesenchymal and induced-pluripotent stem cells as models to study biological processes 

  Ambele, Melvin Anyasi; Miranda, Catarina O. (Frontiers Media, 2024-07)

  No abstract available.
• Neonatal encephalopathy due to suspected hypoxic ischemic encephalopathy : pathophysiology, current, and emerging treatments 

  Babbo, Carina Corte-Real; Mellet, Juanita; Van Rensburg, Jeanette; Pillay, Shakti; Horn, Alan Richard; Nakwa, Firdose Lambey; Velaphi, Sithembiso Christopher; Kali, Gugulabatembunamahlubi Tenjiwe Jabulile; Coetzee, Melantha; Masemola, Mogomane Yvonne Khomotso; Ballot, Daynia Elizabeth; Pepper, Michael Sean (Springer, 2024-11)

  BACKGROUND : Neonatal encephalopathy (NE) due to suspected hypoxic-ischemic encephalopathy (HIE), referred to as NESHIE, is a clinical diagnosis in late preterm and term newborns. It occurs as a result of impaired ...
• Probing the effects of retinoblastoma binding protein 6 (RBBP6) knockdown on the sensitivity of cisplatin in cervical cancer cells 

  Mehta, Harshini; Ambele, Melvin Anyasi; Mokgautsi, Ntlotlang; Moela, Pontsho (MDPI, 2024-04-02)

  Cervical cancer is a major cause of death in women despite the advancement of current treatment modalities. The conventional therapeutic agent, cisplatin (CCDP), is the standard treatment for CC; however, resistance often ...
• Prescribing probiotic drugs in clinical practice - are they indicated? 

  Van Niekerk, Andre; Delport, Suzanne D. (Allergy Society of South Africa, 2024-06-01)

  The past two decades will be remembered for the rapid advances in our understanding of the significant role that the human microbiome plays in health, illness and longevity, but it remains a vast concept, one that is ...
• Sulfamoylated estradiol analogs targeting the actin and microtubule cytoskeletons demonstrate anti-cancer properties in vitro and in ovo 

  Mercier, Anne Elisabeth; Joubert, Anna Margaretha; Viallet, Jean; Desroches-Castan, Agnes; De Koning, Leanne; Mabeta, Peaceful Lucy; Helena, Jolene Michelle; Pepper, Michael Sean; Lafanechere, Laurence (MDPI, 2024-10)

  The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We therefore designed two 2-ME analogs ...
• Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells 

  Mellet, Juanita; Hendricks, Candice Laverne; Stivaktas, Voula; Durandt, Chrisna; Ambele, Melvin Anyasi; Pepper, Michael Sean (BMC, 2024-09)

  BACKGROUND : Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical cord blood (UCB) as a source of stem cells for ...
• Human cloning as reproductive means in future : a qualitative thematic study of underpinning values 

  Castelyn, Camille De Villebois; Van Staden, Werdie; Pepper, Michael Sean (Frontiers Media, 2024-02)

  BACKGROUND AND OBJECTIVE: The possibility of using human cloning to reproduce has been met with unease, shock, and prohibition in many countries, as well as the International Committee for Monitoring Assisted ...
• Leadership in healthcare during a pandemic : for a systems leadership approach 

  Castelyn, Camille De Villebois (Frontiers Media, 2024-05)

  No abstract available.
• The curious case of the hypothalamic-pituitary-gonadal axis dysfunction in subordinate female naked mole-rats (Heterocephalus glaber) : no apparent role of opioids and glucocorticoids 

  Hart, Daniel William; Roberts, Elise; O'Riain, M. Justin; Millar, Robert P.; Bennett, Nigel C. (Wiley, 2024-10)

  The naked mole-rat (Heterocephalus glaber) is a unique model mammal in which to study socially induced inhibition of the hypothalamic–pituitary–gonadal (HPG) axis. Naked mole-rat groups exhibit a high degree of reproductive ...
• Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer : a report of the international immuno-oncology biomarker working group on breast cancer 

  Thagaard, Jeppe; Broeckx, Glenn; Page, David B.; Jahangir, Chowdhury Arif; Verbandt, Sara; Kos, Zuzana; Gupta, Rajarsi R.; Khiroya, Reena; Abduljabbar, Khalid; Haab, Gabriela Acosta; Acs, Balazs; Akturk, Guray; Almeida, Jonas S.; Alvarado‐Cabrero, Isabel; Amgad, Mohamed; Azmoudeh‐Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Balslev, Eva; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R.M.; Botinelly Mendonça Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Chardas, Alexandros; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A.D.; Coosemans, M.; Corredor, German; Dahl, Anders B.; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Hansen, Johan Dore; Dudgeon, Sarah N.; Ebstrup, Thomas; Elghazawy, Mahmoud; Fernandez‐Martín, Claudio; Fox, Stephen B.; Gallagher, William M.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez‐Ericsson, Paula I.; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hart, Steven N.; Hartman, Johan; Hauberg, Søren; Hewitt, Stephen; Hida, Akira I.; Horlings, Hugo M.; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel A.M.; Kahila, Mohamed; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I.; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Kovacs, Aniko; Laenkholm, Anne‐Vibeke; Lang‐Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K.; Manur Narasimhamurthy, Vidya; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault‐Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto‐Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Reis‐Filho, Jorge S.; Ribeiro, Joana M.; Rimm, David; Roslind, Anne; Vincent-Salomon, Anne; Salto‐Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Scott, Ely; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Fineberg, Susan; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; Van der Laak, Jeroen; Van Diest, Paul J.; Verghese, Gregory E.; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Md Zin, Reena; Adams, Sylvia; Bartlett, John; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Stovgaard, Elisabeth Specht (Wiley, 2023-08-23)

  The clinical significance of the tumor-immune interaction in breast cancer is now established, and tumor-infiltrating lymphocytes (TILs) have emerged as predictive and prognostic biomarkers for patients with triple-negative ...
• UNITY : a low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings 

  Abate, F.; Adu-Amankwah, A.; Ae-Ngibise, K.A.; Agbokey, F.; Agyemang, V.A.; Agyemang, C.T.; Akgun, C.; Ametepe, J.; Arichi, T.; Asante, K.P.; Balaji, S.; Baljer, L.; Basser, P.J.; Beauchemin, J.; Bennallick, C.; Berhane, Y.; Boateng-Mensah, Y.; Bourke, N.J.; Bradford, L.; Bruchhage, M.M.K.; Cano Lorente, R.; Cawley, P.; Cercignani, M.; D Sa, V.; De Canha, A.; Navarro, N.D.; Dean, D.C., III; Delarosa, J.; Donald, K.A.; Dvorak, A.; Edwards, A.D.; Field, D.; Frail, H.; Freeman, B.; George, T.; Gholam, J.; Guerrero-Gonzalez, J.; Hajnal, J.V.; Haque, R.; Hollander, W.; Hoodbhoy, Z.; Huentelman, M.; Jafri, S.K.; Jones, D.K.; Joubert, Fourie; Karaulanov, T.; Kasaro, M.P.; Knackstedt, S.; Kolind, S.; Koshy, B.; Kravitz, R.; Lafayette, S.L.; Lee, A.C.; Lena, B.; Lepore, N.; Linguraru, M.; Ljungberg, E.; Lockhat, Zarina I.; Loth, E.; Mannam, P.; Masemola, K.M.; Moran, R.; Murphy, D.; Nakwa, F.L.; Nankabirwa, V.; Nelson, C.A.; North, K.; Nyame, S.; O Halloran, R.; O'Muircheartaigh, J.; Oakley, B.F.; Odendaal, H.; Ongeti, C.M.; Onyango, D.; Oppong, S.A.; Padormo, F.; Parvez, D.; Paus, T.; Pepper, Michael Sean; Phiri, K.S.; Poorman, M.; Ringshaw, J.E.; Rogers, J.; Rutherford, M.; Sabir, H.; Sacolick, L.; Seal, M.; Sekoli, M.L.; Shama, T.; Siddiqui, K.; Sindano, N.; Spelke, M.B.; Springer, P.E.; Suleman, Farhana Ebrahim; Sundgren, P.C.; Teixeira, R.; Terekegn, W.; Traughber, M.; Tuuli, M.G.; Van Rensburg, Jeanne; Váša, F.; Velaphi, S.; Velasco, P.; Viljoen, I.M.; Vokhiwa, M.; Webb, A.; Weiant, C.; Wiley, N.; Wintermark, P.; Yibetal, K.; Deoni, S.C.L.; Williams, S.C.R. (Elsevier, 2024-10)

  Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact ...
• Glycemic control and cardiometabolic risk in black Zimbabweans with Type 2 diabetes mellitus 

  Chiveto, Dexter Tadiwanashe; Musarurwa, Cuthbert; Mapira, Herbert T.; Kaseke, Farayi; Nyengerai, Tawanda; Kaseke, Timothy; Gori, Elizabeth (Dove Medical Press, 2024-08)

  PURPOSE : Type 2 diabetes mellitus (T2DM) frequently presents with modified cardiometabolic risk profiles, indicative of an elevated susceptibility to cardiovascular disease (CVD). Cardiometabolic risk factors such as ...
• Dataset of cell viability and analytes released by cancer cell lines exposed to low pH and conditioned medium 

  Worsley, Catherine M.; Veale, Rob B.; Mayne, Elizabeth S. (Elsevier, 2024-06)

  Cancer cells influence their microenvironment by secreting factors that promote tumour growth and survival while evading immune-mediated destruction. We previously determined the expression of secreted factors in breast ...
• Effect of 2-methoxyestradiol on mammary tumor initiation and progression 

  Peta, Kimberly; Durandt, Chrisna; Van Heerden, Marlene B.; Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2024-04)

  BACKGROUND : The anti-cancer agent 2-methoxyestradiol (2-ME) has been shown to have anti-proliferative and anti-angiogenic properties. Previously, the effect of 2-ME on early- and late-stage breast cancer (BC) was ...
• Th1 and Th2 epitopes of Cowdria polymorphic gene 1 of Ehrlichia ruminantium 

  Ngoepe, Tlou A.; Pretorius, Alri; Steyn, Helena C.; Van Kleef, Mirinda (AOSIS, 2023-03-23)

  Cowdria polymorphic gene 1 (cpg1, Erum2510, ERUM_RS01380) has been shown to induce 30% and 100% protection in sheep immunised by deoxyribonucleic acid (DNA) prime combined with DNA boost and DNA prime combined with protein ...

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