• Unveiling the link : the potential roles of vitamin D in keloid pathophysiology 

  Kotze, Jaco; Nortje, Evangeline; Phulukdaree, Alisa; Fear, Mark William; Wood, Fiona; Bester, Janette (Wiley, 2025-02)

  Keloid disease, a fibroproliferative skin disorder, is characterised by scar tissue growth that extends beyond the original wound boundaries. Despite advancements, current treatments, particularly surgical excision, often ...
• Development of water-soluble nanoformulations of novel pyrazolone derivatives and the evaluation of their antibacterial and antioxidant activities 

  Igbokwe, Nkeiruka N.; Ismail, Eman A.; Obakachi, Vincent A.; Ntsethe, Aviwe; Gamede, Mlindeli; Karpoormath, Rajshekhar; Faya, Mbuso A. (Springer, 2025-02)

  Poor aqueous solubility and stability hinder the clinical translation of pyrazolone-based derivatives despite their various biological activities. This study aimed to address these issues by developing water-soluble ...
• Health status of senior netball players, their medication use and attitudes towards doping 

  De Abreu, Micaela; Nolte, Kim; Janse van Rensburg, Dina Christina; Swart, Xan (Frontiers Media, 2024-09)

  Limited research exists on the health and injuries of South African senior netball players. Senior netball players may be at greater risk of injuries and chronic disease due to their age. To treat these conditions, they ...
• A highly sensitive RP HPLC-PDA analytical method for detection and quantification of a newly synthesized (E-2-((E)-4-(5-ethoxy-3-methyl-1-phenyl-1H-pyrazole-4-yl)but-3-en-2-ylidene)) hydrazine-1-carbothioamide in nanosuspension 

  Igbokwe, Nkeiruka N.; Ismail, Eman A.; Obakachi, Vincent A.; Gamede, Mlindeli; Karpoormath, Rajshekhar; Faya, Mbuso (Wiley, 2025-01)

  Analytical methods development and validation are vital for the precise detection, quantification, and characterization of novel therapeutic compounds, especially those with poor aqueous solubility, such as pyrazolone ...
• Protective effect of β-sitosterol against high-fructose diet-induced oxidative stress, and hepatorenal derangements in growing female Sprague-Dawley rats 

  Gumede, Nontobeko Myllet; Lembede, Busisani W.; Nkomozepi, Pilani; Brooksbank, Richard L.; Erlwanger, Kennedy H.; Chivandi, Eliton (BioMed Central, 2024-08-26)

  BACKGROUND Chronic consumption of a high-fructose diet causes oxidative stress that compromises kidney and liver health. β-sitosterol (Bst), a phytosterol, is a functional nutrient with health benefits. β-sitosterol ...
• The malaria burden : a South African perspective 

  Balmith, Marissa; Basson, Charlize; Brand, Sarel Jacobus (Wiley, 2024-02-23)

  Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization ...
• Mapping evidence on the regulations affecting accessibility, availability and management of snake antivenom globally : a scoping review protocol 

  Majeed, Ramsha; Bester, Janette; Kgarosi, Kabelo; Strydom, Morné (BMJ Publishing Group, 2024-12)

  INTRODUCTION: Snakebite envenomation has been declared a neglected tropical disease by the WHO since 2017. The disease is endemic in affected areas due to the lack of availability and access to antivenom, despite it being ...
• Prevalence of metabolic dysfunction-associated steatotic liver disease in people living with HIV and on antiretroviral treatment : a systematic review and meta-analysis protocol 

  Sedibe, Amogelang; Maswanganyi, Khanyisa; Mzimela, Nomusa C.; Gamede, Mlindeli (Wiley, 2024-11)

  INTRODUCTION: Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become the most common hepatic condition globally. The prevalence of MASLD continues to increase, paralleling the consistent rising rates ...
• Angiogenesis and pancreatic cancer : novel approaches to overcome treatment resistance 

  Grobbelaar, C.W. (Craig); Kgomo, Mpho K.; Mabeta, Peaceful Lucy (Bentham Science Publishers, 2024-01)

  Pancreatic cancer (PCa) is acknowledged as a significant contributor to global cancer- related mortality and is widely recognized as one of the most challenging malignant diseases to treat. Pancreatic ductal adenocarcinoma ...
• The role of neutrophil extracellular trap formation in kidney transplantation : implications from donors to the recipient 

  Van Zyl, Maryna; Cramer, Elodie; Sanders, Jan-Stephan F.; Leuvenink, Henri G.D.; Lisman, Ton; Van Rooy, Mia-Jeanne; Hillebrands, Jan-Luuk (Elsevier, 2024-09)

  Kidney transplantation remains the gold standard for patients with end-stage renal disease, but severe donor organ shortage has led to long waiting lists. The utilization of expanded criteria donor kidneys within the ...
• Sulfamoylated estradiol analogs targeting the actin and microtubule cytoskeletons demonstrate anti-cancer properties in vitro and in ovo 

  Mercier, Anne Elisabeth; Joubert, Anna Margaretha; Viallet, Jean; Desroches-Castan, Agnes; De Koning, Leanne; Mabeta, Peaceful Lucy; Helena, Jolene Michelle; Pepper, Michael Sean; Lafanechere, Laurence (MDPI, 2024-10)

  The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We therefore designed two 2-ME analogs ...
• A unifying hypothesis for the genome dynamics proposed to underlie neuropsychiatric phenotypes 

  Gericke, George S. (MDPI, 2024-04)

  The sheer number of gene variants and the extent of the observed clinical and molecular heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified downstream effects initiated by a smaller ...
• The association between menstrual cycle phase, menstrual irregularities, contraceptive use and musculoskeletal injury among female athletes : a scoping review 

  MacMillan, Candice; Olivier, Benita; Viljoen, Carel Thomas; Janse van Rensburg, Dina Christina; Sewry, Nicola Ann (Springer, 2024-10)

  BACKGROUND : The influence of menstrual cycle phases (MCPs), menstrual irregularities (MI) and hormonal contraceptive (HC) use on injury among female athletes has been scrutinised. Existing systematic reviews investigating ...
• Editorial : Athlete vulnerabilities and doping 

  Nolte, Kim; Schneider, Angela Jo-Anne (Frontiers Media, 2024-02)

  No abstract available.
• In vitro effects of L-kynurenine and quinolinic acid on adhesion, migration and apoptosis in B16 F10 melanoma cells 

  Basson, Charlise; Serem, June Cheptoo; Bipath, Priyesh; Hlophe, Y. (Elsevier, 2024-12)

  INTRODUCTION : The inhibition of melanoma adhesion through adhesion molecules, such as integrins and E-cadherin, may represent a promising strategy for managing melanoma metastasis. Compounds, namely l-kynurenine (L-kyn) ...
• Thymoquinone : a comprehensive review of its potential role as a monotherapy for metabolic syndrome 

  Ibrahim, Kasimu Ghandi; Hudu, Shuaibu Abdullahi; Jega, Amina Yusuf; Taha, Ahmad; Yusuf, Abdurrahman Pharmacy; Usman, Dawoud; Adeshina, Kehinde Ahmad; Umar, Zayyanu Usman; Nyakudya, Trevor Tapiwa; Erlwanger, Kennedy Honey (Mashhad University of Medical Sciences, 2024-10)

  Metabolic syndrome (MetS) is a widespread global epidemic that affects individuals across all age groups and presents a significant public health challenge. Comprising various cardio-metabolic risk factors, MetS contributes ...
• Poor health behaviour in medical students at a South African university: a cross-sectional survey study 

  Celie, Bert; Laubscher, Ria; Bac, Martin; Schwellnus, Marianne; Nolte, Kim; Wood, Paola Silvia; Camacho, Tanya Chantelle de Sousa; Basu, Debashis; Borresen, Jill (MDPI, 2024-07)

  BACKGROUND : Personal health behaviours and lifestyle habits of health professionals influence their counselling practices related to non-communicable diseases (NCDs). There are limited data on the prevalence of unhealthy ...
• An evaluation of knowledge and perception of pharmacology in undergraduate oral hygiene students and recent graduates at a single higher institution in Pretoria 

  Balmith, Marissa; Cordier, Werner; Bhayat, Ahmed; Basson, Charlize; Morule, Mpho; Schellack, Natalie (Wiley, 2024-11)

  INTRODUCTION : Pharmacology is an increasingly important area of study for oral hygienists, as it provides the scientific basis for safe and effective oral healthcare. However, a lack of fundamental understanding of the ...
• Evolution of drug development and regulatory affairs: the demonstrated power of artificial intelligence 

  Nene, Linda; Flepisi, Brian Thabile; Brand, Sarel Jacobus; Basson, Charlize; Balmith, Marissa (Elsevier, 2024-08)

  PURPOSE : Artificial intelligence (AI) refers to technology capable of mimicking human cognitive functions and has important applications across all sectors and industries, including drug development. This has considerable ...
• L-kynurenine and quinolinic acid inhibited markers of cell survival in B16 F10 melanoma cells in vitro 

  Basson, Charlise; Serem, June Cheptoo; Bipath, Priyesh; Hlophe, Yvette Nkondo (Wiley, 2024-07)

  Melanoma is an aggressive malignancy and remains a major cause of skin cancer mortality, highlighting the need for new treatment strategies. Recent findings revealed that L-kynurenine and quinolinic acid induce cytotoxicity ...

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