Matsoukas, Minos-Timotheos; Radomsky, Tarryn; Panagiotopoulos, Vasilis; Du Preez, Robin; Papadourakis, Michail; Tsianakas, Konstantinos; Millar, Robert P.; Anderson, Ross Calley; Spyroulias, Georgios A.; Newton, Claire L.(American Chemical Society, 2024-08-29)
The growth hormone-releasing hormone receptor (GHRHR) belongs to Class B1 of G protein-coupled receptors
(GPCRs). Class B1 GPCR peptides such, as growth hormone-releasing hormone (GHRH), have been proposed to bind in a ...
Otto, Monique(American Academy of Sleep Medicine, 2024-05)
Despite ongoing research, the association of in-hospital medical
emergency team activation (META) among patients with
atrial fibrillation (AF) who are at risk for obstructive sleep
apnea (OSA) is unclear. Using sleep ...
Otto, Monique(American Academy of Sleep Medicine, 2024-11)
It has been established that exercise is an essential component
of obstructive sleep apnea (OSA) treatment. However, despite
ongoing research and important findings reported in the last
decade,1–17 the effects of exercise ...
CONTEXT : SARS-CoV-2 infection can affect the exercise
response in athletes. Factors associated with the exercise
response have not been reported.
OBJECTIVE : To (1) describe heart rate (HR), systolic blood
pressure ...
De Vos, Brunhildé; Kasonga, Abe E.; Joubert, Anna Margaretha; Nyakudya, Trevor Tapiwa(MDPI, 2024-12)
Objective: Ensuring adequate bone health is crucial for preventing conditions such as
osteoporosis and fractures. Zingerone, a phytonutrient isolated from cooked ginger, has gained
attention for its potential benefits ...
BACKGROUND : Glioblastoma (GBM) is an aggressive therapy-resistant brain tumour that may impacts the integrity of the blood–brain barrier (BBB). The BBB is a protective barrier of the central nervous system formed mainly ...
Duraj, Tomás; Kalamian, Miriam; Zuccoli, Giulio; Maroon, Joseph C.; D’Agostino, Dominic P.; Scheck, Adrienne C.; Poff, Angela; Winter, Sebastian F.; Hu, Jethro; Klement, Rainer J.; Hickson, Alicia; Lee, Derek C.; Cooper, Isabella; Kofler, Barbara; Schwartz, Kenneth A.; Phillips, Matthew C.L.; Champ, Colin E.; Zupec-Kania, Beth; Tan-Shalaby, Jocelyn; Serfaty, Fabiano M.; Omene, Egiroh; Arismendi-Morillo, Gabriel; Kiebish, Michael; Cheng, Richard; El-Sakka, Ahmed M.; Pflueger, Axel; Mathews, Edward H. (Eddie); Worden, Donese; Shi, Hanping; Cincione, Raffaele I.; Spinosa, Jean P.; Slocum, Abdul K.; Iyikesici, Mehmet S.; Yanagisawa, Atsuo; Pilkington, Geoffrey J.; Chaffee, Anthony; Abdel-Hadi, Wafaa; Elsamman, Amr K.; Klein, Pavel; Hagihara, Keisuke; Clemens, Zsófia; Yu, George W.; Evangeliou, Athanasios E.; Nathan, Janak K.; Smith, Kris; Fortin, David; Dietrich, Jorg; Mukherjee, Purna; Seyfried, Thomas N.(BioMed Central, 2024-12)
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic ...
Cronje, Rouxzan; Beukes, Johanni; Masenge, Andries; Du Toit, P.J.; Bipath, Priyesh(International Society for Neurofeedback & Research, 2024-03-29)
The aim of this study was to investigate whether the inflammatory marker neopterin and certain neurophysiological measurements could be used as complementary markers for stress and anxiety symptoms as determined by the ...
Keloid disease, a fibroproliferative skin disorder, is characterised by scar tissue growth that extends beyond the original wound boundaries. Despite advancements, current treatments, particularly surgical excision, often ...
Igbokwe, Nkeiruka N.; Ismail, Eman A.; Obakachi, Vincent A.; Ntsethe, Aviwe; Gamede, Mlindeli; Karpoormath, Rajshekhar; Faya, Mbuso A.(Springer, 2025-02)
Poor aqueous solubility and stability hinder the clinical translation of pyrazolone-based derivatives despite their various biological activities. This study aimed to address these issues by developing water-soluble ...
De Abreu, Micaela; Nolte, Kim; Janse van Rensburg, Dina Christina; Swart, Xan(Frontiers Media, 2024-09)
Limited research exists on the health and injuries of South African senior netball
players. Senior netball players may be at greater risk of injuries and chronic
disease due to their age. To treat these conditions, they ...
Igbokwe, Nkeiruka N.; Ismail, Eman A.; Obakachi, Vincent A.; Gamede, Mlindeli; Karpoormath, Rajshekhar; Faya, Mbuso(Wiley, 2025-01)
Analytical methods development and validation are vital for the precise detection, quantification, and characterization of novel therapeutic compounds, especially those with poor aqueous solubility, such as pyrazolone ...
BACKGROUND Chronic consumption of a high-fructose diet causes oxidative stress that compromises kidney and
liver health. β-sitosterol (Bst), a phytosterol, is a functional nutrient with health benefits. β-sitosterol ...
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization ...
INTRODUCTION: Snakebite envenomation has been declared a neglected tropical disease by the WHO since 2017. The disease is endemic in affected areas due to the lack of availability and access to antivenom, despite it being ...
INTRODUCTION: Metabolic dysfunction‐associated steatotic liver disease (MASLD) has
become the most common hepatic condition globally. The prevalence of MASLD
continues to increase, paralleling the consistent rising rates ...
Pancreatic cancer (PCa) is acknowledged as a significant contributor to global cancer- related mortality and is widely recognized as one of the most challenging malignant diseases to treat. Pancreatic ductal adenocarcinoma ...
Van Zyl, Maryna; Cramer, Elodie; Sanders, Jan-Stephan F.; Leuvenink, Henri G.D.; Lisman, Ton; Van Rooy, Mia-Jeanne; Hillebrands, Jan-Luuk(Elsevier, 2024-09)
Kidney transplantation remains the gold standard for patients with end-stage renal disease,
but severe donor organ shortage has led to long waiting lists. The utilization of expanded
criteria donor kidneys within the ...
Mercier, Anne Elisabeth; Joubert, Anna Margaretha; Viallet, Jean; Desroches-Castan, Agnes; De Koning, Leanne; Mabeta, Peaceful Lucy; Helena, Jolene Michelle; Pepper, Michael Sean; Lafanechere, Laurence(MDPI, 2024-10)
The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and
anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We
therefore designed two 2-ME analogs ...
The sheer number of gene variants and the extent of the observed clinical and molecular heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified downstream
effects initiated by a smaller ...