• The role of neutrophil extracellular trap formation in kidney transplantation : implications from donors to the recipient 

  Van Zyl, Maryna; Cramer, Elodie; Sanders, Jan-Stephan F.; Leuvenink, Henri G.D.; Lisman, Ton; Van Rooy, Mia-Jeanne; Hillebrands, Jan-Luuk (Elsevier, 2024-09)

  Kidney transplantation remains the gold standard for patients with end-stage renal disease, but severe donor organ shortage has led to long waiting lists. The utilization of expanded criteria donor kidneys within the ...
• Sulfamoylated estradiol analogs targeting the actin and microtubule cytoskeletons demonstrate anti-cancer properties in vitro and in ovo 

  Mercier, Anne Elisabeth; Joubert, Anna Margaretha; Viallet, Jean; Desroches-Castan, Agnes; De Koning, Leanne; Mabeta, Peaceful Lucy; Helena, Jolene Michelle; Pepper, Michael Sean; Lafanechere, Laurence (MDPI, 2024-10)

  The microtubule-disrupting agent 2-methoxyestradiol (2-ME) displays anti-tumor and anti-angiogenic properties, but its clinical development is halted due to poor pharmacokinetics. We therefore designed two 2-ME analogs ...
• A unifying hypothesis for the genome dynamics proposed to underlie neuropsychiatric phenotypes 

  Gericke, George S. (MDPI, 2024-04)

  The sheer number of gene variants and the extent of the observed clinical and molecular heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified downstream effects initiated by a smaller ...
• The association between menstrual cycle phase, menstrual irregularities, contraceptive use and musculoskeletal injury among female athletes : a scoping review 

  MacMillan, Candice; Olivier, Benita; Viljoen, Carel Thomas; Janse van Rensburg, Dina Christina; Sewry, Nicola Ann (Springer, 2024-10)

  BACKGROUND : The influence of menstrual cycle phases (MCPs), menstrual irregularities (MI) and hormonal contraceptive (HC) use on injury among female athletes has been scrutinised. Existing systematic reviews investigating ...
• Editorial : Athlete vulnerabilities and doping 

  Nolte, Kim; Schneider, Angela Jo-Anne (Frontiers Media, 2024-02)

  No abstract available.
• In vitro effects of L-kynurenine and quinolinic acid on adhesion, migration and apoptosis in B16 F10 melanoma cells 

  Basson, Charlise; Serem, June Cheptoo; Bipath, Priyesh; Hlophe, Y. (Elsevier, 2024-12)

  INTRODUCTION : The inhibition of melanoma adhesion through adhesion molecules, such as integrins and E-cadherin, may represent a promising strategy for managing melanoma metastasis. Compounds, namely l-kynurenine (L-kyn) ...
• Thymoquinone : a comprehensive review of its potential role as a monotherapy for metabolic syndrome 

  Ibrahim, Kasimu Ghandi; Hudu, Shuaibu Abdullahi; Jega, Amina Yusuf; Taha, Ahmad; Yusuf, Abdurrahman Pharmacy; Usman, Dawoud; Adeshina, Kehinde Ahmad; Umar, Zayyanu Usman; Nyakudya, Trevor Tapiwa; Erlwanger, Kennedy Honey (Mashhad University of Medical Sciences, 2024-10)

  Metabolic syndrome (MetS) is a widespread global epidemic that affects individuals across all age groups and presents a significant public health challenge. Comprising various cardio-metabolic risk factors, MetS contributes ...
• Poor health behaviour in medical students at a South African university: a cross-sectional survey study 

  Celie, Bert; Laubscher, Ria; Bac, Martin; Schwellnus, Marianne; Nolte, Kim; Wood, Paola Silvia; Camacho, Tanya Chantelle de Sousa; Basu, Debashis; Borresen, Jill (MDPI, 2024-07)

  BACKGROUND : Personal health behaviours and lifestyle habits of health professionals influence their counselling practices related to non-communicable diseases (NCDs). There are limited data on the prevalence of unhealthy ...
• An evaluation of knowledge and perception of pharmacology in undergraduate oral hygiene students and recent graduates at a single higher institution in Pretoria 

  Balmith, Marissa; Cordier, Werner; Bhayat, Ahmed; Basson, Charlize; Morule, Mpho; Schellack, Natalie (Wiley, 2024-11)

  INTRODUCTION : Pharmacology is an increasingly important area of study for oral hygienists, as it provides the scientific basis for safe and effective oral healthcare. However, a lack of fundamental understanding of the ...
• Evolution of drug development and regulatory affairs: the demonstrated power of artificial intelligence 

  Nene, Linda; Flepisi, Brian Thabile; Brand, Sarel Jacobus; Basson, Charlize; Balmith, Marissa (Elsevier, 2024-08)

  PURPOSE : Artificial intelligence (AI) refers to technology capable of mimicking human cognitive functions and has important applications across all sectors and industries, including drug development. This has considerable ...
• L-kynurenine and quinolinic acid inhibited markers of cell survival in B16 F10 melanoma cells in vitro 

  Basson, Charlise; Serem, June Cheptoo; Bipath, Priyesh; Hlophe, Yvette Nkondo (Wiley, 2024-07)

  Melanoma is an aggressive malignancy and remains a major cause of skin cancer mortality, highlighting the need for new treatment strategies. Recent findings revealed that L-kynurenine and quinolinic acid induce cytotoxicity ...
• An exploratory study on the effect of kynurenine metabolites on sEnd-2 endothelioma cells 

  Nkandeu, D.S. (Danielle Sandra); Joubert, Anna Margaretha; Serem, June Cheptoo; Bipath, Priyesh; Hlophe, Yvette Nkondo (Wiley, 2024-06)

  Cancer is the second leading cause of mortality worldwide. The development of anticancer therapy plays a crucial role in mitigating tumour progression and metastasis. Epithelioid hemangioendothelioma is a very rare cancer, ...
• Effect of 2-methoxyestradiol on mammary tumor initiation and progression 

  Peta, Kimberly; Durandt, Chrisna; Van Heerden, Marlene B.; Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2024-04)

  BACKGROUND : The anti-cancer agent 2-methoxyestradiol (2-ME) has been shown to have anti-proliferative and anti-angiogenic properties. Previously, the effect of 2-ME on early- and late-stage breast cancer (BC) was ...
• Development of a rugby shoulder function (RSF) questionnaire : an online Delphi study 

  Partner, Richard; Tee, Jason C.; Darrall-Jones, Josh; Jones, Ben (Elsevier, 2023-05)

  OBJECTIVE : Develop a questionnaire to monitor symptoms of player perceived shoulder function/dysfunction. DESIGN : 3-Stage Online Delphi Study. METHODS : Participants: surgeons, sports and exercise medics, ...
• Clinical characteristics of gradual onset injuries in recreational road cyclists-SAFER XXVII study over 5 years in 62758 race entrants 

  Du Toit, Francois; Schwellnus, Martin Peter; Jordaan, Esme; Swanevelder, Sonja; Wood, Paola Silvia (Taylor and Francis, 2023)

  OBJECTIVE : Gradual onset injuries (GOIs) in recreational cyclists are common but not well described. The aim of this study is to describe the clinical characteristics of GOIs (main anatomical regions, specific anatomical ...
• The effect of aspirin and lipopolysaccharide binding protein on hypercoagulability induced by lipopolysaccharide 

  Sibanda, Sthembile Valencia (University of Pretoria, 2019)

  Inflammation is a well-known underlying cause in many diseases. Chronic inflammation has a role in a host of common and often deadly diseases, including Alzheimer’s disease, rheumatoid arthritis, cancer, type 2 diabetes, ...
• The effects of whole body electromyostimulation exercise training on physical fitness in middle aged sedentary females 

  Burbidge, Michael (University of Pretoria, 2019)

  The purpose of this study was to determine the effects of whole-body electromyostimulation (WB-EMS) augmented calisthenic training on physique, maximum strength, balance and aerobic endurance and compare said effects to ...
• Lycopene : a potent antioxidant with multiple health benefits 

  Shafe, Mercy Omoye; Gumede, Nontobeko Myllet; Nyakudya, Trevor Tapiwa; Chivandi, Eliton (Wiley Open Access, 2024-06)

  Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato-based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used ...
• Restoring function to inactivating G protein-coupled receptor variants in the hypothalamic–pituitary–gonadal axis1 

  Radomsky, Tarryn; Anderson, Ross Calley; Millar, Robert P.; Newton, Claire L. (Wiley, 2024-09)

  G protein-coupled receptors (GPCRs) are central to the functioning of the hypothalamic–pituitary–gonadal axis (HPG axis) and include the rhodopsin-like GPCR family members, neurokinin 3 receptor, kappa-opioid receptor, ...
• Editorial : Women in anti-doping sciences & integrity in sport : 2021/22 

  Petroczi, Andrea; Nolte, Kim; Schneider, Angela Jo-Anne (Frontiers Media, 2023-07-11)

  No abstract available.

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