Recently added

Medical Microbiology: Recent submissions

  • Human papillomavirus (HPV) vaccines 
    Visser, Adele; Hoosen, Anwar Ahmed (Health and Medical Publishing Group, 2012-01)
    Human papillomavirus (HPV) infection has been estimated to cause 270 000 deaths worldwide annually from cervical cancer and approximately 80% of these occur in resource-poor countries.1 In South Africa, cervical cancer ...
  • Combination vaccines in the South African setting 
    Visser, Adele; Hoosen, Anwar Ahmed (Elsevier, 2012-09-07)
    The number of vaccines available and included as part of the national immunization schedules, has increased significantly over the past few decades. This impacts on patient/parent compliance and creates a challenge for ...
  • Haemophilus influenzae type b conjugate vaccines : a South African perspective 
    Visser, Adele; Hoosen, Anwar Ahmed; Hussey, Greg (Elsevier, 2012-09-07)
    Introduction of Hib vaccine is known to positively impact on reduction of both morbidity and mortality in children less than 5 years of age. Incorporation of this vaccine into a National EPI, however, does come at a ...
  • In vitro activity of tigecycline against clinical isolates of carbapenem resistant Acinetobacter baumannii complex in Pretoria, South Africa 
    Ahmed, Nahid H.; Baba, Kamaldeen A.; Clay, Cornelius G.; Lekalakala, M. Ruth; Hoosen, Anwar Ahmed (BioMed Central, 2012-05-03)
    BACKGROUND: The presence of multi-drug resistant Acinetobacter baumannii raises a big therapeutic challenge in our hospital. Tigecycline, a new glycylcycline with expanded broad spectrum of activity against multi-drug ...
  • Causes of hyperferritinaemia classified by HIV status in a tertiary-care setting in South Africa 
    Visser, Adele; Mostert, Chris J. (Cambridge University Press, 2012-03)
    This study included all patients, with known HIV-1 status, admitted to hospital over a 5-year period with serum ferritin values exceeding 1500 mg/l. Markedly elevated serum ferritin levels are associated with a host of ...
  • The Centre for Tuberculosis : from reference laboratory to public health institution 
    Ismail, Nazir Ahmed; Ihekweazu, Chikwe; Koornhof, Hendrik; Madhi, Shabir A. (Federation of Infectious Diseases Societies of South Africa, 2012)
    Tuberculosis (TB) continues to be one of the biggest public health challenges of our time, and as epidemiology of the disease evolves in an era of high HIV prevalence in South Africa, so must the response. With exciting ...
  • Fresh-frozen plasma use in a South African tertiary hospital 
    Visser, Adele; Geldenhuys, Annelize; Du Preez, Samantha; Van de Vyver, Annemarie (Health and Medical Publishing Group, 2012-06)
    Despite available guidelines on indications for fresh-frozen plasma (FFP) transfusion, inappropriate use is increasing worldwide. We evaluated FFP administration to patients admitted to the Steve Biko Academic Hospital ...
  • Systemic shigellosis in South Africa 
    Keddy, Karen H.; Sooka, Arvinda; Crowther-Gibson, Penny; Quan, Vanessa; Meiring, Susan; Cohen, Cheryl; Nana, Trusha; Sriruttan, Charlotte; Seetharam, Sharona; Hoosen, Anwar Ahmed; Naicker, Preneshni; Elliott, Eugenne; Haffejee, Summaya; Whitelaw, Andrew; Klugman, Keith P. (University of Chicago Press, 2012-05-15)
    BACKGROUND: Systemic disease due to shigellae is associated with human immunodeficiency virus (HIV), malnutrition, and other immunosuppressed states. We examined the clinical and microbiologic characteristics of systemic ...
  • Antimicrobial susceptibility patterns of selected bacteraemic isolates from South African public sector hospitals, 2010 
    Bamford, Colleen; Bonorchis, Kim; Ryan, Anthea; Simpson, John; Elliott, Eugenne; Hoffmann, Rena; Naicker, Preneshni; Ismail, Nazir Ahmed; Mbelle, Nontombi Marylucy; Nchabeleng, Maphoshane; Nana, Trusha; Sriruttan, Charlotte; Seetharam, Sharona; Wadula, Jeannette (Federation of Infectious Diseases Societies of South Africa, 2011)
    We report on antimicrobial susceptibility surveillance data for six key bloodstream pathogens (Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus ...
  • Evaluation of the GenoType (R) MTBDRsl assay for susceptibility testing of second-line anti-tuberculosis drugs 
    Said, Halima Mohammed; Kock, Marleen M.; Ismail, Nazir Ahmed; Baba, Kamaldeen A.; Omar, Shaheed Vally; Osman, Ayman Gassim Elamin; Hoosen, Anwar Ahmed; Ehlers, Marthie Magdaleen (International Union Against Tuberculosis and Lung Disease, 2012-01)
    BACKGROUND: The GenoType® MTBDRsl assay (Hains, Lifesciences, Germany) is a new rapid assay for detection of resistance to second-line anti-tuberculosis drugs. METHOD: The MTBDRsl assay was evaluated on 342 MDR-TB isolates ...
  • Molecular basis of virulence in clinical isolates of Escherichia coli and Salmonella species from a tertiary hospital in the Eastern Cape, South Africa 
    Bisi-Johnson, Mary A.; Obi, Chikwelu Larry; Vasaikar, Sandeep D.; Baba, Kamaldeen A.; Hattori, Toshio (BioMed Central, 2011-06-10)
    BACKGROUND: Apart from localized gastrointestinal infections, Escherichia coli and Salmonella species are major causes of systemic disease in both humans and animals. Salmonella spp. cause invasive infections such as ...
  • Serotype and antimicrobial profile distribution of invasive pneumococcal isolates in the pre-vaccine introduction era in Pretoria, South Africa, 2005 through 2009 
    Ismail, Nazir Ahmed; Hoosen, Anwar Ahmed; Silberbauer, Eduard Johan; Von Gottberg, Anne (Elsevier, 2011-11)
    A description of invasive Streptococcus pneumoniae isolates over a 5-year period from blood culture and cerebrospinal fluid culture follows, in Pretoria South Africa January 2005 through December 2009. Isolates were ...
  • Meningococcal infections in hospitalised patients in Pretoria 
    Moodley, Teshni; Lekalakala, M. Ruth; De Gouveia, L.; Dangor, Yusuf; Hoosen, Anwar Ahmed (Health and Medical Publishing Group, 2011-10)
    We report on 13 patients diagnosed with meningococcal infections in patients attending state-owned hospitals serving an indigent population in Pretoria in 2009. The case fatality rate was 27%. Ceftriaxone was the main ...
  • Analytical performance of the Roche Lightcycler® Mycobacterium Detection Kit for the diagnosis of clinically important mycobacterial species 
    Omar, Shaheed Vally; Roth, Andreas; Ismail, Nazir Ahmed; Erasmus, Linda; Ehlers, Marthie Magdaleen; Kock, Marleen M.; Paulse, Nuraan; Said, H.M. (Halima Mohammed); Hoosen, Anwar Ahmed; Reischl, Udo (Public Library of Science, 2011-09-22)
    BACKGROUND: The LightCyclerH Mycobacterium Detection Kit based on real-time PCR technology for the detection of Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii was recently developed. This study ...
  • Part IV. Human infections and antibiotic resistance 
    Crowther-Gibson, Penny; Govender, N.; Lewis, D.A.; Bamford, C.; Brink, A.; Von Gottberg, Anne; Klugman, Keith P.; Du Plessis, M.; Fali, A.; Harris, B.; Keddy, Karen H.; Botha, M. (Health and Medical Publishing Group, 2011-08)
    South Africa has a high burden of infectious diseases, including a large portion that are of bacterial origin. This section reviews the national burden of disease and levels of antibiotic resistance in common bacterial ...
  • Part V. Surveillance activities 
    Bamford, C.; Brink, A.; Govender, N.; Lewis, D.A.; Perovic, Olga; Botha, M.; Harris, B.; Keddy, Karen H.; Gelband, H.; Duse, A.G. (Health and Medical Publishing Group, 2011-08)
    The critical importance of robust antimicrobial resistance (AMR) surveillance in South Africa cannot be overemphasised. Without knowing what the resistance situation is, it is impossible to develop appropriate antibiotic ...
  • Part VII : Interventions 
    Visser, Adele; Moore, D.P.; Whitelaw, Andrew; Lowman, W.; Kantor, G.; Hoosen, Anwar Ahmed; Madhi, Shabir A.; Brink, A.; Van den Bergh, D.; Devenish, L.; Moodley, P.; Apalata, T.; Duse, A.G.; Gelband, H. (Health and Medical Publishing Group, 2011-08)
    Antimicrobial resistance (AMR) surveillance activities in South Africa have been described in Part V of this report. Surveillance – knowing the levels of resistance and the trends around the country and in different ...
  • Infection prevention and control for viral infections 
    Lekalakala, M. Ruth (Health and Medical Publishing Group, 2011-05)
    Infection prevention and control (IPC) is the new terminology used for what was previously referred to as simply 'infection control'. It is an important component of health care and all health care workers (doctors, nurses, ...
  • More about... medical virology : Human papillomavirus (HPV) 
    Visser, Adele; Hoosen, Anwar Ahmed (Health and Medical Publishing Group, 2011-05)
    The WHO advocates introduction of routine HPV vaccination as part of a national EPI programme provided HPV prevention is considered a health priority, and the programme is logistically feasible and financially sustainable. ...
  • Latex allergy in health care workers : prevalence and knowledge at a tertiary teaching hospital in a developing country 
    Ismail, Nazir Ahmed; Hoosen, Anwar Ahmed; Mehtar, Shaheen (International Federation of Infection Control (IFIC), 2010)
    Latex allergy is an important concern from an occupational safety aspect and affects compliance of glove usage, which directly influences infection control practices aimed at providing safe medical care for both the health ...