Medical Microbiology: Recent submissions

Now showing items 221-240 of 426

Plasmid evolution in carbapenemase‐producing Enterobacteriaceae : a review

Kopotsa, Katlego; Osei Sekyere, John; Mbelle, Nontombi Marylucy (Wiley, 2019-12)

Please read abstract in the article.
Complete genome sequence of escherichia coli J53, an azide- resistant laboratory strain used for conjugation experiments

Matsumura, Yasufumi; Peirano, Gisele; Pitout, Johann D.D. (American Society for Microbiology, 2018-05-24)

We report here the complete genome sequence of Escherichia coli J53, which is used as a recipient in conjugation experiments and is a laboratory strain derived from E. coli K-12. This genome sequence will help in the ...
Adult gonorrhea, chlamydia and syphilis prevalence, incidence, treatment and syndromic case reporting in South Africa : estimates using the Spectrum-STI model, 1990-2017

Kularatne, Ranmini S.; Niit, Ronelle; Rowley, Jane; Kufa-Chakezha, Tendesayi; Peters, Remco P.H.; Taylor, Melanie M.; Johnson, Leigh F.; Korenromp, Eline L. (Public Library of Science, 2018-10-15)

OBJECTIVES : To estimate trends in prevalence and incidence of syphilis, gonorrhea and chlamydia in adult men and women in South Africa. METHODS : The Spectrum-STI tool estimated trends in prevalence and incidence of ...
Acceptability and feasibility of integrating point-of-care diagnostic testing of sexually transmitted infections into a South African antenatal care program for HIV-infected pregnant women

Morikawa, E.; Mudau, M.; Olivier, D.; De Vos, L.; Davey, Dvora L. Joseph; Price, C.; McIntyre, J.A.; Peters, Remco P.H.; Klausner, J.D.; Medina-Marino, A. (Hindawi, 2018-05-09)

BACKGROUND : Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections may increase the risk of vertical transmission of the human immunodeficiency virus (HIV). In resource-limited ...
Acinetobacter baumannii : epidemiological and beta-lactamase data from two tertiary academic hospitals in Tshwane, South Africa

Lowe, Michelle; Ehlers, Marthie Magdaleen; Ismail, Farzana; Peirano, Gisele; Becker, Piet J.; Pitout, Johann D.D.; Kock, Marleen M. (Frontiers Media, 2018-06-12)

Acinetobacter baumannii is an opportunistic pathogen that is increasingly responsible for hospital-acquired infections. The increasing prevalence of carbapenem resistant A. baumannii has left clinicians with limited ...
In vitro study of stepwise acquisition of rv0678 and atpE mutations conferring bedaquiline resistance

Ismail, Nabila; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Peters, Remco P.H. (American Society for Microbiology, 2019-08)

Bedaquiline resistance within Mycobacterium tuberculosis may arise through efflux-based (rv0678) or target-based (atpE) pathway mutations. M. tuberculosis mutant populations from each of five sequential steps in a passaging ...
Molecular characteristics and genotypic diversity of enterohaemorrhagic Escherichia coli O157:H7 isolates in Gauteng region, South Africa

Bolukaoto, John Y.; Kock, Marleen M.; Strydom, Kathy-Anne; Mbelle, Nontombi Marylucy; Ehlers, Marthie Magdaleen (Elsevier, 2019-11)

Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is one of the major foodborne and waterborne pathogens causing severe diseases and outbreaks worldwide. There is scarcity of EHEC O157:H7 data in South Africa. This study ...
Cutaneous tuberculosis in HIV-infected individuals : lessons learnt from a case series

Tshisevhe, V.S.; Mbelle, Nontombi Marylucy; Peters, Remco P.H. (AOSIS Open Journals, 2019-03-12)

INTRODUCTION : Extrapulmonary tuberculosis (TB) causes a significant burden of disease worldwide, especially among HIV-infected individuals and those with other immunosuppressive conditions. Cutaneous TB is an important ...
Comparison of Xpert GBS v. culture for rapid detection of group B streptococcus in pregnant women : sensitivity, specificity and predictive values

Said, Mohamed; Dangor, Yusuf; Mbelle, Nontombi Marylucy; Sihlabela, A.; Lekalakala, M.R.; Ismail, Farzana (Health and Medical Publishing Group, 2018-12)

BACKGROUND. Group B streptococcus (GBS) is a leading cause of invasive disease, particularly in newborns. Seventy-five percent of neonates will be colonised by mothers carrying the organism. Confirmation of maternal ...
Multicentre study to establish interpretive criteria for clofazimine drug susceptibility testing

Ismail, Nazir Ahmed; Said, H.M.; Rodrigues, C.; Omar, Shaheed Vally; Ajbani, K.; Sukhadiad, N.; Kohl, T.A.; Niemann, S.; Kranzer, K.; Diels, M.; Rigouts, L.; Rusch-Gerdes, S.; Siddiqi, S. (International Union Against Tuberculosis and Lung Disease, 2019-05)

To conduct a multicentre study to establish the critical concentration (CC) for clofazimine (CFZ) for drug susceptibility testing (DST) of Mycobacterium tuberculosis on the MGIT™960™ system using the distribution of minimum ...
Community‐based strategies to identify the unmet need for care of individuals with sexually transmitted infection‐associated symptoms in rural South Africa

Hoffman, Charlotte M.; Fritz, Lise; Matlakala, Nthabiseng; Mbambazela, Nontembeko; Railton, Jean P.; McIntyre, James A.; Dubbink, Jan Henk; Peters, Remco P.H. (Wiley, 2019-08)

OBJECTIVES : To determine the unmet need for care and barriers for consulting sexually transmitted infection (STI) services at six primary healthcare (PHC) facilities in rural South Africa. METHODS : Cross‐sectional study ...
Genetic relatedness of Staphylococcus aureus isolates obtained from cystic fibrosis patients at a tertiary academic hospital in Pretoria, South Africa

Goolam Mahomed, Tanweer; Kock, Martha Magdalena; Masekela, R.; Hoosien, E.; Ehlers, Marthie Magdaleen (Nature Publishing Group, 2018-08-15)

Cystic fibrosis (CF) is an inherited recessive disease that affects mucocillary clearance in the lung, allowing it to be colonised with bacteria such as Staphylococcus aureus. To survive in the CF lung S. aureus adapts ...
Laboratory based antimicrobial resistance surveillance for Pseudomonas aeruginosa blood isolates from South Africa

Singh-Moodley, Ashika; Duse, Adriano; Naicker, Preneshni; Kularatne, Ranmini; Nana, Trusha; Lekalakala, Ruth; Mbelle, Nontombi Marylucy; Dawood, Halima; Swe Swe Han, Khine; Ramjathan, Praksha; Bhola, Prathna; Whitelaw, Andrew; Perovic, Olga (Journal of Infection in Developing Countries, 2018)

INTRODUCTION : Antimicrobial resistant bacterial infections are widespread globally and increases in antimicrobial resistance presents a major threat to public health. Pseudomonas aeruginosa is an opportunistic ...
Sexual behaviors of human immunodeficiency virus–infected pregnant women and factors associated with sexually transmitted infection in South Africa

Davey, Dvora L. Joseph; Peters, Remco P.H.; Kojima, Noah; Mudau, Maanda; De Vos, Lindsey; Olivier, Dawie; McIntyre, James A.; Klausner, Jeffrey; Medina-Marino, Andrew (Lippincott, Williams and Wilkins, 2018-11)

BACKGROUND : Sexual behaviors in human immunodeficiency virus (HIV)-infected pregnant women in South Africa are not well understood. METHODS : Human immunodeficiency virus-infected pregnant women were recruited into a ...
Drug resistant tuberculosis in Africa : current status, gaps and opportunities

Ismail, Nazir Ahmed; Ismail, Farzana; Omar, Shaheed Vally; Blows, Linsay; Gardee, Yasmin; Koornhof, Hendrik; Onyebujoh, Philip C. (AOSIS Open Journals, 2018-12-06)

BACKGROUND : The World Health Organization End TB Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. OBJECTIVE : We ...
Spatial patterns of extensively drug-resistant tuberculosis transmission in KwaZulu-Natal, South Africa

Nelson, Kristin N.; Shah, N. Sarita; Mathema, Barun; Ismail, Nazir Ahmed; Brust, James C.M.; Brown, Tyler S.; Auld, Sara C.; Omar, Shaheed Vally; Morris, Natashia; Campbell, Angie; Allana, Salim; Moodley, Pravi; Mlisana, Koleka; Gandhi, Neel R. (Oxford University Press, 2018-12-15)

BACKGROUND : Transmission is driving the global drug-resistant tuberculosis (TB) epidemic; nearly three-quarters of drug-resistant TB cases are attributable to transmission. Geographic patterns of disease incidence, combined ...
Mcr colistin resistance gene : a systematic review of current diagnostics and detection methods

Osei Sekyere, John (Wiley, 2019-04)

Resistance to colistin, mediated by chromosomal mutations and more recently, by plasmid-borne mcr genes, is increasingly being reported in bacterial isolates taken from humans, animals, farms, foods, and the environment. ...
Disruption in the regulation of immune responses in the placental subtype of preeclampsia

Geldenhuys, Janri; Rossouw, Theresa M.; Lombaard, Hendrik Andries; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Frontiers Media, 2018-07-20)

Preeclampsia is a pregnancy-specific disorder, of which one of its major subtypes, the placental subtype is considered a response to an ischemic placental environment, impacting fetal growth and pregnancy outcome. ...
In vitro approaches for generation of Mycobacterium tuberculosis mutants resistant to bedaquiline, clofazimine or linezolid and identification of associated genetic variants

Ismail, Nazir Ahmed; Omar, Shaheed Vally; Ismail, Nabila; Peters, Remco P.H. (Elsevier, 2018-10)

Bedaquiline, clofazimine and linezolid are pertinent drugs for drug-resistant tuberculosis. Drug-resistant mutants provide insight into important resistance acquisition mechanisms. Methods for in vitro Mycobacterium ...
Clofazimine exposure in vitro selects efflux pump mutants and bedaquiline resistance

Ismail, Nabila; Peters, Remco P.H.; Ismail, Nazir Ahmed; Omar, Shaheed Vally (American Society for Microbiology, 2019-03)

Six in vitro clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline ...

Now showing items 221-240 of 426

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