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Medical Microbiology: Recent submissions

  • Genetic variation in the MBL2 gene is associated with Chlamydia trachomatis infection and host humoral response to Chlamydia trachomatis infection 
    Verweij, Stephan P.; Peters, Remco P.H.; Catsburg, Arnold; De Vries, Henry J.C.; Ouburg, Sander; Morre, Servaas A. (MDPI, 2022-08-18)
    This study aims to assess the potential association of MBL2 gene single nucleotide polymorphisms (SNPs) to Chlamydia trachomatis infection. We analysed a selected sample of 492 DNA and serum specimens from Dutch Caucasian ...
  • Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning 
    Ahmadpour, Ehsan; Beshir Ahmed, Muktar; Akalu, Temesgen Yihunie; Al- Aly, Ziyad; Alanezi, Fahad Mashhour; Alanzi, Turki M.; Alipour, Vahid; Andrei, Catalina Liliana; Ansari, Fereshteh; Ansha, Mustafa Geleto; Anvari, Davood; Appiah, Seth Christopher Yaw; Arabloo, Jalal; Arnold, Benjamin F.; Ausloos, Marcel; Ayanore, Martin Amogre; Baig, Atif Amin; Banach, Maciej; Barac, Aleksandra; Barnighausen, Till Winfried; Bayati, Mohsen; Bhattacharyya, Krittika; Bhutta, Zulfiqar A.; Bibi, Sadia; Bijani, Ali; Bohlouli, Somayeh; Bohluli, Mahdi; Brady, Oliver J.; Bragazzi, Nicola Luigi; Butt, Zahid A.; Carvalho, Felix; Chatterjee, Souranshu; Chattu, Vijay Kumar; Chattu, Soosanna Kumary; Cormier, Natalie Maria; Dahlawi, Saad M.A.; Damiani, Giovanni; Daoud, Farah; Darwesh, Aso Mohammad; Daryani, Ahmad; Deribe, Kebede; Dharmaratne, Samath Dhamminda; Diaz, Daniel; Do, Hoa Thi; Zaki, Maysaa El Sayed; Tantawi, Maha El; Elemineh, Demelash Abewa; Faraj, Anwar; Harandi, Majid Fasihi; Fatahi, Yousef; Feigin, Valery L.; Fernandes, Eduarda; Foigt, Nataliya A.; Foroutan, Masoud; Franklin, Richard Charles; Gubari, Mohammed Ibrahim Mohialdeen; Guido, Davide; Guo, Yuming; Haj-Mirzaian, Arvin; Abdullah, Kanaan Hamagharib; Hamidi, Samer; Herteliu, Claudiu; De Hidru, Hagos Degefa; Higazi, Tarig B.; Hossain, Naznin; Hosseinzadeh, Mehdi; Househ, Mowafa; Ilesanmi, Olayinka Stephen; Ilic, Milena D.; Ilic, Irena M.; Iqbal, Usman; Irvani, Seyed Sina Naghibi; Jha, Ravi Prakash; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Kabir, Zubair; Kalankesh, Leila R.; Kalhor, Rohollah; Matin, Behzad Karami; Karimi, Salah Eddin; Kasaeian, Amir; Kavetskyy, Taras; Kayode, Gbenga A.; Karyani, Ali Kazemi; Kelbore, Abraham Getachew; Keramati, Maryam; Khalilov, Rovshan; Khan, Ejaz Ahmad; Khan, Md Nuruzzaman Nuruzzaman; Khatab, Khaled; Khater, Mona M.; Kianipour, Neda; Kibret, Kelemu Tilahun; Kim, Yun Jin; Kosen, Soewarta; Krohn, Kris J.; Kusuma, Dian; La Vecchia, Carlo; Lansingh, Charles; Lee, Paul H.; LeGrand, Kate E.; Li, Shanshan; Longbottom, Joshua; Abd El Razek, Hassan Magdy; Abd El Razek, Muhammed Magdy; Maleki, Afshin; Mamun, Abdullah A.; Manafi, Ali; Manafi, Navid; Mansournia, Mohammad Ali; Martins- Melo, Francisco Rogerlandio; Mazidi, Mohsen; McAlinden, Colm; Meharie, Birhanu Geta; Mendoza, Walter; Mengesha, Endalkachew Worku; Mengistu, Desalegn Tadese; Mereta, Seid Tiku; Mestrovic, Tomislav; Miller, Ted R.; Miri, Mohammad; Moghadaszadeh, Masoud; Mohammadian-Hafshejani, Abdollah; Mohammadpourhodki, Reza; Mohammed, Shafiu; Mohammed, Salahuddin; Moradi, Masoud; Moradzadeh, Rahmatollah; Moraga, Paula; Mosser, Jonathan F.; Naderi, Mehdi; Nagarajan, Ahamarshan Jayaraman; Naik, Gurudatta; Negoi, Ionut; Nguyen, Cuong Tat; Nguyen, Huong Lan Thi; Nguyen, Trang Huyen; Nikbakhsh, Rajan; Oancea, Bogdan; Olagunju, Tinuke O.; Olagunju, Andrew T.; Bali, Ahmed Omar; Onwujekwe, Obinna E.; Pana, Adrian; Pourjafar, Hadi; Rahim, Fakher; Rahman, Mohammad Hifz Ur; Rathi, Priya; Rawaf, Salman; Rawaf, David Laith; Rawassizadeh, Reza; Resnikoff, Serge; Reta, Melese Abate; Rezapour, Aziz; Rubagotti, Enrico; Rubino, Salvatore; Sadeghi, Ehsan; Saghafipour, Abedin; Sajadi, S. Mohammad (Public Library of Science, 2021-07-28)
    Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys ...
  • Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections : moving towards best practice 
    Peters, Remco P.H.; Garret, Nigel; Chandiwana, Nomathemba; Kularatne, Ranmini; Brink, Adrian J.; Cohen, Karen; Cohen, Karen; Chidarikire, Thato; Wattrus, Camilla; Nel, Jeremy S.; Moosa, Mahomed Y.S.; Bekker, Linda‑Gail (AOSIS, 2022-09-27)
    Sexually transmitted infections (STIs) are among the most common acute conditions worldwide with sub-Saharan Africa ranking among the regions with the highest burdens globally. Adolescent girls and young women (AGYW), people ...
  • Evaluating the usefulness of the estimated glomerular filtration rate for determination of imipenem dosage in critically ill patients 
    Mitton, Barend; Paruk, Fathima; Gous, A.; Chausse, J.; Milne, M.; Becker, Piet J.; Said, Mohamed (South African Medical Association, 2022-09)
    BACKGROUND. Antibiotic dosing in critically ill patients is complicated by variations in the pharmacokinetics of antibiotics in this group. The dosing of imipenem/cilastatin is usually determined by severity of illness and ...
  • Immunological non-inferiority of a new fully liquid presentation of the MenACWY-CRM vaccine to the licensed vaccine : results from a randomized, controlled, observer-blind study in adolescents and young adult 
    Diez Domingo, Javier; Tinoco, Juan Carlos; Poder, Airi; Dinleyici, Ener Cagri; Nell, Haylene; Salamanca de la Cueva, Ignacio; Ince, Tolga; Moreira, Edson Duarte Jr; Ahmed, Khatija; Luz, Kleber; Kovshirina, Yulia; Medina Pech, Carlos Eduardo; Akhund, Tauseefullah; Romolini, Valerio; Costantini, Marco; Mzolo, Thembile; Kunnel, Barry; Lechevin, Isabelle; Aggravi, Marianna; Tiberi, Paola; Narendran, K.; Garcia Martinez, Juan Antonio; Basile, Venere; Fragapane, Elena; Lattanz, Maria; Pellegrini, Michele (Taylor and Francis, 2022)
    A fully liquid MenACWY-CRM vaccine presentation has been developed, modifying the meningococcal serogroup A (MenA) component from lyophilized to liquid. The safety and immunogenicity of the liquid presentation at the end ...
  • Molecular epidemiological analysis of Mycoplasma genitalium shows low prevalence of azithromycin resistance and a well-established epidemic in South Africa 
    Laumen, Jolein G.E.; Van Alphen, Lieke B.; Maduna, Liteboho Daniel; Hoffman, Charlotte M.; Klausner, Jeffrey D; Medina‑Marino, Andrew; Kock, Marleen M.; Peters, Remco P.H. (BMJ Publishing Group, 2021-03)
    OBJECTIVES: Macrolide resistance in Mycoplasma genitalium is emerging globally. There is paucity of data from sub-Saharan Africa where syndromic management is used to treat sexually transmitted infections (STIs). We conducted ...
  • Lack of macrolide resistance in Mycoplasma genitalium infections in a cohort of pregnant women in South Africa 
    Peters, Remco P.H.; Jung, Hyunsul; Muller, Etienne E.; Kock, Marleen M.; Myer, Landon; Klausner, Jeffrey D; Davey, Dvora L. Joseph (BMJ Publishing Group, 2021-12)
    No abstract available.
  • Single-dose azithromycin for genital lymphogranuloma venereum biovar Chlamydia trachomatis infection in HIV-infected women in South Africa : an observational study 
    Peters, Remco P.H.; Maduna, Liteboho Daniel; Kock, Marleen M.; McIntyre, James A.; Klausner, Jeffrey D; Medina‑Marino, Andrew (Lippincott Williams and Wilkins, 2021-02)
    We conducted an observational study of lymphogranuloma venereum (LGV) biovar Chlamydia trachomatis infection in HIV-infected women in South Africa. The LGV biovar was detected in vaginal specimens of 17 (20%) of 85 women ...
  • Acinetobacter baumannii complex, national laboratory-based surveillance in South Africa, 2017 to 2019 
    Perovic, Olga; Duse, Adrian; Chibabhai, Vindana; Black, Marianne; Said, Mohamed; Prentice, Elizabeth; Wadula, Jeannette; Mahabeer, Yesholata; Han, Swe Swe; Mogokotleng, Ruth; Strasheim, Wilhelmina; Lowe, Michelle; Jallow, Sabelle; Ismail, Husna (Public Library of Science, 2022-08-04)
    OBJECTIVE : We aimed to provide an analysis of A. baumannii complex (ABC) isolated from blood cultures in South Africa. MATERIALS AND METHODS : ABC surveillance was conducted from 1 April 2017 to 30 September 2019 at ...
  • Global epidemiology, genetic environment, risk factors and therapeutic prospects of MCR genes : a current and emerging update 
    Mmatli, Masego; Mbelle, Nontombi Marylucy; Osei Sekyere, John (Frontiers Media S.A., 2022-08-26)
    BACKGROUND : Mobile colistin resistance (mcr) genes modify Lipid A molecules of the lipopolysaccharide, changing the overall charge of the outer membrane. RESULTS AND DISCUSSION: Ten mcr genes have been described to date ...
  • Population structure, biogeography and transmissibility of mycobacterium tuberculosis 
    Freschi, Luca; Vargas Jr., Roger; Husain, Ashaque; Kamal, S.M. Mostofa; Skrahina, Alena; Tahseen, Sabira; Ismail, Nazir Ahmed; Barbova, Anna; Niemann, Stefan; Cirillo, Daniela Maria; Dean, Anna S.; Zignol, Matteo; Farhat, Maha Reda (Nature Research, 2021-10-20)
    Mycobacterium tuberculosis is a clonal pathogen proposed to have co-evolved with its human host for millennia, yet our understanding of its genomic diversity and biogeography remains incomplete. Here we use a combination ...
  • HLA diversity in Saudi population : high frequency of homozygous HLA alleles and haplotypes 
    Chentoufi, Aziz Alami; Uyar, F. Aytul; Chentouf, Hiba A.; Alzahrani, Khalid; Paz, Maria; Bahnassy, Ahmed; Elyamany, Ghaleb; Elghazaly, Assem (Frontiers Media S.A., 2022-06-09)
    Human leukocyte antigens (HLA) diversity has a tremendous impact on shaping the transplantation practices, transfusion-associated graft versus host disease prevention strategies, and host–pathogen interactions. Here, we ...
  • The ins and outs of susceptibility testing for new b-lactam/b-lactamase inhibitor combinations for gram-negative organisms 
    Dingle, Tanis; Pitout, Johann D.D. (Journal of Clinical Microbiology, 2022-07)
    Ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam are among the newest b-lactam/b-lactamase inhibitors (BL/BLIs) introduced to the North American antibiotic market. All have broad Gram-negative activity, ...
  • Antimicrobial resistance in Neisseria gonorrhoeae and Mycoplasma genitalium isolates from the private healthcare sector in South Africa : a pilot study 
    Maduna, Liteboho Daniel; Peters, Remco P.H.; Kingsburgh, C.; Strydom, K.A.; Kock, Marleen M. (SA MEDICAL ASSOC, 2021-10)
    BACKGROUND. Reports have emerged globally of antimicrobial resistance (AMR) in Neisseria gonorrhoeae and Mycoplasma genitalium infections. In South Africa (SA), there are substantial differences between private and public ...
  • Spinal epidural abscess caused by Aspergillus spp masquerading as spinal tuberculosis in a person with HIV 
    Rule, Roxanne; Mitton, Barend C.; Govender, Nelesh P.; Hoffmann, Daniel; Said, Mohamed (Elsevier, 2021-11)
    Spinal epidural abscess caused by Aspergillus spp is a debilitating form of invasive aspergillosis that can easily be misdiagnosed as spinal tuberculosis due to shared risk factors and clinical features. In this Grand ...
  • Iqbal Haroon Master, 5 December 1962-15 January 2021 
    Ndjeka, Norbert; Reuter, Anja; Conradie, Francesca; Enwerem, Martin; Ferreira, Hannetjie; Hughes, Jennifer; Ismail, Farzana; Ismail, Nazir Ahmed; Kock, Yulene; Padanilam, Xavier; Romero, Rodolfo; Schaaf, H. Simon; Te Riel, Julian; Variava, Ebrahim; Meintjes, Graeme; Maartens, Gary (Health and Medical Publishing Group, 2021-04)
    No abstract available.
  • Non-vaccine serotype pneumococcal carriage in healthy infants in South Africa following introduction of the 13-valent pneumococcal conjugate vaccine 
    Skosana, Z.; Von Gottberg, A; Olorunju, S.; Mohale, T.; Du Plessis, M.; Adams, T.; Mbelle, Nontombi Marylucy (Health and Medical Publishing Group, 2021-02)
    BACKGROUND. Pneumococcal carriage studies provide a baseline for measuring the impact of pneumococcal conjugate vaccines (PCVs). The advent of conjugate vaccines has led to reductions in vaccine serotypes (VTs) in ...
  • Adjunctive host-directed therapies for pulmonary tuberculosis : a prospective, open-label, phase 2, randomised controlled trial 
    Wallis, Robert S.; Ginindza, Sibuse; Beattie, Trevor; Arjun, Nishanee; Sebe, Modulakgotla; Likoti, Morongwe; Edward, Vinodh A.; Rassool, Mohammed; Ahmed, Khatija; Fielding, Katherine; Ahidjo, Bintou A.; Vangu, Mboyo D.T.; Churchyard, Gavin (Elsevier, 2021-08)
    BACKGROUND : Current tuberculosis treatments leave patients with clinically significant lung injury and increased all-cause mortality post-cure. Adjunctive host-directed therapies could protect the lungs, improve long-term ...
  • Indicator-focussed technical assistance in South Africa’s HIV programme : a stepped-wedge evaluation 
    Jobson, Geoffrey; Railton, Jean.; Mutasa, Barry; Ranoto, Lucy; Maluleke, Christine; McIntyre, James; Struthers, Helen; Peters, Remco P.H. (AOSIS, 2021-06-15)
    BACKGROUND : There is a lack of research on technical assistance (TA) interventions in low- and middle-income countries. Variation in local contexts requires tailor-made approaches to TA that are structured and replicable ...
  • Prevalence, incidence and associated risk factors of STIs during pregnancy in South Africa 
    Nyemba, Dorothy C.; Medina‑Marino, Andrew; Peters, Remco P.H.; Klausner, Jeffrey D; Ngwepe, p; Myer, Landon; Johnson, Leigh Francis; Davey, Dvora L. Joseph (BMJ Publishing Group, 2021-08)
    OBJECTIVE : STIs during pregnancy increase adverse pregnancy and birth outcomes and may increase HIV risk. STI syndromic management is standard of care in South Africa. Our study evaluated the prevalence and incidence of ...