Recently added

Medical Microbiology: Recent submissions

  • Klebsiella pneumoniae ST147 : and then there were three carbapenemases 
    Mataseje, L.F.; Chen, L.; Peirano, Gisele; Fakharuddin, K.; Kreiswith, B.; Mulvey, M.; Pitout, Johann D.D. (Springer, 2022-12)
    Please read abstract in the article.
  • Sexually transmitted infection screening to prevent adverse birth and newborn outcomes: study protocol for a randomized‑controlled hybrid‑effectiveness trial 
    Medina‑Marino, Andrew; Cleary, Susan; Muzny, Christina A.; Taylor, Christopher; Tamhane, Ashutosh; Ngwepe, Phuti; Bezuidenhout, Charl; Facente, Shelley N.; Mlisana, Koleka; Peters, Remco P.H.; Klausner, Jeffrey D (BMC, 2022-05)
    BACKGROUND : Sexually transmitted infections (STIs) during pregnancy are associated with adverse birth outcomes, including preterm birth, low birth weight, perinatal death, and congenital infections such as increased ...
  • Assessment of the efficacy of clofazimine alone and in combination with primary agents against Mycobacterium tuberculosis in vitro 
    Mashele, Sizeka Aubrey; Steel, Helen C.; Matjokotja, Maborwa T.; Rasehlo, S.S.M. (Sipho); Anderson, Ronald; Cholo, Moloko C. (Elsevier, 2022-06)
    OBJECTIVES : The chemotherapeutic regimens of patients with drug-susceptible (DS)- tuberculosis (TB) comprise four primary anti-TB drugs: rifampicin (RMP), isoniazid (INH), ethambutol (EMB) and pyrazinamide (PZA), administered ...
  • Exploring a community’s understanding of HIV vaccine‑induced seropositivity in a South African research setting 
    Malahleha, Mookho; Dilraj, A.; Jean, J.; Morar, N.S.; Dietrich, J.J.; Ross, M.; Mbatsane, E.; Keefer, M.C.; Ahmedm, K. (Health and Medical Publishing Group, 2022-01)
    BACKGROUND. The high HIV prevalence and incidence in South Africa makes it suitable for recruitment of participants for large-scale HIV preventive vaccine trials. However, fear of vaccine-induced seropositivity (VISP) may ...
  • The lung microbiome in HIV‑positive patients with active pulmonary tuberculosis 
    Ueckermann, Veronica; Lebre, Pedro H.; Geldenhuys, Janri; Hoosien, Ebrahim; Cowan, Don A.; Janse van Rensburg, Luricke; Ehlers, Marthie Magdaleen (Nature Research, 2022-05-28)
    Tuberculosis poses one of the greatest infectious disease threats of our time, especially when associated with human immunodeficiency virus (HIV) infection. Very little data is available on the lung microbiome in pulmonary ...
  • Molecular screening of clinical multidrug-resistant gram-negative bacteria shows endemicity of carbapenemases, coexistence of multiple carbapenemases, and rarity of mcr in South Africa 
    Mmatli, Masego; Leshaba, Tumisho Mmatumelo Seipei; Skosana, Lebogang Busisiwe; Mbelle, Nontombi Marylucy; Osei Sekyere, John (Mary Ann Liebert, 2022-11)
    Please read abstract in the article.
  • Genetic variation in the MBL2 gene is associated with Chlamydia trachomatis infection and host humoral response to Chlamydia trachomatis infection 
    Verweij, Stephan P.; Peters, Remco P.H.; Catsburg, Arnold; De Vries, Henry J.C.; Ouburg, Sander; Morre, Servaas A. (MDPI, 2022-08-18)
    This study aims to assess the potential association of MBL2 gene single nucleotide polymorphisms (SNPs) to Chlamydia trachomatis infection. We analysed a selected sample of 492 DNA and serum specimens from Dutch Caucasian ...
  • Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning 
    Ahmadpour, Ehsan; Beshir Ahmed, Muktar; Akalu, Temesgen Yihunie; Al- Aly, Ziyad; Alanezi, Fahad Mashhour; Alanzi, Turki M.; Alipour, Vahid; Andrei, Catalina Liliana; Ansari, Fereshteh; Ansha, Mustafa Geleto; Anvari, Davood; Appiah, Seth Christopher Yaw; Arabloo, Jalal; Arnold, Benjamin F.; Ausloos, Marcel; Ayanore, Martin Amogre; Baig, Atif Amin; Banach, Maciej; Barac, Aleksandra; Barnighausen, Till Winfried; Bayati, Mohsen; Bhattacharyya, Krittika; Bhutta, Zulfiqar A.; Bibi, Sadia; Bijani, Ali; Bohlouli, Somayeh; Bohluli, Mahdi; Brady, Oliver J.; Bragazzi, Nicola Luigi; Butt, Zahid A.; Carvalho, Felix; Chatterjee, Souranshu; Chattu, Vijay Kumar; Chattu, Soosanna Kumary; Cormier, Natalie Maria; Dahlawi, Saad M.A.; Damiani, Giovanni; Daoud, Farah; Darwesh, Aso Mohammad; Daryani, Ahmad; Deribe, Kebede; Dharmaratne, Samath Dhamminda; Diaz, Daniel; Do, Hoa Thi; Zaki, Maysaa El Sayed; Tantawi, Maha El; Elemineh, Demelash Abewa; Faraj, Anwar; Harandi, Majid Fasihi; Fatahi, Yousef; Feigin, Valery L.; Fernandes, Eduarda; Foigt, Nataliya A.; Foroutan, Masoud; Franklin, Richard Charles; Gubari, Mohammed Ibrahim Mohialdeen; Guido, Davide; Guo, Yuming; Haj-Mirzaian, Arvin; Abdullah, Kanaan Hamagharib; Hamidi, Samer; Herteliu, Claudiu; De Hidru, Hagos Degefa; Higazi, Tarig B.; Hossain, Naznin; Hosseinzadeh, Mehdi; Househ, Mowafa; Ilesanmi, Olayinka Stephen; Ilic, Milena D.; Ilic, Irena M.; Iqbal, Usman; Irvani, Seyed Sina Naghibi; Jha, Ravi Prakash; Joukar, Farahnaz; Jozwiak, Jacek Jerzy; Kabir, Zubair; Kalankesh, Leila R.; Kalhor, Rohollah; Matin, Behzad Karami; Karimi, Salah Eddin; Kasaeian, Amir; Kavetskyy, Taras; Kayode, Gbenga A.; Karyani, Ali Kazemi; Kelbore, Abraham Getachew; Keramati, Maryam; Khalilov, Rovshan; Khan, Ejaz Ahmad; Khan, Md Nuruzzaman Nuruzzaman; Khatab, Khaled; Khater, Mona M.; Kianipour, Neda; Kibret, Kelemu Tilahun; Kim, Yun Jin; Kosen, Soewarta; Krohn, Kris J.; Kusuma, Dian; La Vecchia, Carlo; Lansingh, Charles; Lee, Paul H.; LeGrand, Kate E.; Li, Shanshan; Longbottom, Joshua; Abd El Razek, Hassan Magdy; Abd El Razek, Muhammed Magdy; Maleki, Afshin; Mamun, Abdullah A.; Manafi, Ali; Manafi, Navid; Mansournia, Mohammad Ali; Martins- Melo, Francisco Rogerlandio; Mazidi, Mohsen; McAlinden, Colm; Meharie, Birhanu Geta; Mendoza, Walter; Mengesha, Endalkachew Worku; Mengistu, Desalegn Tadese; Mereta, Seid Tiku; Mestrovic, Tomislav; Miller, Ted R.; Miri, Mohammad; Moghadaszadeh, Masoud; Mohammadian-Hafshejani, Abdollah; Mohammadpourhodki, Reza; Mohammed, Shafiu; Mohammed, Salahuddin; Moradi, Masoud; Moradzadeh, Rahmatollah; Moraga, Paula; Mosser, Jonathan F.; Naderi, Mehdi; Nagarajan, Ahamarshan Jayaraman; Naik, Gurudatta; Negoi, Ionut; Nguyen, Cuong Tat; Nguyen, Huong Lan Thi; Nguyen, Trang Huyen; Nikbakhsh, Rajan; Oancea, Bogdan; Olagunju, Tinuke O.; Olagunju, Andrew T.; Bali, Ahmed Omar; Onwujekwe, Obinna E.; Pana, Adrian; Pourjafar, Hadi; Rahim, Fakher; Rahman, Mohammad Hifz Ur; Rathi, Priya; Rawaf, Salman; Rawaf, David Laith; Rawassizadeh, Reza; Resnikoff, Serge; Reta, Melese Abate; Rezapour, Aziz; Rubagotti, Enrico; Rubino, Salvatore; Sadeghi, Ehsan; Saghafipour, Abedin; Sajadi, S. Mohammad (Public Library of Science, 2021-07-28)
    Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys ...
  • Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections : moving towards best practice 
    Peters, Remco P.H.; Garret, Nigel; Chandiwana, Nomathemba; Kularatne, Ranmini; Brink, Adrian J.; Cohen, Karen; Cohen, Karen; Chidarikire, Thato; Wattrus, Camilla; Nel, Jeremy S.; Moosa, Mahomed Y.S.; Bekker, Linda‑Gail (AOSIS, 2022-09-27)
    Sexually transmitted infections (STIs) are among the most common acute conditions worldwide with sub-Saharan Africa ranking among the regions with the highest burdens globally. Adolescent girls and young women (AGYW), people ...
  • Evaluating the usefulness of the estimated glomerular filtration rate for determination of imipenem dosage in critically ill patients 
    Mitton, Barend; Paruk, Fathima; Gous, A.; Chausse, J.; Milne, M.; Becker, Piet J.; Said, Mohamed (South African Medical Association, 2022-09)
    BACKGROUND. Antibiotic dosing in critically ill patients is complicated by variations in the pharmacokinetics of antibiotics in this group. The dosing of imipenem/cilastatin is usually determined by severity of illness and ...
  • Immunological non-inferiority of a new fully liquid presentation of the MenACWY-CRM vaccine to the licensed vaccine : results from a randomized, controlled, observer-blind study in adolescents and young adult 
    Diez Domingo, Javier; Tinoco, Juan Carlos; Poder, Airi; Dinleyici, Ener Cagri; Nell, Haylene; Salamanca de la Cueva, Ignacio; Ince, Tolga; Moreira, Edson Duarte Jr; Ahmed, Khatija; Luz, Kleber; Kovshirina, Yulia; Medina Pech, Carlos Eduardo; Akhund, Tauseefullah; Romolini, Valerio; Costantini, Marco; Mzolo, Thembile; Kunnel, Barry; Lechevin, Isabelle; Aggravi, Marianna; Tiberi, Paola; Narendran, K.; Garcia Martinez, Juan Antonio; Basile, Venere; Fragapane, Elena; Lattanz, Maria; Pellegrini, Michele (Taylor and Francis, 2022)
    A fully liquid MenACWY-CRM vaccine presentation has been developed, modifying the meningococcal serogroup A (MenA) component from lyophilized to liquid. The safety and immunogenicity of the liquid presentation at the end ...
  • Molecular epidemiological analysis of Mycoplasma genitalium shows low prevalence of azithromycin resistance and a well-established epidemic in South Africa 
    Laumen, Jolein G.E.; Van Alphen, Lieke B.; Maduna, Liteboho Daniel; Hoffman, Charlotte M.; Klausner, Jeffrey D; Medina‑Marino, Andrew; Kock, Marleen M.; Peters, Remco P.H. (BMJ Publishing Group, 2021-03)
    OBJECTIVES: Macrolide resistance in Mycoplasma genitalium is emerging globally. There is paucity of data from sub-Saharan Africa where syndromic management is used to treat sexually transmitted infections (STIs). We conducted ...
  • Lack of macrolide resistance in Mycoplasma genitalium infections in a cohort of pregnant women in South Africa 
    Peters, Remco P.H.; Jung, Hyunsul; Muller, Etienne E.; Kock, Marleen M.; Myer, Landon; Klausner, Jeffrey D; Davey, Dvora L. Joseph (BMJ Publishing Group, 2021-12)
    No abstract available.
  • Single-dose azithromycin for genital lymphogranuloma venereum biovar Chlamydia trachomatis infection in HIV-infected women in South Africa : an observational study 
    Peters, Remco P.H.; Maduna, Liteboho Daniel; Kock, Marleen M.; McIntyre, James A.; Klausner, Jeffrey D; Medina‑Marino, Andrew (Lippincott Williams and Wilkins, 2021-02)
    We conducted an observational study of lymphogranuloma venereum (LGV) biovar Chlamydia trachomatis infection in HIV-infected women in South Africa. The LGV biovar was detected in vaginal specimens of 17 (20%) of 85 women ...
  • Acinetobacter baumannii complex, national laboratory-based surveillance in South Africa, 2017 to 2019 
    Perovic, Olga; Duse, Adrian; Chibabhai, Vindana; Black, Marianne; Said, Mohamed; Prentice, Elizabeth; Wadula, Jeannette; Mahabeer, Yesholata; Han, Swe Swe; Mogokotleng, Ruth; Strasheim, Wilhelmina; Lowe, Michelle; Jallow, Sabelle; Ismail, Husna (Public Library of Science, 2022-08-04)
    OBJECTIVE : We aimed to provide an analysis of A. baumannii complex (ABC) isolated from blood cultures in South Africa. MATERIALS AND METHODS : ABC surveillance was conducted from 1 April 2017 to 30 September 2019 at ...
  • Global epidemiology, genetic environment, risk factors and therapeutic prospects of MCR genes : a current and emerging update 
    Mmatli, Masego; Mbelle, Nontombi Marylucy; Osei Sekyere, John (Frontiers Media S.A., 2022-08-26)
    BACKGROUND : Mobile colistin resistance (mcr) genes modify Lipid A molecules of the lipopolysaccharide, changing the overall charge of the outer membrane. RESULTS AND DISCUSSION: Ten mcr genes have been described to date ...
  • Population structure, biogeography and transmissibility of mycobacterium tuberculosis 
    Freschi, Luca; Vargas Jr., Roger; Husain, Ashaque; Kamal, S.M. Mostofa; Skrahina, Alena; Tahseen, Sabira; Ismail, Nazir Ahmed; Barbova, Anna; Niemann, Stefan; Cirillo, Daniela Maria; Dean, Anna S.; Zignol, Matteo; Farhat, Maha Reda (Nature Research, 2021-10-20)
    Mycobacterium tuberculosis is a clonal pathogen proposed to have co-evolved with its human host for millennia, yet our understanding of its genomic diversity and biogeography remains incomplete. Here we use a combination ...
  • HLA diversity in Saudi population : high frequency of homozygous HLA alleles and haplotypes 
    Chentoufi, Aziz Alami; Uyar, F. Aytul; Chentouf, Hiba A.; Alzahrani, Khalid; Paz, Maria; Bahnassy, Ahmed; Elyamany, Ghaleb; Elghazaly, Assem (Frontiers Media S.A., 2022-06-09)
    Human leukocyte antigens (HLA) diversity has a tremendous impact on shaping the transplantation practices, transfusion-associated graft versus host disease prevention strategies, and host–pathogen interactions. Here, we ...
  • The ins and outs of susceptibility testing for new b-lactam/b-lactamase inhibitor combinations for gram-negative organisms 
    Dingle, Tanis; Pitout, Johann D.D. (Journal of Clinical Microbiology, 2022-07)
    Ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam are among the newest b-lactam/b-lactamase inhibitors (BL/BLIs) introduced to the North American antibiotic market. All have broad Gram-negative activity, ...
  • Antimicrobial resistance in Neisseria gonorrhoeae and Mycoplasma genitalium isolates from the private healthcare sector in South Africa : a pilot study 
    Maduna, Liteboho Daniel; Peters, Remco P.H.; Kingsburgh, C.; Strydom, K.A.; Kock, Marleen M. (SA MEDICAL ASSOC, 2021-10)
    BACKGROUND. Reports have emerged globally of antimicrobial resistance (AMR) in Neisseria gonorrhoeae and Mycoplasma genitalium infections. In South Africa (SA), there are substantial differences between private and public ...