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Browsing Medical Microbiology by Title

Now showing items 1-20 of 440

1,4,7-Triazacyclononane restores the activity of β-lactam antibiotics against metallo-β-lactamase-producing Enterobacteriaceae : exploration of potential metallo-β-lactamase inhibitors

Somboro, Anou M.; Amoako, Daniel G.; Osei Sekyere, John; Kumalo, Hezekiel M.; Khan, René; Bester, Linda A.; Essack, Sabiha Y. (American Society for Microbiology, 2019-02)

Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use. The discovery and development of MBL inhibitors ...
A 10-year cohort analysis of routine paediatric ART data in a rural South African setting

Lilian, R.P.; Mutasa, B.; Railton, J.; Mongwe, W.; McIntyre, J.A.; Struthers, H.E.; Peters, Remco P.H. (Cambridge University Press, 2017-01)

South Africa’s paediatric antiretroviral therapy (ART) programme is managed using a monitoring and evaluation tool known as TIER.Net. This electronic system has several advantages over paper-based systems, allowing ...
18F-FDG PET/CT as a noninvasive biomarker for assessing adequacy of treatment and predicting relapse in patients treated for pulmonary tuberculosis

Lawal, Ismaheel Opeyemi; Fourie, Bernard P.; Mathebula, Matsontso; Moagi, Ingrid; Lengana, Thabo; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hatherill, Mark; Sathekge, Mike Machaba (Society of Nuclear Medicine, 2020-03)

Microbial culture is the gold standard for determining the effectiveness of tuberculosis treatment. End-of-treatment (EOT) 18F-FDG PET/CT findings are variable among patients with negative microbial culture results after ...
[18F]FDG PET and CT findings at therapy completion of pulmonary tuberculosis: comparison between HIV-positive and HIV-negative patients and impact on treatment response assessment

Ismaila, Aisha; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mathebula, Matsontso; Moagi, Ingrid; Mokoala, Kgomotso M.G.; Honest, Ndlovu; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hikuam, Chris; Hatherill, Mark; Fourie, P.B. (Petrus Bernardus); Sathekge, Mike Machaba (Springer, 2024-12)

BACKGROUND : [18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...
Acceptability and feasibility of integrating point-of-care diagnostic testing of sexually transmitted infections into a South African antenatal care program for HIV-infected pregnant women

Morikawa, E.; Mudau, M.; Olivier, D.; De Vos, L.; Davey, Dvora L. Joseph; Price, C.; McIntyre, J.A.; Peters, Remco P.H.; Klausner, J.D.; Medina-Marino, A. (Hindawi, 2018-05-09)

BACKGROUND : Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections may increase the risk of vertical transmission of the human immunodeficiency virus (HIV). In resource-limited ...
Acinetobacter baumannii : epidemiological and beta-lactamase data from two tertiary academic hospitals in Tshwane, South Africa

Lowe, Michelle; Ehlers, Marthie Magdaleen; Ismail, Farzana; Peirano, Gisele; Becker, Piet J.; Pitout, Johann D.D.; Kock, Marleen M. (Frontiers Media, 2018-06-12)

Acinetobacter baumannii is an opportunistic pathogen that is increasingly responsible for hospital-acquired infections. The increasing prevalence of carbapenem resistant A. baumannii has left clinicians with limited ...
Acinetobacter baumannii complex, national laboratory-based surveillance in South Africa, 2017 to 2019

Perovic, Olga; Duse, Adrian; Chibabhai, Vindana; Black, Marianne; Said, Mohamed; Prentice, Elizabeth; Wadula, Jeannette; Mahabeer, Yesholata; Han, Swe Swe; Mogokotleng, Ruth; Strasheim, Wilhelmina; Lowe, Michelle; Jallow, Sabelle; Ismail, Husna (Public Library of Science, 2022-08-04)

OBJECTIVE : We aimed to provide an analysis of A. baumannii complex (ABC) isolated from blood cultures in South Africa. MATERIALS AND METHODS : ABC surveillance was conducted from 1 April 2017 to 30 September 2019 at ...
Addressing missed visits to improve retention of young South African women in clinical trials

Ahmed, Khatija; Malahleha, Mookho; Mbatsane, Thulisile E.; Thindisa, Dineo; Bailey, Veronique C.; Seocharan, Ishen; Dilraj, Athmanundh (Academy of Science of South Africa, 2023-07)

In clinical trials, a vital protocol requirement for participants is adherence to scheduled visits. A substantial number of missed visits and the resultant missing data could affect generalisability of the findings ...
Adjunctive host-directed therapies for pulmonary tuberculosis : a prospective, open-label, phase 2, randomised controlled trial

Wallis, Robert S.; Ginindza, Sibuse; Beattie, Trevor; Arjun, Nishanee; Sebe, Modulakgotla; Likoti, Morongwe; Edward, Vinodh A.; Rassool, Mohammed; Ahmed, Khatija; Fielding, Katherine; Ahidjo, Bintou A.; Vangu, Mboyo D.T.; Churchyard, Gavin (Elsevier, 2021-08)

BACKGROUND : Current tuberculosis treatments leave patients with clinically significant lung injury and increased all-cause mortality post-cure. Adjunctive host-directed therapies could protect the lungs, improve long-term ...
Adult gonorrhea, chlamydia and syphilis prevalence, incidence, treatment and syndromic case reporting in South Africa : estimates using the Spectrum-STI model, 1990-2017

Kularatne, Ranmini S.; Niit, Ronelle; Rowley, Jane; Kufa-Chakezha, Tendesayi; Peters, Remco P.H.; Taylor, Melanie M.; Johnson, Leigh F.; Korenromp, Eline L. (Public Library of Science, 2018-10-15)

OBJECTIVES : To estimate trends in prevalence and incidence of syphilis, gonorrhea and chlamydia in adult men and women in South Africa. METHODS : The Spectrum-STI tool estimated trends in prevalence and incidence of ...
Analytical performance of the Roche Lightcycler® Mycobacterium Detection Kit for the diagnosis of clinically important mycobacterial species

Omar, Shaheed Vally; Roth, Andreas; Ismail, Nazir Ahmed; Erasmus, Linda; Ehlers, Marthie Magdaleen; Kock, Marleen M.; Paulse, Nuraan; Said, H.M. (Halima Mohammed); Hoosen, Anwar Ahmed; Reischl, Udo (Public Library of Science, 2011-09-22)

BACKGROUND: The LightCyclerH Mycobacterium Detection Kit based on real-time PCR technology for the detection of Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii was recently developed. This study ...
Anterior chamber paracentesis to improve diagnosis and treatment of infectious uveitis in South Africa

Schaftenaar, E.; Lecuona, K.A.; Baarsma, G.S.; Meenken, C.; Verjans, G.M.G.M.; McIntyre, J.A.; Peters, Remco P.H. (Health and Medical Publishing Group, 2015-08)

Infectious uveitis is a significant cause of blindness in South Africa, especially among HIV-infected individuals. The visual outcome of uveitis depends on early clinical and laboratory diagnosis to guide therapeutic ...
Antibiotic resistance of Mycobacterium tuberculosis complex in Africa : a systematic review of current reports of molecular epidemiology, mechanisms and diagnostics

Osei Sekyere, John; Reta, Melese Abate; Maningi, Nontuthuko Excellent; Fourie, Petrus Bernard (Elsevier, 2019-12)

BACKGROUND : Tuberculosis (TB) remains a main global public health problem. However, a systematic review of TB resistance epidemiology in Africa is wanting. METHODS : A comprehensive systematic search of PubMed, Web of ...
Antifungal susceptibility profile of yeast isolates from sterile sites at a tertiary hospital in South Africa

Makhado, Ndivhuho Agnes; Ismail, Farzana; Dangor, Yusuf; Chephe, Tlou J.H.; Hoosen, Anwar Ahmed; Nchabeleng, Maphoshane (MedPharm Publications, 2014)

Invasive infections caused by yeasts are associated with high mortality and morbidity, and resistance to antifungal agents is increasing. Candida spp. has emerged as the leading cause of systemic nosocomial fungal infections. ...
The antimicrobial effect of colistin methanesulfonate (polymyxin E) on Mycobacterium tuberculosis in vitro

Van Breda, Shane Vontelin (University of Pretoria, 2016)

Polymyxins have previously been described to have activity against M. tuberculosis (M. tb), but further research was abandoned due to systemic toxicity concerns to achieve the required MIC. Colistin methanesulfonate (CMS), ...
Antimicrobial resistance in Neisseria gonorrhoeae and Mycoplasma genitalium isolates from the private healthcare sector in South Africa : a pilot study

Maduna, Liteboho Daniel; Peters, Remco P.H.; Kingsburgh, C.; Strydom, K.A.; Kock, Marleen M. (SA MEDICAL ASSOC, 2021-10)

BACKGROUND. Reports have emerged globally of antimicrobial resistance (AMR) in Neisseria gonorrhoeae and Mycoplasma genitalium infections. In South Africa (SA), there are substantial differences between private and public ...
Antimicrobial resistance mechanisms of linezolid resistant staphylococci and enterococci collected in Gauteng, South Africa

Addison, Karen (University of Pretoria, 2019)

Staphylococci and enterococci are key human pathogens responsible for infections associated with healthcare settings. Linezolid is crucial for managing multidrug-resistant (MDR) infections. The monitoring of resistance to ...
Antimicrobial resistance of Neisseria gonorrhoeae isolates from high-risk men in Johannesburg, South Africa

Maduna, Liteboho Daniel; Kock, Marleen M.; Van der Veer, Brian M.J.W.; Radebe, Oscar; McIntyre, James; Van Alphen, Lieke B.; Peters, Remco P.H. (American Society for Microbiology, 2020-11)

Neisseria gonorrhoeae antimicrobial drug resistance has emerged worldwide; however, the situation in sub-Saharan Africa is not well documented. We investigated the molecular epidemiology and occurrence of antimicrobial ...
Antimicrobial resistance patterns of Acinetobacter baumannii and Klebsiella pneumoniae isolated from dogs presented at a veterinary academic hospital in South Africa

Sebola, Dikeledi Carol; Oguttu, James W.; Kock, Marleen M.; Qekwana, Daniel Nenene (Veterinary World, 2023-09-17)

BACKGROUND : Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic bacterial pathogens responsible for hospital-acquired infections in veterinary medicine. Infection with these bacteria always requires urgent ...
Antimicrobial susceptibility and serotype distribution of Streptococcus agalactiae rectovaginal colonising isolates from pregnant women at a tertiary hospital in Pretoria, South Africa : an observational descriptive study

Said, Mohamed; Dangor, Yusuf; Mbelle, Nontombi Marylucy; Madhi, S.A.; Kwatra, G.; Ismail, F. (Health and Medical Publishing Group, 2020-09)

BACKGROUND. Streptococcus agalactiae or group B streptococcus (GBS) is a significant cause of neonatal sepsis. Intrapartum antibiotic prophylaxis is recommended for pregnant women identified to be rectovaginally colonised ...

Now showing items 1-20 of 440

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