• In vitro evaluation of the binding activity of novel mouse IgG1 opsonic monoclonal antibodies to Mycobacterium tuberculosis and other selected mycobacterial species 

  Nyazema, Kudzai B.; Shey, Bong-Akee; Sei, Clara J.; Peters, Remco P.H.; Maningi, Nontuthuko Excellent; Fischer, Gerald W.; Fourie, P.B. (Petrus Bernardus) (Elsevier, 2024-05)

  Antimicrobial resistance alongside other challenges in tuberculosis (TB) therapeutics have stirred renewed interest in host-directed interventions, including the role of antibodies as adjunct therapeutic agents. This ...
• Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone 

  Jiang, Jianping; Cienfuegos-Galletd, Astrid V.; Long, Tengfei; Peirano, Gisele; Chu, Tingyu; Pitout, Johann D.D.; Kreiswirth, Barry N.; Chen, Liang (BMC, 2025-01)

  BACKGROUND : Klebsiella pneumoniae is one of the most prevalent pathogens responsible for multiple infections in healthcare settings and the community. K. pneumoniae CG147, primarily including ST147 (the founder ST), ST273, ...
• Sodium, potassium-adenosine triphosphatase as a potential target of the anti-tuberculosis agents, clofazimine and bedaquiline 

  Mmakola, Khomotso Madimetsa Shelboy; Balmith, Marissa [; Steel, Helen C.; Said, Mohamed; Potjo, Moliehi; Van der Mescht, Mieke Adri; Hlatshwayo, Nomsa; Meyer, Pieter Willem Adriaan; Tintinger, Gregory Ronald; Anderson, Ronald; Cholo, Moloko C. (MDPI, 2024-12-04)

  Multidrug-resistant tuberculosis (MDR-TB) patients are treated with a standardised, short World Health Organization (WHO) regimen which includes clofazimine (CFZ) and bedaquiline (BDQ) antibiotics. These two antibiotics ...
• Spiritual holy water sites in Ethiopia : unrecognized high-risk settings for transmission of pulmonary tuberculosis 

  Reta, Melese Abate; Maningi, Nontuthuko Excellent; Wubetu, Gizachew Yismaw; Olorunju, Steve A.S.; Fourie, P.B. (Petrus Bernardus) (Wiley-Hindawi, 2024-04-08)

  Ethiopia is a high-tuberculosis (TB) burden country with 157 new cases per 100,000 people, with 23,800 TB-related deaths in 2020. In Ethiopia, TB patients have different healthcare-seeking behaviors. They frequently visit ...
• Genetic diversity of Mycobacterium tuberculosis strains isolated from spiritual holy water site attendees in Northwest Ethiopia : a cross-sectional study 

  Reta, Melese Abate; Said, Halima M.; Maningi, Nontuthuko Excellent; Wubetu, Gizachew Yismaw; Agonafir, Mulualem; Fourie, P.B. (Petrus Bernardus) (Elsevier, 2024-06)

  BACKGROUND : The genetic diversity of Mycobacterium tuberculosis complex (MTBC) strains was characterized among isolates from individuals with pulmonary tuberculosis (PTB) symptoms attended holy water sites (HWSs) in the ...
• Clostridioides difficile hypervirulent strain ST1 isolated from clinical stool specimens obtained from three Provinces in South Africa 

  Shirinda, Hlambani; Smith, Anthony M.; Prinsloo, Ben; Kock, Marleen M.; Moodley, Mishalan; Ehlers, Marthie Magdaleen (Elsevier, 2025-02)

  Please read abstract in the article.
• CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli 

  Chen, Liang; Peirano, G.; Yen, Kelly; Wang, Bingjie; Terlecky, Austin; DeVinney, Rebekah; Kreiswirth, Barry N.; Pitout, Johann D.D. (American Society for Microbiology, 2024-01)

  IncF plasmids are commonly found in extra-intestinal pathogenic Escherichia coli (ExPEC) strains, serving as reservoirs for antimicrobial resistance (AMR) genes and virulence factors, persistently coexisting with ExPEC ...
• Prevalence of intestinal parasitic infections and associated factors among food handlers in East Africa : a systematic review and meta-analysis 

  Ashagre, Agenagnew; Misganaw, Tadesse; Abebe, Wagaw; Dejazmach, Zelalem; Amare, Gashaw Azanaw; Wondmagegn, Yenesew Mihret; Worku, Kassahun Misgana; Adugna, Adane; Ahmed, Hassen; Gedifie, Solomon; Kumie, Getinet; Nigatie, Marye; Jemal, Abdu; Kasahun, Woldeteklehaimanot; Ayana, Sisay; Asmare, Zelalem; Gashaw, Yalewayker; Getachew, Ermias; Gashaw, Muluken; Sisay, Assefa; Tadesse, Selamyhun; Abate, Biruk Beletew; Kidie, Atitegeb Abera; Reta, Melesse Abate (Springer, 2025-01)

  BACKGROUND : Intestinal parasitic infections are a significant public health concern, especially among food handlers, who can transmit these infections to the public through food preparation and handling. This systematic ...
• Genomics sequence data of a drug-resistant Pseudomonas aeruginosa producing Tripoli Metallo-β-lactamase 1 isolated from Sudan 

  Mohammed, Sara E.; Hamid, Omnia; Abdelrahim, Mohammed; Ismail, Arshad; Smith, Anthony M.; Allam, Mushal (Elsevier, 2024-12)

  Please read abstract in article.
• Molecular epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa hospital, South Africa 

  Osei Sekyere, John; Mmatli, Masego; Bosch, Anel; Ntsoane, Ramathetje V.; Naidoo, Harishia; Doyisa, Sinenhlanhla; Maningi, Nontuthuko Excellent; Mbelle, Nontombi Marylucy; Said, Mohamed (Frontiers Media, 2024-02)

  BACKGROUND: An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within a tertiary hospital in South Africa resulted in the mortality of 10 ...
• Editorial : Molecular mechanisms of resistance to “last resort” antimicrobials in Enterobacterales 

  Osei Sekyere, John; Schneiders, Thamarai; Majewski, Piotr (Frontiers Media, 2024-05)

  No abstract available.
• True and false positive HIV point of care test results in a prospective multinational study of at-risk African women : implications for large-scale repeat HIV testing in HIV prevention programs 

  Morrison, Susan; Batting, Joanne; Wanga, Valentine; Beesham, Ivana; Deese, Jennifer; Hofmeyr, G. Justus; Kasaro, Margaret P.; Louw, Cheryl; Morrison, Charles; Mugo, Nelly R.; Palanee-Phillips, Thesla; Pleaner, Melanie; Reddy, Krishnaveni; Scoville, Caitlin W.; Smit, Jenni; Stringer, Jeffrey S.A.; Ahmed, Khatija; Bukusi, Elizabeth; Kotze, Philip; Baeten, Jared M. (Wolters Kluwer Health, 2024-12)

  BACKGROUND : Accurate HIV point of care testing is the cornerstone of prevention and treatment efforts globally, although false (both negative and positive) results are expected to occur. SETTING : We assessed the ...
• Escherichia coli sequence type 410 with carbapenemases : a paradigm shift within E. coli toward multidrug resistance 

  Pitout, Johann D.D.; Peirano, Gisele; Matsumura, Yasufumi; DeVinney, Rebekah; Chen, Liang (American Society for Microbiology, 2024-02)

  Escherichia coli sequence type ST410 is an emerging carbapenemase-producing multidrug-resistant (MDR) high-risk One-Health clone with the potential to significantly increase carbapenem resistance among E. coli. ST410 ...
• Southern African HIV Clinicians Society guideline for the clinical management of syphilis 

  Peters, Remco P.H.; Nel, Jeremy; Sadiq, Eitzaz; Kufa, Tendesayi; Smit, Derrick P.; Sorour, Gillian; Garrett, Nigel; Gill, Katherine; Makhakhe, Lehlohonolo; Chandiwana, Nomathemba C.; Moran, Neil F.; Cohen, Karen; Wattrus, Camilla; Moosa, Mahomed Yunus (AOSIS, 2024-04-30)

  Syphilis, ‘the great imitator’, caused by Treponema pallidum infection, remains a complex and multifaceted disease with a rich history of clinical diversity. This guideline aims to be a comprehensive guide for healthcare ...
• Occurrence and characterization of ESKAPE organisms on the hands of veterinary students before patient contact at a veterinary academic hospital, South Africa 

  Sebola, Dikeledi; Oguttu, James Wabwire; Malahlela, M.N. (Mogaugedi); Kock, Marleen M.; Qekwana, Daniel Nenene (BMC, 2024-10)

  OBJECTIVE: This study aimed to investigate the presence of ESKAPE organisms on the hands of students working in the intensive care unit (ICU) at a veterinary academic hospital. METHODS: A cross-sectional study was conducted ...
• Prevalence and incidence of sexually transmitted infections among South African women initiating injectable and long-acting contraceptives 

  Harryparsad, Rushil; Meyer, Bahiah; Taku, Ongeziwe; Serrano, Myrna; Chen, Pai Lien; Gao, Xiaoming; Williamson, Anna-Lise; Mehou-Loko, Celia; D’Hellencourt, Florence Lefebvre; Smit, Jennifer; Strauss, Jerome; Nanda, Kavita; Ahmed, Khatija; Beksinska, Mags; Buck, Gregory; Morrison, Charles; Deese, Jennifer; Masson, Lindi (Public Library of Science, 2023-11-10)

  BACKGROUND : South Africa is among the countries with the highest prevalence of sexually transmitted infections (STIs), including Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). In 2017, there were an estimated ...
• Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia 

  Reta, Melese Abate; Maningi, Nontuthuko Excellent; Fourie, Bernard (Frontiers Media, 2024-03)

  PURPOSE: This study examined the patterns and frequency of genetic changes responsible for resistance to first-line (rifampicin and isoniazid), fluoroquinolones, and second-line injectable drugs in drug-resistant ...
• Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches 

  Khong, Wei Xin; Marimuthu, Kalisvar; Teo, Jeanette; Ding, Yichen; Xia, Eryu; Lee, Jia Jun; Ong, Rick Twee-Hee; Venkatachalam, Indumathi; Cherng, Benjamin; Pada, Surinder Kaur; Choong, Weng Lam; Smitasin, Nares; Ooi, Say Tat; Deepak, Rama Narayana; Kurup, Asok; Fong, Raymond; Van La, My; Tan, Thean Yen; Koh, Tse Hsien; Lin, Raymond Tzer Pin; Tan, Eng Lee; Krishnan, Prabha Unny; Singh, Siddhar; Pitout, Johann D.D.; Teo, Yik-Ying; Yang, Liang; Ng, Oon Tek (Oxford University Press, 2016-11)

  Please read abstract in the article.
• Genomic epidemiology and molecular characteristics of blaNDM-1-positive carbapenem-resistant Pseudomonas aeruginosa belonging to international high-risk clone ST773 in the Gauteng region, South Africa 

  Jung, Hyunsul; Pitout, Johann D.D.; Matsumura, Yasufumi; Strydom, Kathy-Anne; Kingsburgh, Chanel; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Springer, 2024-04)

  Please read abstract in the article.
• Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals 

  Salvador-Oke, Kafilat Taiwo; Pitout, Johann D.D.; Peirano, Gisele; Strydom, Kathy-Anne; Kingsburgh, Chanel; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Springer, 2024-11)

  This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug ...

View more