• Clostridioides difficile hypervirulent strain ST1 isolated from clinical stool specimens obtained from three Provinces in South Africa 

  Shirinda, Hlambani; Smith, Anthony M.; Prinsloo, Ben; Kock, Marleen M.; Moodley, Mishalan; Ehlers, Marthie Magdaleen (Elsevier, 2025-02)

  Please read abstract in the article.
• CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic Escherichia coli 

  Chen, Liang; Peirano, G.; Yen, Kelly; Wang, Bingjie; Terlecky, Austin; DeVinney, Rebekah; Kreiswirth, Barry N.; Pitout, Johann D.D. (American Society for Microbiology, 2024-01)

  IncF plasmids are commonly found in extra-intestinal pathogenic Escherichia coli (ExPEC) strains, serving as reservoirs for antimicrobial resistance (AMR) genes and virulence factors, persistently coexisting with ExPEC ...
• Prevalence of intestinal parasitic infections and associated factors among food handlers in East Africa : a systematic review and meta-analysis 

  Ashagre, Agenagnew; Misganaw, Tadesse; Abebe, Wagaw; Dejazmach, Zelalem; Amare, Gashaw Azanaw; Wondmagegn, Yenesew Mihret; Worku, Kassahun Misgana; Adugna, Adane; Ahmed, Hassen; Gedifie, Solomon; Kumie, Getinet; Nigatie, Marye; Jemal, Abdu; Kasahun, Woldeteklehaimanot; Ayana, Sisay; Asmare, Zelalem; Gashaw, Yalewayker; Getachew, Ermias; Gashaw, Muluken; Sisay, Assefa; Tadesse, Selamyhun; Abate, Biruk Beletew; Kidie, Atitegeb Abera; Reta, Melesse Abate (Springer, 2025-01)

  BACKGROUND : Intestinal parasitic infections are a significant public health concern, especially among food handlers, who can transmit these infections to the public through food preparation and handling. This systematic ...
• Genomics sequence data of a drug-resistant Pseudomonas aeruginosa producing Tripoli Metallo-β-lactamase 1 isolated from Sudan 

  Mohammed, Sara E.; Hamid, Omnia; Abdelrahim, Mohammed; Ismail, Arshad; Smith, Anthony M.; Allam, Mushal (Elsevier, 2024-12)

  Please read abstract in article.
• Molecular epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa hospital, South Africa 

  Osei Sekyere, John; Mmatli, Masego; Bosch, Anel; Ntsoane, Ramathetje V.; Naidoo, Harishia; Doyisa, Sinenhlanhla; Maningi, Nontuthuko Excellent; Mbelle, Nontombi Marylucy; Said, Mohamed (Frontiers Media, 2024-02)

  BACKGROUND: An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within a tertiary hospital in South Africa resulted in the mortality of 10 ...
• Editorial : Molecular mechanisms of resistance to “last resort” antimicrobials in Enterobacterales 

  Osei Sekyere, John; Schneiders, Thamarai; Majewski, Piotr (Frontiers Media, 2024-05)

  No abstract available.
• True and false positive HIV point of care test results in a prospective multinational study of at-risk African women : implications for large-scale repeat HIV testing in HIV prevention programs 

  Morrison, Susan; Batting, Joanne; Wanga, Valentine; Beesham, Ivana; Deese, Jennifer; Hofmeyr, G. Justus; Kasaro, Margaret P.; Louw, Cheryl; Morrison, Charles; Mugo, Nelly R.; Palanee-Phillips, Thesla; Pleaner, Melanie; Reddy, Krishnaveni; Scoville, Caitlin W.; Smit, Jenni; Stringer, Jeffrey S.A.; Ahmed, Khatija; Bukusi, Elizabeth; Kotze, Philip; Baeten, Jared M. (Wolters Kluwer Health, 2024-12)

  BACKGROUND : Accurate HIV point of care testing is the cornerstone of prevention and treatment efforts globally, although false (both negative and positive) results are expected to occur. SETTING : We assessed the ...
• Escherichia coli sequence type 410 with carbapenemases : a paradigm shift within E. coli toward multidrug resistance 

  Pitout, Johann D.D.; Peirano, Gisele; Matsumura, Yasufumi; DeVinney, Rebekah; Chen, Liang (American Society for Microbiology, 2024-02)

  Escherichia coli sequence type ST410 is an emerging carbapenemase-producing multidrug-resistant (MDR) high-risk One-Health clone with the potential to significantly increase carbapenem resistance among E. coli. ST410 ...
• Southern African HIV Clinicians Society guideline for the clinical management of syphilis 

  Peters, Remco P.H.; Nel, Jeremy; Sadiq, Eitzaz; Kufa, Tendesayi; Smit, Derrick P.; Sorour, Gillian; Garrett, Nigel; Gill, Katherine; Makhakhe, Lehlohonolo; Chandiwana, Nomathemba C.; Moran, Neil F.; Cohen, Karen; Wattrus, Camilla; Moosa, Mahomed Yunus (AOSIS, 2024-04-30)

  Syphilis, ‘the great imitator’, caused by Treponema pallidum infection, remains a complex and multifaceted disease with a rich history of clinical diversity. This guideline aims to be a comprehensive guide for healthcare ...
• Occurrence and characterization of ESKAPE organisms on the hands of veterinary students before patient contact at a veterinary academic hospital, South Africa 

  Sebola, Dikeledi; Oguttu, James Wabwire; Malahlela, M.N. (Mogaugedi); Kock, Marleen M.; Qekwana, Daniel Nenene (BMC, 2024-10)

  OBJECTIVE: This study aimed to investigate the presence of ESKAPE organisms on the hands of students working in the intensive care unit (ICU) at a veterinary academic hospital. METHODS: A cross-sectional study was conducted ...
• Prevalence and incidence of sexually transmitted infections among South African women initiating injectable and long-acting contraceptives 

  Harryparsad, Rushil; Meyer, Bahiah; Taku, Ongeziwe; Serrano, Myrna; Chen, Pai Lien; Gao, Xiaoming; Williamson, Anna-Lise; Mehou-Loko, Celia; D’Hellencourt, Florence Lefebvre; Smit, Jennifer; Strauss, Jerome; Nanda, Kavita; Ahmed, Khatija; Beksinska, Mags; Buck, Gregory; Morrison, Charles; Deese, Jennifer; Masson, Lindi (Public Library of Science, 2023-11-10)

  BACKGROUND : South Africa is among the countries with the highest prevalence of sexually transmitted infections (STIs), including Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). In 2017, there were an estimated ...
• Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia 

  Reta, Melese Abate; Maningi, Nontuthuko Excellent; Fourie, Bernard (Frontiers Media, 2024-03)

  PURPOSE: This study examined the patterns and frequency of genetic changes responsible for resistance to first-line (rifampicin and isoniazid), fluoroquinolones, and second-line injectable drugs in drug-resistant ...
• Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches 

  Khong, Wei Xin; Marimuthu, Kalisvar; Teo, Jeanette; Ding, Yichen; Xia, Eryu; Lee, Jia Jun; Ong, Rick Twee-Hee; Venkatachalam, Indumathi; Cherng, Benjamin; Pada, Surinder Kaur; Choong, Weng Lam; Smitasin, Nares; Ooi, Say Tat; Deepak, Rama Narayana; Kurup, Asok; Fong, Raymond; Van La, My; Tan, Thean Yen; Koh, Tse Hsien; Lin, Raymond Tzer Pin; Tan, Eng Lee; Krishnan, Prabha Unny; Singh, Siddhar; Pitout, Johann D.D.; Teo, Yik-Ying; Yang, Liang; Ng, Oon Tek (Oxford University Press, 2016-11)

  Please read abstract in the article.
• Genomic epidemiology and molecular characteristics of blaNDM-1-positive carbapenem-resistant Pseudomonas aeruginosa belonging to international high-risk clone ST773 in the Gauteng region, South Africa 

  Jung, Hyunsul; Pitout, Johann D.D.; Matsumura, Yasufumi; Strydom, Kathy-Anne; Kingsburgh, Chanel; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Springer, 2024-04)

  Please read abstract in the article.
• Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals 

  Salvador-Oke, Kafilat Taiwo; Pitout, Johann D.D.; Peirano, Gisele; Strydom, Kathy-Anne; Kingsburgh, Chanel; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Springer, 2024-11)

  This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug ...
• Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005) : a post-hoc analysis of a randomised, phase 1b–2a trial 

  Madhi, Shabir A.; Kwatra, Gaurav; Richardson, Simone I.; Koen, Anthonet L.; Baillie, Vicky; Cutland, Clare L.; Fairlie, Lee; Padayachee, Sherman D.; Dheda, Keertan; Barnabas, Shaun L.; Bhorat, Qasim Ebrahim; Briner, Carmen; Ahmed, Khatija; Aley, Parvinder K.; Bhikha, Sutika; Bhorat, A.E.; Esmail, Aliasgar; Horne, Elizea; Kaldine, Haajira; Mukendi, Christian K.; Madzorera, Vimbai Sharon; Manamela, Nelia; Masilela, Mduduzi; Hermanus, S. Tandile; Motlou, Thopisang; Mzindle, Nonkululeko; Oelofse, Suzette; Patel, Faeezah; Rhead, Sarah; Rossouw, Lindie; Taoushanis, Carol; Van Eck, Samuel; Lambe, Teresa; Gilbert, Sarah C.; Pollard, Andrew J.; Moore, Penny L.; Izu, Alane (Elsevier, 2023-03)

  BACKGROUND : COVID-19 vaccine rollout is lagging in Africa, where there has been a high rate of SARS-CoV-2 infection. We aimed to evaluate the effect of SARS-CoV-2 infection before vaccination with the ChAdOx-nCoV19 (AZD1222) ...
• Global diversity and antimicrobial resistance of typhoid fever pathogens : insights from a meta-analysis of 13,000 Salmonella Typhi genomes 

  Carey, Megan E.; Dyson, Zoe A.; Ingle, Danielle J.; Amir, Afreenish; Aworh, Mabel K.; Chattaway, Marie Anne; Chew, Ka Lip; Crump, John A.; Feasey, Nicholas A.; Howden, Benjamin P.; Keddy, Karen H.; Maes, Mailis; Parry, Christopher M.; Van Puyvelde, Sandra; Webb, Hattie E.; Afolayan, Ayorinde Oluwatobiloba; Alexander, Anna P.; Anandan, Shalini; Andrews, Jason R.; Ashton, Philip M.; Basnyat, Buddha; Bavdekar, Ashish; Bogoch, Isaac I.; Clemens, John D.; Da Silva, Kesia Esther; De Ligt, Joep; Guevara, Paula Lucia Diaz; Dolecek, Christiane; Dutta, Shanta; Ehlers, Marthie Magdaleen; Watkins, Louise Francois; Garrett, Denise O.; Godbole, Gauri; Gordon, Melita A.; Greenhill, Andrew R.; Griffin, Chelsey; Gupta, Madhu; Hendriksen, Rene S.; Heyderman, Robert S.; Hooda, Yogesh; Hormazabal, Juan Carlos; Ikhimiukor, Odion O.; Iqbal, Junaid; Jacob, Jobin John; Jenkins, Claire; Jinka, Dasaratha Ramaiah; John, Jacob; Kang, Gagandeep; Kanteh, Abdoulie; Kapil, Arti; Karkey, Abhilasha; Kariuki, Samuel; Kingsley, Robert A.; Mary Koshy, Roshney; Lauer, A.C.; Levine, Myron M.; Lingegowda, Ravikumar Kadahalli; Luby, Stephen P.; Mackenzie, Grant Austin; Mashe, Tapfumanei; Msefula, Chisomo; Mutreja, Ankur; Nagaraj, Geetha; Nagaraj, Savitha; Nair, Satheesh; Naseri, Take K.; Nimarota-Brown, Susana; Njamkepo, Elisabeth; Okeke, Iruka N.; Perumal, Sulochana Putli Bai; Pollard, Andrew J.; Pragasam, Agila Kumari; Qadri, Firdausi; Qamar, Farah N.; Rahman, Sadia Isfat Ara; Rambocus, Savitra Devi; Rasko, David A.; Ray, Pallab; Robins-Browne, Roy; Rongsen-Chandola, Temsunaro; Rutanga, Jean Pierre; Saha, Samir K.; Saha, Senjuti; Saigal, Karnika; Sajib, Mohammad Saiful Islam; Seidman, Jessica C.; Shakya, Jivan; Shamanna, Varun; Shastri, Jayanthi; Shrestha, Rajeev; Sia, Sonia; Sikorski, Michael J.; Singh, Ashita; Smith, .Anthony M.; Tagg, Kaitlin A.; Tamrakar, Dipesh; Tanmoy, Arif Mohammed; Thomas, Maria; Thomas, Mathew S.; Thomsen, Robert; Thomson, Nicholas R.; Tupua, Siaosi; Vaidya, Krista; Valcanis, Mary; Veeraraghavan, Balaji; Weill, Francois-Xavier; Wright, Jackie; Dougan, Gordon; Argimon, Silvia; Keane, Jacqueline A.; Aanensen, David M.; Baker, Stephen; Holt, Kathryn E.; Global Typhoid Genomics Consortium Group Authorship (eLife Sciences Publications, 2023-09-12)

  BACKGROUND : The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health ...
• [18F]FDG PET and CT findings at therapy completion of pulmonary tuberculosis: comparison between HIV-positive and HIV-negative patients and impact on treatment response assessment 

  Ismaila, Aisha; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mathebula, Matsontso; Moagi, Ingrid; Mokoala, Kgomotso M.G.; Honest, Ndlovu; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hikuam, Chris; Hatherill, Mark; Fourie, P.B. (Petrus Bernardus); Sathekge, Mike Machaba (Springer, 2024-12)

  BACKGROUND : [18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...
• Prevalence of carbapenem-resistant gram-negative bacteria among neonates suspected for sepsis in Africa : a systematic review and meta-analysis 

  Sisay, Assefa; Asmare, Zelalem; Kumie, Getinet; Gashaw, Yalewayker; Getachew, Ermias; Ashagre, Agenagnew; Nigatie, Marye; Ayana, Sisay; Misganaw, Tadesse; Dejazmach, Zelalem; Abebe, Wagaw; Gedfie, Solomon; Tadesse, Selamyhun; Gashaw, Muluken; Jemal, Abdu; Kassahun, Woldeteklehymanot; Kidie, Atitegeb Abera; Abate, Biruk Beletew; Mulugeta, Chalie; Alamrew, Abebaw; Reta, Melese Abate (BMC, 2024-08)

  BACKGROUND: The emergence and rapid spread of gram-negative bacteria resistant to carbapenems among newborns is concerning on a global scale. Nonetheless, the pooled estimate of gram-negative bacteria resistant to carbapenem ...
• Extended clinical sample incubation in the cepheid Xpert MTB/XDR test sample reagent : enhancing flexibility and workflows in high-volume laboratories 

  Qumbelo, Yamkela; Kachingwe, Elizabeth; Omar, Shaheed Vally (Elsevier, 2024-12)

  Cepheid Xpert MTB/RIF ULTRA (ULTRA) and Xpert MTB/XDR are tests for detecting Mycobacterium tuberculosis (MTB) and drug resistance. Both tests involve a sample pre-processing step using the test's sample reagent (SR). The ...

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