• Molecular epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa hospital, South Africa 

  Osei Sekyere, John; Mmatli, Masego; Bosch, Anel; Ntsoane, Ramathetje V.; Naidoo, Harishia; Doyisa, Sinenhlanhla; Maningi, Nontuthuko Excellent; Mbelle, Nontombi Marylucy; Said, Mohamed (Frontiers Media, 2024-02)

  BACKGROUND: An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within a tertiary hospital in South Africa resulted in the mortality of 10 ...
• Editorial : Molecular mechanisms of resistance to “last resort” antimicrobials in Enterobacterales 

  Osei Sekyere, John; Schneiders, Thamarai; Majewski, Piotr (Frontiers Media, 2024-05)

  No abstract available.
• True and false positive HIV point of care test results in a prospective multinational study of at-risk African women : implications for large-scale repeat HIV testing in HIV prevention programs 

  Morrison, Susan; Batting, Joanne; Wanga, Valentine; Beesham, Ivana; Deese, Jennifer; Hofmeyr, G. Justus; Kasaro, Margaret P.; Louw, Cheryl; Morrison, Charles; Mugo, Nelly R.; Palanee-Phillips, Thesla; Pleaner, Melanie; Reddy, Krishnaveni; Scoville, Caitlin W.; Smit, Jenni; Stringer, Jeffrey S.A.; Ahmed, Khatija; Bukusi, Elizabeth; Kotze, Philip; Baeten, Jared M. (Wolters Kluwer Health, 2024-12)

  BACKGROUND : Accurate HIV point of care testing is the cornerstone of prevention and treatment efforts globally, although false (both negative and positive) results are expected to occur. SETTING : We assessed the ...
• Escherichia coli sequence type 410 with carbapenemases : a paradigm shift within E. coli toward multidrug resistance 

  Pitout, Johann D.D.; Peirano, Gisele; Matsumura, Yasufumi; DeVinney, Rebekah; Chen, Liang (American Society for Microbiology, 2024-02)

  Escherichia coli sequence type ST410 is an emerging carbapenemase-producing multidrug-resistant (MDR) high-risk One-Health clone with the potential to significantly increase carbapenem resistance among E. coli. ST410 ...
• Southern African HIV Clinicians Society guideline for the clinical management of syphilis 

  Peters, Remco P.H.; Nel, Jeremy; Sadiq, Eitzaz; Kufa, Tendesayi; Smit, Derrick P.; Sorour, Gillian; Garrett, Nigel; Gill, Katherine; Makhakhe, Lehlohonolo; Chandiwana, Nomathemba C.; Moran, Neil F.; Cohen, Karen; Wattrus, Camilla; Moosa, Mahomed Yunus (AOSIS, 2024-04-30)

  Syphilis, ‘the great imitator’, caused by Treponema pallidum infection, remains a complex and multifaceted disease with a rich history of clinical diversity. This guideline aims to be a comprehensive guide for healthcare ...
• Occurrence and characterization of ESKAPE organisms on the hands of veterinary students before patient contact at a veterinary academic hospital, South Africa 

  Sebola, Dikeledi; Oguttu, James Wabwire; Malahlela, M.N. (Mogaugedi); Kock, Marleen M.; Qekwana, Daniel N. (BMC, 2024-10)

  OBJECTIVE: This study aimed to investigate the presence of ESKAPE organisms on the hands of students working in the intensive care unit (ICU) at a veterinary academic hospital. METHODS: A cross-sectional study was conducted ...
• Prevalence and incidence of sexually transmitted infections among South African women initiating injectable and long-acting contraceptives 

  Harryparsad, Rushil; Meyer, Bahiah; Taku, Ongeziwe; Serrano, Myrna; Chen, Pai Lien; Gao, Xiaoming; Williamson, Anna-Lise; Mehou-Loko, Celia; D’Hellencourt, Florence Lefebvre; Smit, Jennifer; Strauss, Jerome; Nanda, Kavita; Ahmed, Khatija; Beksinska, Mags; Buck, Gregory; Morrison, Charles; Deese, Jennifer; Masson, Lindi (Public Library of Science, 2023-11-10)

  BACKGROUND : South Africa is among the countries with the highest prevalence of sexually transmitted infections (STIs), including Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). In 2017, there were an estimated ...
• Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia 

  Reta, Melese Abate; Maningi, Nontuthuko Excellent; Fourie, Bernard (Frontiers Media, 2024-03)

  PURPOSE: This study examined the patterns and frequency of genetic changes responsible for resistance to first-line (rifampicin and isoniazid), fluoroquinolones, and second-line injectable drugs in drug-resistant ...
• Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches 

  Khong, Wei Xin; Marimuthu, Kalisvar; Teo, Jeanette; Ding, Yichen; Xia, Eryu; Lee, Jia Jun; Ong, Rick Twee-Hee; Venkatachalam, Indumathi; Cherng, Benjamin; Pada, Surinder Kaur; Choong, Weng Lam; Smitasin, Nares; Ooi, Say Tat; Deepak, Rama Narayana; Kurup, Asok; Fong, Raymond; Van La, My; Tan, Thean Yen; Koh, Tse Hsien; Lin, Raymond Tzer Pin; Tan, Eng Lee; Krishnan, Prabha Unny; Singh, Siddhar; Pitout, Johann D.D.; Teo, Yik-Ying; Yang, Liang; Ng, Oon Tek (Oxford University Press, 2016-11)

  Please read abstract in the article.
• Genomic epidemiology and molecular characteristics of blaNDM-1-positive carbapenem-resistant Pseudomonas aeruginosa belonging to international high-risk clone ST773 in the Gauteng region, South Africa 

  Jung, Hyunsul; Pitout, Johann D.D.; Matsumura, Yasufumi; Strydom, Kathy-Anne; Kingsburgh, Chanel; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Springer, 2024-04)

  Please read abstract in the article.
• Klebsiella pneumoniae with carbapenemases : high prevalence of sequence type 307 with blaOXA181 in South African community hospitals 

  Salvador-Oke, Kafilat Taiwo; Pitout, Johann D.D.; Peirano, Gisele; Strydom, Kathy-Anne; Kingsburgh, Chanel; Ehlers, Marthie Magdaleen; Kock, Marleen M. (Springer, 2024-09)

  This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug ...
• Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005) : a post-hoc analysis of a randomised, phase 1b–2a trial 

  Madhi, Shabir A.; Kwatra, Gaurav; Richardson, Simone I.; Koen, Anthonet L.; Baillie, Vicky; Cutland, Clare L.; Fairlie, Lee; Padayachee, Sherman D.; Dheda, Keertan; Barnabas, Shaun L.; Bhorat, Qasim Ebrahim; Briner, Carmen; Ahmed, Khatija; Aley, Parvinder K.; Bhikha, Sutika; Bhorat, A.E.; Esmail, Aliasgar; Horne, Elizea; Kaldine, Haajira; Mukendi, Christian K.; Madzorera, Vimbai Sharon; Manamela, Nelia; Masilela, Mduduzi; Hermanus, S. Tandile; Motlou, Thopisang; Mzindle, Nonkululeko; Oelofse, Suzette; Patel, Faeezah; Rhead, Sarah; Rossouw, Lindie; Taoushanis, Carol; Van Eck, Samuel; Lambe, Teresa; Gilbert, Sarah C.; Pollard, Andrew J.; Moore, Penny L.; Izu, Alane (Elsevier, 2023-03)

  BACKGROUND : COVID-19 vaccine rollout is lagging in Africa, where there has been a high rate of SARS-CoV-2 infection. We aimed to evaluate the effect of SARS-CoV-2 infection before vaccination with the ChAdOx-nCoV19 (AZD1222) ...
• Global diversity and antimicrobial resistance of typhoid fever pathogens : insights from a meta-analysis of 13,000 Salmonella Typhi genomes 

  Carey, Megan E.; Dyson, Zoe A.; Ingle, Danielle J.; Amir, Afreenish; Aworh, Mabel K.; Chattaway, Marie Anne; Chew, Ka Lip; Crump, John A.; Feasey, Nicholas A.; Howden, Benjamin P.; Keddy, Karen H.; Maes, Mailis; Parry, Christopher M.; Van Puyvelde, Sandra; Webb, Hattie E.; Afolayan, Ayorinde Oluwatobiloba; Alexander, Anna P.; Anandan, Shalini; Andrews, Jason R.; Ashton, Philip M.; Basnyat, Buddha; Bavdekar, Ashish; Bogoch, Isaac I.; Clemens, John D.; Da Silva, Kesia Esther; De Ligt, Joep; Guevara, Paula Lucia Diaz; Dolecek, Christiane; Dutta, Shanta; Ehlers, Marthie Magdaleen; Watkins, Louise Francois; Garrett, Denise O.; Godbole, Gauri; Gordon, Melita A.; Greenhill, Andrew R.; Griffin, Chelsey; Gupta, Madhu; Hendriksen, Rene S.; Heyderman, Robert S.; Hooda, Yogesh; Hormazabal, Juan Carlos; Ikhimiukor, Odion O.; Iqbal, Junaid; Jacob, Jobin John; Jenkins, Claire; Jinka, Dasaratha Ramaiah; John, Jacob; Kang, Gagandeep; Kanteh, Abdoulie; Kapil, Arti; Karkey, Abhilasha; Kariuki, Samuel; Kingsley, Robert A.; Mary Koshy, Roshney; Lauer, A.C.; Levine, Myron M.; Lingegowda, Ravikumar Kadahalli; Luby, Stephen P.; Mackenzie, Grant Austin; Mashe, Tapfumanei; Msefula, Chisomo; Mutreja, Ankur; Nagaraj, Geetha; Nagaraj, Savitha; Nair, Satheesh; Naseri, Take K.; Nimarota-Brown, Susana; Njamkepo, Elisabeth; Okeke, Iruka N.; Perumal, Sulochana Putli Bai; Pollard, Andrew J.; Pragasam, Agila Kumari; Qadri, Firdausi; Qamar, Farah N.; Rahman, Sadia Isfat Ara; Rambocus, Savitra Devi; Rasko, David A.; Ray, Pallab; Robins-Browne, Roy; Rongsen-Chandola, Temsunaro; Rutanga, Jean Pierre; Saha, Samir K.; Saha, Senjuti; Saigal, Karnika; Sajib, Mohammad Saiful Islam; Seidman, Jessica C.; Shakya, Jivan; Shamanna, Varun; Shastri, Jayanthi; Shrestha, Rajeev; Sia, Sonia; Sikorski, Michael J.; Singh, Ashita; Smith, .Anthony M.; Tagg, Kaitlin A.; Tamrakar, Dipesh; Tanmoy, Arif Mohammed; Thomas, Maria; Thomas, Mathew S.; Thomsen, Robert; Thomson, Nicholas R.; Tupua, Siaosi; Vaidya, Krista; Valcanis, Mary; Veeraraghavan, Balaji; Weill, Francois-Xavier; Wright, Jackie; Dougan, Gordon; Argimon, Silvia; Keane, Jacqueline A.; Aanensen, David M.; Baker, Stephen; Holt, Kathryn E.; Global Typhoid Genomics Consortium Group Authorship (eLife Sciences Publications, 2023-09-12)

  BACKGROUND : The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health ...
• [18F]FDG PET and CT findings at therapy completion of pulmonary tuberculosis: comparison between HIV-positive and HIV-negative patients and impact on treatment response assessment 

  Ismaila, Aisha; Lawal, Ismaheel Opeyemi; Popoola, Gbenga O.; Mathebula, Matsontso; Moagi, Ingrid; Mokoala, Kgomotso M.G.; Honest, Ndlovu; Moeketsi, Nontando; Nchabeleng, Maphoshane; Hikuam, Chris; Hatherill, Mark; Fourie, P.B. (Petrus Bernardus); Sathekge, Mike Machaba (Springer, 2024)

  BACKGROUND : [18F]FDG-PET/CT is a sensitive non-invasive tool for assessing treatment response in patients with pulmonary tuberculosis. The data on the performance of [18F]FDG-PET/CT for response assessment among patients ...
• Prevalence of carbapenem-resistant gram-negative bacteria among neonates suspected for sepsis in Africa : a systematic review and meta-analysis 

  Sisay, Assefa; Asmare, Zelalem; Kumie, Getinet; Gashaw, Yalewayker; Getachew, Ermias; Ashagre, Agenagnew; Nigatie, Marye; Ayana, Sisay; Misganaw, Tadesse; Dejazmach, Zelalem; Abebe, Wagaw; Gedfie, Solomon; Tadesse, Selamyhun; Gashaw, Muluken; Jemal, Abdu; Kassahun, Woldeteklehymanot; Kidie, Atitegeb Abera; Abate, Biruk Beletew; Mulugeta, Chalie; Alamrew, Abebaw; Reta, Melese Abate (BMC, 2024-08)

  BACKGROUND: The emergence and rapid spread of gram-negative bacteria resistant to carbapenems among newborns is concerning on a global scale. Nonetheless, the pooled estimate of gram-negative bacteria resistant to carbapenem ...
• Extended clinical sample incubation in the cepheid Xpert MTB/XDR test sample reagent : enhancing flexibility and workflows in high-volume laboratories 

  Qumbelo, Yamkela; Kachingwe, Elizabeth; Omar, Shaheed Vally (Elsevier, 2024-12)

  Cepheid Xpert MTB/RIF ULTRA (ULTRA) and Xpert MTB/XDR are tests for detecting Mycobacterium tuberculosis (MTB) and drug resistance. Both tests involve a sample pre-processing step using the test's sample reagent (SR). The ...
• Association of diabetes, smoking, and alcohol use with subclinical-to-symptomatic spectrum of tuberculosis in 16 countries: an individual participant data meta-analysis of national tuberculosis prevalence surveys 

  Hamada, Yohhei; Quartagno, Matteo; Law, Irwin; Malik, Farihah; Bonsu, Frank Adae; Adetifa, Ifedayo M.O.; Adusi-Poku, Yaw; D’Alessandro, Umberto; Bashorun, Adedapo Olufemi; Begum, Vikarunnessa; Lolong, Dina Bisara; Boldoo, Tsolmon; Dlamini, Themba; Donkor, Simon; Dwihardiani, Bintari; Egwaga, Saidi; Farid, Muhammad N.; Garfin, Anna Marie Celina G.; Gaviola, Donna Mae G.; Husain, Mohammad Mushtuq; Ismail, Farzana; Kaggwa, Mugagga; Kamara, Deus V.; Kasozi, Samuel; Kaswaswa, Kruger; Kirenga, Bruce; Klinkenberg, Eveline; Kondo, Zuweina; Lawanson, Adebola; Macheque, David; Manhiça, Ivan; Maama-Maime, Llang Bridget; Mfinanga, Sayoki; Moyo, Sizulu; Mpunga, James; Mthiyane, Thuli; Mustikawati, Dyah Erti; Mvusi, Lindiwe; Nguyen, Hoa Binh; Nguyen, Hai Viet; Pangaribuan, Lamria; Patrobas, Philip; Rahman, Mahmudur; Rahman, Mahbubur; Rahman, Mohammed Sayeedur; Raleting, Thato; Riono, Pandu; Ruswa, Nunurai; Rutebemberwa, Elizeus; Rwabinumi, Mugabe Frank; Senkoro, Mbazi; Sharif, Ahmad Raihan; Sikhondze, Welile; Sismanidis, Charalambos; Sovd, Tugsdelger; Stavia, Turyahabwe; Sultana, Sabera; Suriani, Oster; Thomas, Albertina Martha; Tobing, Kristina; Van der Walt, Martie; Walusimbi, Simon; Zaman, Mohammad Mostafa; Floyd, Katherine; Copas, Andrew; Abubakar, Ibrahim; Rangaka, Molebogeng X. (Elsevier, 2023-09)

  BACKGROUND Non-communicable diseases (NCDs) and NCD risk factors, such as smoking, increase the risk for tuberculosis (TB). Data are scarce on the risk of prevalent TB associated with these factors in the context ...
• Strategies to close the PrEP uptake gap among transgender people and men who have sex with men in Tshwane, South Africa : perspectives from the community 

  Perez-Urbano, India; Dilraj, Athmanundh; Pitsi, Annah; Hlongwane, Naomi; Abdelatif, Nada; Dietrich, Janan; Ahmed, Khatija (Springer, 2024-06)

  HIV Pre-exposure Prophylaxis (PrEP) uptake among transgender (TG) people and gay men and other men who have sex with men (MSM) remains low, despite South Africa being the first African country to approve PrEP. This ...
• Usability of a novel lateral flow assay for the point-of-care detection of Neisseria gonorrhoeae : a qualitative time-series assessment among healthcare workers in South Africa 

  De Vos, Lindsey; Daniels, Joseph; Gebengu, Avuyonke; Mazzola, Laura; Gleeson, Birgitta; Piton, Jeremie; Mdingi, Mandisa; Gigi, Ranjana; Ferreyra, Cecilia; Peters, Remco P.H. (Public Library of Science, 2023-06-02)

  Accurate and user-friendly rapid point-of-care diagnostic tests (POCT) are needed to optimize treatment of Neisseria gonorrhoeae, especially in low-resource settings where syndromic management is the standard of care for ...
• Prospective acceptability of a multipurpose technology (MPT) implant in preclinical development to prevent HIV and unplanned pregnancy : qualitative insights from women end users and health care providers in South Africa and Zimbabwe 

  Nkomo, Sikhanyisiwe; Makoni, Wanzirai; Shapley-Quinn, Mary Kate; Luecke, Ellen; Mbatsane, Enough; Manenzhe, Kgahlisho; Ahmed, Khatija; Johnson, Leah M.; Mahaka, Imelda; Van der Straten, Ariane (Public Library of Science, 2023-06)

  BACKGROUND : Given the high rates of both HIV and unintended pregnancies in sub-Saharan Africa, the SCHIELD program aims to develop a multipurpose technology implant for HIV and pregnancy prevention. An end-user evaluation ...

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