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Browsing Biochemistry by Type "Thesis"
Now showing items 1-20 of 50
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(University of Pretoria, 2011-10-24)Ultra-high throughput DNA sequencing technologies have rapidly changed the face of genomic research projects. Technologies such as mRNA-Seq have the potential to rapidly profile the expressed gene-catalog of non-model ...
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(University of Pretoria, 2010-10-23)South Africa currently has the highest incidence of TB per 100 000 people in the world. In 2007 alone 112 000 people died of TB in South Africa, of which 94 000 were co-infected with HIV. Although TB treatments exist, poor ...
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(University of Pretoria, 2009-06-02)Accurate diagnosis of active tuberculosis is required to improve treatment, reduce transmission of the disease and control the emergence of drug resistance. A rapid and reliable test would make a considerable contribution ...
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(University of Pretoria, 2013)Background: HIV/AIDS is one of the most devastating diseases in the world with approximately 36 million people living with the virus in 2012 and approximately 2.7 million new infections in that same year. Antiretroviral ...
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(University of Pretoria, 2006-03-01)In this study we investigated methods to increase tea quality by developing quality markers for the breeder, as well as methods to improve quality during the manufacturing process. The compounds investigated for identifying ...
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(University of Pretoria, 2011-06-27)Most studies on innate immunity in ticks have focused on the antimicrobial peptides from hemolymph, such as defensins and lysozyme, while less is known about bacterial recognition molecules, or antimicrobial mechanisms in ...
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(University of Pretoria, 2011)Malaria is prevalent in over 100 countries which is populated by half of the world’s population and culminates in approximately one million deaths per annum, 85% of which occurs in sub-Saharan Africa. The combined resistance ...
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(University of Pretoria, 2012-06-07)Plasmodium falciparum causes the most severe form of human malaria, and the continual development of resistance of this parasite to current anti-malarial drugs underpins a pressing need for the discovery of novel ...
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(University of Pretoria, 2017)The main focus of this research was to study in detail the selected plant growth promoting bacteria (PGPR) from Bacillus group. PGPR have been described as possible solution to the negative effects of chemicals fertilizers ...
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(University of Pretoria, 2013)Thermus bacteria are of special interest because of their ability to live in high temperature environments. Their enzymes exhibit higher and stable activity in industry as compared to mesophilic or synthetic counterparts. ...
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Comparing biochemical and biophysical methodologies for the characterization of induced cell death (University of Pretoria, 2015)Background: In specific circumstances, the induction of cell death can be an appropriate treatment of disease. Cell death can occur because of internal programming or external stress caused by infection, radiation or ...
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(University of Pretoria, 2007-05-02)The high incidence of malaria, coupled to the increasing occurrence of parasite resistance against commonly used anti-malaria drugs and the absence of an effective vaccine, makes the implementation of alternative strategies ...
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(University of Pretoria, 2020)Diabetes mellitus which is characterized by a high levels of blood glucose is a major source of mortality, morbidity and health costs worldwide. Major gaps exist in efforts to comprehend the burden nationally and globally, ...
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(University of Pretoria, 2013-05-17)Although conventional two-dimensional (2D) cell culture is convenient for routine work, researchers are turning to three-dimensional (3D) cell culture for more accurate, physiologically representative information on the ...
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(University of Pretoria, 2013)Nitric oxide is a small diatomic molecule and is part of the nitrogen radical species. As a gas, it diffuses easily across cell membranes and is involved in numerous physiological processes and inflammation. This peculiar ...
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(University of Pretoria, 2005-09-05)African horse sickness (AHS) is a lethal disease of horses. The aetiological agent is African horsesickness virus (AHSV) (genus Orbivirus; family: Reoviridae). Immunity to all nine serotypes is needed for full protection. ...
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(University of Pretoria, 2009-06-02)Malaria affects the daily lives of more than 2 billion people worldwide and has been estimated to result in 300-500 million clinical cases annually leading to approximately 2 million deaths, mainly caused by the most ...
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(University of Pretoria, 2009-06-02)Structural biology forms the basis of all functions in an organism from how enzymes work to how a cell is assembled. In silico structural biology has been a rather isolated domain due to the perceived difficulty of working ...
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(University of Pretoria, 2018)Metagenomic approaches have revealed the complexity of environmental microbiomes and the advancement in whole genome sequencing showed a significant level of genetic heterogeneity on species level. It has become clear that ...
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(University of Pretoria, 2013)Bacterial diversity has always been associated with micro-evolutionary events such as horizontal gene transfer and DNA mutations. Such events influence the rapid evolution of bacteria as a result of the environmental ...
Now showing items 1-20 of 50