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Browsing Biochemistry by Type "Dissertation"
Now showing items 1-20 of 120
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(University of Pretoria, 2018)The aim of this study was to create a genomic resource for a typical plant genome from Illumina short reads, using Psidium guajava as a case study. Here we present a bioinformatics approach to produce a de novo plant genome ...
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(University of Pretoria, 2008-07-04)The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be ...
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(University of Pretoria, 2011-10-24)Genetic polymorphisms can be seen as the occurrence of more than one form of a DNA- or protein sequence at a single locus in a group of organisms, where these different forms occur more frequently than can be attributed ...
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(University of Pretoria, 2018-12-06)The growing occurrence of antimicrobial resistance (AMR) is a global cause for concern due to the decreased availability of effective antimicrobial drugs. Therefore, treating resistant infections can become costly or even ...
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(University of Pretoria, 2015)Lipopolysaccharides (LPS), when released from the outer membrane of Gram-negative bacteria, bind to macrophages, inducing production of pro-inflammatory cytokines and mediator molecules. In addition, associated overproduction ...
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(University of Pretoria, 2006-05-19)The need for new anti- TB drugs is increasingly rising because of the resistance of M. tuberculosis to existing drugs. The mycobacterial cell wall serves as an impermeable protective barrier for the bacilli from toxins and ...
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The Antiatherogenic Potential of Two triterpenes from Protorhus longifolia stem bark (Benrh.) Engl. (University of Pretoria, 2024-01)Atherocardiovascular diseases (ACVDs) are considered among the major causes of death in South Africa and worldwide. Hypercholesterolemia, which is the main major risk factor of atherosclerosis, increases the occurrence of ...
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(University of Pretoria, 2022-01)The disastrous effects of the foodborne pathogen Listeria monocytogenes have been observed overtime by global listeriosis outbreaks claiming many lives. The spread of this pathogen is being reported at high levels with ...
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(University of Pretoria, 2020-07)Candida albicans is a fungus found in the normal biota of humans, but in immuno-compromised individuals, C. albicans forms complex biofilms on the surface of medical prosthetics, skin, oral cavities, the urinary tract, ...
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(University of Pretoria, 2008-08-14)Malaria is the cause of over one million deaths per year, primarily in African children. The parasite responsible for the most virulent form of malaria, is Plasmodium falciparum. Protein structure plays a pivotal role in ...
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(University of Pretoria, 2014)Transcription is a complex biological phenomenon, whereby RNA is transcribed from single stranded template DNA by assembling targeted regulatory inputs at the promoter region. Transcription is regulated through many ...
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(University of Pretoria, 2014)With the emergence of drug resistant bacteria, the need for new antimicrobial agents is growing. Antimicrobial peptides (AMPs) are natural antibiotics which have a broad spectrum of activity and also due to a great diversity ...
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(University of Pretoria, 2012)Background: Decades after its discovery, the Human Immunodeficiency Virus-1 (HIV-1) remains a major threat to public health. Highly Active Antiretroviral Therapy (HAART) has been successful in the treatment of the virus; ...
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(University of Pretoria, 1992)Malaria parasites are responsible for an increase in the morbidity and mortality in several tropical regions in Southern Africa. In this thesis, research was undertaken on Plasmodium, which is responsible for more than 95% ...
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(University of Pretoria, 2007-02-08)Mans (2002) hypothesized that the two domains of savignin interact with each other, giving a globular form in the absence of thrombin. Binding of the C-terminal domain of the inhibitor to the fibrinogen-binding site of ...
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(University of Pretoria, 2006-06-23)The saliva of hematophagous ectoparasites contains a cocktail of vasodilators, anticoagulants and immunosuppressors that maintain blood in a liquid state at the site of the lesion and evade the host's defense mechanisms ...
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(University of Pretoria, 2015)In 1963 the study of marine natural products was just beginning and there were only a handful of public records with only one of these publications reporting a new compound. There has since been 9220 papers published, ...
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(University of Pretoria, 2009-11-03)Tea is made from the young leaves of Camellia sinensis, an evergreen, outbreeding tree species. The replacing of seedling with clonal plantations and the use of small numbers of parental plants in breeding programs could ...
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(University of Pretoria, 2010-11-05)Background : Host protein beta-2 microglobulin (β2m) is incorporated into the human immunodeficiency virus (HIV) -1 coat during budding. Antibodies directed to R7V, an epitope contained in β2m, increased with the duration ...
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(University of Pretoria, 2014)No abstract
Now showing items 1-20 of 120