• The Antiatherogenic Potential of Two triterpenes from Protorhus longifolia stem bark (Benrh.) Engl. 

  Ramasia, Naleli Nthabiseng (University of Pretoria, 2024-01)

  Atherocardiovascular diseases (ACVDs) are considered among the major causes of death in South Africa and worldwide. Hypercholesterolemia, which is the main major risk factor of atherosclerosis, increases the occurrence of ...
• Inhibiting amylolytic enzymes by both acarbose and cellobiose as a prelude to treating type II diabetes mellitus 

  Maluleke, Kamogelo C (University of Pretoria, 2024-02-14)

  Inhibition of starch-degrading enzymes, α-amylase and α-glucosidase, provides a measure to ameliorate type II diabetes mellitus (T2D) by limiting the amount of glucose produced from dietary starch that would subsequently ...
• Exploring the mode of action of MMV1580843 against Plasmodium falciparum 

  Schultz, Dana Caitlin Jr (University of Pretoria, 2023-12-12)

  Although malaria is both preventable and curable, it is a parasitic disease with the highest fatality rate in history, causing over half a million deaths worldwide each year, with 95 % of the cases occurring in Africa. ...
• Development of a conditional gene knockout system to investigate the functional importance of regulatory genes in Plasmodium falciparum 

  Van Zyl, Christea (University of Pretoria, 2023-12-14)

  Malaria cases have surged in recent years, with the World Health Organization reporting 619 000 deaths in 2021. A recently approved malaria vaccine has been recommended for children younger than 5 years; this vaccine, ...
• Nutritional composition and cytoyoxicity studies of black monkey (Strychnos madagascariensis) ripe fruit 

  Oboh, M.; Zharare, G.; Osunsanmi, F.; Mosa, Rebamang Anthony; Opoku, A.R. (African Scholarly Science Communications Trust (ASSCAT), 2023-02)

  Strychnos madagascariensis also known as black monkey orange is found in tropical and subtropical Africa including South Africa, Lesotho, Zimbabwe, and Swaziland. The fruit is consumed traditionally as food in the northern ...
• Mitochondrial genes from 18 angiosperms fill sampling gaps for phylogenomic inferences of the early diversification of flowering plants 

  Xue, Jia-Yu; Dong, Shan-Shan; Wang, Ming-Qiang; Song, Tian-Qiang; Zhou, Guang-Can; Li, Zhen; Van de Peer, Yves; Shao, Zhu-Qing; Wang, Wei; Chen, Min; Zhang, Yan-Mei; Sun, Xiao-Qin; Chen, Hong-Feng; Zhang, Yong-Xia; Zhang, Shou-Zhou; Chen, Fei; Zhang, Liang-Sheng; Cox, Cymon; Liu, Yang; Wang, Qiang; Hang, Yue-Yu (Wiley, 2022-07)

  The early diversification of angiosperms is thought to have been a rapid process, which may complicate phylogenetic analyses of early angiosperm relationships. Plastid and nuclear phylogenomic studies have raised several ...
• Cultivated hawthorn (Crataegus pinnatifida var. major) genome sheds light on the evolution of Maleae (apple tribe) 

  Zhang, Ticao; Qiao, Qin; Du, Xiao; Zhang, Xiao; Hou, Yali; Wei, Xin; Sun, Chao; Zhang, Rengang; Yun, Quanzheng; Crabbe, M. James C.; Van de Peer, Yves; Dong, Wenxuan (Wiley, 2022-08)

  Cultivated hawthorn (Crataegus pinnatifida var. major) is an important medicinal and edible plant with a long history of use for health protection in China. Herein, we provide a de novo chromosomelevel genome sequence ...
• Protective immunity of plant-produced African horse sickness virus serotype 5 chimaeric virus-like particles (VLPs) and viral protein 2 (VP2) vaccines in IFNAR-/- mice 

  O'Kennedy, Martha Magaretha; Coetzee, Peter; Koekemoer, Otto; Du Plessis, Lissinda; Lourens, Carina W.; Kwezi, Lusisizwe; Du Preez, Ilse; Mamputha, Sipho; Mokoena, Nobalanda B.; Rutkowska, Daria A.; Verschoor, J.A. (Jan Adrianus), 1953-; Lemmer, Yolandy (Elsevier, 2022-08)

  Next generation vaccines have the capability to contribute to and revolutionise the veterinary vaccine industry. African horse sickness (AHS) is caused by an arbovirus infection and is characterised by respiratory distress ...
• syntenet : an R/Bioconductor package for the inference and analysis of synteny networks 

  Almeida-Silva, Fabricio; Zhao, Tao; Ullrich, Kristian K.; Schranz, M. Eric; Van de Peer, Yves (Oxford University Press, 2023-01)

  Interpreting and visualizing synteny relationships across several genomes is a challenging task. We previously proposed a network-based approach for better visualization and interpretation of large-scale microsynteny ...
• Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model 

  Mambwe, Dickson; Korkor, Constance M.; Mabhula, Amanda; Ngqumba, Zama; Cloete, Cleavon; Kumar, Malkeet; Barros, Paula Ladeia; Leshabane, Meta Kgaogelo; Coertzen, Dina; Taylor, Dale; Gibhard, Liezl; Njoroge, Mathew; Lawrence, Nina; Reader, Janette; Moreira, Diogo Rodrigo; Birkholtz, Lyn-Marie; Wittlin, Sergio; Egan, Timothy J.; Chibale, Kelly (American Chemical Society, 2022-12)

  Please read abstract in the article.
• Population genetics of a lethally managed medium-sized predator 

  Slater, K.; De Jager, Deon; Van Wyk, A.M.; Dalton, Desire Lee; Kropff, Anna S.; Du Preez, Ilse (Wiley, 2022-09)

  Globally, levels of human–wildlife conflict are increasing as a direct consequence of the expansion of people into natural areas resulting in competition with wildlife for food and other resources. By being forced into ...
• Chromosome-scale assembly of the Moringa oleifera Lam. genome uncovers polyploid history and evolution of secondary metabolism pathways through tandem duplication 

  Chang, Jiyang; Marczuk-Rojas, Juan Pablo; Waterman, Carrie; Garcia-Llanos, Armando; Chen, Shiyu; Ma, Xiao; Hulse-Kemp, Amanda; Van Deynze, Allen; Van de Peer, Yves; Carretero-Paulet, Lorenzo (Wiley Open Access, 2022-09)

  The African Orphan Crops Consortium (AOCC) selected the highly nutritious, fast growing and drought tolerant tree crop moringa (Moringa oleifera Lam.) as one of the first of 101 plant species to have its genome sequenced ...
• Investigating the role of African horse sickness virus VP7 protein crystalline particles on virus replication and release 

  Bekker, Shani; Potgieter, Christiaan A.; Van Staden, Vida; Theron, Jacques (MDPI, 2022-10-04)

  African horse sickness is a deadly and highly infectious disease of equids, caused by African horse sickness virus (AHSV). AHSV is one of the most economically important members of the Orbivirus genus. AHSV is transmitted ...
• Evolutionary history and pan-genome dynamics of strawberry (Fragaria spp.) 

  Qiao, Qin; Edger, Patrick P.; Xue, Li; Qiong, La; Lu, Jie; Zhang, Yichen; Cao, Qiang; Yocca, Alan E.; Platts, Adrian E.; Knapp, Steven J.; Van Montagu, Marc; Van de Peer, Yves; Lei, Jiajun; Zhang, Ticao (National Academy of Sciences, 2021-10)

  Strawberry (Fragaria spp.) has emerged as a model system for various fundamental and applied research in recent years. In total, the genomes of five different species have been sequenced over the past 10 y. Here, we report ...
• Methicillin-resistant staphylococci among school children in Mariental, Namibia 

  Walter, Sunette; Beukes, Mervyn; Mumbengegwi, Davis; Bock, Ronnie (Elsevier, 2022-03)

  Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to beta-lactam antibiotics, while some strains are multi-drug resistant and may produce disease-causing toxins. Drug resistant strains are often responsible ...
• The genome of hibiscus hamabo reveals its adaptation to saline and waterlogged habitat 

  Wang, Zhiquan; Xue, Jia-Yu; Hu, Shuai-Ya; Zhang, Fengjiao; Yu, Ranran; Chen, Dijun; Van de Peer, Yves; Jiang, Jiafu; Song, Aiping; Ni, Longjie; Hua, Jianfeng; Lu, Zhiguo; Yu, Chaoguang; Yin, Yunlong; Gu, Chunsun (Oxford University Press, 2022-03-23)

  Hibiscus hamabo is a semi-mangrove species with strong tolerance to salt and waterlogging stress. However, the molecular basis and mechanisms that underlie this strong adaptability to harsh environments remain poorly ...
• MicroRNA-mediated post-transcriptional regulation of Pinus pinaster response and resistance to pinewood nematode 

  Modesto, Ines; Inacio, Vera; Van de Peer, Yves; Miguel, Celia (Nature Research, 2022-03-25)

  Pine wilt disease (PWD), caused by the parasitic nematode Bursaphelenchus xylophilus, or pinewood nematode (PWN), is a serious threat to pine forests in Europe. Pinus pinaster is highly susceptible to the disease and it ...
• Adapt or die : targeting unique transmission-stage biology for malaria elimination 

  Van der Watt, Mariette Elizabeth; Reader, Janette; Birkholtz, Lyn-Marie (Frontiers Media S.A., 2022-06-09)

  Plasmodium parasites have a complex life cycle that includes development in the human host as well as the Anopheles vector. Successful transmission of the parasite between its host and vector therefore requires the ...
• SNP detection in Pinus pinaster transcriptome and association with resistance to pinewood nematode 

  Modesto, Ines; Inacio, Vera; Novikova, Polina; Carrasquinho, Isabel; Van de Peer, Yves; Miguel, Celia (MDPI, 2022-06-17)

  Pinewood nematode (PWN, Bursaphelenchus xylophilus) is the causal agent of pine wilt disease (PWD), which severely affects Pinus pinaster stands in southwestern Europe. Despite the high susceptibility of P. pinaster, ...
• Genomic and metabolomic analyses of the marine fungus Emericellopsis cladophorae: insights into saltwater adaptability mechanisms and its biosynthetic potential 

  Goncalves, Micael; Hilario, Sandra; Van de Peer, Yves; Esteves, Ana; Alves, Artur (MDPI, 2022-01)

  The genus Emericellopsis is found in terrestrial, but mainly in marine, environments with a worldwide distribution. Although Emericellopsis has been recognized as an important source of bioactive compounds, the range of ...

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