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Research Articles (Medical Virology): Recent submissions

  • mAb therapy controls CNS-resident lyssavirus infection via a CD4 T cell-dependent mechanism 
    Mastraccio, Kate E.; Huaman, Celeste; Coggins, Si’Ana A.; Clouse, Caitlyn; Rader, Madeline; Yan, Lianying; Mandal, Pratyusha; Hussain, Imran; Ahmed, Anwar E.; Ho, Trung; Feasley, Austin; Vu, Bang K.; Smith, Ina L.; Markotter, Wanda; Weir, Dawn L; Laing, Eric D.; Broder, Christopher C; Schaefer, Brian C. (Springer, 2023-09-20)
    Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, ...
  • Survey of West Nile and Banzi viruses in mosquitoes, South Africa, 2011–2018 
    MacIntyre, Caitlin; Guarido, Milehna M.; Riddin, Megan A.; Johnson, Todd; Braack, L.E.O.; Schrama, Maarten; Gorsich, Erin; Almeida, Antonio Paulo Gouveia; Venter, Marietjie (Centers for Disease Control and Prevention, 2023-01)
    We collected >40,000 mosquitoes from 5 provinces in South Africa during 2011–2018 and screened for zoonotic flaviviruses. We detected West Nile virus in mosquitoes from conservation and periurban sites and potential new ...
  • Detection of neutralizing antibodies in COVID-19 patients from Steve Biko Academic Hospital Complex : a pilot study 
    Kgatle, Mankgopo; Chalwe, Joseph Musonda; Van der Westhuizen, Donald; Xu, Shuting; Damane, Botle Precious; Mathebela, Precious; Ueckermann, Veronica; Mayaphi, Simnikiwe; Rodrigues, Hosana Gomes; Moura-Alves, Pedro; Ndlovu, Honest; Mzizi, Yonwaba; Zongo, Lusanda; Hairwadzi, Henry; Vorster, Mariza; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-07-03)
    A correlation between neutralization activity after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and protection against coronavirus disease 2019 (COVID-19) has been demonstrated by several ...
  • The role of wastewater-based epidemiology for SARS-CoV-2 in developing countries : cumulative evidence from South Africa supports sentinel site surveillance to guide public health decision-making 
    Iwu-Jaja, Chinwe Juliana; Ndlovu, Nkosenhle Lindo; Rachida, Said; Yousif, Mukhlid; Taukobong, Setshaba; Macheke, Mokgaetji; Mhlanga, Laurette; Van Schalkwyk, Cari; Pulliam, Juliet R.C.; Moultrie, Tom; Le Roux, Wouter; Schaefer, Lisa; Pocock, Gina; Coetzee, Leanne Z.; Mans, Janet; Bux, Faizal; Pillay, Leanne; De Villiers, Dariah; Du Toit, A.P.; Jambo, Don; Gomba, Annancietar; Groenink, Shaun; Madgewick, Neil; Van der Walt, Martie; Mutshembele, Awelani; Berkowitz, Natascha; Suchard, Melinda S.; McCarthy, Kerrigan M. (Elsevier, 2023-12)
    The uptake of wastewater-based epidemiology (WBE) for SARS-CoV-2 as a complementary tool for monitoring population-level epidemiological features of the COVID-19 pandemic in low-and-middle-income countries (LMICs) is low. ...
  • Validation of ASCL1 and LHX8 methylation analysis as primary cervical cancer screening strategy in South African women with human immunodeficiency virus 
    Vink, Frederique J.; Meijer, Chris J.L.M.; Lissenberg-Witte, Birgit I.; Visser, Cathy; Duin, Sylvia; Snyman, Leon Cornelius; Richter, Karin Louise; Van der Merwe, Frederick H.; Botha, Matthys H.; Steenbergen, Renske D.M.; Dreyer, Greta (Oxford University Press, 2023-02-01)
    BACKGROUND : Compared with women who are human immunodeficiency virus (HIV) negative, women with human immunodeficiency virus (WWH) have a higher human papillomavirus (HPV) prevalence and increased cervical cancer ...
  • Enhancing cervical cancer prevention in South African women : primary HPV mRNA screening with different genotype combinations 
    Sorbye, Sveinung Wergeland; Falang, Bente Marie; Botha, Matthys H.; Snyman, Leon Cornelius; Van der Merwe, Haynes; Visser, Cathy; Richter, Karin Louise; Dreyer, Greta (MDPI, 2023-11-17)
    BACKGROUND : Cervical cancer prevention in regions with limited access to screening and HPV vaccination necessitates innovative approaches. This study explored the potential of a test-and-treat strategy using mRNA HPV tests ...
  • Economic evaluation of rotavirus vaccination in children aged under five years in South Africa 
    Mohy, Ahmed; Page, N.A. (Nicola); Boyce, Welekazi; Gomez, Jorge A. (Springer, 2023-11)
    BACKGROUND AND OBJECTIVE Evidence on the economic value of rotavirus vaccines in middle-income countries is limited. We aimed to model the implementation of three vaccines (human rotavirus, live, attenuated, oral vaccine ...
  • Changes in prevalence and seasonality of pathogens identified in acute respiratory tract infections in hospitalised individuals in rural and urban settings in South Africa; 2018–2022 
    Davids, Michaela; Johnstone, Siobhan; Mendes, Adriano; Brecht, Gadean; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; De Villiers, Maryke; Page, N.A. (Nicola); Venter, Marietjie (MDPI, 2024-03)
    Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and ...
  • West Nile virus, an underdiagnosed cause of acute fever of unknown origin and neurological disease among hospitalized patients in South Africa 
    MacIntyre, Caitlin; Lourens, Carla; Mendes, Adriano; De Villiers, Maryke; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; Leendertz, Fabian; Venter, Marietjie (MDPI, 2023-11-02)
    West Nile virus (WNV), a mosquito-borne flavivirus, is endemic to South Africa. However, its contribution to acute febrile and neurological disease in hospitalized patients in South Africa is unknown. This study examined ...
  • Robust evidence for bats as reservoir hosts is lacking in most African virus studies : a review and call to optimize sampling and conserve bats 
    Weber, Natalie; Nagy, Martina; Markotter, Wanda; Schaer, Juliane; Puechmaille, Sebastien J.; Sutton, Jack; Davalos, Liliana M.; Dusabe, Marie-Claire; Ejotre, Imran; Fenton, M. Brock; Knornschild, Mirjam; Lopez-Baucells, Adria; Medellin, Rodrigo A.; Mubareka, Samira; Nsengimana, Olivier; O’Mara, M. Teague; Racey, Paul A.; Tuttle, Merlin; Twizeyimana, Innocent; Vicente-Santos, Amanda; Tschapka, Marco; Voigt, Christian C.; Wikelski, Martin; Dechmann, Dina K.N.; Reeder, DeeAnn M. (Royal Society, 2023-11)
    Africa experiences frequent emerging disease outbreaks among humans, with bats often proposed as zoonotic pathogen hosts. We comprehensively reviewed virus–bat findings from papers published between 1978 and 2020 to ...
  • Viral maintenance and excretion dynamics of coronaviruses within an Egyptian rousette fruit bat maternal colony : considerations for spillover 
    Geldenhuys, Marike; Ross, Noam; Dietrich, Muriel; De Vries, J. Low; Mortlock, Marinda; Epstein, Jonathan H.; Weyer, Jacqueline; Paweska, Janusz Tadeusz; Markotter, Wanda (Nature Reseach, 2023-09)
    Novel coronavirus species of public health and veterinary importance have emerged in the first two decades of the twenty-first century, with bats identified as natural hosts for progenitors of many coronaviruses. Targeted ...
  • Stem cell transplant in immune-deficiency-associated vaccine-derived poliovirus 
    Ranchod, Heena; Howard, Wayne; Roux, Adele; Van Zyl, Walda B.; Ekermans, Pieter; Van den Berg, Sylvia; Seakamela, Lerato; Makua, Koketso; Yousif, Mukhlid; Sibiya, Rosinah; Du Plessis, Heleen; Phalane, Emmanuel; McCarthy, Kerrigan; Moonsamy, Shelina; Reynders, David; Hincks, Jeffrey; Suchard, Melinda S.; Du Plessis, Nicolette Marie (Oxford University Press, 2024-01)
    Patients with severe primary immunodeficiency are at risk for complications from live-attenuated vaccines. Here, we report a case of a vaccine-associated paralytic polio and Bacille Calmette-Guérin disease in a 6-month-old ...
  • Vector-borne protozoan and bacterial pathogen occurrence and diversity in ectoparasites of the Egyptian Rousette bat 
    Szentivanyi, Tamara; Heintz, Anne-Caroline; Markotter, Wanda; Wassef, Jerome; Christe, Philippe; Glaizot, Olivier (Wiley, 2023-06)
    Bats are known reservoir hosts for a wide variety of parasites and pathogens, including bacteria and protozoans. Some of these pathogens are vector-borne, and although their role is poorly studied, ectoparasites may ...
  • Race in health research : considerations for researchers and research ethics committees 
    Van Staden, Werdie; Nienaber, A.; Rossouw, T.; Turner, A.C. (Astrid); Filmalter, Cecilia Jacoba; Nel, Jan Gert; Bapela, S.; Beetge, Mia-Michaela; Blumenthal, Ryan; Castelyn, Camille De Villebois; De Witt-Jordaan, T.W. (Wilma); Dlagnekova, Antonia; Kotze, Carla; Mangwane, S.; Napoles, Lizeka; Somers, R.; Sykes, Leanne M.; Van Zyl, W.B.; Venter, Marietjie; Uys, Andre; Warren, Nichola (South African Medical Association, 2023-04)
    This article provides ethical guidance on using race in health research as a variable or in defining the study population. To this end, a plain, non-exhaustive checklist is provided for researchers and research ethics ...
  • The One Health high-level expert panel (OHHLEP) 
    Mettenleiter, Thomas C.; Markotter, Wanda; Charron, Dominique F.; Adisasmito, Wiku B.; Almuhairi, Salama; Behravesh, Casey Barton; Bilivogui, Pepe; Bukachi, Salome A.; Casas, Natalia; Becerra, Natalia Cediel; Chaudhary, Abhishek; Ciacci Zanella, Janice R.; Cunningham, Andrew A.; Dar, Osman; Debnath, Nitish; Dungu, Baptiste; Farag, Elmoubasher; Gao, George F.; Hayman, David T.S.; Khaitsa, Margaret; Koopmans, Marion P.G.; Machalaba, Catherine; Mackenzie, John S.; Morand, Serge; Smolenskiy, Vyacheslav; Zhou, Lei (BMC, 2023-12)
    No abstract available.
  • Developing One Health surveillance systems 
    Hayman, David T.S.; Adisasmito, Wiku B.; Almuhairi, Salama; Behravesh, Casey Barton; Bilivogui, Pépé; Bukachi, Salome A.; Casas, Natalia; Becerra, Natalia Cediel; Charron, Dominique F.; Chaudhary, Abhishek; Ciacci Zanella, Janice R.; Cunningham, Andrew A.; Dar, Osman; Debnath, Nitish; Dungu, Baptiste; Farag, Elmoubasher; Gao, George F.; Khaitsa, Margaret; Machalaba, Catherine; Mackenzie, John S.; Markotter, Wanda; Mettenleiter, Thomas C.; Morand, Serge; Smolenskiy, Vyacheslav; Zhou, Lei; Koopmans, Marion (Elsevier, 2023-12)
    The health of humans, domestic and wild animals, plants, and the environment are inter-dependent. Global anthropogenic change is a key driver of disease emergence and spread and leads to biodiversity loss and ecosystem ...
  • Microorganisms detected in intussusception cases and controls in children <3 years in South Africa from 2013 to 2017 
    Page, N.A. (Nicola); Netshikweta, Rembuluwani; Tate, Jacqueline E.; Madhi, Shabir A.; Parashar, Umesh D.; Groome, Michelle J. (Oxford University Press, 2023-09)
    A matched case-control evaluated infectious etiologies in children <3 years in post-rotavirus vaccine intussusception surveillance. Adenovirus and adenovirus types C, A, and B were detected more frequently in cases versus ...
  • Why the world needs more transparency on the origins of novel pathogens 
    Venter, Marietjie (Nature Research, 2023-06)
    Collaboration and openness are essential to minimize the risks of future pandemics, says the World Health Organization’s scientific advisory group, SAGO.
  • Multicountry study of SARS-CoV-2 and associated risk factors among healthcare workers in Cote d’Ivoire, Burkina Faso and South Africa 
    Kribi, Sarah; Toure, Fidele; Mendes, Adriano; Sanou, Soufiane; Some, Arsene; Aminou, Abdoul M.; Belarbi, Essia; Griessel, Rosemary; Hema, Arsene; Kabore, Firmin; Pitzinger, Paul; Strydom, Amy; Vietor, Ann Christin; Traore, Korotimi; Zongo, Arsene; Anoh, Etile A.; Grossegesse, Marica; Hofmann, Natalie; Ouangraoua, Soumeya; Poda, Armel; Kagone, Therese; Schubert, Grit; Eckmanns, Tim; Venter, Marietjie; Leendertz, Fabian; Akoua-Koffi, Chantal; Tomczyk, Sara (Oxford University Press, 2023-03)
    BACKGROUND : Reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread across Africa have varied, including among healthcare workers (HCWs). This study assessed the comparative SARS-CoV-2 burden and ...
  • Comparative neutralization activity of commercial rabies immunoglobulin against diverse lyssaviruses 
    Coertse, Jessica; Viljoen, Natalie; Weyer, Jacqueline; Markotter, Wanda (MDPI, 2023-07-18)
    Novel lyssaviruses, the causative agents of rabies, continue to be described mostly due to increased surveillance in bat hosts. Biologicals for the prevention of rabies in humans have, however, remained largely unchanged ...