Browsing Research Articles (Medical Virology) by Issue Date

Browsing Research Articles (Medical Virology) by Issue Date

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  • HHV-8 subtypes in South Africa : identification of a case suggesting a novel B variant 
    Treurnicht, Florette K.; Engelbrecht, Susan; Taylor, Maureen B.; Schneider, Johann W.; Janse van Rensburg, Estrelita (Wiley, 2002-02)
    Human herpesvirus 8 (HHV-8) has been identified as the causative agent for all forms of Kaposi's sarcoma and is also associated with the development of body cavity-based B-cell lymphomas and multicentric Castleman's disease. ...
  • Functional analysis of novel SLC11A1 (NRAMP1) promoter variants in susceptibility to HIV-1 
    Donninger, Howard; Cashmore, T.J.; Scriba, Thomas Jens; Petersen, Desiree C.; Janse van Rensburg, Estrelita; Hayes, Vanessa M. (BMJ Publishing Group, 2004-04)
    The divalent cation transporter is the natural resistance associated macrophage protein 1 (formerly NRAMP1 and now named SLC11A1) for solute carrier 11A1 (OMIM accession number 600266). The gene that codes for this ...
  • Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences 
    Scriba, Thomas Jens; Zur Megede, Jan; Glashoff, Richard H.; Treurnicht, Florette K.; Barnett, Susan W.; Janse van Rensburg, Estrelita (Elsevier, 2005-01-19)
    The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the viral life cycle and CTL ...
  • Biolog identification of non-sorbitol fermenting bacteria isolated on E. coli O157 selective CT-SMAC agar 
    Muller, Etienne E.; Ehlers, Marthie Magdaleen (Water Research Council, 2005-04)
    E. coli O157:H7 is recognised as an important human pathogen world-wide and has been associated with diseases such as haemorrhagic colitis (HC), haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura ...
  • Prevalence of vaccine-derived polioviruses in sewage and river water in South Africa 
    Pavlov, Dobromir Nikolov; Van Zyl, Walda B.; Van Heerden, J.; Grabow, W.O.K.; Ehlers, Marthie Magdaleen (Elsevier, 2005-09)
    Polioviruses (PVs) are not associated with waterborne transmission to the same extent as many other enteric viruses. However, they are typically transmitted by the faecal-oral route, which implies that the risk of infection ...
  • An automated genotyping system for analysis of HIV-1 and other microbial sequences 
    De Oliveira, Tulio; Deforche, Koen; Cassol, Sharon; Salminen, M.; Paraskevis, D.; Seebreghts, C.; Snoeck, J.; Janse van Rensburg, Estrelita; Wensing, A.M.J.; Van der Vijver, D.A.; Boucher, C.A.; Camacho, R.; Vandamme, Anne-Mieke (Oxford University Press, 2005-10-01)
    Motivation: Genetic analysis of HIV-1 is important not only for vaccine development, but also to guide treatment strategies, track the emergence of new viral variants and ensure that diagnostic assays are contemporary and ...
  • Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population 
    Petersen, Desiree C.; Glashoff, Richard H.; Sherestha, Sadeep; Bergeron, Julie; Laten, Anette; Gold, Bert; Janse van Rensburg, Estrelita; Dean, Michael; Hayes, Vanessa M. (Lippincott Williams and Wilkins, 2005-12-15)
    CXC chemokine ligand 12 (CXCL12), or stromal cell–derived factor 1 (SDF1), is the only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 ...
  • Poliovirus vaccine strains detected in stool specimens of immunodeficient children in South Africa 
    Pavlov, Dobromir Nikolov; Van Zyl, Walda B.; Kruger, Marlena C.; Blignaut, Liezl; Grabow, W.O.K.; Ehlers, Marthie Magdaleen (Elsevier, 2006)
    After exposure to the oral poliovirus vaccine (OPV), immunocompetent persons excrete poliovirus (PV) vaccine strains for a limited period. In contrast, immunodeficient individuals remain sometimes chronically infected, and ...
  • HPV detection in primary intra-oral squamous cell carcinomas – commensal, aetiological agent or contamination? 
    Boy, Sonja Catharina; Janse van Rensburg, Estrelita; Engelbrecht, Susan; Dreyer, Leonora; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Blackwell, 2006-02)
    Background: High-risk human papilloma viruses (HPV) are reported to be significant independent risk factors for oral squamous cell carcinoma (OSCC). The prevalence of HPV in OSCC in a South African population sample was ...
  • Absence of Helicobacter pylori within the oral cavities of members of a healthy South African community 
    Olivier, Brenda J.; Bond, Robert P.; Van Zyl, Walda B.; Delport, Maraliese; Slavik, Tomas; Ziady, Christopher; Terhaar sive Droste, Jochim S.; Lastovica, Albert; Van der Merwe, Schalk Willem (American Society for Microbiology, 2006-02)
    Our study aimed to evaluate the oral cavity as a reservoir from where Helicobacter pylori may be transmitted. Histology and PCR amplification were performed. Eighty-four percent of the stomach biopsies tested positive; ...
  • Masstag polymerase chain reaction for differential diagnosis of viral hemorrhagic fevers 
    Palacios, Gustavo; Briese, Thomas; Kapoor, Vishal; Jabado, Omar; Liu, Zhiqiang; Venter, Marietjie; Zhai, Junhui; Renwick, Neil; Grolla, Allen; Geisbert, Thomas W.; Drosten, Christian; Towner, Jonathan S.; Ju, Jingyue; Paweska, Janusz Tadeusz; Nichol, Stuart T.; Swanepoel, Robert; Feldmann, Heinz; Jahrling, Peter B.; Lipkin, Ian W. (Centers for Disease Control and Prevention, 2006-04)
    Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in clinical management. We ...
  • Molecular epidemiology of group A Rotaviruses in water sources and selected raw vegetables in Southern Africa 
    Van Zyl, Walda B.; Page, Nicola Anne; Grabow, W.O.K.; Steele, Andrew Duncan; Taylor, Maureen B. (American Society for Microbiology, 2006-07)
    Group A rotaviruses (RVs) are the most important cause of acute viral gastroenteritis in infants and young children. In this study raw and treated drinking water supplies at plants in two geographic areas, as well as ...
  • Diagnosis and monitoring of HIV infection 
    Glass, Allison J. (Medpharm Publications, 2006-09)
    The latest statistics indicate that the number of people infected with human immunodeficiency virus type 1 (HIV-1) worldwide is 40.3 million, 25.8 million of whom live in sub-Saharan Africa. In 2004, 29.5% of South African ...
  • The basics of viral vaccines 
    Richter, Karin Louise (Medpharm Publications, 2006-09)
    The family practitioner plays an important role in preventing disease. An estimated two million people die globally from vaccine-preventable diseases each year. Immunisation of children does not only benefit the immunised ...
  • Prevalence of vaccine-derived polioviruses in stools of immunodeficient children in South Africa 
    Pavlov, Dobromir Nikolov; Van Zyl, Walda B.; Van Heerden, J.; Kruger, Marlena C.; Blignaut, Liezl; Grabow, W.O.K.; Ehlers, Marthie Magdaleen (Blackwell, 2006-12)
    Aims: The aim of the study was to determine the prevalence of vaccine-derived polioviruses (VDPVs) in stool specimens of immunodeficient patients such as HIV-positive children (including those with an AIDS indicator ...
  • Rapid molecular strategy for filovirus detection and characterization 
    Zhai, Junhui; Palacios, Gustavo; Towner, Jonathan S.; Jabado, Omar; Kapoor, Vishal; Venter, Marietjie; Grolla, Allen; Briese, Thomas; Paweska, Janusz Tadeusz; Swanepoel, Robert; Feldmann, Heinz; Nichol, Stuart T.; Lipkin, Ian W. (American Society for Microbiology, 2007-01)
    Filoviruses have the capacity to cause lethal outbreaks of hemorrhagic fever in primates. Here we present a simple consensus reverse transcription-PCR method for filovirus recognition and characterization and demonstrate ...
  • Astrovirus infection in young Kenyan children with diarrhoea 
    Kiulia, Nicholas M.; Mwenda, Jason M.; Nyachieo, Atunga; Nyaundi, Julia K.; Steele, Andrew Duncan; Taylor, Maureen B. (Oxford University Press, 2007-06)
    Human astroviruses (HAstV) have been commonly identified worldwide as important aetiological agents of acute gastroenteritis in all age groups including the young, elderly and immunocompromised. However, limited data exist ...
  • Histopathology and genotyping in infectious spondylitis of HIV- and HIV+ patients 
    Danaviah, S.; Govender, S.; Cassol, Sharon (Lippincott Williams and Wilkins, 2007-07)
    Approximately 2 million South Africans are HIV/TB coinfected, and many develop skeletal disease. The resurgence of spinal tuberculosis, including atypical forms, is due largely to HIV-associated immune suppression. We ...
  • Short-term effectiveness and safety of HAART in the form of a generic fixed-dose combination of stavudine, lamivudine and nevirapine (Triviro) in HIV-1-infected adults in Zimbabwe 
    Duse, A.G.; Morar, A.; Landman, I.; Vermaak, William J.H.; Schoeman, H.; Kruger, M.J.; Janse van Rensburg, E.S. (Elsie); Luthy, R.; Singh, S. (Health and Medical Publishing Group, 2008)
    OBJECTIVES. To assess the effectiveness and safety of a twice-daily regimen of a generic fixed-dose combination (FDC) of stavudine, lamivudine and nevirapine (Triviro) in a cohort of Zimbabwean HIV-1-positive adults. DESIGN: ...
  • Human papilloma virus types in the oral and cervical mucosa of HIV-positive South African women prior to antiretroviral therapy 
    Richter, Karin Louise; Janse van Rensburg, Estrelita; Van Heerden, Willem Francois Petrus; Boy, Sonja Catharina (Wiley-Blackwell, 2008)
    BACKGROUND: To evaluate the prevalence of human papilloma virus (HPV) infection and types in the oral and cervix mucosa of treatment-naïve HIV-1-positive women with CD4 counts less than 300 cells per ml with no HPV-associated ...