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Research Articles (Oral Pathology and Oral Biology): Recent submissions

  • Senescent cells in cancer : wanted or unwanted citizens 
    Niklander, Sven E.; Lambert, Daniel W.; Hunter, K.D. (Keith) (MDPI, 2021-11-26)
    Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer. Senescent cells are unable to proliferate, ...
  • Slc7a8 deletion is protective against diet-induced obesity and attenuates lipid accumulation in multiple organs 
    Pitere, Reabetswe R.; Van Heerden, Marlene B.; Pepper, Michael Sean; Ambele, Melvin Anyasi (MDPI, 2022-02)
    Adipogenesis, through adipocyte hyperplasia and/or hypertrophy, leads to increased adiposity, giving rise to obesity. A genome-wide transcriptome analysis of in vitro adipogenesis in human adipose-derived stromal/stem ...
  • Radiological spectrum of metastasis to the oral and maxillofacial region 
    Nel, Chane; Uys, Andre; Robinson, Liam; Nortje, Christoffel Johannes (Springer, 2022-01)
    OBJECTIVE : Oral and maxillofacial metastasis may be the first indication of an undiscovered malignancy in a significant number of cases. Therefore, the rationale of this article is to highlight the clinical and radiological ...
  • The need for communication between clinicians and pathologists in the context of oral and maxillofacial diseases 
    Perez-de-Oliveira, Maria Eduarda; Van Heerden, Willem Francois Petrus; Motta, Ana Carolina Fragoso; Rodrigues-Fernandes, Carla Isabelly; Romanach, Mario Jose; Agostini, Michelle; Gueiros, Luiz Alcino Monteiro; Vargas, Pablo Agustin; Lopes, Marcio Ajudarte; Ribeiro, Ana Carolina Prado; Brandao, Thaís Bianca; De Almeida, Oslei Paes; Khurram, Syed Ali; Santos-Silva, Alan Roger (Brazilian Oral Research, 2022-01)
    Good communication between clinicians and pathologists is a vital element in the diagnostic process, and poor communication can adversely affect patient care. There is a lack of research about communication in diagnostic ...
  • Ghost cell odontogenic carcinoma arising in the background of a calcifying odontogenic cyst 
    Nel, Chane; Robinson, Liam; Van Heerden, Willem Francois Petrus (Springer, 2021-07)
    Ghost cell odontogenic carcinoma (GCOC) is a rare malignant neoplasm, representing 3% of all ghost cell lesions of the jaws. They can arise de novo or from a pre-existing calcifying odontogenic cyst (COC) or dentinogenic ...
  • BDNF/TrkB/Akt signaling pathway epithelial odontogenic tumors and keratocyst : an immunohistochemical study comparative with dental germs 
    Dornelles, Florencia M.L.; Wagner, Vivian P.; Fonseca, Felipe Paiva; Ariotti, Carla; Carrard, Vinicius C.; Vargas, Pablo Agustin; Sanchez-Romero, Celeste; Beovide, Veronica; Bologna-Molina, Ronell; Martins, Manoela D. (Lippincott Williams and Wilkins, 2021-05)
    Odontogenic lesions (OL) are an important group of oral and maxillofacial diseases represented by odontogenic cysts, benign, and malignant tumors. The brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase ...
  • Validation of Roberts’ method using root canal width patterns as a mandibular maturity marker in determining the 18-year threshold 
    Davidson, Christy Lana; Nel, Chane; Bernitz, Herman; Van Staden, Paul Jacobus; Uys, Andre (Springer, 2021-07)
    The South African Bill of Rights and the Children’s Act define a ‘child’ as a person under the age of 18 years. The age of 18 years is therefore significant for legal purposes in South Africa. The third molar is an important ...
  • Salivary gland cancer in Southern Brazil : a prognostic study of 107 cases 
    Zanella, Virgilio Gonzales; Wagner, Vivian Petersen; Schmidt, Tuany Rafaeli; Thieme, Stefanie; Correa, Cintia; Fonseca, Felipe Paiva; Rigon, Pettala; Barra, Marinez Bizarro; Kroef, Ricardo Gallicchio; Vargas, Pablo Agustin; Martins, Manoela Domingues (Medicina Oral S.L., 2021-05)
    BACKGROUND : Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south ...
  • Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity : an update 
    Wagner, Vivian Petersen; Rodrigues-Fernandes, Carla Isabelly; Carvalho, Marcus Vinícius Ribeiro; Dos Santos, Jean Nunes; Barra, Marinez Bizarro; Hunter, K.D. (Keith); Aguirre-Urizar, Jose Manuel; Van Heerden, Willem Francois Petrus; Vargas, Pablo Agustin; Fonseca, Felipe Paiva; Manoela Domingues Martins (Wiley, 2021-07)
    BACKGROUND : Although uncommon, mature small B-cell lymphomas may arise in the oral/maxillofacial area and oral pathologists must be aware of the key characteristics of these neoplasms to perform an accurate diagnosis. ...
  • Oral plasmablastic lymphoma : a clinicopathological study of 113 cases 
    Fonseca, Felipe Paiva; Robinson, Liam; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Wiley, 2021-07)
    BACKGROUND : Plasmablastic lymphoma (PBL) is an aggressive neoplasm that commonly develops in HIV-positive patients, usually affecting the oral cavity. EBV is present in the majority of cases, therefore, playing an ...
  • The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype 
    Niklander, Sven; Crane, Hannah L.; Darda, Lav; Lambert, Daniel W.; Hunter, K.D. (Keith) (The Company of Biologists, 2021-02)
    There is compelling evidence that senescent cells, through the senescence-associated secretory phenotype (SASP), can promote malignant transformation and invasion. Interleukin-1 (IL-1) is a key mediator of this cytokine ...
  • Biological consequences of cancer radiotherapy in the context of oral squamous cell carcinoma 
    Feller, Gal; Khammissa, Razia Abdool Gafaar; Nemutandani, M.S.; Feller, Liviu (BioMed Central, 2021-08-26)
    Approximately 50% of subjects with cancer have been treated with ionizing radiation (IR) either as a curative, adjuvant, neoadjuvant or as a palliative agent, at some point during the clinical course of their disease. IR ...
  • Calcifying odontogenic cysts : a 20-year retrospective clinical and radiological review 
    Nel, Chane; Robinson, Liam; Oliveira Correa Roza, Ana Luiza; Vargas, Pablo Agustin; Nortje, Christoffel Johannes; Van Heerden, Willem Francois Petrus (British Institute of Radiology, 2021-02)
    OBJECTIVE : Calcifying odontogenic cysts (COCs) exhibit diverse clinical behaviours and may be associated with other benign odontogenic tumours. In this study, the clinical and radiological features of COCs were analysed ...
  • Rarβ expression in keratinocytes from potentially malignant oral lesions : the functional consequences of re-expression by de-methylating agents 
    Radhakrishnan, Raghu; Crane, Hannah L.; Daigneault, Marc; Ram Padam, Kanaka Sai; Hunter, K.D. (Keith) (MDPI, 2021-08-12)
    Loss of RARβ2 expression by promoter methylation is an early event in oral carcinogenesis. Understanding the mechanisms and consequences of RARβ loss may aid in understanding the disappointing results of retinoid chemoprevention ...
  • Benign lymphoproliferative disorders in the immunosuppressed patient: an update 
    Robinson, Liam; Fonseca, Felipe Paiva; Van Heerden, Willem Francois Petrus (Wiley, 2021-07)
    Immunosuppressed patients may be affected by a wide range of lymphoproliferative disorders (LPDs) ranging from self-limiting disorders to malignant lymphoid proliferations. These LPDs may be associated with systemic immune ...
  • Visual assessment is no substitute for radiographic analysis - a forensic case report 
    Robinson, Liam; Nel, Chane; Bernitz, Herman (South African Dental Association, 2020-07)
    While preparing the foundations for a new house, a builder happened to find a small mandible buried just below the surface. Human skeletal remains in the form of a mandible were submitted to the forensic odontology unit ...
  • Dental images - their use and abuse 
    Sykes, Leanne M.; Uys, Andre; Bradfield, Charles F.; Van Reede van Oudtshoorn, Nicolaas W. (South African Dental Association, 2020-11)
    Patients’ exposure to medical and dental radiographic examination has increased over the years,1 with dental X-ray procedures now accounting for almost one-third of all radiographic examinations.2 Although they ...
  • Forensic case book : mirror image ‘selfie’ causes confusion 
    Robinson, Liam; Makhoba, Aubrey Musa; Bernitz, Herman (South African Dental Association, 2020-04)
    The body of a decomposed female was found immersed in a water purification plant in a small town. The South African Police Service (SAPS) believed that the body could be that of a person they had been searching for since ...
  • Giant cell lichenoid stomatitis - an oral medicine case book 
    Robinson, Liam; Kotze, Leande; Van Heerden, Willem Francois Petrus (South African Dental Association, 2020-11)
    A 53-year-old female patient presented with a two-week history of intermittently painful oral mucosal lesions when eating spicy, salty or sour foods. The patient reported a long-term history of psoriasis treated by ...
  • Focal dermal hypoplasia - a radiographic case report 
    Yakoob, Zarah; Nel, Chane (South African Dental Association, 2020-05)
    Focal dermal hypoplasia (FDH) is an unusual X-linked dominant disorder that affects ectoderm and mesoderm derived tissues with females affected in 90% of cases. A case report of a 12 year old female diagnosed with FDH ...