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Research Articles (Oral Pathology and Oral Biology): Recent submissions

  • Head and neck rhabdomyosarcoma in pediatric patients : an international collaborative study 
    Gallagher, Karen Patricia Dominguez; Hunter, Keith D.; Arboleda, Lady Paola Aristizabal; Pedroso, Caique Mariano; Mariz, Bruno Augusto Linhares Almeida; Penafort, Paulo Victor Mendes; De Souza, Lucas Lacerda; Rodrigues-Fernandes, Carla Isabelly; Tager, Elena Maria Jose Roman; Carlos, Roman; Robinson, Liam; Schouwstra, Ciska-Mari; Villanueva-Sanchez, Francisco German; Gomez, Francisco Jose Paz; Gonzalez-Galvan, Maria del Carmen; Martins-de-Barros, Allan Vinicius; De Vasconcelos Carvalho, Marianne; Cavalcante, Roberta Barroso; Turatti, Eveline; Pontes, Helder Antonio Rebelo; Siqueira, Sheila Aparecida Coelho; De Mendonca, Regina Maria Holanda; Innocentini, Lara Maria Alencar Ramos; De Macedo, Leandro Dorigan; Ribeiro-Silva, Alfredo; Abrahao, Aline Correa; Romanach, Mario Jose; Van Heerden, W.F.P. (Willem Francois Petrus); Vargas, Pablo Agustin; Santos-Silva, Alan Roger (Wiley, 2025-02)
    BACKGROUND : Rhabdomyosarcoma (RMS), a rare malignant tumor, frequently affects pediatric patients, with 35%–40% occurring in the head and neck. This study analyzes the clinicopathologic profile of pediatric head and neck ...
  • A radiologic-pathologic study of the histopathologic variants of ameloblastomas and their proliferation indices 
    Smit, Chane; Robinson, Liam; Van Heerden, M.B. (Marlene); Meyer, Pieter Willem Adriaan; Ogunsakin, Ropo Ebenezer; Fonseca, Felipe Paiva; Uys, Andre; Van Heerden, Willem Francois Petrus (Elsevier, 2024-09)
    OBJECTIVES: This study aimed to analyze the clinicoradiologic features and Ki-67 proliferation indices between the histopathologic variants of ameloblastomas (ABs) for possible associations. STUDY DESIGN: The diagnosis ...
  • Radiologic specific growth rate of ameloblastomas : a clinicopathological correlation 
    Smit, Chane; Robinson, Liam; Van Heerden, Marlene B.; Meyer, Pieter Willem Adriaan; Fonseca, Felipe P.; Van Heerden, Willem Francois Petrus; Uys, Andre (Wiley, 2025-01)
    BACKGROUND : The study aimed to assess the radiologic-specific growth rate of ameloblastomas, evaluating potential associations with demographics, radiologic features, histopathologic variants and proliferation indices. ...
  • Head and neck myofibroma : a case series of 16 cases and literature review 
    De Souza, Lucas Lacerda; Fonseca, Felipe Paiva; De Caceres, Cinthia Veronica Bardalez Lopez; Soares, Ciro Dantas; Gurgel, Alberto da Costa; Pontes, Helder Antonio Rebelo; Pontes, Flavia Sirotheau Correa; Paradela, Carolina Almeida; Correia-Neto, Ivan Jose; Kalinin, Yuri; Lopes, Marcio Ajudarte; Santos- Silva, Alan Roger; De Almeida, Oslei Paes; Vargas, Pablo Agustin; Robinson, Liam; Van Heerden, Willem Francois Petrus (Medicina Oral S.L., 2024-11)
    BACKGROUND : This study aimed to explore the clinical, histopathologic, and immunohistochemical characteristics of myofibromas (MFs) affecting the head and neck region. MATERIAL AND METHODS : Formalin-fixed paraffin-embedded ...
  • The relevance of taurodontism in forensic dental age estimation 
    Timme, Maximilian; Smit, Chane; Robinson, Liam; Bernitz, Herman; Guo, Yu-Cheng; Schmeling, Andreas (Elsevier, 2024-09)
    Taurodontism is a dental morphological anomaly characterized by enlarged pulp cavities repositioned towards the apical region of the tooth, coupled with shortened root structures. Molars are commonly affected by ...
  • Advances in nano-delivery of phytochemicals for glioblastoma treatment 
    Ambele, Melvin Anyasi; Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Kungoane, Tsholofelo; Damane, Botle Precious (SpringerOpen, 2024-12)
    Glioblastoma (GBM) is an aggressive brain tumor characterized by cellular and molecular diversity. This diversity presents significant challenges for treatment and leads to poor prognosis. Surgery remains the primary ...
  • Probing the effects of retinoblastoma binding protein 6 (RBBP6) knockdown on the sensitivity of cisplatin in cervical cancer cells 
    Mehta, Harshini; Ambele, Melvin Anyasi; Mokgautsi, Ntlotlang; Moela, Pontsho (MDPI, 2024-04-02)
    Cervical cancer is a major cause of death in women despite the advancement of current treatment modalities. The conventional therapeutic agent, cisplatin (CCDP), is the standard treatment for CC; however, resistance often ...
  • Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells 
    Mellet, Juanita; Hendricks, Candice Laverne; Stivaktas, Voula; Durandt, Chrisna; Ambele, Melvin Anyasi; Pepper, Michael Sean (BMC, 2024-09)
    BACKGROUND : Ex vivo haematopoietic stem/progenitor cell (HSPCs) expansion constitutes an important area of research, and has the potential to improve access to umbilical cord blood (UCB) as a source of stem cells for ...
  • Studying eruption patterns of mandibular third molars for forensic age assessment : introducing current reference data from a population of black South Africans 
    Timme, Maximilian; Viktorov, Jan; Steffens, Laurin; Streeter, Adam; Karch, Andre; Smit, Chane; Robinson, Liam; Bernitz, Herman; Schmeling, Andreas (Springer, 2024-09)
    INTRODUCTION : Evaluation of the eruption of mandibular third molars in orthopantomograms (OPGs) is a method of forensic age assessment. The objective of our study was to provide valid reference data for this trait ...
  • Insights into dental age estimation : introducing multiple regression data from a Black South African population on modified Gustafson's criteria 
    Rudolphi, Fabian; Steffens, Laurin; Shay, Denys; Smit, Chane; Robinson, Liam; Bernitz, Herman; Schmeling, Andreas; Timme, Maximilian (Springer, 2025-01)
    Dental Age Estimation (DAE) is an effective instrument of the rule of law for verifying dubious age claims in living individuals. Once tooth development is complete, only degenerative dental characteristics can be used for ...
  • Surrogate immunohistochemical markers of proliferation and embryonic stem cells in distinguishing Ameloblastoma from ameloblastic carcinoma 
    Robinson, Liam; Smit, Chane; Van Heerden, M.B. (Marlene); Moolla, Haroon; Afrogheh, Amir H.; Opperman, Johan F.; Ambele, Melvin Anyasi; Van Heerden, Willem Francois Petrus (Springer, 2024-10)
    PURPOSE : The current study aimed to investigate the use of surrogate immunohistochemical (IHC) markers of proliferation and stem cells to distinguish ameloblastoma (AB) from ameloblastic carcinoma (AC). METHODS : The ...
  • Effect of 2-methoxyestradiol on mammary tumor initiation and progression 
    Peta, Kimberly Thando; Durandt, Chrisna; Van Heerden, Marlene B.; Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2024-04)
    BACKGROUND : The anti-cancer agent 2-methoxyestradiol (2-ME) has been shown to have anti-proliferative and anti-angiogenic properties. Previously, the effect of 2-ME on early- and late-stage breast cancer (BC) was ...
  • Resolution of apical periodontitis-induced mental nerve paresthesia through nonsurgical endodontic retreatment : a case report 
    Buchanan, Glynn Dale; Smit, Chane; Gamieldien, Mohamed Yasin; ElSheshtawy, Ahmed S. (Elsevier, 2023-07)
    Paresthesia is a potential consequence of unsuccessful root canal treatment. Persistent infection resulting in apical periodontitis may enlarge sufficiently to involve the mental neurovascular bundle. The case presented ...
  • Clinicoradiologic features of ameloblastomas : a single-centre study of 155 cases 
    Smit, Chane; Robinson, Liam; Ker-Fox, Jason; Fonseca, Felipe Paiva; Van Heerden, Willem Francois Petrus; Uys, Andre (Wiley, 2024-02)
    BACKGROUND : The purpose of the current study was to report on the clinical presentation and radiologic features of 155 cases of ameloblastoma (AB), representing a detailed, large, single-centre radiologic study. METHODS ...
  • Ameloblastic carcinoma : a systematic review 
    Robinson, Liam; Abreu, Lucas Guimaraes; Fonseca, Felipe Paiva; Hunter, K.D. (Keith); Ambele, Melvin Anyasi; Van Heerden, Willem Francois Petrus (Wiley, 2024-03)
    BACKGROUND : Ameloblastic carcinoma (AC) is the most common odontogenic malignancy, constituting approximately 30% of cases in this category. Literature is sparse on malignant odontogenic neoplasms, with a large proportion ...
  • Mantle cell lymphoma involving the oral and maxillofacial region : a study of 20 cases 
    Ribeiro Carvalho, Marcus Vinicius; Rodrigues-Fernandes, Carla Isabelly; Lopez de Caceres, Cinthia Veronica Bardalez; Mesquita, Ricardo Alves; Martins, Manoela Domingues; Jose Roman Tager, Elena Maria; Carlos, Roman; Pires, Fabio Ramoa; Robinson, Liam; Van Heerden, Willem Francois Petrus; Valente, Vitor Bonetti; Caldeira Xavier-Junior, Jose Candido; Bernabe, Daniel Galera; Rebelo Pontes, Helder Antonio; Soares, Ciro Dantas; Melo da Costa, Mauro Henrique; Vargas, Pablo Agustin; Fonseca, Felipe Paiva (Elsevier, 2023-01)
    OBJECTIVE : To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region. METHODS : The MCL cases were retrieved from the pathosis database of 6 pathology ...
  • An ulcerative nodule on the dorsal tongue in an 8-year-old boy 
    Giraldo-Roldan, Daniela; Fernandes, Diego Tetzner; Louredo, Brendo Vinicius Rodrigues; Penafort, Paulo Victor Mendes; Roza, Ana Luiza Oliveira Correa; Santos-Silva, Alan Roger; Vargas, Pablo Agustin (Elsevier, 2023-08)
    An otherwise healthy 8-year-old boy was consulted in July 2020, presenting with a 20-day history of a painless tongue growth associated with trauma. According to his parents, the lesion initially appeared as a “blood-filled ...
  • A pigmented nodule in the buccal mucosa 
    Souza, L.L.; Roza, Ana Luiza Oliveira Correa; Leite, Amanda Almeida; Gallagher, Karen Patricia Dominguez; Mariz, Bruno Augusto Linhares Almeida; Santos, Mariana Rates Gonzaga; Santos-Silva, Alan Roger; Vargas, Pablo Agustin (Elsevier, 2023-04)
    A 59-year-old woman presented with a chief complaint of a 1-year history of a slow-growing painless nodule in the left buccal mucosa. She had no past or familial history of head and neck diseases, although she reported ...
  • Human examination and artificial intelligence in cephalometric landmark detection—is AI ready to take over? 
    Indermun, Suvarna; Shaik, Shoayeb; Nyirenda, Clement; Johannes, Keith; Mulder, Riaan (Oxford University Press, 2023-09)
    OBJECTIVES : To compare the precision of two cephalometric landmark identification methods, namely a computer-assisted human examination software and an artificial intelligence program, based on South African data. METHODS ...
  • Fibrodysplasia ossificans progressiva 
    Smit, Chane; Uys, Andre (Wiley, 2023-11)
    Fibrodysplasia ossificans progressiva is a rare condition with an estimated prevalence of one in two million individuals. The condition is characterized by widespread heterotrophic ossification of skeletal muscles and ...